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https://www.readbyqxmd.com/read/28551943/targeting-histamine-receptors-in-irritable-bowel-syndrome-a-critical-appraisal
#1
REVIEW
Adam Fabisiak, Jakub Włodarczyk, Natalia Fabisiak, Martin Storr, Jakub Fichna
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed...
May 27, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28551551/the-protective-effect-of-quercetin-on-cyclophosphamide-induced-lung-toxicity-in-rats
#2
Emin Şengül, Volkan Gelen, Semin Gedikli, Seçkin Özkanlar, Cihan Gür, Fikret Çelebi, Ali Çınar
Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been suggested that CYP causes toxicity in many organs, including the lungs and testes. Many studies have indicated that some antioxidants have possible protective effects against CYP's side effects. This study aimed to investigate the protective effect of quercetin (QUE) on CYP-induced lung toxicity in rats using histologic and biochemical methods. In the study, 50 male Sprague-Dawley rats weighing 220-250g were used. There were 4 experimental groups and 1 control group...
May 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28550985/opioid-hypersensitivity-predictors-of-allergy-and-role-of-drug-provocation-testing
#3
Philip H Li, Kok Loong Ue, Annette Wagner, Ryszard Rutkowski, Krzysztof Rutkowski
BACKGROUND: True IgE-mediated hypersensitivity to opioids is rare and many reactions are due to direct mast cell degranulation. Opioid drug provocation testing (DPT) is the gold standard for diagnosis but is underutilized. OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and predictors of opioid hypersensitivity, as well as outcomes of opioid DPT. METHODS: Patients referred for opioid DPT over the past 9 years were studied...
May 24, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28549244/ll-37-induced-human-mast-cell-activation-through-g-protein-coupled-receptor-mrgx2
#4
Yangyang Yu, Yuanyuan Zhang, Yarui Zhang, Yihong Lai, Wenwen Chen, Zhangang Xiao, Wei Zhang, Meiling Jin, Bo Yu
Human LL-37 is an important class of cationic antimicrobial peptide (CAP) that is known to stimulate mast cell activation. While many studies have been conducted on LL-37, to date little is known about the functional receptors for LL-37-induced human mast cell activation, in particular in terms of the release of de novo synthesized mediators. Thus, the aim of the present study is to identify the functional receptors for LL-37-induced human mast cell activation in terms of the degranulation and release of de novo synthesized mediators and investigate the downstream signalling pathways involved in mast cell activation...
May 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28547979/association-of-infiltrating-cells-with-microvessel-density-in-oral-squamous-cell-carcinoma
#5
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
Several lines of evidence indicate that immune cells in the tumor microenvironment play an important role in regulating tumor progression. An immunohistochemical method was used to examine the abundance of natural killer (NK) cells, mucosal dendritic cells (DCs), macrophages, mast cells, and microvessel density in 78 cases of oral squamous cell carcinoma (OSCC): with better prognosis - OSCCBP (n = 37), and with poorer prognosis - OSCCPP (n = 41), and 18 controls. The mean numbers of macrophages and microvessels were significantly higher in the OSCCPP group in comparison to both OSCCBP and control groups...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28546715/unusual-histology-in-hodgkin-s-lymphoma-report-of-an-interesting-case
#6
Sujata Jetley, Shaan Khetrapal, Mukta Pujani, Mohd Jaseem Hassan, Abhinav Jain
Hodgkin's lymphoma has a significant presence in the Indian subcontinent. Microscopically, the hallmark of Hodgkin's lymphoma (HL) is the Hodgkin and Reed-Sternberg (HRS) cell, which is usually surrounded by a cellular infiltrate of non-malignant inflammatory cells that constitute the majority of the tumor tissue. Cells which are known to be histologic mimics of HRS cells include immunoblasts, plasmablasts and rarely dendritic cells. We report a case of a 70-year-old male who presented with fever and lymphadenopathy...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28545868/ameliorative-effect-of-atractylenolide-iii-in-the-mast-cell-proliferation-induced-by-tslp
#7
Myoung-Schook Yoou, Sun-Young Nam, Mu Hyun Jin, So Young Lee, Mi-Sun Kim, Seok Seon Roh, In Hwa Choi, Nariyah Woo, SeokWon Lim, Dong Hyun Kim, Jae-Bum Jang, Hyung-Min Kim, Hyun-Ja Jeong
Atractylenolide III (ATL-III) is an active compound of Atractylodes lancea, which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation, and many anti-inflammatory agents are also used to treat cancer. We investigated the influence of ATL-III on thymic stromal lymphopoietin (TSLP)-induced inflammatory reactions. Pretreatment with ATL-III suppressed murine double minute 2 levels and promoted p53 levels in TSLP-treated human mast cell, HMC-1 cells. Mast cell proliferation increased by TSLP or IL-3 stimulation was significantly decreased by ATL-III pretreatment...
May 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28544776/comparison-of-histologic-margin-status-in-low-grade-cutaneous-and-subcutaneous-canine-mast-cell-tumours-examined-by-radial-and-tangential-sections
#8
C B Dores, M Milovancev, D S Russell
BACKGROUND: Radial sections are widely used to estimate adequacy of excision in canine cutaneous mast cell tumours (MCTs); however, this sectioning technique estimates only a small fraction of total margin circumference. This study aimed to compare histologic margin status in grade II/low grade MCTs sectioned using both radial and tangential sectioning techniques. MATERIALS AND METHODS: A total of 43 circumferential margins were evaluated from 21 different tumours...
May 23, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28542986/tryptase-expression-as-a-prognostic-marker-in-patients-with-resected-gastric-cancer
#9
C Lin, H Liu, H Zhang, Y Cao, R Li, S Wu, H Li, H He, J Xu, Y Sun
BACKGROUND: Mast cells play important roles in the progression of various malignancies, but their prognostic value in gastric cancer is unknown. Tryptase expression, as an indicator of mast cell activity, was therefore evaluated to see whether this could be incorporated usefully into a prognostic nomogram after surgery in patients with gastric cancer. METHODS: Tissue microarrays from patients with gastric cancer were created from formalin-fixed, paraffin-embedded resection specimens...
May 24, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28536479/circulating-microrna-214-and-126-as-potential-biomarkers-for-canine-neoplastic-disease
#10
Kazuki Heishima, Yukie Ichikawa, Kyoko Yoshida, Ryota Iwasaki, Hiroki Sakai, Takayuki Nakagawa, Yuiko Tanaka, Yuki Hoshino, Yasuhiko Okamura, Mami Murakami, Kohji Maruo, Yukihiro Akao, Takashi Mori
Circulating microRNAs in the blood may provide diagnostic and prognostic information about canine neoplastic diseases, and their profiles may be conserved between human and canine species. We performed RT-qPCR to obtain the profiles of circulating plasma microRNA-214 and -126 in total 181 cases of canine neoplastic diseases and healthy controls. MicroRNA-214 levels were high in 2 epithelial tumours (thyroid and mammary carcinomas) and 4 non-epithelial tumours (osteosarcoma, histiocytic sarcoma, chondrosarcoma, and hemangiosarcoma)...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28535416/the-role-of-timing-in-the-treatment-of-spinal-cord-injury
#11
REVIEW
Amene Saghazadeh, Nima Rezaei
Regeneration failure after primary spinal cord injury (SCI) leads to diverse clinical complications in a severity- and level of SCI-dependent manner. The cost of treating both of them (initial regeneration failure and following complications) would be prohibitive, particularly in less developed nations. The well-recognized circumstances arose from primary SCI include excitotoxicity and inflammation. SCI increases concentrations of extracellular amino acids (EAAs) in the severity-dependent manner and the maximum level of EAAs at the injury site will be reduced by distance from the injury site...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28533777/alternative-anaphylactic-routes-the-potential-role-of-macrophages
#12
REVIEW
María M Escribese, Domenico Rosace, Tomas Chivato, Tahia D Fernández, Angel L Corbí, Domingo Barber
Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. The second one, IgG-dependent anaphylaxis is induced by Ag cross-linking of Ag-specific IgG bound to IgG receptors (FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, and FcγRIIIA) on macrophages, neutrophils, and basophils...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28532897/mast-cells-improve-functional-recovery-of-transected-peripheral-nerve-a-novel-preliminary-study
#13
Behrooz Ilkhanizadeh, Leila Zarei, Negin Farhad, Mehran Bahrami-Bukani, Rahim Mohammadi
BACKGROUND: Employment of regenerative properties of cells at the service of nerve repair has been initiated during recent decades. Effects of local transplantation of bone marrow-derived mast cells on peripheral nerve regeneration were studied using a rat sciatic nerve transection model. MATERIALS AND METHODS: A 10-mm sciatic nerve defect was bridged using a conduit chitosan-based hybrid conduit filled with BMMCs in BMMC group. In positive control group (Pos), the conduit was filled with phosphate-buffered saline alone...
May 11, 2017: Injury
https://www.readbyqxmd.com/read/28527346/inhibitory-effects-of-2-oxo-2h-chromen-4-yl-4-methylbenzenesulfonate-on-allergic-inflammatory-responses-in-rat-basophilic-leukemia-cells
#14
Gaeun Yoo, Kooyeon Lee, Deug-Chan Lee
Mast cells play crucial roles in the initiation of allergic inflammatory responses by releasing various mediators such as histamines, cytokines, and leukotrienes. In addition, signaling cascade pathways, such as the mitogen-activated protein kinase (MAPK) pathway, contribute to the regulation of mast cell degranulation. Accordingly, different research strategies have been pursued to develop anti-inflammatory and anti-allergic drugs by regulating these signaling pathways. The development of new drugs that inhibit mast cell degranulation may help in the treatment of allergies...
May 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28526609/effects-of-l-dopa-benserazide-co-treatment-on-colonic-excitatory-cholinergic-motility-and-enteric-inflammation-following-dopaminergic-nigrostriatal-neurodegeneration
#15
C Pellegrini, L Antonioli, R Colucci, E Tirotta, D Gentile, C Ippolito, C Segnani, G Levandis, S Cerri, F Blandini, E Barocelli, V Ballabeni, N Bernardini, C Blandizzi, M Fornai
INTRODUCTION: The mainstay therapy for Parkinson's disease (PD) relies on L-3,4-dihydroxyphenylalanine (L-DOPA) plus a DOPA-decarboxylase inhibitor. However, their effects on colonic dysmotility and inflammation observed in PD are undetermined. This study examined the effects of L-DOPA plus benserazide (BE) on colonic motility and inflammation in rats with central nigrostriatal dopaminergic denervation. METHODS: Neurodegeneration was induced by 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB)...
May 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28524239/oral-contraceptive-pills-risky-or-protective-in-case-of-trichinella-spiralis-infection
#16
Marwa A Hasby Saad, Dina A Radi, Eiman A Hasby
AIM: to investigate how Trichinella spiralis infection can be affected by contraceptive pills invivo. METHODS: included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured (two gender worm counts, gravidity, larvae/muscle and RCI). Histopathological examination, immunohistochemical detection of C-kit mast cells & Foxp3+ T-reg...
May 19, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28523173/thrombotic-responses-to-coronary-stents-bioresorbable-scaffolds-and-the-kounis-hypersensitivity-associated-acute-thrombotic-syndrome
#17
REVIEW
Nicholas G Kounis, Ioanna Koniari, Anastasios Roumeliotis, Grigorios Tsigas, George Soufras, Nicholas Grapsas, Periklis Davlouros, George Hahalis
Percutaneous transluminal coronary angioplasty with coronary stent implantation is a life-saving medical procedure that has become, nowadays, the most frequent performed therapeutic procedure in medicine. Plain balloon angioplasty, bare metal stents, first and second generation drug-eluting stents, bioresorbable and bioabsorbable scaffolds have offered diachronically a great advance against coronary artery disease and have enriched our medical armamentarium. Stented areas constitute vulnerable sites for endothelial damage, endothelial dysfunction, flow turbulence, hemorheologic changes, platelet dysfunction, coagulation changes and fibrinolytic disturbances...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28523000/mast-cells-and-mcpt4-chymase-promote-renal-impairment-after-partial-ureteral-obstruction
#18
Maguelonne Pons, Liza Ali, Walid Beghdadi, Luca Danelli, Marianne Alison, Lydia Celia Madjène, Jessica Calvo, Julien Claver, Shamila Vibhushan, Magnus Åbrink, Gunnar Pejler, Marie-Laurence Poli-Mérol, Michel Peuchmaur, Alaa El Ghoneimi, Ulrich Blank
Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions are reproduced using a model of partial unilateral ureteral obstruction (pUUO) in newborn mice. Based on data showing significant mast cell (MC) infiltration in patients, we investigated the role of MC and murine MCPT4, a MC-released chymase, in pUUO using MC- (W(sh/sh)), MCPT4-deficient (Mcpt4(-/-)), and wild-type (WT) mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28522910/comparison-of-the-analgesic-effects-between-electro-acupuncture-and-moxibustion-with-visceral-hypersensitivity-rats-in-irritable-bowel-syndrome
#19
Ji-Meng Zhao, Liang Li, Liu Chen, Yin Shi, Yu-Wei Li, Hai-Xia Shang, Lu-Yi Wu, Zhi-Jun Weng, Chun-Hui Bao, Huan-Gan Wu
AIM: To observe whether there are differences in the effects of electro-acupuncture (EA) and moxibustion (Mox) in rats with visceral hypersensitivity. METHODS: EA at 1 mA and 3 mA and Mox at 43 °C and 46 °C were applied to the Shangjuxu (ST37, bilateral) acupoints in model rats with visceral hypersensitivity. Responses of wide dynamic range neurons in dorsal horns of the spinal cord were observed through the extracellular recordings. Mast cells (MC) activity in the colons of rats were assessed, and 5-hydroxytryptamine (5-HT), 5-hydroxytryptamine 3 receptor (5-HT3R) and 5-HT4R expressions in the colons were measured...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28520972/r634w-kit-mutation-in-an-adult-with-systemic-mastocytosis
#20
John M Astle, Michal G Rose, Frederick K Racke, Christopher A Tormey, Alexa J Siddon
Mastocytosis is a clonal neoplasm with the potential to affect various organs within the body. It can range in clinical severity from benign to extremely aggressive. Mastocytosis can be separated into cutaneous, systemic, and leukemic forms, as well as mast-cell sarcoma and extracutaneous mastocytoma. It is most often an acquired condition but can be inherited; the most commonly identified genetic aberrations leading to mastocytosis are activating mutations involving codon 816 of the KIT gene. Herein, we present the case of a 30-year-old Caucasian man with systemic mastocytosis discovered to have a p...
May 18, 2017: Laboratory Medicine
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