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Skeletal muscle relaxant

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https://www.readbyqxmd.com/read/29143566/electromyographic-evaluation-in-children-orthodontically-treated-for-skeletal-class-ii-malocclusion-comparison-of-two-treatment-techniques
#1
Eleonora Ortu, Davide Pietropaoli, Fray Adib, Chiara Masci, Mario Giannoni, Annalisa Monaco
Objective To compare the clinical efficacy of two techniques for fabricating a Bimler device by assessing the patient's surface electromyography (sEMG) activity at rest before treatment and six months after treatment. Methods Twenty-four patients undergoing orthodontic treatment were enrolled in the study; 12 formed the test group and wore a Bimler device fabricated with a Myoprint impression using neuromuscular orthodontic technique and 12 formed the control group and were treated by traditional orthodontic technique with a wax bite in protrusion...
November 16, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/29106420/a-small-graphene-oxide-sheet-polyvinylidene-fluoride-bilayer-actuator-with-large-and-rapid-responses-to-multiple-stimuli
#2
Guochuang Xu, Miao Zhang, Qinqin Zhou, Hongwu Chen, Tiantian Gao, Chun Li, Gaoquan Shi
A high-performance actuator should be able to deliver large-shape deformations, fast actuations and sensitive responses to multiple stimuli. Here, we report such an actuator constructed from one layer of polyvinylidene fluoride (PVDF) with a high coefficient of thermal expansion (CTE), and another layer of small sheets of graphene oxide (SGO) with a negative CTE. The opposite deformations of both actuation layers make the SGO/PVDF bilayer actuator highly sensitive to the temperature stimulus with a large bending sensitivity of 1...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29099684/skeletal-muscle-relaxants-340
#3
Brittany Hardek, Jennifer Pruskowski
No abstract text is available yet for this article.
November 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29096122/effect-of-cryopreservation-at-80%C3%A2-c-on-visco-hyperelastic-properties-of-skeletal-muscle-tissue
#4
Naïm Jalal, Mustapha Zidi
This paper investigated the effect of cryopreservation at -80°C on mechanical visco-hyperelastic properties of skeletal muscle. For that, both tensile and compression relaxation tests were performed on porcine tissues samples in fibre and cross-fibre directions. Material parameters were identified by using first order Ogden's strain energy function coupled with second order Maxwell's model. The results revealed that the cryopreservation conditions at -80°C with conservative and cryoprotectant solution significantly affected the mechanical properties of the skeletal muscle...
October 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29081402/conformational-memory-in-the-association-of-the-transmembrane-protein-phospholamban-with-the-sarcoplasmic-reticulum-calcium-pump-serca
#5
Serena Smeazzetto, Gareth P Armanious, Marai Rosa Moncelli, Jessi J Bak, M Joanne Lemieux, Howard S Young, Francesco Tadini-Buoninsegni
The sarcoplasmic reticulum Ca2+-ATPase SERCA promotes muscle relaxation by pumping calcium ions from the cytoplasm into the sarcoplasmic reticulum. SERCA activity is regulated by a variety of small transmembrane peptides, most notably by phospholamban in cardiac muscle and sarcolipin in skeletal muscle. However, how phospholamban and sarcolipin regulate SERCA is not fully understood. In the present study, we evaluated the effects of phospholamban and sarcolipin on calcium translocation and ATP hydrolysis by SERCA under conditions that mimic environments in sarcoplasmic reticulum membranes...
October 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29074883/bi-component-t1%C3%AF-and-t2-relaxation-mapping-of-skeletal-muscle-in-vivo
#6
Azadeh Sharafi, Gregory Chang, Ravinder R Regatte
The goal of this paper was to evaluate the possibility of bi-component T1ρ and T2 relaxation mapping of human skeletal muscle at 3 T in clinically feasible scan times. T1ρ- and T2-weighted images of calf muscle were acquired using a modified 3D-SPGR sequence on a standard 3 T clinical MRI scanner. The mono- and biexponential models were fitted pixel-wise to the series of T1ρ and T2 weighted images. The biexponential decay of T1ρ and T2 relaxations was detected in ~30% and ~40% of the pixels across all volunteers, respectively...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051191/role-of-thyroid-hormone-in-skeletal-muscle-physiology
#7
Flavia F Bloise, Aline Cordeiro, Tania Maria Ortiga-Carvalho
Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic metabolism are influenced by TH. These effects depend on the presence of the TH transporters MCT8 and MCT10 in the plasma membrane, the expression of TH receptors (THRA or THRB) and hormone availability, which is determined either by the activation of thyroxine (T4) into triiodothyronine (T3) by type 2 iodothyronine deiodinases (D2) or by the inactivation of T4 into reverse T3 by deiodinases type 3 (D3)...
October 19, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29040646/statins-affect-skeletal-muscle-performance-evidence-for-disturbances-in-energy-metabolism
#8
Neeltje A E Allard, Tom J J Schirris, Rebecca J Verheggen, Frans G M Russel, Richard J Rodenburg, Jan A M Smeitink, Paul D Thompson, Maria T E Hopman, Silvie Timmers
Context: Statin myopathy is linked to disturbances in mitochondrial function and exercise intolerance. Objectives: To determine whether differences exist in exercise performance, muscle function and mitochondrial oxidative capacity and content between symptomatic and asymptomatic statin users, and non-statin using controls. Design: Cross-sectional study. Setting: Department of Physiology of the Radboud University Medical Center...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29027725/severity-of-ineffective-esophageal-motility-is-associated-with-utilization-of-skeletal-muscle-relaxant-medications
#9
V Rangan, N S George, F Khan, Z Geng, S Gabbard, A Kichler, H Gittleman, R Fass
BACKGROUND: Ineffective esophageal motility (IEM) is the most common finding on high-resolution esophageal manometry (HREM). The underlying mechanisms for IEM remain to be fully elucidated. The aim of this study was to determine if utilization of skeletal muscle relaxants is associated with IEM, and with more severe subtypes of the disorder. METHODS: Patients with diagnosis of IEM were gender and age matched to patients with normal HREM. Demographic information, symptoms, endoscopic findings, medication usage and medical comorbidities were recorded...
October 13, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29022202/clove-oil-induces-anaesthesia-and-blunts-muscle-contraction-power-in-three-amazon-fish-species
#10
Rodrigo Yudi Fujimoto, Débora Martins Pereira, Jessica Cristina Souza Silva, Laís Cássia Araújo de Oliveira, Luis Antonio Kioshi Aoki Inoue, Moisés Hamoy, Vanessa Jóia de Mello, Marcelo Ferreira Torres, Luis André Luz Barbas
Clove oil is used as an anaesthetic for many species of fish worldwide; however, relatively few studies have assessed its effectiveness on Amazon fish species and no compelling evidence has ever been reported on the relaxant properties of this oil for skeletal muscle of fish. Thus, the objective of this study was to evaluate the latencies to deep anaesthesia and recovery, along with the myorelaxant effect of clove oil on three Amazon fish species: cardinal tetra, Paracheirodon axelrodi, banded cichlid, Heros severus and angelfish, Pterophyllum scalare, submitted to short-term anaesthetic baths...
October 12, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28985857/cyclooxygenase-2-contributes-to-bradykinin-induced-microvascular-responses-in%C3%A2-peripheral-arterioles-after-cardiopulmonary-bypass
#11
Jun Feng, Kelsey Anderson, Yuhong Liu, Arun K Singh, Afshin Ehsan, Frank W Sellke
BACKGROUND: Diabetic patients are associated with impaired peripheral microvascular function after cardiopulmonary bypass (CPB) and cardiac surgery. We hypothesized that upregulation of the inducible cyclooxygenase 2 (COX-2) contributes to altered microvascular reactivity of peripheral arterioles in diabetic patients undergoing CPB and cardiac surgery. METHODS: Skeletal muscle samples of nondiabetic (ND) patients and patients with diabetes mellitus (DM; n = 8 per group) undergoing cardiac surgery were harvested before and after CPB...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28970784/tonically-active-%C3%AE-5gabaa-receptors-reduce-motoneuron-excitability-and-decrease-the-monosynaptic-reflex
#12
Martha Canto-Bustos, Emanuel Loeza-Alcocer, Carlos A Cuellar, Paulina Osuna, David Elias-Viñas, Vinicio Granados-Soto, Elías Manjarrez, Ricardo Felix, Rodolfo Delgado-Lezama
Motoneurons, the final common path of the Central Nervous System (CNS), are under a complex control of its excitability in order to precisely translate the interneuronal pattern of activity into skeletal muscle contraction and relaxation. To fulfill this relevant function, motoneurons are provided with a vast repertoire of receptors and channels, including the extrasynaptic GABAA receptors which have been poorly investigated. Here, we confirmed that extrasynaptic α5 subunit-containing GABAA receptors localize with choline acetyltransferase (ChAT) positive cells, suggesting that these receptors are expressed in turtle motoneurons as previously reported in rodents...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28938418/androgens-support-male-acrobatic-courtship-behavior-by-enhancing-muscle-speed-and-easing-the-severity-of-its-tradeoff-with-force
#13
Matthew J Fuxjager, Meredith C Miles, Franz Goller, John Petersen, Julia Yancey
Steroid hormone action in the brain regulates many animals' elaborate social displays used for courtship and competition, but it is increasingly recognized that the periphery may also be a site for potent steroidal modulation of complex behavior. However, the mechanisms of such "bottom-up" regulation of behavioral outflow are largely unclear. To study this problem, we examined how androgenic sex hormones act through the skeletal muscular system to mediate elaborate courtship acrobatics in a tropical bird called the golden-collared manakin...
November 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28930871/reliability-and-measurement-error-of-tensiomyography-to-assess-mechanical-muscle-function-a-systematic-review
#14
Saúl Martín-Rodríguez, Irineu Loturco, Angus M Hunter, David Rodríguez-Ruiz, Diego Munguia-Izquierdo
Interest in studying mechanical skeletal muscle function through tensiomyography (TMG) has increased in recent years. This systematic review aimed to (a) report the reliability and measurement error of all TMG parameters [i.e., maximum radial displacement of the muscle belly (Dm), contraction time (Tc), delay time (Td), half-relaxation time (½ Tr), and sustained contraction time (Ts)] and (b) to provide critical reflection on how to perform accurate and appropriate measurements for informing clinicians, exercise professionals, and researchers...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28912570/a-focus-on-extracellular-ca-2-entry-into-skeletal-muscle
#15
REVIEW
Chung-Hyun Cho, Jin Seok Woo, Claudio F Perez, Eun Hui Lee
The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca(2+) in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca(2+) level is mainly determined by Ca(2+) movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca(2+) entry from extracellular spaces to the cytosol has gained significant attention over the past decade...
September 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28878687/no-sgc-pathway-modulates-ca-2-release-and-muscle-contraction-in-zebrafish-skeletal-muscle
#16
Zhou Xiyuan, Rainer H A Fink, Matias Mosqueira
Vertebrate skeletal muscle contraction and relaxation is a complex process that depends on Ca(2+) ions to promote the interaction of actin and myosin. This process can be modulated by nitric oxide (NO), a gas molecule synthesized endogenously by (nitric oxide synthase) NOS isoforms. At nanomolar concentrations NO activates soluble guanylate cyclase (sGC), which in turn activates protein kinase G via conversion of GTP into cyclic GMP. Alternatively, NO post-translationally modifies proteins via S-nitrosylation of the thiol group of cysteine...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28871556/lessons-from-a-tarantula-new-insights-into-muscle-thick-filament-and-myosin-interacting-heads-motif-structure-and-function
#17
REVIEW
Lorenzo Alamo, Natalia Koubassova, Antonio Pinto, Richard Gillilan, Andrey Tsaturyan, Raúl Padrón
The tarantula skeletal muscle X-ray diffraction pattern suggested that the myosin heads were helically arranged on the thick filaments. Electron microscopy (EM) of negatively stained relaxed tarantula thick filaments revealed four helices of heads allowing a helical 3D reconstruction. Due to its low resolution (5.0 nm), the unambiguous interpretation of densities of both heads was not possible. A resolution increase up to 2.5 nm, achieved by cryo-EM of frozen-hydrated relaxed thick filaments and an iterative helical real space reconstruction, allowed the resolving of both heads...
October 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28826559/magnetic-resonance-monitoring-of-disease-progression-in-mdx-mice-on-different-genetic-backgrounds
#18
Ravneet Vohra, Abhinandan Batra, Sean C Forbes, Krista Vandenborne, Glenn A Walter
Genetic modifiers alter disease progression in both preclinical models and subjects with Duchenne muscular dystrophy (DMD). Using multiparametric magnetic resonance (MR) techniques, we compared the skeletal and cardiac muscles of two different dystrophic mouse models of DMD, which are on different genetic backgrounds, the C57BL/10ScSn-Dmdmdx (B10-mdx) and D2.B10-Dmdmdx (D2-mdx). The proton transverse relaxation constant (T2) using both MR imaging and spectroscopy revealed significant age-related differences in dystrophic skeletal and cardiac muscles as compared with their age-matched controls...
September 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28826478/extensive-alternative-splicing-transitions-during-postnatal-skeletal-muscle-development-are-required-for-calcium-handling-functions
#19
Amy E Brinegar, Zheng Xia, James Anthony Loehr, Wei Li, George Gerald Rodney, Thomas A Cooper
Postnatal development of skeletal muscle is a highly dynamic period of tissue remodeling. Here, we used RNA-seq to identify transcriptome changes from late embryonic to adult mouse muscle and demonstrate that alternative splicing developmental transitions impact muscle physiology. The first 2 weeks after birth are particularly dynamic for differential gene expression and alternative splicing transitions, and calcium-handling functions are significantly enriched among genes that undergo alternative splicing...
August 11, 2017: ELife
https://www.readbyqxmd.com/read/28801956/evidence-of-er-stress-and-upr-activation-in-patients-with-brody-disease-and-brody-syndrome
#20
V Guglielmi, N C Voermans, A Oosterhof, D Nowis, B G van Engelen, G Tomelleri, G Vattemi
Brody disease (BD, OMIM #601003) is an inherited skeletal muscle disease clinically characterized by exercise-induced impairment of muscle relaxation and stiffness due to the delay in the Ca(2+) re-uptake in the sarcoplasmic reticulum (SR)[1, 2]. The delayed muscle relaxation mainly affects legs, harms, hands and eyelids and usually improves after a few minutes rest [1-3]. Patients frequently report myalgia, painless or mildly painful cramps whereas recurrent rhabdomyolysis have been described in a few cases [2, 3]...
August 12, 2017: Neuropathology and Applied Neurobiology
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