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Pneumonia etiology

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https://www.readbyqxmd.com/read/28641650/-changes-of-thrombopoietin-levels-in-patients-with-acute-inflammatory-disease-and-its-significance
#1
Lei Liu, Wan-Hua Xu, Li-Xia Zhou, Mo Yang
OBJECTIVE: To investigate the changes of TPO levels in patients with acute inflammatory response disease of different etiologies. METHODS: In the case -control study, 65 patients with acute inflammatory response disease were enrolled in the case group (15 patients with acute myocardial infarction, 15 patients with acute cerebral infarction, 25 patients with acute trauma and 10 patients with acute pneumonia), and 42 healthy subjects were selected as the control group...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28640135/hospitalization-with-hypoglycemia-in-patients-without-diabetes-mellitus-a-retrospective-study-using-a-national-inpatient-database-in-japan-2008-2012
#2
Akahito Sako, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Hidetaka Hamasaki, Hisayuki Katsuyama, Tetsuro Tsujimoto, Atsushi Goto, Hidekatsu Yanai
We aimed to examine prevalence, patient characteristics, etiology, and clinical outcomes of hospitalized patients who had hypoglycemia without a diagnosis of diabetes mellitus, using a Japanese nationwide database.This was a retrospective observational study using a national database of acute-care inpatients in Japan. Nondiabetic patients aged ≥15 years who were hospitalized for hypoglycemia were eligible. We estimated the annual numbers of hospitalized cases in Japan. We also investigated the patient characteristics, and risk factors of in-hospital mortality...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28631692/-multidisciplinary-problems-of-rheumatology-and-pulmonology
#3
L P Ananyeva
Damage to the respiratory system worsens prognosis and increases mortality in all systemic immunoinflammatory rheumatic diseases (SIRDs). Leading pulmonary manifestations in each disease are different, so the typical picture of each nosological entity is very peculiar. In all SIRDs, the disease starts with lung involvement in 10-20% of cases, preceding the expanded clinical presentation of a systemic disease. At a certain stage, lung damage may be the only manifestation of the disease or predominate in its clinical picture, determining the severity of a condition...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28628338/community-acquired-tsukamurella-pneumonia-in-a-young-immunocompetent-adult-a-case-misdiagnosed-as-pulmonary-tuberculosis-and-literature-review
#4
LiKun Yang, Yan Cao, Zijun Dan, Zhongyuan Wang, Xinjing Wang
This report describes a case of Tsukamurella pneumonia in a 24-year-old immunocompetent woman. The patient was diagnosed as having pulmonary tuberculosis and was treated for nearly 9 months. The correct diagnosis was suspected only when the results of mycobacteria nucleic acid amplification tests on cultural colonies were negative. Tsukamurella was identified from the patient's sputum and bronchoalveolar lavage fluid by using 16S rRNA sequence analysis. Here, the clinical presentation, diagnosis, and treatment strategies of Tsukamurella pneumonia are discussed, along with a literature review...
June 19, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28626631/chronic-eosinophilic-pneumonia-adjunctive-therapy-with-inhaled-steroids
#5
Christopher Chan, David DeLapp, Perry Nystrom
Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare form of diffuse parenchymal lung disease first identified by Carrington et al. in 1969. It is characterized by the presence of constitutional and respiratory symptoms with associated peripheral opacities on imaging and elevated serum and/or bronchoalveolar eosinophilia. Although data is limited regarding etiology or prevalence, it is known that ICEP has a 2:1 female: male predominance and typically affects non-smokers. Diagnosis rests on the clinical constellation of respiratory symptoms of at least 2-4 weeks duration, the presence of diffuse pulmonary alveolar consolidation, classically described as the "photographic negative of pulmonary edema", the presence of eosinophils ≥40% on bronchoalveolar lavage or ≥1000/mm(3) eosinophils on peripheral blood and the exclusion of other known causes of eosinophilic lung diseases such as drugs, toxins, fungi, parasites, and collagen-vascular disorders...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28621243/retrospective-evaluation-of-patients-with-organizing-pneumonia-is-cryptogenic-organizing-pneumonia-different-from-secondary-organizing-pneumonia
#6
Saliha Yılmaz, Berna Akıncı Özyürek, Yurdanur Erdoğan, Burcu Cirit Koçer, Funda Demirağ, Yeliz Dadalı, Sertaç Büyükyaylacı Özden
Introduction: Organizing pneumonia (OP) is an uncommon clinic opathological situation among lung diseases. If no underlying cause can be detected, it is named as cryptogenic OP (COP). In this study, the etiologic and clinical characteristics of patients diagnosed as OP in our hospital in the last ten years were evaluated retrospectively. It was also aimed to make a comparison between COP and secondary OP patients. Materials and Methods: One hundred sixty-five patients diagnosed as OP pathologically in the 10 year period from August 2003 to August 2013 were included into that study...
March 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28618727/analysis-of-epidemiology-and-risk-factors-for-mortality-in-ventilator-associated-pneumonia-attacks-in-intensive-care-unit-patients
#7
Ayşe But, Meltem Arzu Yetkin, Dilek Kanyilmaz, Halide Aslaner, Aliye Baştuğ, Adalet Aypak, Pınar Öngürü, Esragül Akinci, Nevzat Mehmet Mutlu, Hürrem Bodur
BACKGROUND/AIM: The aim of this study was to investigate the epidemiologic characteristics, the causative microorganisms and their antimicrobial susceptibility patterns, and the prognostic risk factors for mortality in critically ill patients with ventilator-associated pneumonia (VAP). MATERIALS AND METHODS: In this retrospective observational study, all the critically ill patients with VAP hospitalized in a medical/surgical intensive care unit (ICU) between January 2010 and June 2015 were evaluated...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28611227/lung-injury-etiology-and-other-factors-influencing-the-relationship-between-dead-space-fraction-and-mortality-in-ards
#8
Richard H Kallet, Hanjing Zhuo, Kelly Ho, Michael S Lipnick, Antonio Gomez, Michael A Matthay
BACKGROUND: In ARDS, elevated pulmonary dead-space fraction (VD/VT) is a particularly strong indicator of mortality risk. Whether the magnitude of VD/VT is modified by the underlying etiology of ARDS and whether this influences the strength of its association with mortality remains unknown. We sought to elucidate the impact of ARDS etiology on VD/VT and also to determine whether ARDS severity, as classified by the Berlin definition, has correspondence with changes in VD/VT. METHODS: This single-center, retrospective, observational study (2010-2016) measured VD/VT in 685 subjects with ARDS as part of clinical management with lung-protective ventilation...
June 13, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28592028/-analysis-of-12-cases-of-exogenous-lipoid-pneumonia-confirmed-by-pathology
#9
Y X Wang, F Fang, Y F Guo, Y M Li, T Y Sun, M Zhang, J Chen, B M Fang
Objective: To study the etiological, clinical, radiological, diagnostic, therapeutic, and prognostic manifestations of exogenous lipoid pneumonia (ELP), and therefore to improve the diagnosis and treatment of this disease. Methods: The clinical data of 12 cases of ELP confirmed by pathology were retrospectively analyzed. Results: The patients consisted of 9 males and 3 females, with an average age of 73.8 years (range, 44 to 100 years). The underlying diseases were variable, including diseases affecting the general condition (multiple organ failure, chronic heart and renal insufficiency, pemphigoid, etc) and conditions with increased risk of aspiration (sequelae of cerebrovascular disease, Alzheimer's disease, advanced stage of nasopharyngeal carcinoma, paralytic ileus, etc)...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28589425/comparison-of-the-immuview-and-the-binaxnow-antigen-tests-in-detection-of-streptococcus-pneumoniae-and-legionella-pneumophila-in-urine
#10
S Athlin, A Iversen, V Özenci
The use of urinary antigen tests (UATs) may provide early etiology in pneumonia, and facilitates rapid and directed antibiotic treatment. In this study, we evaluated the novel lateral flow ImmuView Streptococcus pneumoniae and Legionella pneumophila UAT, which detects pneumococcal and L. pneumophila serogroup 1 antigens in a combined test. We compared the ImmuView UAT with the BinaxNOW S. pneumoniae UAT and the BinaxNOW L. pneumophila UAT in 147 patients with pneumococcal bacteremia (n = 48), non-pneumococcal non-Legionella bacteremia (n = 93) and Legionella infections in the lower airways (L...
June 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28585603/etiological-and-epidemiological-factors-in-hearing-impaired-students-in-van-east-of-turkey-a-case-series
#11
Ahmet Faruk Kiroglu, Muzaffer Ari, Nazim Bozan, Mehmet Parlak, Hakan Cankaya
The aim of the present case series was to investigate the causes of hearing loss in the children studying at a primary School for the deaf in Van Province, Turkey. The present series included 95 children with sensorineural hearing loss. Otoscopic and ophthalmological examinations, pure-tone audiometry, and tympanometry were performed for each patient. Measles IgG, rubella IgG, cytomegalovirus (CMV) IgG, toxoplasma IgG, herpes simplex virus (HSV) Type I (HSV-I) IgG, HSV Type II (HSV-II) IgG, and Mycoplasma pneumonia IgG were evaluated in serum samples...
June 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28584988/methodology-for-anti-cryptococcal-vaccine-development
#12
Ashok K Chaturvedi, Floyd L Wormley
Cryptococcus neoformans and Cryptococcus gattii, the predominant etiological agents of cryptococcosis, are fungal pathogens that cause disease ranging from a mild pneumonia to life-threatening infections of the central nervous system (CNS). C. neoformans is widely considered an opportunistic fungal pathogen which targets individuals with impaired immune systems, while C. gattii is predominantly associated with fungal infections in immunocompetent individuals. However, C. neoformans and C. gattii have certainly been identified as the causative agent of cryptococcosis in both immune compromised and immune competent individuals...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28583738/predictors-of-mortality-in-nursing-home-residents-with-pneumonia-a-multicenter-study
#13
Marco Falcone, Alessandro Russo, Flaminia Gentiloni Silverj, Daniela Marzorati, Renzo Bagarolo, Massimo Monti, Rosella Velleca, Roberto D'Angelo, Antonino Frustaglia, Ginetto Carlo Zuccarelli, Roberto Prina, Marco Vignati, Maria Grazia Marnati, Mario Venditti, Marco Tinelli
OBJECTIVES: To evaluate predictors of mortality in patients residing in nursing-homes (NHs) or long-term care facilities (LTCFs) with diagnosis of NH-acquired pneumonia (NHAP). METHODS: We conducted an observational, prospective study (December 2013-December 2015) of patients residing in 9 NHs/LTCFs of Central and Northern Italy with diagnosis of NHAP. Data on demographics, comorbidities, microbiology, and therapies were entered in an electronic database. To identify risk factors associated with 30-day mortality, we performed univariable and multivariable analyses, and predictors were internally validated using a bootstrap resampling procedure...
June 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28583371/bacterial-infections-after-pediatric-heart-transplantation-epidemiology-risk-factors-and-outcomes
#14
Christina A Rostad, Karla Wehrheim, James K Kirklin, David Naftel, Elizabeth Pruitt, Timothy M Hoffman, Thomas L'Ecuyer, Katie Berkowitz, William T Mahle, Janet N Scheel
BACKGROUND: Bacterial infections represent a major cause of morbidity and mortality in heart transplant recipients. However, data describing the epidemiology and outcomes of these infections in children are limited. METHODS: We analyzed the Pediatric Heart Transplant Study database of patients transplanted between 1993 and 2014 to determine the etiologies, risk factors and outcomes of children with bacterial infections post-heart transplantation. RESULTS: Of 4,458 primary transplants in the database, there were 4,815 infections that required hospitalization or intravenous therapy, 2,047 (42...
May 11, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28575375/association-of-c-reactive-protein-with-bacterial-and-respiratory-syncytial-virus-associated-pneumonia-among-children-aged-5-years-in-the-perch-study
#15
Melissa M Higdon, Tham Le, Katherine L O'Brien, David R Murdoch, Christine Prosperi, Henry C Baggett, W Abdullah Brooks, Daniel R Feikin, Laura L Hammitt, Stephen R C Howie, Karen L Kotloff, Orin S Levine, J Anthony G Scott, Donald M Thea, Juliet O Awori, Vicky L Baillie, Stephanie Cascio, Somchai Chuananon, Andrea N DeLuca, Amanda J Driscoll, Bernard E Ebruke, Hubert P Endtz, Anek Kaewpan, Geoff Kahn, Angela Karani, Ruth A Karron, David P Moore, Daniel E Park, Mohammed Ziaur Rahman, Rasheed Salaudeen, Phil Seidenberg, Somwe Wa Somwe, Mamadou Sylla, Milagritos D Tapia, Scott L Zeger, Maria Deloria Knoll, Shabir A Madhi
Background.: Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia. We evaluated the sensitivity and specificity of CRP for identifying bacterial vs respiratory syncytial virus (RSV) pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) multicenter case-control study. Methods.: We measured serum CRP levels in cases with World Health Organization-defined severe or very severe pneumonia and a subset of community controls...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28575374/evaluation-of-pneumococcal-load-in-blood-by-polymerase-chain-reaction-for-the-diagnosis-of-pneumococcal-pneumonia-in-young-children-in-the-perch-study
#16
Maria Deloria Knoll, Susan C Morpeth, J Anthony G Scott, Nora L Watson, Daniel E Park, Henry C Baggett, W Abdullah Brooks, Daniel R Feikin, Laura L Hammitt, Stephen R C Howie, Karen L Kotloff, Orin S Levine, Katherine L O'Brien, Donald M Thea, Dilruba Ahmed, Martin Antonio, Juliet O Awori, Vicky L Baillie, James Chipeta, Andrea N Deluca, Michel Dione, Amanda J Driscoll, Melissa M Higdon, Anchalee Jatapai, Ruth A Karron, Razib Mazumder, David P Moore, James Mwansa, Sammy Nyongesa, Christine Prosperi, Phil Seidenberg, Duangkamon Siludjai, Samba O Sow, Boubou Tamboura, Scott L Zeger, David R Murdoch, Shabir A Madhi
Background.: Detection of pneumococcus by lytA polymerase chain reaction (PCR) in blood had poor diagnostic accuracy for diagnosing pneumococcal pneumonia in children in 9 African and Asian sites. We assessed the value of blood lytA quantification in diagnosing pneumococcal pneumonia. Methods.: The Pneumonia Etiology Research for Child Health (PERCH) case-control study tested whole blood by PCR for pneumococcus in children aged 1-59 months hospitalized with signs of pneumonia and in age-frequency matched community controls...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28575373/is-higher-viral-load-in-the-upper-respiratory-tract-associated-with-severe-pneumonia-findings-from-the-perch-study
#17
Daniel R Feikin, Wei Fu, Daniel E Park, Qiyuan Shi, Melissa M Higdon, Henry C Baggett, W Abdullah Brooks, Maria Deloria Knoll, Laura L Hammitt, Stephen R C Howie, Karen L Kotloff, Orin S Levine, Shabir A Madhi, J Anthony G Scott, Donald M Thea, Peter V Adrian, Martin Antonio, Juliet O Awori, Vicky L Baillie, Andrea N DeLuca, Amanda J Driscoll, Bernard E Ebruke, Doli Goswami, Ruth A Karron, Mengying Li, Susan C Morpeth, John Mwaba, James Mwansa, Christine Prosperi, Pongpun Sawatwong, Samba O Sow, Milagritos D Tapia, Toni Whistler, Khalequ Zaman, Scott L Zeger, Katherine L O' Brien, David R Murdoch
Background.: The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of children with World Health Organization-defined severe and very severe pneumonia and age-matched community controls. Methods.: In the 9 developing country sites, nasopharyngeal/oropharyngeal swabs from children with and without pneumonia were tested using quantitative real-time polymerase chain reaction for 17 viruses...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28575372/addressing-the-analytic-challenges-of-cross-sectional-pediatric-pneumonia-etiology-data
#18
Laura L Hammitt, Daniel R Feikin, J Anthony G Scott, Scott L Zeger, David R Murdoch, Katherine L O'Brien, Maria Deloria Knoll
Despite tremendous advances in diagnostic laboratory technology, identifying the pathogen(s) causing pneumonia remains challenging because the infected lung tissue cannot usually be sampled for testing. Consequently, to obtain information about pneumonia etiology, clinicians and researchers test specimens distant to the site of infection. These tests may lack sensitivity (eg, blood culture, which is only positive in a small proportion of children with pneumonia) and/or specificity (eg, detection of pathogens in upper respiratory tract specimens, which may indicate asymptomatic carriage or a less severe syndrome, such as upper respiratory infection)...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28575371/detection-of-pneumococcal-dna-in-blood-by-polymerase-chain-reaction-for-diagnosing-pneumococcal-pneumonia-in-young-children-from-low-and-middle-income-countries
#19
Susan C Morpeth, Maria Deloria Knoll, J Anthony G Scott, Daniel E Park, Nora L Watson, Henry C Baggett, W Abdullah Brooks, Daniel R Feikin, Laura L Hammitt, Stephen R C Howie, Karen L Kotloff, Orin S Levine, Shabir A Madhi, Katherine L O'Brien, Donald M Thea, Peter V Adrian, Dilruba Ahmed, Martin Antonio, Charatdao Bunthi, Andrea N DeLuca, Amanda J Driscoll, Louis Peter Githua, Melissa M Higdon, Geoff Kahn, Angela Karani, Ruth A Karron, Geoffrey Kwenda, Sirirat Makprasert, Razib Mazumder, David P Moore, James Mwansa, Sammy Nyongesa, Christine Prosperi, Samba O Sow, Boubou Tamboura, Toni Whistler, Scott L Zeger, David R Murdoch
Background.: We investigated the performance of polymerase chain reaction (PCR) on blood in the diagnosis of pneumococcal pneumonia among children from 7 low- and middle-income countries. Methods.: We tested blood by PCR for the pneumococcal autolysin gene in children aged 1-59 months in the Pneumonia Etiology Research for Child Health (PERCH) study. Children had World Health Organization-defined severe or very severe pneumonia or were age-frequency-matched community controls...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28575370/bayesian-estimation-of-pneumonia-etiology-epidemiologic-considerations-and-applications-to-the-pneumonia-etiology-research-for-child-health-study
#20
Maria Deloria Knoll, Wei Fu, Qiyuan Shi, Christine Prosperi, Zhenke Wu, Laura L Hammitt, Daniel R Feikin, Henry C Baggett, Stephen R C Howie, J Anthony G Scott, David R Murdoch, Shabir A Madhi, Donald M Thea, W Abdullah Brooks, Karen L Kotloff, Mengying Li, Daniel E Park, Wenyi Lin, Orin S Levine, Katherine L O'Brien, Scott L Zeger
In pneumonia, specimens are rarely obtained directly from the infection site, the lung, so the pathogen causing infection is determined indirectly from multiple tests on peripheral clinical specimens, which may have imperfect and uncertain sensitivity and specificity, so inference about the cause is complex. Analytic approaches have included expert review of case-only results, case-control logistic regression, latent class analysis, and attributable fraction, but each has serious limitations and none naturally integrate multiple test results...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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