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JOURNAL ARTICLE
Chongyang Wu, Li Xiong, Quanfeng Liao, Weili Zhang, Yuling Xiao, Yi Xie
BACKGROUND: Elizabethkingia is emerging as an opportunistic pathogen in humans. The aim of this study was to investigate the clinical epidemiology, antimicrobial susceptibility, virulence factors, and genome features of Elizabethkingia spp. METHODS: Clinical data from 71 patients who were diagnosed with Elizabethkingia-induced pneumonia and bacteremia between August 2019 and September 2021 were analyzed. Whole-genome sequencing was performed on seven isolates, and the results were compared with a dataset of 83 available Elizabethkingia genomes...
April 10, 2024: Annals of Clinical Microbiology and Antimicrobials
#22
JOURNAL ARTICLE
Yuquan Gao, Xudong Feng, Ting Yuan, Min Li, Muyun Wei, Shuangshuang Li
Data on people suspected with acute respiratory infections (ARIs) from August 2022 to December 2023 in southern China were analyzed. Following the COVID-19 pandemic, the positive detection rates of respiratory pathogens increased to 56.9%. Influenza A virus (IAV) emerged as the predominant prevalence pathogen (52.1%), followed by Mycoplasma pneumoniae (Mp: 21.2%), and SARS-CoV-2 (11.6%). Mp, IAV, and Human rhinovirus (HRV) infection were the primary etiologies of ARIs patients under age 18, accounting for 49...
April 4, 2024: Diagnostic Microbiology and Infectious Disease
#23
JOURNAL ARTICLE
Surmani Huidrom, Pulok K Mukherjee, Sarangthem Indira Devi
Fermented foods have been recognized as a source of probiotic bacteria which can have a positive effect when administered to humans and animals. Discovering new probiotics in fermented food products poses a global economic and health importance. In this study, we investigated the antimicrobial and probiotic potential of lactobacilli isolated from fermented beverages produced traditionally by ethnic groups in Northeast India. Out of thirty Lactobacilli, fifteen exhibited strong antimicrobial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes with significant anti-biofilm and anti-quorum sensing activity...
April 10, 2024: Current Microbiology
#24
JOURNAL ARTICLE
Sarah M McLeod, Alita A Miller, Khurram Rana, David Altarac, Samir H Moussa, Adam B Shapiro
BACKGROUND: In a previous study, the efficacy and safety of sulbactam-durlobactam vs colistin for the treatment of patients with carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRABC) infections were evaluated in a randomized controlled phase 3 trial. Both arms were dosed on a background of imipenem-cilastatin to treat coinfecting gram-negative pathogens. Thirty-six percent of infections in the primary efficacy population were polymicrobial. METHODS: A subset analysis was performed to compare clinical and microbiological outcomes at test of cure (7 ± 2 days after the last dose) for patients with monomicrobial and polymicrobial CRABC infections...
April 2024: Open Forum Infectious Diseases
#25
JOURNAL ARTICLE
Bohui Qian, Kazuhiro Ishikawa, Tomoaki Nakamura, Katsuhito Kinoshita, Tetsuhiro Masaki, Takahiro Matsuo, Fujimi Kawai, Nobuyoshi Mori
BACKGROUND Shewanella spp. are gram-negative facultative anaerobic, oxidase-positive, motile bacilli that are ubiquitous but commonly occur in seawater and can cause opportunistic infection. Reports on the risk factors for Shewanella infection, its severity, antibiotic susceptibility, and prognosis are limited. This report is of a 78-year-old man with alcoholic cirrhosis presenting with bacteremia and empyema due to infection with Shewanella spp. CASE REPORT A 78-year-old man with alcoholic cirrhosis (Child-Pugh B) presented to our emergency room with a high fever...
April 10, 2024: American Journal of Case Reports
#26
JOURNAL ARTICLE
Yu Ning, Tieshan Teng, Xuehan Wu, Menglu Wang, Xin Jiao, Jinjuan Qiao
Pseudomonas aeruginosa is a Gram-negative bacterium associated with life-threatening healthcare-associated infections (HAIs), including burn wound infections, pneumonia and sepsis. Moreover, P. aeruginosa has been considered a pathogen of global concern due to its rising antibiotic resistance. Efficient identification of P. aeruginosa would significantly benefit the containment of bacterial infections, prevent pathogen transmission, and provide orientated treatment options. The accuracy and specificity of bacterial detection are primarily dictated by the biorecognition molecules employed...
April 6, 2024: Enzyme and Microbial Technology
#27
JOURNAL ARTICLE
Kanao Kobayashi, Satoshi Takahashi, Mitsuru Yasuda, Jun Miyazaki, Koichiro Wada, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Naoki Hasegawa, Intetsu Kobayashi, Naoya Masumori, Takahiro Kimura, Hiroki Yamada, Tohru Nakagawa, Tomoyuki Kaneko, Kazumasa Matsumoto, Tetsuya Fujimura, Jun Kamei, Kiyohito Ishikawa, Kiyohide Fujimoto, Yasushi Nakai, Katsumi Shigemura, Takuya Sadahira, Nobuyuki Hinata, Hiroyuki Kitano, Masuo Yamashita, Tomihiko Yasufuku, Hisao Komeda, Yoshiki Hiyama, Yoshito Takahashi, Sojun Kanamaru, Masaya Murakami, Soichi Arakawa, Daisuke Yamada, Koji Mita, Ryoichi Hamasuna, Kazushi Tanaka, Masanori Matsukawa, Eiichiro Takaoka, Masanobu Shigeta, Tadasu Takenaka, Masashi Nishino, Satoshi Ishitoya, Shohei Hayakawa, Kazuhiro Okumura, Masakatsu Ueda
INTRODUCTION: Antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using the national surveillance data, comprising 793 bacterial strains from eight clinically relevant species. MATERIALS AND METHODS: Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology...
April 6, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#28
JOURNAL ARTICLE
Francina Escobar-Arregocés, Mayra-Alexandra Eras, Andrea Bustos, Angela Suárez-Castillo, Dabeiba-Adriana García-Robayo, Maria Del Pilar Bernal
OBJECTIVE: To identify the characteristics of the oral microbiota and the relationship of the dental caries and periodontal status in patients aged 0 to 18 years with non-syndromic cleft lip and palate (CLP). MATERIALS AND METHODS: A systematic review of the literature was carried out. Five databases were consulted, including publications in English, Spanish and Portuguese. The evaluations of the quality of the observational studies and the experimental studies were carried out with the Newcastle-Ottawa scale and CONSORT guidelines, respectively...
April 8, 2024: Clinical Oral Investigations
#29
JOURNAL ARTICLE
Stefano Amadesi, Caterina Vocale, Davide Guariglia, Monica Cricca, Tiziana Lazzarotto, Vittorio Sambri, Paolo Gaibani
Streptococcus pneumoniae is a major global health concern, being a common cause of meningitis in both children and adults. Here, we report the complete genome sequence of P10_PNE_LCR, a S. pneumoniae 11A strain isolated in Northern Italy from an adult patient diagnosed with meningitis.
April 8, 2024: Microbiology Resource Announcements
#30
JOURNAL ARTICLE
Yingjian Liu, Qian Zhu, Gongjie Guo, Zhipeng Xie, Senlin Li, Chengyang Lai, Yonglin Wu, Liansheng Wang, Shilong Zhong
BACKGROUND: Inflammation serves as a key pathologic mediator in the progression of infections and various diseases, involving significant alterations in the gut microbiome and metabolism. This study aims to probe into the potential causal relationships between gut microbial taxa and human blood metabolites with various serum inflammatory markers (CRP, SAA1, IL-6, TNF-α, WBC, and GlycA) and the risks of seven common infections (gastrointestinal infections, dysentery, pneumonia, bacterial pneumonia, bronchopneumonia and lung abscess, pneumococcal pneumonia, and urinary tract infections)...
2024: Frontiers in Microbiology
#31
REVIEW
Zhujun Yang, Junjun Zhou, Nana Su, Zifan Zhang, Jiaxin Chen, Peng Liu, Peng Ling
Mycoplasma pneumoniae causes respiratory tract infections, affecting both children and adults, with varying degrees of severity ranging from mild to life-threatening. In recent years, a new class of regulatory RNAs called long non-coding RNAs (lncRNAs) has been discovered to play crucial roles in regulating gene expression in the host. Research on lncRNAs has greatly expanded our understanding of cellular functions involving RNAs, and it has significantly increased the range of functions of lncRNAs. In lung cancer, transcripts associated with lncRNAs have been identified as regulators of airway and lung inflammation in a process involving protein complexes...
2024: Frontiers in Microbiology
#32
JOURNAL ARTICLE
Aurora Piazza, Vittoria Mattioni Marchetti, Alessandra Bielli, Gherard Batisti Biffignandi, Francesca Piscopiello, Riccardo Giudici, Livia Tartaglione, Marco Merli, Chiara Vismara, Roberta Migliavacca
INTRODUCTION: Aim of the study was the molecular characterization of 21 ceftazidime/avibactam resistant (CZA-R) Klebsiella pneumoniae strains, collected in the period October 2021-March 2022 from an Intensive Care COVID Unit in a Northern Italian Hospital. METHODS: After growth on selective/chromogenic culture media and susceptibility tests assessment, resistance genes content was ascertained for all the isolates by the HybriSpot 12 multiplexing, PCR and Whole-Genome Sequencing (WGS)...
March 29, 2024: Journal of Microbiology Immunology and Infection
#33
REVIEW
Connor Prosty, Khaled Katergi, Mark Sorin, Marianne Bou Rjeily, Guillaume Butler-Laporte, Emily G McDonald, Todd C Lee
BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is a common opportunistic infection among people living with HIV (PLWH), particularly among new and untreated cases. Several regimens are available for the prophylaxis of PCP including trimethoprim-sulfamethoxazole (TMP-SMX), dapsone-based regimens (DBRs), aerosolized pentamidine (AP), and atovaquone. OBJECTIVE: To compare the efficacy and safety of PCP prophylaxis regimens in PLWH by network meta-analysis. DATA SOURCES: Embase, MedLine, and CENTRAL from inception to June 21, 2023...
April 5, 2024: Clinical Microbiology and Infection
#34
JOURNAL ARTICLE
Yang Han, Xiaoshuang Liu, Qian Jia, Jiayu Xu, Jinlong Shi, Xiang Li, Guotong Xie, Xiaojing Zhao, Kunlun He
BACKGROUND: Gut microbiota is significantly influenced by altitude. However, the dynamics of gut microbiota in relation to altitude remains undisclosed. METHODS: In this study, we investigated the microbiome profile of 610 healthy young men from three different places in China, grouped by altitude, duration of residence, and ethnicity. We conducted widely targeted metabolomic profiling and clinical testing to explore metabolic characteristics. RESULTS: Our findings revealed that as the Han individuals migrated from low altitude to high latitude, the gut microbiota gradually converged towards that of the Tibetan populations but reversed upon returning to lower altitude...
April 5, 2024: Microbiome
#35
JOURNAL ARTICLE
Ricardo Calderon-Gonzalez, Amy Dumigan, Joana Sá-Pessoa, Adrien Kissenpfennig, José A Bengoechea
In vivo single-cell approaches have transformed our understanding of the immune populations in tissues. Mass cytometry (CyTOF), that combines the resolution of mass spectrometry with the ability to conduct multiplexed measurements of cell molecules at the single cell resolution, has enabled to resolve the diversity of immune cell subsets, and their heterogeneous functionality. Here we assess the feasibility of taking CyTOF one step further to immuno profile cells while tracking their interactions with bacteria, a method we term Bac-CyTOF...
April 5, 2024: PLoS Pathogens
#36
JOURNAL ARTICLE
Xu Cao, Lan Huang, Min Tang, Yue Liang, Xinpeng Liu, Huijin Hou, Shufang Liang
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed enormous challenges to global public health. The use of antibiotics has greatly increased during the SARS-CoV-2 epidemic owing to the presence of bacterial co-infection and secondary bacterial infections. The antibiotics daptomycin (DAP) is widely used in the treatment of infectious diseases caused by gram-positive bacteria owing to its highly efficient antibacterial activity. It is pivotal to study the antibiotics usage options for patients of coronavirus infectious disease (COVID-19) with pneumonia those need admission to receive antibiotics treatment for bacterial co-infection in managing COVID-19 disease...
April 5, 2024: Virulence
#37
JOURNAL ARTICLE
Shahinda Rezk, Nourhan Ashraf, Hassan Heshmat, Gamal Elsawaf, Amel Elsheredy
Bloodstream infections (BSIs) caused by multidrug-resistant bacteria are a critical life-threatening challenge which necessitates the urgency to trigger life-saving treatment in a timely manner. This study aimed to evaluate the time required for rapid detection of carbapenemase-producing Enterobacterales (CPE) directly from blood culture bottles to optimize empirical treatment of BSI, especially in pediatric and infant patients, using a cost-effective method. This study included 419 Gram-negative bacteria, of which Klebsiella pneumoniae and Escherichia coli were the most common CPE causing BSI in pediatric and neonatal patients...
April 4, 2024: Acta Microbiologica et Immunologica Hungarica
#38
JOURNAL ARTICLE
Xueyun Zhu, Caixia Guo, Shengxi Xu, Fei Lv, Zhusheng Guo, Sisi Lin, CongZhu Yang, Zhuliang Deng, Shaofeng Chen, Ya Huang, Zuguo Zhao, Lu Li
INTRODUCTION: Bacterial resistance is a major threat to public health worldwide. To gain an understanding of the clinical infection distribution, drug resistance information, and genotype of CRE in Dongguan, China, as well as the resistance of relevant genotypes to CAZ-AVI, this research aims to improve drug resistance monitoring information in Dongguan and provide a reliable basis for the clinical control and treatment of CRE infection. METHODS: VITEK-2 Compact automatic analyzer was utilized to identify 516 strains of CRE collected from January 2017 to June 2023...
2024: Frontiers in Cellular and Infection Microbiology
#39
Flavia Zendri, Vanessa Schmidt, Norman Mauder, Anette Loeffler, Rosanne Ellen Jepson, Cajsa Isgren, Gina Pinchbeck, Sam Haldenby, Dorina Timofte
[This corrects the article DOI: 10.3389/fmicb.2024.1334268.].
2024: Frontiers in Microbiology
#40
JOURNAL ARTICLE
Tasson da Costa Rodrigues, Patricia Zorzete, Eliane Namie Miyaji, Viviane Maimoni Gonçalves
Streptococcus pneumoniae can cause diseases with high mortality and morbidity. The licensed vaccines are based on capsular polysaccharides and induce antibodies with low cross reactivity, leading to restricted coverage of serotypes. For surpassing this limitation, new pneumococcal vaccines are needed for induction of broader protection. One important candidate is the pneumococcal surface protein A (PspA), which can be classified in 6 clades and 3 families. We have reported an efficient process for production and purification of untagged recombinant PspA from clade 4 (PspA4Pro)...
April 4, 2024: Applied Microbiology and Biotechnology
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