Hiam Abdala-Valencia, Mackenzie E Coden, Sergio E Chiarella, Elizabeth A Jacobsen, Bruce S Bochner, James J Lee, Sergejs Berdnikovs
Eosinophils play homeostatic roles in different tissues and are found in several organs at a homeostatic baseline, though their tissue numbers increase significantly in development and disease. The morphological, phenotypical, and functional plasticity of recruited eosinophils are influenced by the dynamic tissue microenvironment changes between homeostatic, morphogenetic, and disease states. Activity of the epithelial-mesenchymal interface, extracellular matrix, hormonal inputs, metabolic state of the environment, as well as epithelial and mesenchymal-derived innate cytokines and growth factors all have the potential to regulate the attraction, retention, in situ hematopoiesis, phenotype, and function of eosinophils...
April 14, 2018: Journal of Leukocyte Biology