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withdrawal of antiepileptic

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https://www.readbyqxmd.com/read/29747241/stiripentol-add-on-therapy-for-focal-refractory-epilepsy
#1
REVIEW
Francesco Brigo, Stanley C Igwe, Nicola Luigi Bragazzi
BACKGROUND: This is an updated version of the Cochrane review last published in 2015 (Issue 10). For nearly 30% of people with epilepsy, seizures are not controlled by current treatments. Stiripentol is a new antiepileptic drug (AED) that was developed in France and was approved by the European Medicines Agency (EMA) in 2007 for the treatment of Dravet syndrome as an adjunctive therapy with valproate and clobazam, with promising effects. OBJECTIVES: To evaluate the efficacy and tolerability of stiripentol as add-on treatment for people with focal refractory epilepsy who are taking AEDs...
May 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29708173/uncertainties-from-a-worldwide-survey-on-antiepileptic-drug-withdrawal-after-seizure-remission
#2
Luca Bartolini, Shahram Majidi, Mohamad Z Koubeissi
Background: We sought to determine differences in practice for discontinuation of antiepileptic drugs (AEDs) after seizure remission and stimulate the planning and conduction of withdrawal trials. Methods: We utilized a worldwide electronic survey that included questions about AED discontinuation for 3 paradigmatic cases in remission: (1) focal epilepsy of unknown etiology, (2) temporal lobe epilepsy after surgery, and (3) juvenile myoclonic epilepsy. We analyzed 466 complete questionnaires from 53 countries, including the United States...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#3
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29653328/a-pragmatic-study-on-efficacy-tolerability-and-long-term-acceptance-of-ketogenic-diet-therapy-in-74-south-indian-children-with-pharmacoresistant-epilepsy
#4
Neena Baby, Kollencheri Puthenveettil Vinayan, Nivedita Pavithran, Arun Grace Roy
PURPOSE: Significant challenges exist for Ketogenic Diet (KD) programs in many populations, mainly due to the variations in local dietary preferences. Here we report a single center experience of KD therapy in a cohort of South Indian children with pharmaco-resistant epilepsies. METHODS: Children aged 0-18 years, enrolled in the KD program for pharmacoresistant epilepsies of Amrita institute of Medical Sciences, Kochi, Kerala, India (2010 - 2015) were included in this pragmatic study...
March 21, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29643749/deciding-when-less-is-more-the-crossroads-of-withdrawing-antiepileptic-drugs
#5
COMMENT
Naymee Velez Ruiz
No abstract text is available yet for this article.
January 2018: Epilepsy Currents
https://www.readbyqxmd.com/read/29620012/rapid-antiepileptic-drug-withdrawal-may-obscure-localizing-information-obtained-during-presurgical-eeg-recordings
#6
Yulia Novitskaya, Mandy Hitz, Andreas Schulze-Bonhage
Withdrawal of antiepileptic drugs (AEDs) is a standard procedure during presurgical epilepsy assessment. Rapid and, at times, even pre-hospital withdrawal of medication is performed in some centres to enhance the yield of recorded seizures during video-EEG monitoring. AED withdrawal, however, affects the propensity and speed of propagation of epileptic activity, may evoke more severe seizures, and may cause pitfalls in EEG interpretation. We report a case which had been recommended to undergo intracranial EEG recordings in order to clarify apparently discordant MRI findings and ictal EEG patterns when monitoring was performed following complete AED withdrawal...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29609145/seizure-characteristics-and-the-use-of-anti-epileptic-drugs-in-children-and-young-people-with-brain-tumours-and-epileptic-seizures-analysis-of-regional-paediatric-cancer-service-population
#7
Chiara Pilotto, Jo-Fen Liu, David A Walker, William P Whitehouse
PURPOSE: Epileptic seizures complicate the management of childhood brain tumours. There are no published standards for clinical practice concerning risk factors, treatment selection or strategies to withdraw treatment with antiepileptic drugs (AED). METHOD: we undertook a case note review of 120 patients with newly diagnosed brain tumours, referred to a regional paediatric cancer service. RESULTS: data was available on 117/120 (98%) children <18 years: median age at tumour presentation was 8...
March 21, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29588946/effective-withdrawal-of-antiepileptic-drugs-in-premonitoring-admission-to-capture-seizures-during-limited-video-eeg-monitoring
#8
Kota Kagawa, Koji Iida, Shiro Baba, Akira Hashizume, Masaya Katagiri, Kaoru Kurisu, Hiroshi Otsubo
Objective: Withdrawal of antiepileptic drugs (AEDs) is commonly applied to capture seizures in video-EEG (vEEG) monitoring for patients with infrequent but intractable seizures. Because of the half-life of AEDs, AED withdrawal during only vEEG tends to be inadequate to provoke seizures within the vEEG admission. We hypothesize that prewithdrawal of long-half-life AEDs in premonitoring admission (PMA) is safe and effective to capture seizures in the limited time of vEEG. We determined the effect of half-life on the interval between AED withdrawal and seizure occurrence...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29568997/-severe-skin-reactions-due-to-new-medications
#9
REVIEW
M Mockenhaupt, M Paulmann
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and a specific form of hypersensitivity syndrome which is nowadays called "drug reaction with eosinophilia and systemic symptoms" (DRESS) are severe, mainly drug-induced skin reactions. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as drug reaction, in total only about three quarters of the cases are actually caused by drugs...
April 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29531865/the-protective-effects-of-crocin-in-the-management-of-neurodegenerative-diseases-a-review
#10
REVIEW
Tahereh Farkhondeh, Saeed Samarghandian, Hanieh Shaterzadeh Yazdi, Fariborz Samini
Flavonoids have been used in traditional medicine to promote human health. Crocin has been proposed to be effective in the management of the various diseases including the neurodegenerative diseases. Antiepileptic and anti-Alzheimer effects of crocin have also been indicated. The efficacy of crocis in the treatment of cerebral ischemia and traumatic brain injury was also confirmed by using animal models. Crocin treatment increased dopamine levels in the brain of experimental model of Parkinson's disease. In addition, crocin modulates the opioid system to decrease the withdrawal syndrome...
2018: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/29508243/adjunctive-eslicarbazepine-acetate-in-pediatric-patients-with-focal-epilepsy-a-systematic-review-and-meta-analysis
#11
REVIEW
Simona Lattanzi, Francesco Brigo, Elisabetta Grillo, Claudia Cagnetti, Alberto Verrotti, Gaetano Zaccara, Mauro Silvestrini
BACKGROUND: In the treatment of pediatric epilepsy, there is a critical demand for effective and safe therapeutic options to address patients' unmet clinical needs. Eslicarbazepine acetate is a novel once-daily antiepileptic drug and a third-generation single enantiomer member of the dibenzazepine family. OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of eslicarbazepine acetate as add-on treatment for focal-onset seizures in pediatric patients using meta-analytical techniques...
March 2018: CNS Drugs
https://www.readbyqxmd.com/read/29486396/conversion-to-brivaracetam-monotherapy-for-the-treatment-of-patients-with-focal-seizures-two-double-blind-randomized-multicenter-historical-control-phase-iii-studies
#12
Stephan Arnold, Vincent Badalamenti, Anyzeila Diaz, Teresa Gasalla, Cindy McShea, John Whitesides, Toufic Fakhoury
Brivaracetam (BRV), a selective, high-affinity ligand for synaptic vesicle protein 2A, is a new antiepileptic drug (AED) approved for monotherapy (in the USA) and adjunctive treatment of focal (partial-onset) seizures in adults, at a dose range of 50-200 mg/day taken in two equal doses, with a recommended starting dose of 100 mg/day. Two Phase III, randomized, double-blind, multicenter, historical-controlled, conversion-to-monotherapy studies (N01276, NCT00698581; N01306, NCT00699283) were conducted to evaluate the efficacy, safety, and tolerability of conversion to BRV 50 mg/day monotherapy in adults with uncontrolled focal seizures...
March 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29457009/acneiform-rash-caused-by-an-unlikely-drug-topiramate
#13
Yesenia Bello-Hernández, Jessica Espinoza-Hernández, Gabriela Moreno-Coutiño
Topiramate is an antiepileptic drug that can also be used for migraine prophylaxis, weight control, and even for methamphetamine dependence; the dosage margin is wide, and the list of side effects is shorter than with other anticonvulsants. We present the case of a 35-year-old man with a disseminated rash of the trunk and extremities after treatment with 25 mg of topiramate daily as a prophylactic migraine treatment. This case report is useful, as this patient was not polymedicated and had a score of 7 on the Naranjo Adverse Drug Reaction Probability Scale...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29446447/individualized-prediction-of-seizure-relapse-and-outcomes-following-antiepileptic-drug-withdrawal-after-pediatric-epilepsy-surgery
#14
Herm J Lamberink, Kim Boshuisen, Willem M Otte, Karin Geleijns, Kees P J Braun
The objective of this study was to create a clinically useful tool for individualized prediction of seizure outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery. We used data from the European retrospective TimeToStop study, which included 766 children from 15 centers, to perform a proportional hazard regression analysis. The 2 outcome measures were seizure recurrence and seizure freedom in the last year of follow-up. Prognostic factors were identified through systematic review of the literature...
March 2018: Epilepsia
https://www.readbyqxmd.com/read/29433838/preliminary-asian-experience-of-using-perampanel-in-clinical-practice
#15
Hsing-I Chiang, Siew-Na Lim, Hsiang-Yao Hsieh, Mei-Yun Cheng, Chun-Wei Chang, Wei-En Johnny Tseng, Han-Tao Li, Chin-Yin Lin, Tony Wu
BACKGROUND: To analyze the efficacy and safety of perampanel over a 3-month period in a sample of Asian people with epilepsy. METHODS: The efficacy and safety of perampanel as an adjunctive therapy for patients with epilepsy were retrospectively reviewed and analyzed. Patients were categorized according to seizure type, concomitant antiepileptic drug usage, and perampanel dosage. RESULTS: A total of 210 patients were included in the study and 131 patients completed 3 months of perampanel treatment...
December 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29415871/eslicarbazepine-acetate-as-a-replacement-for-levetiracetam-in-people-with-epilepsy-developing-behavioral-adverse-events
#16
Virupakshi Jalihal, Rohit Shankar, William Henley, Mary Parrett, Phil Tittensor, Brendan N McLean, Ammad Ahmed, Josemir W Sander
BACKGROUND: Psychiatric and behavioral side effects (PBSEs) are a major cause of antiepileptic drug (AED) withdrawal. Levetiracetam (LEV) is a recognized first-line AED with good seizure outcomes but recognized with PBSEs. Eslicarbazepine (ESL) is considered to function similarly to an active metabolite of the commonly used carbamazepine (CBZ). Carbamazepine is used as psychotropic medication to assist in various psychiatric illnesses such as mood disorders, aggression, and anxiety. AIM: The aim was to evaluate the psychiatric profile of ESL in people who had LEV withdrawn due to PBSEs in routine clinical practice to see if ESL can be used as a possible alternative to LEV...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29414538/antiepileptic-drug-reduction-and-increased-risk-of-stimulation-evoked-focal-to-bilateral-tonic-clonic-seizure-during-cortical-stimulation-in-patients-with-focal-epilepsy
#17
Kevin G Hampel, Asier Gómez-Ibáñez, Mercedes Garcés-Sánchez, David Hervás-Marín, Irene Cano-López, Esperanza González-Bono, Rebeca Conde-Sardón, Antonio Gutiérrez-Martín, Vicente Villanueva
INTRODUCTION: Stimulation-evoked focal to bilateral tonic-clonic seizure (FBTCS) can be a stressful and possibly harmful adverse event for patients during cortical stimulation (CS). We evaluated if drug load reduction of antiepileptic drugs (AEDs) during CS increases the risk of stimulation-evoked FBTCS. MATERIAL AND METHODS: In this retrospective cohort study, we searched our local database for patients with drug-resistant epilepsy who underwent invasive video-EEG monitoring and CS in the University Hospital la Fe Valencia from January 2006 to November 2016...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29355908/losigamone-add-on-therapy-for-focal-epilepsy
#18
REVIEW
Yousheng Xiao, Man Luo, Jin Wang, Hongye Luo
BACKGROUND: Epilepsy is a common neurologic disorder, affecting approximately 50 million people worldwide; nearly a third of these people have epilepsy that is not well controlled by a single antiepileptic drug (AED) and they usually require treatment with a combination of two or more AEDs. In recent years, many newer AEDs have been investigated as add-on therapy for focal epilepsy; losigamone is one of these drugs and is the focus of this systematic review. This is an update of a Cochrane review first published in 2012 (Cochrane Database of Systematic Reviews 2012, Issue 6) and updated in 2015...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29324507/determining-when-to-stop-antiepileptic-drug-treatment
#19
Steven C Schachter
PURPOSE OF REVIEW: As the number of patients diagnosed with epilepsy continues to rise and the pharmacological and device-based treatment options for epilepsy increase, determining when to stop antiepileptic drug (AED) treatment continues to be an important issue for patient management and counseling. RECENT FINDINGS: This review focuses on outcomes following AED withdrawal in seizure-free adults with epilepsy. Practical considerations are also discussed because, despite the importance of this topic, relatively little progress has been made in the past year regarding the identification of patients whose risk for recurrent seizures after AED withdrawal is no higher than that of the general population...
April 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29322880/reversible-splenial-lesion-syndrome-due-to-oxcarbazepine-withdrawal-case-report-and-literature-review
#20
Chaoyang Jing, Lichao Sun, Zhuo Wang, Chaojia Chu, Weihong Lin
Background Reversible splenial lesion syndrome is a distinct entity radiologically characterized by a reversible lesion in the splenium of the corpus callosum. According to previous reports, this condition may be associated with antiepileptic drug use or withdrawal. We herein report a case of reversible splenial lesion syndrome associated with oxcarbazepine withdrawal. Case Report A 39-year-old man presented with an 8-year history of epileptic seizures. During the previous 3 years, he had taken oxcarbazepine irregularly...
March 2018: Journal of International Medical Research
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