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epilepsy update

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https://www.readbyqxmd.com/read/27888514/the-burden-of-premature-mortality-of-epilepsy-in-high-income-countries-a-systematic-review-from-the-mortality-task-force-of-the-international-league-against-epilepsy
#1
REVIEW
David J Thurman, Giancarlo Logroscino, Ettore Beghi, W Allen Hauser, Dale C Hesdorffer, Charles R Newton, Fulvio Alexandre Scorza, Josemir W Sander, Torbjörn Tomson
Since previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy...
November 26, 2016: Epilepsia
https://www.readbyqxmd.com/read/27861775/prevalence-of-juvenile-myoclonic-epilepsy-in-people-30-years-of-age-a-population-based-study-in-norway
#2
Marte Syvertsen, Morten Kristoffer Hellum, Gunnar Hansen, Astrid Edland, Karl Otto Nakken, Kaja Kristine Selmer, Jeanette Koht
OBJECTIVE: Despite juvenile myoclonic epilepsy (JME) being considered one of the most common epilepsies, population-based prevalence studies of JME are lacking. Our aim was to estimate the prevalence of JME in a Norwegian county, using updated diagnostic criteria. METHODS: This was a cross-sectional study, based on reviews of the medical records of all patients with a diagnosis of epilepsy at Drammen Hospital in the period 1999-2013. The study population consisted of 98,152 people <30 years of age...
November 16, 2016: Epilepsia
https://www.readbyqxmd.com/read/27829458/retrospective-epidemiological-study-of-canine-epilepsy-in-japan-using-the-international-veterinary-epilepsy-task-force-classification-2015-2003-2013-etiological-distribution-risk-factors-survival-time-and-lifespan
#3
Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi, Michio Fujita
BACKGROUND: Epilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A number of reports on canine epilepsy have been published, reflecting in part updated proposals from the human epilepsy organization, the International League Against Epilepsy. In 2015, the International Veterinary Epilepsy Task Force (IVETF) published a consensus report on the classification and definition of canine epilepsy...
November 9, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27816354/invasive-epilepsy-surgery-evaluation
#4
Stjepana Kovac, Vejay N Vakharia, Catherine Scott, Beate Diehl
Intracranial EEG (iEEG) recordings are widely used for the work up of pharmacoresistant epilepsy. Different iEEG recording techniques namely subdural grids, strips, depth electrodes and stereoencephalography (SEEG) are available with distinct limitations and advantages. Epilepsy centres mastering multiple techniques apply them in an individualised patient approach. These tools are used to map the seizure onset zone which is pivotal in approximating the epileptogenic zone, i.e. the zone which is indispensable for the generation of seizures and when resected will render the patient seizure free...
October 21, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27777862/availability-and-cost-of-major-and-first-line-antiepileptic-drugs-a-comprehensive-evaluation-in-the-capital-of-madagascar
#5
Jeremy Jost, Adeline Raharivelo, Voa Ratsimbazafy, Mandy Nizard, Emilie Auditeau, Charles R Newton, Pierre-Marie Preux
BACKGROUND: The prevalence of epilepsy is high in Madagascar (23.5/1000), as is the treatment gap (estimated at 92 %). The health system of the country is underfunded; some AEDs are used, and the national drug policy does not encourage price regulation or the administration of generic agents. We conducted a cross-sectional study to assess the availability and cost of solid oral AED formulations in Antananarivo, capital of Madagascar. Data were gathered from all officially registered pharmacies (according to the drug agency list, updated in 2015) by means of telephone interviews lasting no more than 10 min and conducted by a native Malagasy speaker...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27774576/neurocysticercosis-a-review-on-status-in-india-management-and-current-therapeutic-interventions
#6
Rumana Ahmad, Tahmeena Khan, Bilal Ahmad, Aparna Misra, Anil K Balapure
Tapeworms (cestodes) are segmented flatworms responsible for causing diseases that may prove fatal and difficult to treat in the absence of proper treatment and efficient drugs. Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a major contributor to epilepsy caused by the metacestode (larva) of the human tapeworm Taenia solium, characterized by a range of pathological symptoms including epileptic seizures, headaches, and hydrocephalus. Cysticercosis is considered as a "biological imprint" of the socioeconomic development of a community in general and a country in particular...
October 24, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27766590/an-updated-overview-on-therapeutic-drug-monitoring-of-recent-antiepileptic-drugs
#7
REVIEW
Shery Jacob, Anroop B Nair
Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs), therapeutic drug monitoring (TDM) can make a significant contribution to the field of epilepsy. The measurement and interpretation of serum drug concentrations can be of benefit in the treatment of uncontrollable seizures and in cases of clinical toxicity; it can aid in the individualization of therapy and in adjusting for variable or nonlinear pharmacokinetics; and can be useful in special populations such as pregnancy. This review examines the potential for TDM of newer AEDs such as eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, perampanel, pregabalin, rufinamide, retigabine, stiripentol, tiagabine, topiramate, vigabatrin, and zonisamide...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27744461/epilepsy-services-in-saudi-arabia-quantitative-assessment-and-identification-of-challenges
#8
Saud M Alfayez, Bandar N Aljafen
OBJECTIVE: To assess the epilepsy services and identify the challenges in hospitals without epilepsy monitoring units (EMUs). In addition, comparisons between governmental and private sectors, as well as between regions, are to be performed. METHODS: A cross sectional study conducted using an online questionnaire distributed to the secondary and tertiary hospitals without EMUs throughout the Kingdom of Saudi Arabia (KSA). The study was conducted from September 2013 to September 2015 and regular updates from all respondents were constantly made...
October 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/27687021/lupus-antiphospholipid-syndrome-and-epilepsy-an-update
#9
A Rosati, R Guerrini, R Cimaz
No abstract text is available yet for this article.
September 29, 2016: Lupus
https://www.readbyqxmd.com/read/27683026/-childhood-absence-epilepsy-an-update
#10
P Garzon, L Lemelle, S Auvin
Childhood absence epilepsy (CAE) is a common pediatric epilepsy syndrome accounting for 10% of all pediatric epilepsies. The aim of this review is to provide an updated overview of this epilepsy syndrome to pediatricians. Most of the patients can be initially managed in private practice or in general pediatric settings. Absence seizures are the only seizure type observed at the time of diagnosis in these patients. An electroencephalogram recording and a clinical evaluation lead to the diagnosis. The underlying mechanisms are not yet fully understood...
September 24, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27659822/an-integrative-molecular-and-genomic-analysis-of-pediatric-hemispheric-low-grade-gliomas-an-update
#11
Alvaro Lassaletta, Michal Zapotocky, Eric Bouffet, Cynthia Hawkins, Uri Tabori
Hemispheric low-grade gliomas account for the second most common location in pediatric low-grade gliomas (PLGGs) after the cerebellum. The pathological spectrum includes gangliogliomas, dysembryoplastic neuroepithelial tumors (DNETs), diffuse astrocytomas, pilocytic astrocytomas, and pleomorphic xanthoastrocytomas (PXAs), among others. Clinically, hemispheric PLGGs represent a well-recognized cause of intractable epilepsy in children and adolescents. With an excellent long-term outcome, surgery remains the cornerstone and patients with gross total resection typically do not need any further therapies...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27648177/temporal-plus-epilepsy-anatomo-electroclinical-subtypes
#12
René Andrade-Machado, Vanessa Benjumea-Cuartas
Background: Mesial temporal lobe epilepsy (TLE) is a remediable epileptic syndrome. About 40% of patients continue to have seizures after standard temporal lobectomy. It has been suggested that some of these patients could actually suffer from a more complex epileptogenic network. Because a few papers have been dedicated to this topic, we decided to write an article updating this theme. Methods: We performed a literature search using the following terminology: "temporal plus epilepsy and networks," "temporal plus epilepsy," "orbito-temporal epilepsy," "temporo-insular epilepsy," "temporo-parieto-occipital (TPO) epilepsy," "parieto-temporal epilepsy," "intracortical evoked potential and temporal plus epilepsy," "temporal lobe connectivity and epilepsy," "intracortical evoked potential and epilepsy surgery," "role of extratemporal structures in TLE," "surgical failure after temporal lobectomy," "Diffusion tensor imaging (DTI) and temporal epilepsy," and "positron emission tomography (PET) in temporal plus lobe epilepsy" in the existing PubMed databases...
July 6, 2016: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/27583247/diacylglycerol-kinases-as-emerging-potential-drug-targets-for-a-variety-of-diseases-an-update
#13
REVIEW
Fumio Sakane, Satoru Mizuno, Suguru Komenoi
Ten mammalian diacylglycerol kinase (DGK) isozymes (α-κ) have been identified to date. Our previous review noted that several DGK isozymes can serve as potential drug targets for cancer, epilepsy, autoimmunity, cardiac hypertrophy, hypertension and type II diabetes (Sakane et al., 2008). Since then, recent genome-wide association studies have implied several new possible relationships between DGK isozymes and diseases. For example, DGKθ and DGKκ have been suggested to be associated with susceptibility to Parkinson's disease and hypospadias, respectively...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27582897/poststroke-epilepsy-update-and-future-directions
#14
REVIEW
Johan Zelano
Stroke is among the most common causes of epilepsy after middle age. Patients with poststroke epilepsy (PSE) differ in several respects from patients with other forms of structural-metabolic epilepsy; not least in age, age-related sensitivity to side effects of antiepileptic drugs (AEDs), and specific drug-drug interaction issues related to secondary-stroke prophylaxis. Encouragingly, there has lately been remarkable activity in the study of PSE. Three developments in PSE research deserve particular focus. First, large prospective trials have established the incidence and risk factors of PSE in the setting of modern stroke care...
September 2016: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/27582254/scarb2-limp2-deficiency-in-action-myoclonus-renal-failure-syndrome
#15
Leanne Dibbens, Michael Schwake, Paul Saftig, Guido Rubboli
Action myoclonus-renal failure syndrome (AMRF) is an autosomal recessive progressive myoclonus epilepsy (PME) associated with renal dysfunction that appears in the second or third decade of life and that is caused by loss-of-function mutations in the SCARB2 gene encoding lysosomal integral membrane protein type 2 (LIMP2). Recent reports have documented cases with PME associated with SCARB2 mutations without renal compromise. Additional neurological features can be demyelinating peripheral neuropathy, hearing loss and dementia...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27573308/insight-an-ontology-based-integrated-database-and-analysis-platform-for-epilepsy-self-management-research
#16
Satya S Sahoo, Priya Ramesh, Elisabeth Welter, Ashley Bukach, Joshua Valdez, Curtis Tatsuoka, Yvan Bamps, Shelley Stoll, Barbara C Jobst, Martha Sajatovic
We present Insight as an integrated database and analysis platform for epilepsy self-management research as part of the national Managing Epilepsy Well Network. Insight is the only available informatics platform for accessing and analyzing integrated data from multiple epilepsy self-management research studies with several new data management features and user-friendly functionalities. The features of Insight include, (1) use of Common Data Elements defined by members of the research community and an epilepsy domain ontology for data integration and querying, (2) visualization tools to support real time exploration of data distribution across research studies, and (3) an interactive visual query interface for provenance-enabled research cohort identification...
October 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27573252/increasing-adherence-to-treatment-in-epilepsy-what-do-the-strongest-trials-show
#17
M da Mota Gomes, T Navarro, A Keepanasseril, R Jeffery, R B Haynes
Patient non-adherence to prescribed anti-epileptic drugs (AEDs) remains a challenge to successful treatment of patients with epilepsy. However, the literature on epilepsy does not document a comprehensive review of interventions to improve adherence as a means to improve clinical outcomes. This study systematically reviews existing literature on interventions to enhance AED adherence and clinical outcomes, and the measures of adherence included in these studies. We selected randomized controlled trials (RCTs) of interventions to enhance adherence with AEDs, which also measured clinical outcomes, with at least 80% follow-up of participants for at least 6 months, from a comprehensive Cochrane review of adherence interventions for medications, complete to January 2013, and updated searches for additional AED studies in multiple bibliographic databases to January 2016...
August 29, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27567266/non-eeg-seizure-detection-systems-and-potential-sudep-prevention-state-of-the-art-review-and-update
#18
REVIEW
Anouk Van de Vel, Kris Cuppens, Bert Bonroy, Milica Milosevic, Katrien Jansen, Sabine Van Huffel, Bart Vanrumste, Patrick Cras, Lieven Lagae, Berten Ceulemans
PURPOSE: Detection of, and alarming for epileptic seizures is increasingly demanded and researched. Our previous review article provided an overview of non-invasive, non-EEG (electro-encephalography) body signals that can be measured, along with corresponding methods, state of the art research, and commercially available systems. Three years later, many more studies and devices have emerged. Moreover, the boom of smart phones and tablets created a new market for seizure detection applications...
October 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27544470/the-expanding-clinical-spectrum-of-genetic-pediatric-epileptic-encephalopathies
#19
Rolla Shbarou, Mohamad A Mikati
Pediatric epileptic encephalopathies represent a clinically challenging and often devastating group of disorders that affect children at different stages of infancy and childhood. With the advances in genetic testing and neuroimaging, the etiologies of these epileptic syndromes are now better defined. The various encephalopathies that are reviewed in this article include the following: early infantile epileptic encephalopathy or Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, West syndrome, severe myoclonic epilepsy in infancy (Dravet syndrome), Landau-Kleffner syndrome, Lennox-Gastaut syndrome, and epileptic encephalopathy with continuous spike-and-wave during sleep...
May 2016: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/27540320/recent-updates-in-neuroprotective-and-neuroregenerative-potential-of-centella-asiatica
#20
REVIEW
Yogeswaran Lokanathan, Norazzila Omar, Nur Nabilah Ahmad Puzi, Aminuddin Saim, Ruszymah Hj Idrus
Centella asiatica, locally well known in Malaysia as pegaga, is a traditional herb that has been used widely in Ayurvedic medicine, traditional Chinese medicine, and in the traditional medicine of other Southeast Asian countries including Malaysia. Although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. In addition to past studies, recent studies also discovered and/or reconfirmed that C. asiatica acts as an antioxidant, reducing the effect of oxidative stress in vitro and in vivo...
January 2016: Malaysian Journal of Medical Sciences: MJMS
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