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https://www.readbyqxmd.com/read/29340159/recurrent-lactic-acidosis-and-hypoglycemia-with-inadvertent-metformin-use-a-case-of-look-alike-pills
#1
Tess Jacob, Renee Garrick, Michael D Goldberg
Metformin is recommended as the first-line agent for the treatment of type 2 diabetes. Although this drug has a generally good safety profile, rare but potentially serious adverse effects may occur. Metformin-associated lactic acidosis, although very uncommon, carries a significant risk of mortality. The relationship between metformin accumulation and lactic acidosis is complex and is affected by the presence of comorbid conditions such as renal and hepatic disease. Plasma metformin levels do not reliably correlate with the severity of lactic acidosis...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29334790/cognitive-work-hardening-for-return-to-work-following-depression-an-intervention-study-le-r%C3%A3-entra%C3%A3-nement-cognitif-au-travail-pour-favoriser-le-retour-au-travail-%C3%A3-la-suite-d-une-d%C3%A3-pression-%C3%A3-tude-d-intervention
#2
Adeena Wisenthal, Terry Krupa, Bonnie H Kirsh, Rosemary Lysaght
BACKGROUND: Work absences due to depression are prevalent; however, few interventions exist to address the return-to-work challenges following a depressive episode. PURPOSE: This mixed-methods study aimed to (a) evaluate the effectiveness of cognitive work hardening in preparing people with depression to return to work and (b) identify key elements of the intervention. METHOD: A single group ( n = 21) pretest-posttest study design was used incorporating self-report measures (Work Ability Index, Multidimensional Assessment of Fatigue, Beck Depression Inventory II) with interviews at intervention completion and at 3-month follow-up...
January 1, 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29330273/rheumatoid-disease-an-unusual-cause-of-relapsing-meningoencephalitis
#3
Sian K Alexander, Maria Di Cicco, Ute Pohl, Alberto Cifelli
A 73-year-old man presented with three episodes of dysphasia and disinhibited behaviour, a single seizure and transient ischaemic attack-like events characterised by right arm and/or leg weakness. These episodes were separated by month-long asymptomatic intervals. Medical history included rheumatoid arthritis, which was clinically quiescent on leflunomide.Repeated cerebrospinal fluid examination showed a persistent lymphocytosis with mildly reduced glucose and elevated protein; oligoclonal bands and viral PCR were negative...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29329913/predicting-extubation-outcomes-a-model-incorporating-heart-rate-characteristics-index
#4
Nitin Goel, Mallinath Chakraborty, William John Watkins, Sujoy Banerjee
OBJECTIVE: To test the hypothesis that in neonates on mechanical ventilation, heart rate characteristics index (HRCi) can be combined with a clinical model for predicting extubation outcomes in neonates. STUDY DESIGN: HRCi and clinical data for all intended intubation-extubation events (episodes) were retrospectively analyzed between June 2014 and January 2015. Each episode started 6 hours pre-extubation or at the time of primary intubation if ventilation duration was shorter than 6 hours (baseline)...
January 10, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29329498/treatment-outcomes-of-acute-bipolar-depressive-episode-with-psychosis
#5
Marco Antonio Caldieraro, Steven Dufour, Louisa G Sylvia, Keming Gao, Terence A Ketter, William V Bobo, Samantha Walsh, Jessica Janos, Mauricio Tohen, Noreen A Reilly-Harrington, Susan L McElroy, Richard C Shelton, Charles L Bowden, Thilo Deckersbach, Andrew A Nierenberg
BACKGROUND: The impact of psychosis on the treatment of bipolar depression is remarkably understudied. The primary aim of this study was to compare treatment outcomes of bipolar depressed individuals with and without psychosis. The secondary aim was to compare the effect of lithium and quetiapine, each with adjunctive personalized treatments (APTs), in the psychotic subgroup. METHODS: We assessed participants with DSM-IV bipolar depression included in a comparative effectiveness study of lithium and quetiapine with APTs (the Bipolar CHOICE study)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29326362/-18f-pbr111-pet-imaging-in-healthy-controls-and-schizophrenia-test-retest-reproducibility-and-quantification-of-neuroinflammation
#6
Julie Ottoy, Livia De Picker, Jeroen Verhaeghe, Steven Deleye, Leonie Wyffels, Lauren Kosten, Bernard Sabbe, Violette Coppens, Maarten Timmers, Luc Van Nueten, Sarah Ceyssens, Sigrid Stroobants, Manuel Morrens, Steven Staelens
Activated microglia express the translocator protein (TSPO) on the outer mitochondrial membrane. 18F-PBR111 is a second-generation positron emission tomography (PET) ligand that specifically binds the TSPO, allowing in-vivo visualization and quantification of neuroinflammation. The aim of this study is to evaluate if the test-retest variability of 18F-PBR111 in healthy controls is acceptable to detect a psychosis-associated neuroinflammatory signal in schizophrenia. Methods: Dynamic 90-min 18F-PBR111 scans were obtained in 17 healthy male controls (HC) and 11 male schizophrenia patients during a psychotic episode (SP)...
January 11, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29322308/quality-of-life-of-patients-with-type-1-diabetes-mellitus-using-insulin-analog-glargine-compared-with-nph-insulin-a-systematic-review-and-policy-implications
#7
REVIEW
Paulo H R F Almeida, Thales B C Silva, Francisco de Assis Acurcio, Augusto A Guerra Júnior, Vania E Araújo, Leonardo M Diniz, Brian Godman, Alessandra M Almeida, Juliana Alvares
INTRODUCTION: Insulin analog glargine (GLA) has been available as one of the therapeutic options for patients with type 1 diabetes mellitus to enhance glycemic control. Studies have shown that a decrease in the frequency of hypoglycemic episodes improves the quality of life (QoL) of diabetic patients. However, there are appreciable acquisition cost differences between different insulins. Consequently, there is a need to assess their impact on QoL to provide future guidance to health authorities...
January 10, 2018: Patient
https://www.readbyqxmd.com/read/29317609/apolipoprotein-e-apoe-%C3%AE%C2%B54-and-cognitive-decline-over-the-adult-life-course
#8
Mark James Rawle, Daniel Davis, Rebecca Bendayan, Andrew Wong, Diana Kuh, Marcus Richards
We tested the association between APOE-ε4 and processing speed and memory between ages 43 and 69 in a population-based birth cohort. Analyses of processing speed (using a timed letter search task) and episodic memory (a 15-item word learning test) were conducted at ages 43, 53, 60-64 and 69 years using linear and multivariable regression, adjusting for gender and childhood cognition. Linear mixed models, with random intercepts and slopes, were conducted to test the association between APOE and the rate of decline in these cognitive scores from age 43 to 69...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29295687/the-differential-contributions-of-visual-imagery-constructs-on-autobiographical-thinking
#9
Cagla Aydin
There is a growing theoretical and empirical consensus on the central role of visual imagery in autobiographical memory. However, findings from studies that explore how individual differences in visual imagery are reflected on autobiographical thinking do not present a coherent story. One reason for the mixed findings was suggested to be the treatment of visual imagery as an undifferentiated construct while evidence shows that there is more than one type of visual imagery. The present study investigates the relative contributions of different imagery constructs; namely, object and spatial imagery, on autobiographical memory processes...
February 2018: Memory
https://www.readbyqxmd.com/read/29289675/dissociation-of-immediate-and-delayed-effects-of-emotional-arousal-on-episodic-memory
#10
Dirk Schümann, Janine Bayer, Deborah Talmi, Tobias Sommer
Emotionally arousing events are usually better remembered than neutral ones. This phenomenon is in humans mostly studied by presenting mixed lists of neutral and emotional items. An emotional enhancement of memory is observed in these studies often already immediately after encoding and increases with longer delays and consolidation. A large body of animal research showed that the more efficient consolidation of emotionally arousing events is based on an activation of the central noradrenergic system and the amygdala (Modulation Hypothesis; Roozendaal & McGaugh, 2011)...
December 28, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29289475/center-effects-and-peritoneal-dialysis-peritonitis-outcomes-analysis-of-a-national-registry
#11
Htay Htay, Yeoungjee Cho, Elaine M Pascoe, Darsy Darssan, Annie-Claire Nadeau-Fredette, Carmel Hawley, Philip A Clayton, Monique Borlace, Sunil V Badve, Kamal Sud, Neil Boudville, Stephen P McDonald, David W Johnson
BACKGROUND: Peritonitis is a common cause of technique failure in peritoneal dialysis (PD). Dialysis center-level characteristics may influence PD peritonitis outcomes independent of patient-level characteristics. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Using Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) data, all incident Australian PD patients who had peritonitis from 2004 through 2014 were included...
December 28, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29282832/hiv-prevalence-among-first-presentation-psychotic-patients
#12
A Laher, N Ariefdien, Y Etlouba
OBJECTIVES: First-episode psychosis is a frequent emergency department (ED) presentation that may potentially be secondary to an underlying life-threatening HIV-related condition. The aim of this study was to determine the prevalence of HIV infection in patients presenting with a first episode of psychosis. METHODS: Medical records of 159 consecutive African, Asian, White and mixed ethnicity patients presenting to a tertiary academic hospital ED with a first episode of psychotic features were prospectively reviewed...
December 28, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29275445/issues-on-the-diagnosis-and-etiopathogenesis-of-mood-disorders-reconsidering-dsm-5
#13
REVIEW
Kazuyoshi Ogasawara, Yukako Nakamura, Hiroyuki Kimura, Branko Aleksic, Norio Ozaki
The authors present a narrative review from the diagnostic and nosologic viewpoints of mood disorders (bipolar and depressive ones) by revisiting the revision from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, Text Revision to DSM-5, including the following: the separation of the bipolar and depressive sections; the addition of increased energy and continuation of symptoms to the hypo/manic criteria; the elimination of mixed episodes; the creation of new categories and specifiers ("other specified bipolar and related disorder", "disruptive mood dysregulation disorder", "with anxious distress", "with mixed features", "with peripartum onset"); the categorization of hypo/manic episodes during antidepressant treatment into bipolar disorder; the elimination of the "bereavement exclusion"; the ambiguous separation between bipolar I and II; the insufficient distinction between "other specified bipolar and related disorders" and major depressive disorder; the differentiation regarding borderline personality disorder; agitation; premenstrual dysphoric disorder; and society and psychiatry...
December 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29273665/crowd-medical-services-in-the-english-football-league-remodelling-the-team-for-the-21st-century-using-a-realist-approach
#14
Alison Leary, Anthony Kemp, Peter Greenwood, Nick Hart, James Agnew, John Barrett, Geoffrey Punshon
OBJECTIVES: To evaluate the new model of providing care based on demand. This included reconfiguration of the workforce to manage workforce supply challenges and meet demand without compromising the quality of care. DESIGN: Currently the Sports Ground Safety Authority recommends the provision of crowd medical cover at English Football League stadia. The guidance on provision of services has focused on extreme circumstances such as the Hillsborough disaster in 1989, while the majority of demand on present-day services is from patients with minor injuries, exacerbations of injuries and pre-existing conditions...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29262418/gastro-oesophageal-reflux-and-apnoea-is-there-a-temporal-relationship
#15
Thomas Rossor, Gwendolyn Andradi, Kamal Ali, Ravindra Bhat, Anne Greenough
BACKGROUND: Gastro-oesophageal reflux (GOR) and apnoea are common in infants; whether there is a causal relationship is controversial. OBJECTIVES: To determine whether there was a temporal relationship between GOR and apnoea, in particular, the frequency of obstructive apnoeas and if the frequency of GOR episodes correlated with apnoea frequency when maturity at testing was taken into account. METHODS: Polysomnography and pH/multichannel intraluminal impedance (MII) studies were performed...
December 21, 2017: Neonatology
https://www.readbyqxmd.com/read/29261736/randomized-clinical-trial-to-evaluate-the-effect-of-fecal-microbiota-transplant-for-initial-clostridium-difficile-infection-in-intestinal-microbiome
#16
Adrián Camacho-Ortiz, Eva María Gutiérrez-Delgado, Jose F Garcia-Mazcorro, Soraya Mendoza-Olazarán, Adrián Martínez-Meléndez, Laura Palau-Davila, Simon D Baines, Héctor Maldonado-Garza, Elvira Garza-González
OBJECTIVE: The aim of this study was to evaluate the impact of fecal donor-unrelated donor mix (FMT-FURM) transplantation as first-line therapy for C. difficile infection (CDI) in intestinal microbiome. METHODS: We designed an open, two-arm pilot study with oral vancomycin (250mg every 6 h for 10-14 days) or FMT-FURM as treatments for the first CDI episode in hospitalized adult patients in Hospital Universitario "Dr. Jose Eleuterio Gonzalez". Patients were randomized by a closed envelope method in a 1: 1 ratio to either oral vancomycin or FMT-FURM...
2017: PloS One
https://www.readbyqxmd.com/read/29261647/the-detection-of-cryptic-plasmodium-infection-among-villagers-in-attapeu-province-lao-pdr
#17
Moritoshi Iwagami, Sengdeuane Keomalaphet, Phonepadith Khattignavong, Pheovaly Soundala, Lavy Lorphachan, Emilie Matsumoto-Takahashi, Michel Strobel, Daniel Reinharz, Manisack Phommasansack, Bouasy Hongvanthong, Paul T Brey, Shigeyuki Kano
BACKGROUND: Although the malaria burden in the Lao PDR has gradually decreased, the elimination of malaria by 2030 presents many challenges. Microscopy and malaria rapid diagnostic tests (RDTs) are used to diagnose malaria in the Lao PDR; however, some studies have reported the prevalence of sub-microscopic Plasmodium infections or asymptomatic Plasmodium carriers in endemic areas. Thus, highly sensitive detection methods are needed to understand the precise malaria situation in these areas...
December 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29250869/stepping-stones-to-resiliency-following-a-community-based-two-generation-canadian-preschool-programme
#18
Carla S Ginn, Karen M Benzies, Leslie Anne Keown, Shelley Raffin Bouchal, Wilfreda E Billlie Thurston
Early intervention programmes are designed to address complex inequities for Canadian families living with low income, affecting social relationships, well-being and mental health. However, there is limited understanding of resiliency and change in families living with low income over time. We conducted a mixed methods study with recent immigrant, other Canadian-born, and Aboriginal families living with low income, who attended a two-generation preschool programme (CUPS One World) between 2002 and 2008. The aim of this study was to develop an understanding of the processes of change...
December 18, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29246224/optimizing-clinical-and-organizational-practice-in-cancer-survivor-transitions-between-specialized-oncology-and-primary-care-teams-a-realist-evaluation-of-multiple-case-studies
#19
Dominique Tremblay, Catherine Prady, Karine Bilodeau, Nassera Touati, Maud-Christine Chouinard, Martin Fortin, Isabelle Gaboury, Jean Rodrigue, Marie-France L'Italien
BACKGROUND: Cancer is now viewed as a chronic disease, presenting challenges to follow-up and survivorship care. Models to shift from haphazard, suboptimal and fragmented episodes of care to an integrated cancer care continuum must be developed, tested and implemented. Numerous studies demonstrate improved care when follow-up is assured by both oncology and primary care providers rather than either group alone. However, there is little data on the roles assumed by specialized oncology teams and primary care providers and the extent to which they work together...
December 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29239075/risk-of-recurrence-after-a-single-manic-or-mixed-episode-a-systematic-review-and-meta-analysis
#20
REVIEW
Lars Vedel Kessing, Per Kragh Andersen, Maj Vinberg
OBJECTIVES: For the first time to estimate the risk of recurrence among patients with a single manic/mixed episode by systematically reviewing prior studies on cohorts of adults, and cohorts of children and adolescents, respectively. METHODS: A systematic literature search up to August 2017 was carried out including studies in which < 25% of the participants were estimated to have had a mood episode that required pharmacological treatment prior to the index manic or mixed episode at inclusion...
December 14, 2017: Bipolar Disorders
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