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https://www.readbyqxmd.com/read/29028590/efficacy-and-tolerability-of-lisdexamfetamine-as-an-antidepressant-augmentation-strategy-a-meta-analysis-of-randomized-controlled-trials
#1
Peter Giacobbe, Uros Rakita, Raymond Lam, Roumen Milev, Sidney H Kennedy, Roger S McIntyre
BACKGROUND: Psychostimulants have been used in the treatment of depression, with mixed results. This meta-analysis examines the efficacy and tolerability of the stimulant Lisdexamfetamine (LDX) as an add-on strategy in those with MDD who have failed to respond to an antidepressant. METHOD: Randomized control trials were identified and extracted from Pubmed; Web of Science; PsychINFO; and Cochrane Library. The efficacy of LDX was evaluated using Hedges' g and Odds Ratio, whereas Risk Difference was used to assess the safety and tolerability of LDX...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29027086/the-association-between-somatic-and-psychological-discomfort-and-health-related-quality-of-life-according-to-the-elderly-and-non-elderly
#2
Hyeon-Sook Lee, Siwoo Lee, Sohee Park, Younghwa Baek, Ji-Hye Youn, Dan Bee Cho, Jung-Hyun Jin, Aesun Shin, Sue K Park, Keon Wook Kang, Young-Khi Lim, Chul Hwan Kang, Keun-Young Yoo, Kwang-Pil Ko
PURPOSE: Symptoms and discomfort are common complaints in primary care settings. It has been postulated that the physical symptoms are informative index in estimating Health-related quality of life (HRQOL). Thus, we conducted a community-based cross-sectional study to assess the relationship between somatic and psychological discomfort and HRQOL in elderly and non-elderly people. METHODS: A total of 2467 participants were recruited in 2013 from a population of 17,066 rural residents aged 20 or older...
October 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29025483/depressive-symptoms-and-hazardous-harmful-alcohol-use-are-prevalent-and-correlate-with-stigma-among-tb-hiv-patients-in-lesotho
#3
E Hayes-Larson, Y Hirsch-Moverman, S Saito, K Frederix, B Pitt, L Maama-Maime, A A Howard
SETTING: Limited data exist on the prevalence and correlates, including stigma, of mental health conditions, including depressive symptoms and alcohol use, among patients co-infected with tuberculosis (TB) and the human immunodeficiency virus (HIV) in sub-Saharan Africa, despite their negative impact on health outcomes. OBJECTIVE: To assess the prevalence and correlates of depressive symptoms and hazardous/harmful alcohol use among TB-HIV patients in the Start TB patients on ART and Retain on Treatment (START) study...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29023339/managerial-quality-and-risk-of-depressive-disorders-among-danish-eldercare-workers-a-multi-level-cohort-study
#4
Reiner Rugulies, Louise M Jakobsen, Ida E H Madsen, Vilhelm Borg, Isabella G Carneiro, Birgit Aust
OBJECTIVE: To examine whether low managerial quality predicts risk of depressive disorders. METHODS: Using multilevel mixed-effects logistic regression analyses we examined the prospective association of individual-level and workplace-mean managerial quality with onset of depressive disorders among 5,244 eldercare workers from 274 workplaces during 20 months follow-up. RESULTS: Low managerial quality predicted onset of depressive disorders in both the individual-level (OR = 1...
October 11, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29022251/genetic-and-environmental-relationships-between-eating-behavior-and-symptoms-of-anxiety-and-depression
#5
Yun-Mi Song, Kayoung Lee, Joohon Sung
PURPOSE: To assess gender-specific genetic and environmental correlations between depressive and anxiety symptoms, and concurrent and follow-up eating behavior in Korean twins and their family members. METHODS: Center for Epidemiological Studies Depression Scale and State-Trait Anxiety Inventory were used to measure depressive and anxiety symptoms in subjects. To assess concurrent and follow-up relationships of the symptoms with eating behavior domains (restrained, emotional, and external eating), the Dutch Eating Behavior Questionnaire was administered to 2359 subjects at baseline (men, 48...
October 11, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29021011/intimate-partner-violence-victimization-and-cognitive-function-in-a-mixed-sex-epidemiological-sample-of-urban-adults
#6
Megan R Williams, Christopher M Murphy, Gregory A Dore, Michele K Evans, Alan B Zonderman
Intimate partner violence (IPV) victimization is associated with a wide range of mental and physical health problems, but little is known about the effect of IPV on cognitive decline. Previous research suggests an association between IPV victimization and cognitive dysfunction, but the few studies that have examined this phenomenon were cross-sectional in design and focused only on female victims of IPV. This study examined cognitive function over time among a diverse population of both male and female victims of IPV...
October 11, 2017: Violence and Victims
https://www.readbyqxmd.com/read/29019642/spine-conditions-occupational-spine-conditions
#7
Marc A Childress
Neck and back conditions have significant effects on employee health and productivity. More than $7 billion in lost revenue in the United States annually can be attributed to workplace back pain among employees ages 40 to 65 years. According to the Bureau of Labor Statistics, in 2012 back pain was the most prevalent musculoskeletal condition resulting in workplace absenteeism. The incidence of these conditions is higher among individuals in certain professions, such as bus drivers, police officers, and correctional officers...
October 2017: FP Essentials
https://www.readbyqxmd.com/read/29018074/organisational-and-extraorganisational-determinants-of-volume-of-service-delivery-by-english-community-pharmacies-a-cross-sectional-survey-and-secondary-data-analysis
#8
Mark Hann, Ellen I Schafheutle, Fay Bradley, Rebecca Elvey, Andrew Wagner, Devina Halsall, Karen Hassell, Sally Jacobs
OBJECTIVES: This study aimed to identify the organisational and extraorganisational factors associated with existing variation in the volume of services delivered by community pharmacies. DESIGN AND SETTING: Linear and ordered logistic regression of linked national data from secondary sources-community pharmacy activity, socioeconomic and health need datasets-and primary data from a questionnaire survey of community pharmacies in nine diverse geographical areas in England...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29017594/depression-in-medical-students-insights-from-a-longitudinal-study
#9
Vanessa Silva, Patrício Costa, Inês Pereira, Ricardo Faria, Ana P Salgueira, Manuel J Costa, Nuno Sousa, João J Cerqueira, Pedro Morgado
BACKGROUND: Factors associated with depression of medical students are poorly understood. The purpose of this study is to determine the prevalence of depression in medical students, its change during the course, if depression persists for affected students, what are the factors associated with depression and how these factors change over time. METHODS: A prospective, longitudinal observational study was conducted at the Medical School of the University of Minho, Portugal, between academic years 2009-2010 to 2012-2013...
October 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29017067/clinically-relevant-response-and-remission-outcomes-in-cariprazine-treated-patients-with-bipolar-i-disorder
#10
Willie Earley, Suresh Durgam, Kaifeng Lu, Adam Ruth, György Németh, István Laszlovszky, Lakshmi N Yatham
BACKGROUND: Rates of response and remission are measures that endorse the clinical significance of treatment. Cariprazine is FDA approved for the acute treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Post hoc analyses of pooled data from 3 pivotal trials of cariprazine in manic/mixed episodes associated with bipolar I disorder were conducted to investigate the effect of cariprazine on various criteria of response and remission. METHODS: The constituent studies were 3-week randomized, double-blind, placebo-controlled, multicenter, parallel-group phase II/III studies in adult patients (age 18-65 years) with bipolar I disorder (NCT00488618, NCT01058096, NCT01058668)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29016824/nlrp3-inflammasome-contributes-to-lipopolysaccharide-induced-depressive-like-behaviors-via-indoleamine-2-3-dioxygenase-induction
#11
Seon-A Jeon, Eunju Lee, Inhwa Hwang, Boyoung Han, Sangjun Park, Seunghwan Son, Jungmin Yang, Sujeong Hong, Chul Hoon Kim, Junghyun Son, Je-Wook Yu
Background: Inflammation may play a significant role in the pathogenesis of depression, although the molecular target for the treatment of inflammation-mediated depressive symptoms remains to be elucidated. Recent studies have implicated the NLRP3 inflammasome in various psychiatric disorders, including depression. However, the underlying mechanism by which NLRP3 inflammasome activation mediates the progression of depressive-like behaviors remains poorly understood. Methods: We examined whether NLRP3 deficiency influenced depressive-like behaviors and cerebral inflammation following systemic administration of lipopolysaccharide in mice...
July 31, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29016822/platelet-derived-growth-factor-as-an-antidepressant-treatment-selection-biomarker-higher-levels-selectively-predict-better-outcomes-with-bupropion-ssri-combination
#12
Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Madhukar H Trivedi
Background: Platelet derived growth factor is integral to maintenance of blood brain barrier, increases in response to blood brain barrier disruption, and may reflect neuroinflammation. Based on previous reports of better outcomes with dopaminergic antidepressants in depressed patients with elevated inflammatory biomarkers, we hypothesize that elevated peripheral platelet derived growth factor levels can serve as a powerful biomarker for selecting dopaminergic antidepressants. Methods: Platelet derived growth factor, basic fibroblast growth factor, and granulocyte colony stimulating factor were measured as part of Bioplex Pro human cytokine 27-plex kit in participants of the Combining Medications to Enhance Depression Outcomes trial who provided baseline plasma (n=166) and were treated with either bupropion-plus-escitalopram, escitalopram-plus-placebo, or venlafaxine-plus-mirtazapine...
July 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28992033/veal-calf-health-on-the-day-of-arrival-at-growers-in-ohio
#13
J Pempek, D Trearchis, M Masterson, G Habing, K Proudfoot
Veal calves are at high risk for disease and mortality in early life. Calves face a number of stressors before arriving at the grower, including long transport times, which may contribute to poor health. Our objectives were to 1) estimate the prevalence of poor health outcomes in veal calves on arrival at growers in Ohio; 2) determine risk factors for health outcomes on arrival, including BW and auction site (spread across 5 states in the Northeastern United States); and 3) determine if health outcomes on arrival predict early mortality...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28989706/standard-12-month-dialectical-behaviour-therapy-for-adults-with-borderline-personality-disorder-in-a-public-community-mental-health-setting
#14
Daniel Flynn, Mary Kells, Mary Joyce, Paul Corcoran, Conall Gillespie, Catalina Suarez, Mareike Weihrauch, Padraig Cotter
BACKGROUND: Dialectical behaviour therapy (DBT) is noted to be an intervention with a growing body of evidence that demonstrates its efficacy in treating individuals diagnosed with borderline personality disorder (BPD). Evidence for the effectiveness of DBT in publicly funded community mental health settings is lacking however. No study to our knowledge has been published on the effectiveness of a 12 month standard DBT programme without adaptations for individuals with BPD in a publicly funded community mental health setting and no study has included data across multiple time-points...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28989099/astroglial-correlates-of-neuropsychiatric-disease-from-astrocytopathy-to-astrogliosis
#15
REVIEW
Ronald Kim, Kati L Healey, Marian T Sepulveda-Orengo, Kathryn J Reissner
Complex roles for astrocytes in health and disease continue to emerge, highlighting this class of cells as integral to function and dysfunction of the nervous system. In particular, escalating evidence strongly implicates a range of changes in astrocyte structure and function associated with neuropsychiatric diseases including major depressive disorder, schizophrenia, and addiction. These changes can range from astrocytopathy, degeneration, and loss of function, to astrogliosis and hypertrophy, and can be either adaptive or maladaptive...
October 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28988944/efficacy-of-adding-nutritional-supplements-in-unipolar-depression-a-systematic-review-and-meta-analysis
#16
REVIEW
Cora Schefft, Laura L Kilarski, Tom Bschor, Stephan Köhler
In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc. A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment ("add-on" OR "adjunctive" OR "augmentation")...
October 5, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28986416/subjective-cognitive-decline-and-%C3%AE-amyloid-burden-predict-cognitive-change-in-healthy-elderly
#17
Jacob W Vogel, Monika Varga Doležalová, Renaud La Joie, Shawn M Marks, Henry D Schwimmer, Susan M Landau, William J Jagust
OBJECTIVE: To assess in a longitudinal study whether subjective cognitive decline (SCD) and brain β-amyloid (Aβ) contribute unique information to cognitive decline. METHODS: One hundred thirty-six healthy elderly from the Berkeley Aging Cohort Study were followed up for a mean of 4 years. SCD and affective measures were generated from the Geriatric Depression Scale (GDS) with factor analysis on data from a larger set of 347 healthy, nondepressed (GDS <11) elderly individuals...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28984158/magnitude-and-sources-of-distress-in-mid-life-adults-with-chronic-medical-illness-an-exploratory-mixed-methods-analysis
#18
Elizabeth N Madva, Federico Gomez-Bernal, Rachel A Millstein, Christopher M Celano, Elyse R Park, Carol A Mastromauro, Ariana M Albanese, Eleanor E Beale, Jeff C Huffman
Most mid-life adults have at least one chronic medical condition (CMC) and are at risk for developing additional CMCs. Stressors specific to this life stage may contribute to CMC development by hindering healthy behaviors. The goal of this study was to compare sources and intensity of distress, as they relate to health behaviors, between mid-life and non-mid-life adults with CMCs. We utilized a mixed-methods approach by analyzing quantitative self-report measures of psychiatric symptoms and psychological well-being, with in-depth, semi-structured qualitative interviews to identify sources of stress in three cohorts of patients with CMCs (heart failure, type 2 diabetes, and coronary artery disease)...
October 6, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28984151/testing-the-2%C3%A2-%C3%A3-%C3%A2-2-model-of-perfectionism-in-ecuadorian-adolescent-population
#19
María Vicent, Cándido J Inglés, Carolina Gonzálvez, Ricardo Sanmartín, Virginia Narcisa Ortega-Sandoval, José Manuel García-Fernández
This study aimed to test the 2 × 2 model of dispositional perfectionism in an Ecuadorian sample of 1562 students aged between 12 and 17 years ( M = 14.83 years, standard deviation  = 1.86 years). The Child and Adolescent Perfectionism Scale and the brief 21-item version of the Depression Anxiety Stress Scales were used. Cluster analysis revealed four profiles: Pure Self-Oriented Perfectionism, Pure Socially Prescribed Perfectionism, Mixed Perfectionism, and Non-perfectionism. Mixed Perfectionism and Non-perfectionism obtained, respectively, the highest and lowest scores in anxiety, depression, and stress...
October 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28980599/-the-influence-of-memoplant-monotherapy-on-the-dizziness
#20
A I Kryukov, N L Kunel'skaya, E S Yanyushkina, E V Baybakova, M A Chugunova, M V Tardov, Z O Zaoeva, G N Izotova
The objective of the present work was to study the influence of the dry extract from the leaves of Ginkgo biloba EGb 761 (used as monotherapy at a dose of 120 mg twice daily during 4 months) on the vestibular function of the patients presenting with cochleovestibular pathology of peripheral and mixed genesis. We present the results obtained by the objective and subjective methods for the evaluation of the vestibular function as well as the neurological and psychoemotional state of the 40 patients that was carried out during the four months of memoplant monotherapy...
2017: Vestnik Otorinolaringologii
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