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Hai-yan Zhou, Li-na Zhang, Ming-zhi Zheng, Lin-lin Wang, Ying-ying Chen, Yue-Liang Shen
Levosimendan is a calcium-sensitizing agent shown to prevent myocardical contractile depression in various heart diseases. In this study, we investigated the effect of levosimendan on cardiac dysfunction and apoptosis in hypothermic preservation rat hearts. Isolated rat hearts were preserved in Celsior solution with or without levosimendan. The left ventricular developed pressure (LVDP) recovery rate of isolated rat heart significantly decreased, and the apoptosis index increased after 9 hours of hypothermic preservation...
September 2014: Journal of Cardiovascular Pharmacology
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