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Mast Cells

Maiko Emi-Sugie, Sumika Toyama, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto
Functional CCR7 expression-which enables Erk 1/2 phosphorylation, chemotaxis and enhancement of cytokine production upon exposure to CCR7 ligands-was induced in human mast cells, strongly by IL-33 and weakly by anti-IgE Ab stimulation.
June 18, 2018: Journal of Allergy and Clinical Immunology
Peter Valent, Cem Akin, Patrizia Bonadonna, Karin Hartmann, Sigurd Broesby-Olsen, Knut Brockow, Joseph H Butterfield, Andreas Reiter, Jason Gotlib, Mariana Castells, Joshua D Milner, Melody C Carter, Hirsh Komarow, Deepti Radia, Animesh Pardanani, Karl Sotlar, Massimo Triggiani, Hans-Peter Horny, Michel Arock, Lawrence B Schwartz, Dean D Metcalfe
No abstract text is available yet for this article.
June 18, 2018: Journal of Allergy and Clinical Immunology
Oliver T Burton, Alexandra Epp, Manoussa E Fanny, Samuel J Miller, Amanda J Stranks, Jessica E Teague, Rachael A Clark, Matt van de Rijn, Hans C Oettgen
Immediate hypersensitivity reactions are induced by the interaction of allergens with specific IgE antibodies bound via FcεRI to mast cells and basophils. While these specific IgE antibodies are needed to trigger such reactions, not all individuals harboring IgE exhibit symptoms of allergy. The lack of responsiveness seen in some subjects correlates with the presence of IgG antibodies of the same specificity. In cell culture studies and in vivo animal models of food allergy and anaphylaxis such IgG antibodies have been shown to exert suppression via FcγRIIb...
2018: Frontiers in Immunology
Christopher J Lehiy, Lindsey M Reister-Hendricks, Mark G Ruder, D Scott McVey, Barbara S Drolet
BACKGROUND: Hematophagous Culicoides spp. biting midges are of great agricultural importance as livestock, equine, and wildlife pests and as vectors of the orbiviruses bluetongue, epizootic hemorrhagic disease and African horse sickness. To obtain a blood meal, midges deposit saliva containing allergens, proteases, and anti-hemostatic factors, into the dermis to facilitate feeding. Infected midges deposit virus along with the myriad of salivary proteins during feeding. The extreme efficiency with which midges are able to transmit orbiviruses is not clearly understood, as much is still unknown about the physiological trauma of the bite and immune responses to saliva deposited during feeding...
June 20, 2018: Parasites & Vectors
Anja A Wolf, Helen S Goodridge
Mast cells have been thought to derive from bone marrow hematopoietic stem cells. In this issue of Immunity, Gentek et al. (2018) reveal that mast cells have dual developmental origins in primitive and definitive hematopoiesis and that adult mast cell maintenance is largely bone marrow independent.
June 19, 2018: Immunity
Changqi Liu, Shridhar Krishna Sathe
With the increased global awareness and rise in food allergies, a multifold interest in food allergens is evident. The presence of undeclared food allergens results in expensive food recalls and increase risks of anaphylaxis for the sensitive individuals. Regardless of the allergenic food, the immunogen needs to be identified and detected before making any efforts to inactivate/eliminate it. In type I food allergies, protein immunogen cross-links IgEs leading to basophil/mast cell degranulation resulting in the symptoms that range from mild irritation to anaphylaxis...
June 20, 2018: Journal of Agricultural and Food Chemistry
Anabel Gonzalez-Gil, Ryan N Porell, Steve M Fernandes, Yadong Wei, Huifeng Yu, Daniela J Carroll, Ryan McBride, James C Paulson, Michael Tiemeyer, Kazuhiro Aoki, Bruce S Bochner, Ronald L Schnaar
Human siglecs are a family of 14 sialic acid binding proteins, most expressed on subsets of immune cells where they regulate immune responses. Siglec-8 is expressed selectively on human allergic inflammatory cells - primarily eosinophils and mast cells - where engagement causes eosinophil apoptosis and inhibits mast cell mediator release. Evidence supports a model in which human eosinophils and mast cells bind to Siglec-8 sialoglycan ligands on inflammatory target tissues to resolve allergic inflammation and limit tissue damage...
June 19, 2018: Glycobiology
Letícia Pargendler Peres, Fabiana Bazanella Oliveira, André Cartell, Nicolle Gollo Mazzotti, Tania Ferreira Cestari
BACKGROUND: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established. OBJECTIVE: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. METHODS: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed...
June 2018: Anais Brasileiros de Dermatologia
Nicolas Gaudenzio, Thomas Marichal, Stephen J Galli, Laurent L Reber
Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete diverse products, including some with pro-inflammatory and anti-inflammatory functions. Conflicting results have been obtained regarding pathogenic versus protective roles of MCs in CHS, and this has been attributed in part to the limitations of certain models for studying MC functions in vivo ...
2018: Frontiers in Immunology
Al Caraffa, C Conti, C D Ovidio, C E Gallenga, L Tettamanti, F Mastrangelo, G Ronconi, S K Kritas, P Conti
The activation of brain nociceptors and neurons may lead to neurogenic inflammation, an event that involves immune cells including mast cells (MCs). Microglia are similar to macrophages and secrete pro-inflammatory IL-1 family members and TNF. TNF is rapidly released (first 10 minutes from MC granules) and is subsequently secreted along with other pro-inflammatory cytokines with a new synthesis after several hours. MC-derived TNF is a very powerful pro-inflammatory cytokine which mediates sensitization of the meningeal nociceptors...
May 2018: Journal of Biological Regulators and Homeostatic Agents
L King, I Tsilioni, T C Theoharides
Cachexia is a wasting condition associated with late stages of many chronic illnesses and may be present in up to 80% of patients with advanced cancers. Cachexia is a metabolic derangement resulting in a disturbance to the homeostasis of muscle breakdown and synthesis, favoring catabolism and muscle loss. Despite making strides in treating cancer itself, there have been no major advances in the treatment of cachexia pharmacologically or nutritionally. Clinical trials using anti-TNF biologics and thalidomide have largely failed...
May 2018: Journal of Biological Regulators and Homeostatic Agents
Zahava Vadasz, Elias Toubi
The involvement of the hemostatic system in immune-mediated inflammation is widely reported. Many coagulation factors play a role in the pathogenesis of autoimmune diseases, such as systemic vasculitis and systemic lupus erythematosus. Hemostatic disorders are also involved in asthma and chronic spontaneous urticaria (CSU). Factor XIIa (FXIIa) was one of the first coagulation factors implicated in inducing both humoral and cellular responses and is therefore considered a prime new therapeutic target in immune-mediated inflammation...
June 19, 2018: Seminars in Thrombosis and Hemostasis
Nicole Meyer, Ana Claudia Zenclussen
Mast cells (MCs) are most known because of their prominent role in allergy. In the last years, however, it has become clear that they have pleiotropic functions and a high adaptability to the milieu. This review focuses on negative and positive roles of MCs within the body with particular emphasis on their participation in reproductive processes.
June 19, 2018: American Journal of Reproductive Immunology: AJRI
S du Preez, S L Raidal, G S Doran, M Prescott, K J Hughes
BACKGROUND: Exhaled breath condensate (EBC) analysis is a non-invasive method to assess the lower respiratory tract. In humans, EBC hydrogen peroxide (H2 O2 ), pH and leukotriene B4 (LTB4 ) are useful for detection and monitoring of inflammatory lung diseases, including asthma. OBJECTIVES: To determine associations between EBC biomarkers and cytological and endoscopic definitions of lower airway inflammation whilst controlling for sampling and environmental variables...
June 19, 2018: Equine Veterinary Journal
Duraisamy Kempuraj, Ramasamy Thangavel, Gvindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Smita Zaheer, Sudhanshu P Raikwar, Haris Zahoor, Daniyal Saeed, Iuliia Dubova, Gema Giler, Shelby Herr, Shankar S Iyer, Asgar Zaheer
Inflammatory mediators released from activated microglia, astrocytes, neurons, and mast cells mediate neuroinflammation. Parkinson's disease (PD) is characterized by inflammation-dependent dopaminergic neurodegeneration in substantia nigra. 1-Methyl-4-phenylpyridinium (MPP+ ), a metabolite of parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), induces inflammatory mediators' release from brain cells and mast cells. Brain cells' interaction with mast cells is implicated in neuroinflammation...
June 18, 2018: Molecular Neurobiology
Galina V Ilyinskaya, Elena V Mukhina, Alesya V Soboleva, Olga V Matveeva, Peter M Chumakov
Background: Canine mastocytomas (mast cell tumors) represent a common malignancy among many dog breeds. A typical treatment strategy for canine mastocytomas includes surgery, chemo- and radio-therapy, although in many cases the therapy fails and the disease progression resumes. New treatment approaches are needed. Aims: The goal of this pilot study was to examine safety and efficacy of oncolytic Sendai virus therapy administered to canine patients with cutaneous or subcutaneous mastocytomas. Materials and Methods: Six canine patients, with variable grades and stages of the disease, received virus therapy, either as a monotherapy, or in combination with surgery...
2018: Frontiers in Veterinary Science
Amber R Philp, Texia T Riquelme, Pamela Millar-Büchner, Rodrigo González, Francisco V Sepúlveda, L Pablo Cid, Carlos A Flores
Nearly 70% of cystic fibrosis (CF) patients bear the phenylalanine-508 deletion but disease severity differs greatly, and is not explained by the existence of different mutations in compound heterozygous. Studies demonstrated that genes other than CFTR relate to intestinal disease in humans and CF-mouse. Kcnn4, the gene encoding the calcium-activated potassium channel KCa 3.1, important for intestinal secretion, is present in a locus linked with occurrence of intestinal CF-disease in mice and humans. We reasoned that it might be a CF-modifier gene and bred a CF-mouse with Kcnn4 silencing, finding that lethality was almost abolished...
June 18, 2018: Scientific Reports
Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, Anton Pottegård, David Gaist
BACKGROUND: Hydrochlorothiazide use has been associated with markedly increased risk of squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk of Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST). OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of MCC and MAST. METHODS: Using Danish nationwide health registries, we identified all patients with incident MCC or MAST during 2004-2015 and matched cases individually to cancer-free population controls by risk set sampling...
June 15, 2018: Journal of the American Academy of Dermatology
Jelle Folkerts, Ralph Stadhouders, Frank A Redegeld, See-Ying Tam, Rudi W Hendriks, Stephen J Galli, Marcus Maurer
Many mast cell-associated diseases, including allergies and asthma, have seen a strong increase in prevalence during the past decades, especially in Western(ized) countries. It has been suggested that a Western diet may contribute to the prevalence and manifestation of allergies and asthma through reduced intake of dietary fiber and the subsequent production of their metabolites. Indeed, dietary fiber and its metabolites have been shown to positively influence the development of immune disorders via changes in microbiota composition and the regulation of B- and T-cell activation...
2018: Frontiers in Immunology
Justyna Agier, Joanna Pastwińska, Ewa Brzezińska-Błaszczyk
BACKGROUND: Mast cells (MCs) are long-lived immune cells of the connective tissue which play a key role in development and amplification of inflammatory process initiated inter alia by allergic reactions or microbial infections. They reside in strategic locations in the body that are notably exposed to deleterious factors disturbing homeostasis, which enables them to become one of the first-line defense strategy. MCs have developed a wide range of various mechanisms to deal with invading intruders and harmful endogenic factors...
June 16, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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