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mthfr c677t hca

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https://www.readbyqxmd.com/read/26376956/homocysteine-excess-delineating-the-possible-mechanism-of-neurotoxicity-and-depression
#1
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Pankaj Bhatia, Nirmal Singh
Homocysteine (Hcy) is a nonproteogenic sulfur containing amino acid derived from dietary methionine through demethylation. Homocysteine can be re-methylated to methionine [precursor of S-adenosylmethionine (SAM)] via the re-methylation or 5-methyltetrahydrofolate pathway or undergoes transsulfuration to form cysteine by the action of metabolic enzymes and cofactors. Impaired metabolism due to genetic alteration in metabolic enzymes (methionine synthase, methyltetrahydrofolate reductase (MTHFR), cystathionine β-synthase (CβS), and cystathionine-γ-lyase (CγL) or deficiency in cofactors (vitamin B6 , B12 , folate) may lead to acquired metabolic anomaly known as hyperhomocysteinemia...
December 2015: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/22664498/role-of-homocysteine-mthfr-c677t-gene-polymorphism-as-risk-factors-for-coronary-artery-disease-in-young-indians
#2
Santosh Kumar Gupta, Jyoti Kotwal, Atul Kotwal, Anil Dhall, Salil Garg
BACKGROUND & OBJECTIVES: Hyperhomocysteinaemia (HCA) either due to mutation of MTHFR gene or deficiency of vitamin B 12 and folic acid, has been reported as a risk factor for coronary artery disease (CAD). The present study was aimed to determine plasma homocysteine (Hcy) levels and to evaluate MTHFR C677T gene polymorphism as risk factors for CAD, and to study the role of Hcy in conjunction with a few other risk factors of CAD in young Indians. The effect of vitamin B12 and folic acid supplements on the raised plasma Hcy levels in patients of CAD was also assessed...
April 2012: Indian Journal of Medical Research
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