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https://www.readbyqxmd.com/read/29779228/prevalence-and-clinical-profile-of-rotavirus-a-infection-among-diarrheal-children-and-phylogenetic-analysis-with-vaccine-strains-in-chengdu-west-china-2009-2014
#1
Yu-Hang Chen, Fan Chen, Tao Zhou, Jia-Yi Chen, Tian-Li Zheng, Xin Xu, Xiao-Fang Pei
OBJECTIVES: Rotaviruses are the most common cause of severe diarrheal disease in young children. However, little is known about the epidemiological and clinical profile of rotavirus A (RVA) in diarrheal children or the efficacy of Lanzhou lamb rotavirus vaccine (LLR) in Chengdu, China. This study aimed to determine the prevalence and clinical profile of RVA in diarrheal children and provide gene analysis information for RVA vaccination programs. METHODS: 1121 fecal samples were collected from outpatient children with diarrhea between 2009 and 2014...
May 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29779185/predictive-role-of-measurement-of-pelvic-floor-muscle-thickness-with-static-mri-in-stress-and-mixed-urinary-incontinence
#2
Levent Yaşar, Serpil Ortakuz Telci, Keziban Doğan, Eyüp Kaya, Murat Ekin
INTRODUCTION AND HYPOTHESIS: To investigate the role of measuring the thickness of pelvic floor muscles with static MRI in the physiopathology of urinary incontinence in women with stress and mixed types of urinary incontinence diagnosed with urodynamic studies. METHODS: A retrospective clinical study was designed in collaboration with the radiology department. We recruited only patients who had undergone static pelvic MRI to determine the etiology of pelvic pain and exclude gynecologic disorders...
May 19, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29779159/an-etiological-approach-to-sexual-offender-assessment-case-formulation-incorporating-risk-assessment-cafira
#3
REVIEW
Leam A Craig, Martin Rettenberger
PURPOSE OF REVIEW: Case formulations (CF) have been the cornerstone of effective practice in clinical psychology since the 1950s and now form one of the core competencies in clinical and forensic assessment. The use of CFs within forensic settings is becoming more relevant when working with offenders who have experienced significant trauma, suffered from personality disorder, and have displayed sexually abusive behavior. Furthermore, most North American and European jurisdictions insist that expert witnesses adopt an idiosyncratic approach to risk assessment and consider the characteristics of the individual as part of a wider formulation of the problem behavior...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29779137/ulnar-neuropathy-at-wrist-entrapment-at-a-very-congested-site
#4
Daniele Coraci, Claudia Loreti, Giulia Piccinini, Pietro E Doneddu, Silvia Biscotti, Luca Padua
Ulnar tunnel syndrome indicates ulnar neuropathy at different sites within the wrist. Several classifications of ulnar tunnel syndrome are present in literature, based upon typical nerve anatomy. However, anatomical variations are not uncommon and can complicate assessment. The etiology is also complex, due to the numerous potential causes of entrapment. Clinical examination, neurophysiological testing, and imaging are all used to support the diagnosis. At present, many therapeutic approaches are available, ranging from observation to surgical management...
May 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29779049/biochemical-and-functional-interplay-between-ion-channels-and-the-components-of-the-dystrophin-associated-glycoprotein-complex
#5
REVIEW
Margarita Leyva-Leyva, Alejandro Sandoval, Ricardo Felix, Ricardo González-Ramírez
Dystrophin is a cytoskeleton-linked membrane protein that binds to a larger multiprotein assembly called the dystrophin-associated glycoprotein complex (DGC). The deficiency of dystrophin or the components of the DGC results in the loss of connection between the cytoskeleton and the extracellular matrix with significant pathophysiological implications in skeletal and cardiac muscle as well as in the nervous system. Although the DGC plays an important role in maintaining membrane stability, it can also be considered as a versatile and flexible molecular complex that contribute to the cellular organization and dynamics of a variety of proteins at specific locations in the plasma membrane...
May 19, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29778967/association-between-long-term-exposure-to-ambient-air-pollution-and-diabetes-mortality-in-the-us
#6
Chris C Lim, Richard B Hayes, Jiyoung Ahn, Yongzhao Shao, Debra T Silverman, Rena R Jones, Cynthia Garcia, George D Thurston
OBJECTIVE: Recent mechanistic and epidemiological evidence implicates air pollution as a potential risk factor for diabetes; however, mortality risks have not been evaluated in a large US cohort assessing exposures to multiple pollutants with detailed consideration of personal risk factors for diabetes. RESEARCH DESIGN AND METHODS: We assessed the effects of long-term ambient air pollution exposures on diabetes mortality in the NIH-AARP Diet and Health Study, a cohort of approximately a half million subjects across the contiguous U...
May 17, 2018: Environmental Research
https://www.readbyqxmd.com/read/29778944/activation-and-blockade-of-basolateral-amygdala-5-ht-6-receptor-produce-anxiolytic-like-behaviors-in-an-experimental-model-of-parkinson-s-disease
#7
Yi-Na Sun, Lu Yao, Li-Bo Li, Yong Wang, Cheng-Xue Du, Yuan Guo, Jian Liu
Although the basolateral amygdala (BLA) and serotonin6 (5-HT6 ) receptor are involved in modulation of anxiety, their roles in Parkinson' disease (PD)-related anxiety are still unknown. Thus we perform this study to examine the involvement of BLA 5-HT6 receptor on anxiety in unilateral 6-hydroxydopamine-induced PD rats. The lesion of the medial forebrain bundle (MFB) induced anxiety-like behaviors, and decreased the basal firing rate of BLA glutamate neurons and dopamine (DA) levels in tissues of the medial prefrontal cortex (mPFC), amygdala and ventral part of hippocampus (vHip) in rats...
May 17, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29778684/modeled-and-perceived-rf-emf-noise-and-air-pollution-and-symptoms-in-a-population-cohort-is-perception-key-in-predicting-symptoms
#8
Astrid L Martens, Marije Reedijk, Tjabe Smid, Anke Huss, Danielle Timmermans, Maciej Strak, Wim Swart, Virissa Lenters, Hans Kromhout, Robert Verheij, Pauline Slottje, Roel C H Vermeulen
BACKGROUND: Psychosocial research has shown that perceived exposure can influence symptom reporting, regardless of actual exposure. The impact of this phenomenon on the interpretation of results from epidemiological research on environmental determinants of symptoms is unclear. OBJECTIVE: Our aim was to compare associations between modeled exposures, the perceived level of these exposures and reported symptoms (non-specific symptoms, sleep disturbances, and respiratory symptoms) for three different environmental exposures (radiofrequency electromagnetic fields (RF-EMF), noise, and air pollution)...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778601/diagnosis-classification-and-management-of-fourth-ventriculomegaly-in-adults-report-of-9-cases-and-literature-review
#9
Kaveh Barami, Indro Chakrabarti, James Silverthorn, Jeremy Ciporen, Paul T Akins
OBJECTIVE: An enlarged fourth ventricle otherwise known as fourth ventriculomegaly (4th VM) has been previously reported in the pediatric population yet literature on adults is scant. We report our experience with 4th VM in adults over an 11 year period and review the literature. MATERIAL/METHODS: retrospective chart review of adult patients with the diagnosis of 4th VM admitted to the ICU in a tertiary care center RESULTS: 9 patients were identified with 4th VM...
May 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29778462/altered-mitochondrial-acetylation-profiles-in-a-kainic-acid-model-of-temporal-lobe-epilepsy
#10
Lindsey B Gano, Li-Ping Liang, Kristen Ryan, Cole R Michel, Joe Gomez, Athanassios Vassilopoulos, Nichole Reisdorph, Kristofer S Fritz, Manisha Patel
Impaired bioenergetics and oxidative damage in the mitochondria are implicated in the etiology of temporal lobe epilepsy, and hyperacetylation of mitochondrial proteins has recently emerged as a critical negative regulator of mitochondrial functions. However, the roles of mitochondrial acetylation and activity of the primary mitochondrial deacetylase, SIRT3, have not been explored in acquired epilepsy. We investigated changes in mitochondrial acetylation and SIRT3 activity in the development of chronic epilepsy in the kainic acid rat model of TLE...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29778437/state-level-adoption-of-national-guidelines-for-norovirus-outbreaks-in-health-care-settings
#11
Carl J Grafe, Catherine J Staes, Kensaku Kawamoto, Matthew H Samore, R Scott Evans
BACKGROUND: Clinical decision support (CDS) systems can help investigators use best practices when responding to outbreaks, but variation in guidelines between jurisdictions can make such systems hard to develop and implement. This study aimed to identify (1) the extent to which state-level guidelines adhere to national recommendations for norovirus outbreak response in health care settings and (2) the impact of variation between states on outbreak outcomes. METHODS: State guidelines were obtained from Internet searches and direct contact with state public health officials in early 2016...
May 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29778421/comparison-of-two-groups-for-the-apolipoprotein-e-polymorphisms-by-using-next-generation-sequencing-the-first-group-with-three-consecutive-abortions-and-the-second-group-with-at-most-one-abortion-in-three-consecutive-pregnancies
#12
Evren Gumus
The importance of apolipoprotein E genotypes and allelic polymorphisms in the etiology of recurrent miscarriage is controversial. We plan to investigate this in a two-group study involving more than a thousand participants. In total, 1046 subjects (802 participants in the first group, 244 participants in the second group) were investigated. Women in the first group had a history of ≥3 consecutive spontaneous miscarriage and women in the second group had at most one miscarriage in three consecutive pregnancies...
May 17, 2018: Gene
https://www.readbyqxmd.com/read/29778412/assessing-cancer-risk-factors-faced-by-an-ancestral-puebloan-population-in-the-north-american-southwest
#13
Catrina Banks Whitley, Jeffrey L Boyer
Ancestral Puebloan people in the North American Southwest suffered high rates of disease, poor health, and early age-at-death. Four individuals with skeletal expressions of cancer were found in a pre-Columbian population in the Taos Valley - Reports of malignant neoplasms in the archaeological record are uncommon and their presence in four of 82 individuals is a high occurrence. This study continues Whitley and Boyer's (2012) research testing whether concentrations of ionizing radiation were sufficiently high to induce cancer and related health issues...
August 23, 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29778388/androgen-excess-polycystic-ovary-syndrome-society-position-statement-on-depression-anxiety-quality-of-life-and-eating-disorders-in-polycystic-ovary-syndrome
#14
Anuja Dokras, Elisabeth Stener-Victorin, Bulent O Yildiz, Rong Li, Sasha Ottey, Duru Shah, Neill Epperson, Helena Teede
OBJECTIVE: To formulate clinical consensus recommendations for screening depression, anxiety, health-related quality of life (HRQoL), and disordered eating symptoms in women with polycystic ovary syndrome (PCOS) and review prevalence based on phenotypes and ethnicity, changes over time, etiology, and impact of treatment. DESIGN: Systematic reviews and preparation of position statement. SETTING: Not applicable. PATIENT(S): Women with PCOS and controls screened using validated tools...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778327/an-unusual-etiology-of-vocal-tremor-in-a-professional-singer
#15
REVIEW
Bridget L Hopewell, Cristen Paige, David O Francis
Vocal tremor is a neurologic disorder with myriad etiologies (eg, Parkinson disease, medications, or essential tremor). Vocal tremor can limit intelligibility and social interaction and can result in isolation in nonprofessional voice users. In a professional singer whose entire career is based on voice quality, onset of a vocal tremor is devastating. We report a case of sudden-onset vocal tremor that impeded a young professional singer's ability to perform and record her album. The etiology was determined to be a medication side effect of lamotrigine; a reaction that has not been previously reported...
May 16, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29778284/-clinical-and-epidemiological-profile-of-pediatric-uveitis-course-of-inflammatory-uveitis-treated-with-anti-tnf-alpha
#16
D Osswald, A C Rameau, C Speeg-Schatz, J Terzic, A Sauer
INTRODUCTION: Uveitis is the leading cause of acquired childhood blindness with a prevalence of 30 cases per 100,000 inhabitants. There are multiple causes ; nevertheless, there is no standardized etiological assessment. The goal of our study is to define an epidemiological and clinical profile of uveitis diagnosed in a university hospital and their course when treated with anti-tumor necrosis factor (TNF) α. PATIENTS AND METHODS: All cases of uveitis under 18 years old, from 1994 to 2016, were included...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#17
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777914/the-full-length-microrna-cluster-in-the-intron-of-large-latency-transcript-is-associated-with-the-virulence-of-pseudorabies-virus
#18
Xin Wang, Mei-Mei Zhang, Kai Yan, Qi Tang, Yi-Quan Wu, Wen-Bo He, Huan-Chun Chen, Zheng-Fei Liu
Pseudorabies virus (PRV), the etiological pathogen of Aujeszky's disease, belongs to the Alphaherpesvirus subfamily. Large latency transcript (LLT), the most abundant PRV transcript, harbors a ~ 4.6 kb microRNA (miRNA) cluster-encoding intron. To investigate the function of the LLT miRNA cluster during the life cycle of PRV, we generated a miRNA cluster mutation virus (PRV-∆miR cluster) and revertant virus. Analysis of the growth kinetics of PRV-ΔmiR cluster-infected cells revealed significantly smaller plaques and lower titers than the wild-type and revertant viruses...
May 16, 2018: Virology
https://www.readbyqxmd.com/read/29777895/asymmetry-of-cerebral-peduncles-for-predicting-motor-function-restoration-in-young-patients-before-hemispherectomy
#19
Xiu-Yu Du, Si-Chang Chen, Yu-Guang Guan, Jing-Jing Gu, Meng Zhao, Tian-Fu Li, Jun-Hong Pan, Guo-Ming Luan
OBJECTIVE: Hemispherectomy has been successfully used for medically intractable epilepsy patients. However, it is difficult to predict postoperative motor function. The aim of the present study was to analyze whether the preoperative asymmetry of cerebral peduncles could be used to predict motor function restoration before hemispherectomy for young patients with medically intractable epilepsy. METHODS: The clinical record and MRI data of 53 patients were retrospectively analyzed...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777889/endovascular-management-of-a-ruptured-basilar-perforator-artery-aneurysm-associated-with-a-pontine-arteriovenous-malformation-a-case-report-and-review-of-the-literature
#20
Joseph Lockwood, Tyler Scullen, Mansour Mathkour, Ascher Kaufmann, Ricky Medel, Aaron S Dumont, Peter S Amenta
BACKGROUND: Arteriovenous malformation (AVM)-associated aneurysms are common, being reported in 15% of cases. In regards to ruptured posterior fossa AVMs, associated aneurysms are present in 48% of cases and are the etiology of the bleed in 37%. We present a 75 year-old female who presented with a subarachnoid hemorrhage (SAH) secondary to a ruptured aneurysm arising from a flow-related basilar perforator artery feeder of an anterior pontine AVM. We report the successful treatment of the aneurysm with coil embolization...
May 16, 2018: World Neurosurgery
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