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https://www.readbyqxmd.com/read/29774034/targeting-vegf-vegfr-to-modulate-antitumor-immunity
#1
REVIEW
Ju Yang, Jing Yan, Baorui Liu
In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and hinder the differentiation and activation of dendritic cells (DCs). Recent studies have investigated the role of antiangiogenic agents in antitumor immunity, especially in recent 3 years. Therefore, it is necessary to update the role of targeting VEGF/VEGFR in antitumor immunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29772120/eosinophilic-esophagitis-relevance-of-mast-cell-infiltration
#2
Daniel S Strasser, Shanon Seger, Christian Bussmann, Gabin M Pierlot, Peter M A Groenen, Anna K Stalder, Alex Straumann
BACKGROUND AND AIMS: Eosinophilic esophagitis (EoE) is a chronic-inflammatory disease characterized clinically by symptoms of esophageal dysfunction and histopathologically by a prominent eosinophilic inflammation. Despite eosinophils having histologically a pre-dominant position, their role in the immunopathogenesis of the disease is still questionable. Several other inflammatory cells are involved and may play a critical role as well. The purpose of this study was to characterize the mast cell infiltration, and to correlate it with clinical state of EoE...
May 17, 2018: Histopathology
https://www.readbyqxmd.com/read/29772036/chronic-urticaria-following-practice-guidelines
#3
E P Westby, C Lynde, G Sussman
Histamine is a key inflammatory player in the pathogenesis of urticaria, a mast-cell-driven disease characterized clinically by the development of wheals, angioedema, or both. Changes to the management of chronic spontaneous urticaria have recently been adopted due to increasing literature surrounding the efficacy and safety of up-dosing modern second-generation H1 -antihistamines and the use of omalizamub, a biologic agent, as a third-line treatment. Given the prevalence of chronic urticaria and its impact on quality of life, this editorial aims to provide a summary of the proposed updated guidelines for the management of chronic urticaria as agreed upon at the 5th Consensus Conference on the Update and Revision of the EAACI/GA2 LEN/EDF/WAO Guideline for Urticaria in Berlin in December 2016...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29771451/modulation-of-inflammatory-and-hormonal-parameters-in-response-to-testosterone-therapy-effects-on-the-ventral-prostate-of-adult-rats
#4
Leonardo O Mendes, Anthony C S Castilho, Cristiane F Pinho, Bianca F Gonçalvez, Eduardo M Razza, Luiz Gustavo A Chuffa, Janete A Anselmo-Franci, Wellerson R Scarano, Francisco E Martinez
Testosterone is often recommended in the treatment of several aging-related conditions. However, there are still questions about the consequences of this therapy in terms of hormonal and inflammatory parameters that are crucial for prostate homeostasis.Thus, we investigate if the testosterone therapy (TT) modulates the hormone receptors and inflammatory cytokines in the ventral prostate of adult rats. Wistar rats aging 150 days were divided into two experimental groups(n = 10/group): T: received subcutaneous injections of testosterone cypionate (5mg/kg body weight) diluted in corn oil every other day for 4 weeks; and C: received corn oil as vehicle...
May 17, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29771393/differential-responses-of-picea-asperata-and-betula-albosinensis-to-nitrogen-supply-imposed-by-water-availability
#5
Chunying Yin, Sari Palmroth, Xueyong Pang, Bo Tang, Qing Liu, Ram Oren
A pot experiment was conducted to investigate the effects of nitrogen (N) addition (0, 20, 40 g N m-2 year-1, N0, N20, N40, respectively) on the growth, and biomass accumulation and allocation of coniferous and deciduous (Picea asperata Mast. and Betula albosinensis Burk.) seedlings under a range of soil moisture limitation (40%, 50%, 60%, 80% and 100% of field capacity, FC). At 100% FC, growth of shade-tolerant P. asperata increased with N supply, while that of shade-intolerant B. albosinensis reached a maximum at N20, declining somewhat thereafter...
May 16, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29769763/quantitative-analysis-of-mast-cell-count-and-density-in-chronic-periodontal-disease
#6
Surekha Rathod, Anubha Raj, Ishita Wanikar
Background: Mast cells play a crucial role in activation of acquired immune response to inflammatory conditions of periodontal diseases. They promote inflammation by releasing pro-inflammatory mediators and bring about angiogenesis, degeneration of the extracellular matrix, and tissue remodeling. Since there is little literature regarding the role of mast cells in periodontitis, the present study was aimed to evaluate mast cell count (MCC) and density in periodontitis. Materials and Methods: A total of eighty participants, Group I ( n = 40) healthy participants and Group II ( n = 40) participants with moderate chronic periodontitis, were included in the study...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29769546/effects-of-the-th2-dominant-milieu-on-allergic-responses-in-der-f-1-activated-mouse-basophils-and-mast-cells
#7
Myung-Hee Yi, Hyoung-Pyo Kim, Kyoung Yong Jeong, Ju Yeong Kim, In-Yong Lee, Tai-Soon Yong
Although basophils and mast cells share similar phenotypic and functional properties, little is known about the difference in the initial Th2 immune responses of these cells following exposure to proteolytic allergens. Here, we investigated the mechanisms of Th2-mediated immune responses in mouse bone marrow-derived basophils (BMBs) and mast cells (BMMCs) via stimulation with the cysteine protease allergen Der f 1. Our results showed that Th2 cytokines were induced from BMBs by active recombinant Der f 1 (rDer f 1 independently with Toll-like receptor (TLR) 2 and TLR4...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769506/evaluating-the-role-of-immunological-cells-tissue-eosinophils-and-mast-cells-in-progression-of-oral-squamous-cell-carcinoma
#8
S Saxena, A Singh, P Singh, K S Sundaragiri, B Sankhla, A Bhargava
Mast cells and eosinophils are increased in oral squamous cell carcinoma. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of the study was to study the mast cells and eosinophils between normal oral mucosa, leukoplakia and oral squamous cell carcinoma and to study the significance of mast cells in the progression of the lesion. A retrospective study was done on archival tissue received from January 2015 to December 2015, in the Department of Oral Pathology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769469/-activation-mechanisms-of-mast-cells-in-chronic-spontaneous-urticaria
#9
Yoshimichi Okayama
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29768271/direct-potentiation-of-capsaicin-current-by-histamine-and-its-effect-by-suplatast-on-rat-trigeminal-ganglia-neurons
#10
Jian-Rong Zhou, Tetsuya Shirasaki, Fumio Soeda, Kazumi Yokomizo, Kazuo Takahama
In this study, we investigated the effect of histamine on capsaicin-induced current and its influence by suplatast in rat trigeminal ganglia neurons using a patch-clamp technique. We found that histamine directly potentiated capsaicin-induced currents in rat sensory neurons, and suplatast had little effect on this potentiation. Since it has been known that suplatast suppresses histamine release from mast cells, it is possible that suplatast inhibits the activation of nociceptive fibers in the pathological condition via prevention of histamine-induced potentiation of the transient receptor potential vanilloid 1 receptor-mediated currents...
May 16, 2018: Pharmacology
https://www.readbyqxmd.com/read/29766296/characterization-of-in-vivo-metabolites-in-rat-urine-following-an-oral-dose-of-masitinib-by-liquid-chromatography-tandem-mass-spectrometry
#11
Adnan A Kadi, Sawsan M Amer, Hany W Darwish, Mohamed W Attwa
Masitinib (MST) is an orally administered drug that targets mast cells and macrophages, important cells for immunity, by inhibiting a limited number of tyrosine kinases. It is currently registered in Europe and USA for the treatment of mast cell tumors in dogs. AB Science announced that the European Medicines Agency has accepted a conditional marketing authorization application for MST to treat amyotrophic lateral sclerosis. In our work, we focused on studying in vivo metabolism of MST in Sprague-Dawley rats...
May 15, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29765110/mast-cells-contribute-to-enterovirus-71-infection-induced-pulmonary-edema-in-neonatal-mice
#12
Yuefei Jin, Chao Zhang, Hui Wang, Guangyuan Zhou, Xiangpeng Wang, Rongguang Zhang, Shuaiyin Chen, Jingchao Ren, Lu Chen, Dejian Dang, Peng Zhang, Yuanlin Xi, Weidong Wu, Weiguo Zhang, Guangcai Duan
Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal pulmonary edema. In this study, we established a mouse model for EV71 infection exhibiting high incidence of severe symptoms with pulmonary edema. Mast cells (MCs) accumulation, activation and allergic inflammation were found in the brains, lungs and skeletal muscle of mice after EV71 infection, especially in the lungs of mice. Levels of histamine, platelet-activating factor (PAF), interleukin (IL)-4, IL-5, IL-13, tumor necrosis factor-α (TNF-α), nitric oxide (NO), endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and noradrenaline (NA) were increased in EV71-infected lungs...
May 15, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29765013/a-new-tool-for-detection-of-extracellular-traps
#13
Alizé Proust, Julie-Christine Lévesque, Corinne Barat, Sachiko Sato, Michel J Tremblay
Extracellular traps ejected by various immune cells (neutrophils, macrophages, eosinophils and mast cells) have several immune functions, either protective against pathogens or deleterious in some autoimmune or inflammatory disorders. Since their first description in 2004, the mechanisms of extracellular traps formation have been extensively investigated though still not fully understood. We describe here a new tool for the detection of extracellular traps by fluorescence microscopy in a single-step staining protocol, which does not require any wash...
May 16, 2018: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29764932/distribution-of-mast-cell-subtypes-in-interstitial-cystitis-implications-for-novel-diagnostic-and-therapeutic-strategies
#14
Shabana T Malik, Brian R Birch, David Voegeli, Mandy Fader, Vipul Foria, Alan J Cooper, Andrew F Walls, Bashir A Lwaleed
AIMS: To identify the presence and geographical distribution of mast cell (MC) subtypes: MCT (tryptase positive-chymase negative) and MCTC (tryptase positive-chymase positive) in bladder tissue. METHODS: Bladder tissue was obtained from patients with painful bladder syndrome/interstitial cystitis (n=14) and normal histology from University Hospital Southampton tissue bank. Sequential tissue slices were immunohistochemically stained for MC subtypes using anti-MC tryptase (for MCT and MCTC ) and anti-MC chymase (for MCTC )...
May 15, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29764304/prednisolone-loaded-coatable-polyvinyl-alcohol-alginate-hydrogel-for-the-treatment-of-atopic-dermatitis
#15
Hye Ri Lee, Tae Ho Kim, Se Heang Oh, Jin Ho Lee
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting pruritic, erythema, edema, excoriation, and thickening of the skin, and thus leads to significant impairment in the patient's life. The objective of this study is to develop a steroid drug [prednisolone (PS)]-loaded coatable hydrogel for the treatment of AD. PS-loaded hydrogel was composed of PVA entrapped in mildly crosslinked alginate (PS-loaded PVA/ALG hydrogel). The PS concentration to be loaded in the hydrogel that takes AD efficacy without cell necrosis was determined from the cytotoxicity test using human dermal fibroblasts...
May 15, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29763725/salmonella-infection-may-alter-the-expression-of-toll-like-receptor-4-and-immune-related-cells-in-chicken-bursa-of-fabricius
#16
Abdur Rahman Ansari, Muhammad Arshad, Saima Masood, Hai-Bo Huang, Xing Zhao, Ningya Li, Zhijian Sun, Lei Cui, Yafang Hu, Hua-Zhen Liu
Toll like receptor 4 (TLR4), eosinophils and mast cells play significant role in host immunity during several pathogenic infections. However in vivo tissue expression of TLR4 and distribution pattern of eosinophils and mast cells in chicken bursa of Fabricius (BF) during Salmonella enterica serovar Typhimurium (STm) infection is poorly studied. Therefore, herein, following immunostaining, we found localization of TLR4 in follicular cortex and medulla and its expression was statistical increased after 36h and 72h of STm stimulation...
May 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29763661/prominent-release-of-lipoxygenase-generated-mediators-in-a-murine-house-dust-mite-induced-asthma-model
#17
Johan Kolmert, Sergio Piñeiro-Hermida, Craig E Wheelock, Mats Hamberg, Joshua A Gregory, Icíar P López, Alexander Fauland, Sven-Erik Dahlén, José G Pichel, Mikael Adner
The profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation remains unclear. This experimental study quantified metabolite levels of ω3-, ω6- and ω9-derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of repeated house dust mite (HDM) exposure in a murine (C57BL/6) asthma model. The challenge induced airway hyperresponsiveness, pulmonary eosinophil infiltration, but with low and unchanged mast cell numbers. Of the 112 screened LMs, 26 were increased between 2 to >25-fold in BALF with HDM treatment (p < 0...
May 12, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29763312/deep-sea-derived-butyrolactone-i-suppresses-ovalbumin-induced-anaphylaxis-by-regulating-mast-cell-function-in-a-murine-model
#18
Qingmei Liu, Chun-Lan Xie, Yuanyuan Gao, Bo Liu, Weixiang Lin, Hong Liu, Min-Jie Cao, Wen-Jin Su, Xianwen Yang, Guang-Ming Liu
Deep-sea-derived butyrolactone I (BTL-I) which was identified as a type of butanolide was isolated from Aspergillus sp. Ovalbumin (OVA)-induced BALB/c anaphylaxis was established to explore the anti-food allergic activity of BTL-I. As results, BTL-I was able to alleviate OVA-induced allergy symptoms, reduce the levels of histamine and mouse mast cell proteinases, inhibit OVA-specific IgE, and decrease the population of mast cells in the spleen and mesenteric lymph nodes. BTL-I also significantly suppressed mast-dependent passive cutaneous anaphylaxis...
May 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29761612/acute-radiotherapy-toxicity-in-57-dogs-with-gross-and-microscopic-mast-cell-tumours
#19
L Blackwood, J B Tanis, A Harper, I Amores-Fuster, D R Killick, R Finotello
Mast cell tumours (MCTs) are commonly treated with radiation therapy, most often in a microscopic disease setting. Poorer outcomes are expected in patients with gross disease, and irradiation of gross disease may be associated with greater toxicity. The aim of this study was to compare acute radiation adverse events (AE) in dogs with gross and microscopic MCTs receiving radiotherapy. Fifty-seven dogs were included, 28 with gross disease and 29 with microscopic. In order to assess mucosal and skin toxicity, patients were assigned to 2 groups: head (29 patients, 14 patients with gross and 15 microscopic) and other sites (28 patients, 14 each)...
May 15, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29761594/extracellular-interleukin-17f-has-a-protective-effect-in-oral-tongue-squamous-cell-carcinoma
#20
Rabeia Almahmoudi, Abdelhakim Salem, Meri Sieviläinen, Elias Sundquist, Alhadi Almangush, Sanna Toppila-Salmi, Timo Paavonen, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. METHODS: Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses...
May 14, 2018: Head & Neck
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