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https://www.readbyqxmd.com/read/29773516/lymphoedema-management-to-prevent-acute-dermatolymphangioadenitis-in-podoconiosis-in-northern-ethiopia-golbet-a-pragmatic-randomised-controlled-trial
#1
Henok Negussie, Meseret Molla, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
BACKGROUND: Podoconiosis (also known as endemic, non-filarial elephantiasis) affects about 4 million subsistence farmers in tropical Africa. Poor awareness of the condition and inadequate evidence for the efficacy of treatment mean that no government in an endemic country yet offers lymphoedema management for patients with podoconiosis. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: episodes of acute dermatolymphangioadenitis...
May 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29767340/speculation-as-to-why-the-frequency-of-eosinophilic-esophagitis-is-increasing
#2
REVIEW
Stuart Jon Spechler
PURPOSE OF REVIEW: The frequency of eosinophilic esophagitis (EoE), an immune/antigen-mediated disorder first described in 1993, has been increasing rapidly. The purpose of this review is to consider hypotheses proposed to explain this increase and to speculate on their validity. RECENT FINDINGS: The hygiene hypothesis attributes the rise of EoE to modern hygienic conditions resulting in fewer childhood infections with microbes that might have protected against allergy development...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29758151/clinical-effects-of-stabilized-stannous-fluoride-dentifrice-in-reducing-plaque-microbial-virulence-ii-metabonomic-changes
#3
Michael Cannon, Deepa Khambe, Malgorzata Klukowska, David L Ramsey, Melanie Miner, Tom Huggins, Donald J White
OBJECTIVES: The clinical effects of stannous fluoride (SnF2) dentifrice in reducing symptoms of gingivitis and reducing the virulence of subgingival plaque through suppression of activation of gene expression in toll receptor based reporter cells were previously reported. This study expanded analysis of the clinical study to include evaluation of dentifrice effects on salivary metabolites using 1H Nuclear Magnetic Resonance (1H NMR) systems biology-based metabonomics. METHODS: The clinical design was reported previously (J Clin Dent2017;28:16-26)...
March 2018: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29751492/aluminum-adjuvant-containing-vaccines-in-the-context-of-the-hygiene-hypothesis-a-risk-factor-for-eosinophilia-and-allergy-in-a-genetically-susceptible-subpopulation
#4
REVIEW
Todd D Terhune, Richard C Deth
There are similarities between the immune response following immunization with aluminum adjuvants and the immune response elicited by some helminthic parasites, including stimulation of immunoglobulin E (IgE) and eosinophilia. Immunization with aluminum adjuvants, as with helminth infection, induces a Th2 type cell mediated immune response, including eosinophilia, but does not induce an environment conducive to the induction of regulatory mechanisms. Helminths play a role in what is known as the hygiene hypothesis, which proposes that decreased exposure to microbes during a critical time in early life has resulted in the increased prevalence and morbidity of asthma and atopic disorders over the past few decades, especially in Western countries...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29729305/environmental-factors-and-eosinophilic-esophagitis
#5
Elizabeth T Jensen, Evan S Dellon
The incidence and prevalence of eosinophilic esophagitis (EoE) have markedly increased over the past two decades, outpacing increased detection of the disease. While genetic susceptibility markers for EoE have begun to be elucidated, the rate at which EoE has increased in incidence suggests environmental factors predominate. Despite many advances in the understanding of the pathogenesis of EoE, the etiology of EoE is unknown. This paper reviews the emerging data related to environmental risk factors for EoE...
May 2, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29723193/-s-wash-d-for-worms-a-pilot-study-investigating-the-differential-impact-of-school-versus-community-based-integrated-control-programs-for-soil-transmitted-helminths
#6
Naomi E Clarke, Archie C A Clements, Salvador Amaral, Alice Richardson, James S McCarthy, John McGown, Stuart Bryan, Darren J Gray, Susana V Nery
BACKGROUND: Soil-transmitted helminths (STH) infect nearly 1.5 billion individuals globally, and contribute to poor physical and cognitive development in children. STH control programs typically consist of regular delivery of anthelminthic drugs, targeting school-aged children. Expanding STH control programs community-wide may improve STH control among school-aged children, and combining deworming with improvements to water, sanitation and hygiene (WASH) may further reduce transmission...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29685190/differences-in-epidemiological-features-between-ulcerative-colitis-and-crohn-s-disease-the-early-life-programmed-versus-late-dysbiosis-hypothesis
#7
Laurent Beaugerie, Ebbe Langholz, Nynne Nyboe-Andersen, Bénédicte Pigneur, Harry Sokol
It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered composition of intestinal microbiota, called dysbiosis. We hypothesize that the role of the gut microbiota in Crohn's disease pathogenesis is linked to early-life abnormal crosstalk with the host immune system under construction...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29685149/rationale-for-environmental-hygiene-towards-global-protection-of-fetuses-and-young-children-from-adverse-lifestyle-factors
#8
Jean-Pierre Bourguignon, Anne-Simone Parent, Jos C S Kleinjans, Tim S Nawrot, Greet Schoeters, Nicolas Van Larebeke
BACKGROUND: The regulatory management of chemicals and toxicants in the EU addresses hundreds of different chemicals and health hazards individually, one by one. An issue is that, so far, the possible interactions among chemicals or hazards are not considered as such. Another issue is the anticipated delay of several decades before effective protection of public health by regulatory decisions due to a time consuming process. Prenatal and early postnatal life is highly vulnerable to environmental health hazards with lifelong consequences, and a priority period for reduction of exposure...
April 23, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29674142/usefulness-of-indicator-bacteria-as-potential-marker-of-campylobacter-contamination-in-broiler-carcasses
#9
Anna Roccato, Marzia Mancin, Lisa Barco, Veronica Cibin, Keti Antonello, Francesco Cocola, Antonia Ricci
According to Regulation (EC) No 2017/1495, amending Regulation (EC) No 2073/2005, a slaughterhouse process hygiene criterion based on a limit of 103  CFU/g of Campylobacter for no more than 20 (for the years 2018 and 2019), 15 (for the years 2020-2024) and 10 (starting from 2025) of 50 neck skin samples of broiler carcasses could be an effective measure to reduce the incidence of human campylobacteriosis. In order to stimulate the poultry industry to improve the control of Campylobacter along the slaughter-line, the quantification of indicator bacteria such as Escherichia coli or Enterobacteriaceae could be a useful strategy...
April 4, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29662960/impact-of-oral-hygiene-discontinuation-on-supragingival-and-salivary-microbiomes
#10
D Belstrøm, M L Sembler-Møller, M A Grande, N Kirkby, S L Cotton, B J Paster, S Twetman, P Holmstrup
The purpose of the present study was to characterize and compare supragingival and salivary microbiotas during a 10-d period of oral hygiene discontinuation. We tested the hypothesis that the composition of the salivary microbiota will reflect local microbial changes associated with accumulated biofilm formation and maturation. Pooled supragingival plaque ( n = 145) and stimulated saliva ( n = 145) samples were collected and plaque and gingival indices were recorded from 29 orally healthy individuals at baseline, during oral hygiene discontinuation (days 4, 7, and 10), and 14 d after resumption of oral hygiene...
January 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29650043/experimental-studies-on-effects-of-diet-on-lawsonia-intracellularis-infections-in-fattening-boars-in-a-natural-infection-model
#11
Christian Visscher, Anne Kruse, Saara Sander, Christoph Keller, Jasmin Mischok, Robert Tabeling, Hubert Henne, Ricarda Deitmer, Josef Kamphues
BACKGROUND: Lawsonia intracellularis is one of the most economically important pathogens in swine production. This study tested the hypothesis that the composition of diets for pigs has an impact on the excretion of L. intracellularis in a natural infection model. RESULTS: Fifty boars (~ 90 kg BW) from a SPF-farm with a strict hygiene and management regime for reducing the spread of an L. intracellularis infection up to the beginning of the final fattening period were transported, regrouped and randomly allotted to groups of five animals each at the research facility...
April 12, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29587338/interpretation-of-epigenetic-epidemiology-for-allergic-diseases
#12
Jong-Myon Bae
The hygiene hypothesis (HH) proposed by Strachan in 1989 has expanded to explain an inverse association between occurrence of allergy disorders and risk of infectious diseases and parasite infestation. And the microflora hypothesis (MH) suggests that gut microbial dysbiosis on early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept of epigenetics. The amalgamation of the epidemiology and epigenetics created a science of epigenetic epidemiology...
March 10, 2018: Epidemiology and Health
https://www.readbyqxmd.com/read/29569447/association-between-salivary-cortisol-level-and-caries-in-early-childhood
#13
S Caruso, R Gatto, B Cinque, M G Cifone, A Mattei
AIM: The present study aimed to evaluate the association between caries and oral health status, age, salivary cortisol levels, and parental education in children with and without prior dental caries experience. MATERIALS AND METHODS: An observational case-control study was performed including 122 children aged between 3 and 6 years who were clinically examined for caries experience using the sum of decayed, missing, and filled teeth in the primary (dmft index) and permanent (DMFT index) dentition...
March 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29563402/autoimmune-diseases-and-oral-health-30-year-follow-up-of-a-swedish-cohort
#14
Anna Julkunen, Anna Maria Heikkinen, Birgitta Söder, Per-Östen Söder, Sanna Toppila-Salmi, Jukka H Meurman
Oral infections up-regulate a number of systemic inflammatory reactions that, in turn, play a role in the development of systemic diseases. We investigated the association between oral health and autoimmune diseases in a cohort of Swedish adults. Hypothesis was that poor oral health associates with incidence of autoimmune diseases. Overall 1676 subjects aged 30-40 years old from Stockholm County (Sweden) participated in this study in 1985. Subjects were randomly selected from the registry file of Stockholm region and were followed-up for 30 years...
December 22, 2017: Dentistry journal
https://www.readbyqxmd.com/read/29531744/is-childhood-wheeze-and-asthma-in-latin-america-associated-with-poor-hygiene-and-infection-a-systematic-review
#15
Cristina Ardura-Garcia, Paul Garner, Philip J Cooper
Introduction: High asthma prevalence in Latin-American cities is thought to be caused by poor hygiene and infections. This contradicts the widely accepted 'hygiene hypothesis' for asthma aetiology. Methods: Systematic review of observational studies evaluating the association between poor hygiene exposures or infections and asthma/wheeze among Latin-American children aged 4-16 years. MEDLINE, EMBASE, LILACS and CINAHL electronic databases were searched following a predefined strategy to 18 December 2017...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29528545/low-cytomegalovirus-seroprevalence-in-early-multiple-sclerosis-a-case-for-the-hygiene-hypothesis
#16
E Alari-Pahissa, A Moreira, A Zabalza, R Alvarez-Lafuente, E Munteis, A Vera, R Arroyo, J C Alvarez-Cermeño, L M Villar, M López-Botet, J E Martínez-Rodríguez
BACKGROUND AND PURPOSE: Cytomegalovirus (CMV) infection has recently been associated with a lower multiple sclerosis (MS) susceptibility, although it remains controversial whether it has a protective role or is merely an epiphenomenon related to westernization and early-life viral infections. We aimed to evaluate whether CMV serostatus may differ in patients with early MS as compared with patients with non-early MS, analyzing the putative association of this virus with MS clinical course and humoral immune responses against other herpesviruses...
March 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29521052/probiotics-myths-or-facts-about-their-role-in-allergy-prevention
#17
Edyta Krzych-Fałta, Konrad Furmańczyk, Aneta Tomaszewska, Dominik Olejniczak, Bolesław Samoliński, Urszula Samolińska-Zawisza
BACKGROUND: The hygiene hypothesis proposed by Strachan in the 1980s clearly emphasized the role of microorganisms in atopy prevention. OBJECTIVES: The study objective was to assess the preventive role of probiotics in patients with allergic rhinitis, bronchial asthma, atopic dermatitis, and/or food allergy. MATERIAL AND METHODS: The methods used in the study were the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires for 6-7- and 13-14-year-olds and the European Community Respiratory Health Survey II (ECRHS II) questionnaire targeted for the 20-44 age group...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29516688/hygiene-practices-are-they-protective-factors-for-eczema-symptoms
#18
David Ferrandiz-Mont, Nur Wahyuniati, Hsin-Jen Chen, Mulyadi Mulyadi, Tjut Mariam Zanaria, Dar-Der Ji
INTRODUCTION: Exact etiology and proper treatment of eczema are still unknown. The hygiene hypothesis and epidermal barrier dysfunction hypothesis attempted to give some plausible explanations for these issues but they still remain unclear. The identification of factors, including hygiene practices, related to eczema symptoms (ES) could shed some light on these matters. Therefore, this study aimed to determine risk factors related to ES and the ES prevalence in two disparate areas in terms of urbanization in Aceh, Indonesia...
June 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29510117/antigenic-cross-reactivity-between-schistosoma-mansoni-and-pollen-allergens-from-the-birch-tree-betula-verrucosa-and-timothy-grass-phleum-pratense-involvement-of-shared-glycan-epitopes-and-implications-for-the-hygiene-hypothesis
#19
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Gabriele Schramm, Michael J Doenhoff
Previous studies have shown that schistosome infection can protect against allergic symptoms, but the underlying mechanisms are still not fully understood. Here we have shown that rabbit IgG antibodies raised against Schistosoma mansoni soluble egg antigens (SmSEA) are cross-reactive with a wide array of molecules in Timothy grass pollen (TGP) and birch tree pollen (BTP). Five of the cross-reactive pollen molecules (two from TGP and three from BTP) were selected randomly and identified by tandem mass spectrometric (TMS) analysis to be, respectively, the TGP allergens Phl p 1 and Phl p 5b, and BTP glutathione S-transferase (GST), and the BTP allergens Bet v 1 and Bet v 6...
April 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29476334/oral-health-in-alzheimer-s-disease-a-multicenter-case-control-study
#20
F Aragón, M A Zea-Sevilla, J Montero, P Sancho, R Corral, C Tejedor, B Frades-Payo, V Paredes-Gallardo, A Albaladejo
OBJECTIVES: The aim of this case-control study was to carry out an oral health assessment on a group of Alzheimer's patients and to establish a hypothesis regarding the implication of the characteristics of the disease and the treatment of oral health. MATERIALS AND METHODS: A total of 70 Alzheimer's patients, residents at the Alzheimer Center Reina Sofia Foundation (Madrid, Spain) and at the Alzheimer State Reference Center (Salamanca, Spain), and 36 controls (companions/acquaintances), were studied by oral examination and saliva sampling...
February 23, 2018: Clinical Oral Investigations
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