keyword
https://read.qxmd.com/read/38533208/lncrna-mediated-cerna-network-reveals-the-mechanism-of-action-of-saorilao-4-decoction-against-pulmonary-fibrosis
#1
JOURNAL ARTICLE
Xinyue Fu, Xinni Song, Shufang Niu, Songli Shi, Hong Chang, Jun Qi, Peng Wang, Wanfu Bai
Introduction: Pulmonary fibrosis (PF), a type of interstitial pneumonia with complex etiology and high mortality, is characterized by progressive scarring of the alveolar interstitium and myofibroblastic lesions. In this study, we screened for potential biomarkers in PF and clarified the role of the lncRNA-miRNA-mRNA ceRNA network in the inhibitory effect of SRL-4 on PF. Methods: Healthy male SPF SD rats were randomly divided into three groups, namely, CON, MOD, and SRL-4. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to determine the biological functions of the target genes...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38529473/spectrum-and-antibiotic-sensitivity-of-bacterial-keratitis-a-retrospective-analysis-of-eight-years-in-a-tertiary-referral-hospital-in-southwest-china
#2
JOURNAL ARTICLE
Rui-Qin Guo, Ji Yang, Ya-Bin Yang, Ya-Nan Chen, Yu-Yuan Xiao, Ping Xiang, Meng-Jie Dong, Min-Fang He, Yin-Ting Wang, Yun-Ling Xiao, Hong-Qin Ke, Hai Liu
PURPOSE: The objective of this study was to investigate the epidemiological characteristics, distribution of isolates, prevailing patterns, and antibiotic susceptibility of bacterial keratitis (BK) in a Tertiary Referral Hospital located in Southwest China. METHODS: A retrospective analysis was conducted on 660 cases of bacterial keratitis occurring between January 2015 and December 2022. The demographic data, predisposing factors, microbial findings, and antibiotic sensitivity profiles were examined...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38521722/pediatric-dysphagia
#3
REVIEW
Wade McClain, Jordan Luttrell, Elton Lambert
Pediatric dysphagia is a common condition encountered in clinical practice. We review the physiology and development of swallow, presentation, epidemiology, and etiology of dysphagia. Additionally, comorbidities, associated conditions, and medical management of dysphagia are discussed.
March 23, 2024: Otolaryngologic Clinics of North America
https://read.qxmd.com/read/38520253/etiological-characteristics-of-acute-respiratory-infections-during-the-sars-cov-2-epidemic-in-guizhou-province-china
#4
JOURNAL ARTICLE
Xue Fu, Ming-Wang Long, Zhen-Xuan Ye, Hong-Mei Li, Hai-Yan Zhang, Yu He, Bi-Wei Yang, Bo Xu, Hua Zhang
OBJECTIVE: Acute respiratory infections are a major global public health concern. However, there are few epidemiological studies investigating pathogens associated with respiratory tract infections in Guizhou Province, China. METHODS: We collected 17,850 blood samples from Guizhou Provincial People's Hospital between November 2018 and May 2023 to investigate the epidemiological characteristics of respiratory pathogens and their spread during the SARS-CoV-2 epidemic in Guizhou Province...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38520034/etiology-clinical-presentation-and-outcomes-of-bacterial-meningitis-in-adult-patients-a-retrospective-study-in-lithuania-2018-2021
#5
JOURNAL ARTICLE
Greta Rynkevič, Emilijus Žilinskas, Dovilė Streckytė, Daiva Radzišauskienė, Rūta Mameniškienė
BACKGROUND Bacterial meningitis is a serious and life-threatening condition that requires prompt diagnosis and treatment. This retrospective study aimed to identify causes, presentation, and predictive factors for outcomes of community-acquired bacterial meningitis in 86 adults in Vilnius, Lithuania between 2018 and 2021. MATERIAL AND METHODS We performed a retrospective study of demographic, clinical, and laboratory records of 86 adult patients admitted to Vilnius University Hospital Santaros Clinics with a diagnosis of acute bacterial meningitis during the period of 2018-2021...
March 23, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38515663/bacterial-etiology-of-community-acquired-pneumonia-among-adult-patients-in-ethiopia-a-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
Abdurezak Mohammed Seid, Wondwossen Tadesse, Mesfin Menza, Ritbano Ahmed Abdo, Abdulhakim Mussema
BACKGROUND AND OBJECTIVE: According to the Global Burden of Diseases, Injuries, and Risk Factors, lower respiratory infections cause more than 2.3 million deaths globally, with a majority occurring in sub-Saharan Africa, including Ethiopia.Community-acquired pneumonia (CAP) is a major contributor to global mortality and morbidity. Understanding the prevalence and common bacterial causes of CAP is crucial for clinicians to accurately diagnose and improve patient satisfaction. The purpose of this systematic review was to report the pooled prevalence and common bacterial etiologies of CAP among adult patients in Ethiopia...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38512795/surveillance-for-coccidioidomycosis-histoplasmosis-and-blastomycosis-during-the-covid-19-pandemic-united-states-2019-2021
#7
JOURNAL ARTICLE
Samantha L Williams, Dallas J Smith, Kaitlin Benedict, Jamie R Ahlers, Connie Austin, Rachael Birn, Angel M Carter, Natalie N Christophe, Katie Cibulskas, Paul R Cieslak, Suzanne N Gibbons-Burgener, Michael Gosciminski, Malia J Ireland, Katelyn V Lazenby, Tom Loftus, Kristy Lunquest, Abby A Mathewson, Alyssa D Nguyen, Hanna N Oltean, BreAnne Osborn, Erin M Petro, Danny J Power, Rebecca R Reik, Levi Schlosser, Judi Sedivy, Chad B Smelser, Tom Chiller, Mitsuru Toda
Coccidioidomycosis, histoplasmosis, and blastomycosis are lower respiratory tract fungal infections whose signs and symptoms can resemble those of other respiratory illnesses, including pneumonia caused by bacterial or viral etiologies; this overlap in clinical presentation might lead to missed or delayed diagnoses. The causative fungi live in the environment, often in soil or plant matter. To describe the epidemiologic characteristics of cases of coccidioidomycosis, histoplasmosis, and blastomycosis during the COVID-19 pandemic, CDC analyzed case surveillance data for 2019-2021...
March 21, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38509462/predictors-of-severity-and-prolonged-hospital-stay-of-viral-acute-respiratory-infections-ari-among-children-under-five-years-in-burkina-faso-2016-2019
#8
JOURNAL ARTICLE
Abdoul Kader Ilboudo, Assana Cissé, Jennifer Milucky, Dieudonné Tialla, Sara A Mirza, Alpha Oumar Diallo, Brice W Bicaba, Kondombo Jean Charlemagne, Potiandi Serge Diagbouga, Daniel Owusu, Jessica L Waller, Ndahwouh Talla-Nzussouo, Myrna D Charles, Cynthia G Whitney, Zekiba Tarnagda
BACKGROUND: Viruses are the leading etiology of acute respiratory infections (ARI) in children. However, there is limited knowledge on drivers of severe acute respiratory infection (SARI) cases involving viruses. We aimed to identify factors associated with severity and prolonged hospitalization of viral SARI among children < 5 years in Burkina Faso. METHODS: Data were collected from four SARI sentinel surveillance sites during October 2016 through April 2019...
March 20, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38506028/-acute-and-chronic-rhinosinusitis-age-characteristics
#9
JOURNAL ARTICLE
S V Ryazantsev, I M Kirichenko, E L Savlevich, V I Popadyuk, N S Kozlova, A I Chernolev
Children's and adults' rhinosinusitis are two diseases that have both similarities and differences in anatomy, epidemiology, causes, pathogenesis, diagnosis and treatment. At the same rhinosinusitis is one of the most common in otorhinolaryngology's practice, both in children and adults. The of adults paranasal sinuses (PNS) anatomy differs from children's PNS anatomy. Although ostiomeatal complex occlusion is recognized as a major cause of poor ventilation and drainage of the adult paranasal sinuses, it does not have a strong effect on pediatric rhinosinusitis, but adenoids play a key role...
2024: Vestnik Otorinolaringologii
https://read.qxmd.com/read/38502186/prolonged-exposure-to-lung-derived-cytokines-is-associated-with-activation-of-microglia-in-patients-with-covid-19
#10
JOURNAL ARTICLE
Rogan A Grant, Taylor A Poor, Lango Sichizya, Estefani Diaz, Joseph I Bailey, Sahil Soni, Karolina J Senkow, Xóchitl G Pérez-Leonor, Hiam Abdala-Valencia, Ziyan Lu, Helen K Donnelly, Lacy M Simons, Egon A Ozer, Robert M Tighe, Jon W Lomasney, Richard G Wunderink, Benjamin D Singer, Alexander V Misharin, G R Scott Budinger
BACKGROUND: Survivors of pneumonia, including SARS-CoV-2 pneumonia, are at increased risk for cognitive dysfunction and dementia. In rodent models, cognitive dysfunction following pneumonia has been linked to the systemic release of lung-derived pro-inflammatory cytokines. Microglia are poised to respond to inflammatory signals from the circulation, and their dysfunction has been linked to cognitive impairment in murine models of dementia and in humans. METHODS: We measured the levels of 55 cytokines and chemokines in bronchoalveolar lavage fluid and plasma from a cohort of 341 patients with respiratory failure and 13 healthy control patients, including 93 unvaccinated patients with COVID-19 and 203 patients with other causes of pneumonia...
March 19, 2024: JCI Insight
https://read.qxmd.com/read/38500954/diagnosis-of-pulmonary-hemorrhagic-leptospirosis-complicated-by-invasive-pulmonary-aspergillosis-complemented-by-metagenomic-next-generation-sequencing-a-case-report
#11
Qiong-Fang Yang, Cai-Min Shu, Qiao-Ying Ji
BACKGROUND: Leptospirosis is a bacterial zoonosis with variable clinical manifestations. Pulmonary diffuse hemorrhagic leptospirosis often occurs rapidly and, when not promptly diagnosed and treated, it can be life-threatening. Aspergillus flavus is an opportunistic fungus that is commonly seen in immunosuppressed patients. Invasive pulmonary aspergillosis also progresses rapidly. This case study describes a patient with severe pneumonia caused by pulmonary hemorrhagic leptospirosis combined with invasive pulmonary aspergillosis...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38500898/a-comparison-of-the-effectiveness-of-nintedanib-and-pirfenidone-in-treating-idiopathic-pulmonary-fibrosis-a-systematic-review
#12
REVIEW
Ruzhual K Man, Amaresh Gogikar, Ankita Nanda, Lakshmi Sai Niharika Janga, Hembashima G Sambe, Mohamed Yasir, Shivana Ramphall
Idiopathic pulmonary fibrosis (IPF), which shares a radiographic pattern with the usual interstitial pneumonia (UIP), is a specific form of chronic and progressive interstitial lung disorder resulting in persistent fibrosis and impaired lung function. Most of the patients suffer from dyspnea which adversely affects health-related quality of life (HRQOL). The underlying etiology of the disease is not yet understood, but research done on the subject reveals that aberrant repair mechanisms and dysregulated immune responses may be the cause...
February 2024: Curēus
https://read.qxmd.com/read/38496208/isolated-malignant-pleural-effusion-in-a-child-unusual-presentation-of-acute-leukemia
#13
Srinija Garlapati, Sampada Tambolkar, Sarita Verma, Nakul V Pathak, Manojkumar G Patil
Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non-infectious factors. Notably, Streptococcus pneumoniae stands out as the predominant infectious agent responsible for this condition. Non-infectious causative factors encompass hematolymphoid malignancies, congestive heart failure, hemothorax, hypoalbuminemia, and iatrogenic causes...
February 2024: Curēus
https://read.qxmd.com/read/38496155/profile-of-acute-kidney-injury-in-the-pediatric-age-group-in-a-tertiary-care-hospital-a-prospective-observational-study
#14
JOURNAL ARTICLE
Ishan Kapil, Anil Kumar Goel, Manas R Sahoo
BACKGROUND AND OBJECTIVES: Acute kidney injury (AKI) is a menace in the pediatric intensive care unit (PICU) and is responsible for significant morbidity and mortality all over the world. There are limited data available on pediatric AKI in central India. Our primary objective is to determine the clinical, etiological, and outcome profile of AKI in the pediatric age group of 3 months to 15 years admitted to the All India Institute of Medical Sciences (AIIMS), Raipur. The secondary objective(s) is to predict the association of mortality in children diagnosed with AKI and to estimate the number of patients developing chronic kidney disease (CKD) at three-month follow-up...
February 2024: Curēus
https://read.qxmd.com/read/38490926/lung-ultrasonography-cannot-identify-the-etiology-of-pediatric-pneumonia
#15
Jing Liu
No abstract text is available yet for this article.
March 2, 2024: Archivos de Bronconeumología
https://read.qxmd.com/read/38488375/spectrum-and-antibiotic-resistance-in-community-and-hospital-acquired-urinary-tract-infections-among-adults-experience-from-a-large-tertiary-care-center-in-a-developing-country
#16
JOURNAL ARTICLE
Aya Herbawi, Adham Abu Taha, Banan M Aiesh, Ali Sabateen, Sa'ed H Zyoud
BACKGROUND: It is important to note that the causative agents and patterns of antibiotic resistance vary between urinary tract infections (UTIs) acquired in the community and those acquired in a hospital setting. Therefore, the aim of this study was to compare the types of organisms and patterns of antibiotic resistance in adult patients with community-acquired urinary tract infections (CA-UTIs) and hospital-acquired urinary tract infections (HA-UTIs). METHODS: Retrospectively, we collected urine samples from patients at An-Najah National University Hospital who experienced nonrecurring urinary tract infections (UTIs) between January 2019 and December 2020...
March 15, 2024: Urologia
https://read.qxmd.com/read/38476758/case-report-a-rare-case-of-intramedullary-spinal-cord-abscess-with-brain-abscess-caused-by-klebsiella-pneumoniae-underwent-surgical-intervention
#17
Wenjuan Zhang, Xiangyu Guo, Xuejun Xu, Bing Deng
BACKGROUND: Intramedullary Spinal Cord Abscess (ISCA) is an uncommon infectious disease of the central nervous system. Since its first report in 1830, there have been very few documented cases associated with it. Here, we present a case of ISCA with cerebral abscess caused by Klebsiella pneumoniae. CASE PRESENTATION: A 55-year-old male patient presented with head and neck pain, fever, and left limb weakness for 5 days. The diagnosis of ISCA with brain abscess caused by Klebsiella pneumoniae was confirmed through sputum culture, cerebrospinal fluid gene test, pus culture, and magnetic resonance imaging (MRI) as well as computerized tomography (CT) scan...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38476159/current-approach-to-dysphagia-a-review-focusing-on-esophageal-motility-disorders-and-their-treatment
#18
REVIEW
André Mascarenhas, Rui Mendo, Catarina O'Neill, Ana Rita Franco, Raquel Mendes, Inês Simão, José Pedro Rodrigues
BACKGROUND: Dysphagia is a prevalent condition which may severely impact the patient's quality of life. However, there are still lacking standardized therapeutic options for esophageal motility disorders. SUMMARY: Dysphagia is defined as a subjective sensation of difficulty swallowing which can result from oropharyngeal or esophageal etiologies. Regarding esophageal dysphagia, after excluding structural causes and esophageal mucosal lesions, high-resolution manometry (HRM) is the gold standard for the diagnosis of esophageal motility disorders...
December 2023: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/38472952/differentiating-viral-from-bacterial-pneumonia-in-children-the-diagnostic-role-of-lung-ultrasound-a-prospective-observational-study
#19
JOURNAL ARTICLE
Emil Robert Stoicescu, Roxana Iacob, Adrian Cosmin Ilie, Emil Radu Iacob, Septimiu Radu Susa, Laura Andreea Ghenciu, Amalia Constantinescu, Daiana Marina Cocolea, Cristian Oancea, Diana Luminita Manolescu
This prospective observational study aimed to investigate the utility of lung ultrasound (LUS) in diagnosing and managing pediatric respiratory infections, specifically focusing on viral, bacterial, and SARS-CoV-2 infections. Conducted over a period of 1 year and 8 months, this research involved 85 pediatric patients (showcasing a median age of 14 months) recruited based on specific criteria, including age, confirmed infection through multiplex PCR tests, and willingness to undergo LUS imaging. This study employed a 12-area scoring system for LUS examinations, utilizing the lung ultrasound score (LUSS) to evaluate lung abnormalities...
February 23, 2024: Diagnostics
https://read.qxmd.com/read/38468588/a-rare-ocular-manifestation-of-mycoplasma-pneumoniae-infection
#20
JOURNAL ARTICLE
Sonda Kammoun, Mona Rekik, Kmar Maaloul, Saloua Ben Amor, Amira Trigui
INTRODUCTION: Ocular manifestations of Mycoplasma Pneumoniae infection are rare. We present a case of Mycoplasma Pneumoniae infection revealed by a recurrent retro-bulbar optic neuritis. CASE DESCRIPTION: A 38-year-old woman, initially treated for a typical retro-bulbar optic neuritis of the right eye with corticosteroid therapy at high doses, presented for a recurrent decreased vision in the same eye, associated with blepharospasm and conjunctival hyperemia. The etiological assessment revealed a recent Mycoplasma Pneumoniae infection...
November 5, 2023: La Tunisie Médicale
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