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JOURNAL ARTICLE
Derya Cansız, İsmail Ünal, Mustafa Gani Sürmen, Saime Sürmen, Zehra Sezer, Merih Beler, Elif Güzel, A Ata Alturfan, Ebru Emekli-Alturfan
Given that global prevalence of Parkinson's disease (PD) is expected to rise over the next few decades, understanding the mechanisms and causes of PD is critical. With emphasis on gut-brain axis, we sought to assess the impact of gentisic acid (GA), a diphenolic compound generated from benzoic acid, in rotenone (Rot) induced PD model in zebrafish. For thirty days, adult zebrafish were exposed to GA and rotenone. Tox-Track program was used to analyze locomotor behaviors in the control, GA, Rot, and Rot + GA groups...
April 19, 2024: Brain Research
#2
JOURNAL ARTICLE
Muskan Verma, Manika Garg, Aiysha Siddiq Khan, Pawan Yadav, Saman Saim Rahman, Asghar Ali, Mohan Kamthan
The intricate architecture of the intestinal epithelium, crucial for nutrient absorption, is constantly threatened by environmental factors. The epithelium undergoes rapid turnover, which is essential for maintaining homeostasis, under the control of intestinal stem cells (ISCs). The central regulator, Wnt/β-catenin signaling plays a key role in intestinal integrity and turnover. Despite its significance, the impact of environmental factors on this pathway has been largely overlooked. This study, for the first time, investigates the influence of Cd on the intestinal Wnt signaling pathway using a mouse model...
April 18, 2024: Ecotoxicology and Environmental Safety
#3
JOURNAL ARTICLE
Umit Pehlivan, Saim Ozdemir, Hasan Ozer, Omer Hulusi Dede
The incineration of poultry litter (PL) effectively reduces the volume of waste in line with the United Nations Sustainable Development Goal of "affordable and clean energy". However, mono-incineration is associated with considerable challenges due to the varying moisture, structural and chemical composition and low energy yield. The aim of the present work was to investigate the influence of sweet sorghum bagasse (SS) and pyrolysis oil (PO) on improving the fuel properties of PL and mitigating ash related burdens during incineration...
April 4, 2024: Journal of Environmental Management
#4
JOURNAL ARTICLE
Mengmeng Han, Yunju Yin, Saiming Gong, Hanjing Shi, Qilong Li, Xiao Lian, Yehui Duan, Fengna Li, Qiuping Guo
This study aimed to investigate the effects of dietary Eucommia ulmoides leaf extract (ELE) on meat quality, antioxidant capacity, and lipid metabolism in finishing pigs. A total of 240 "Duroc × Landrace × Yorkshire" crossbred pigs with an initial weight of 74.70 ± 0.77 kg were randomly assigned to two groups: control group and 0.2% ELE group, with each group containing 10 replicates of 12 pigs per pen (half barrows and half gilts). The data showed dietary 0.2% ELE supplementation did not affect growth performance but tended to reduce the backfat thickness of the finishing pigs ( p = 0...
March 6, 2024: Antioxidants (Basel, Switzerland)
#5
RANDOMIZED CONTROLLED TRIAL
S Karagül, A Saime
Myofascial pain syndrome (MPS) is the most common in the musculoskeletal disease. Dry needling techniques and ischemic compression are the most common applications. We aimed to compare the efficacy of dry needling and ischemic compression methods on pain, cervical range of motion and disability in myofascial pain syndrome. This is a randomized, controlled study. 98 patients with MPS were randomly assigned into three groups. Group1 received dry needling (n=33), group 2 (n=33) received ischemic compression and group 3 (n=32) received combined with dry needling and ischemic compression inventions...
January 2024: Georgian Medical News
#6
JOURNAL ARTICLE
Ayhan Verit, Muhammet I Karaman
Saim Erkun (1901-1949) was born in Manisa at Aegean region of Anatolia as an Ottoman citizen. While his early life was spent in late Ottoman times at military actions including military prison camp in British colony; India, his active professional productive period was in early Turkish republic period (Est. 1923, centenary). He had a good education period for medicine with the help of his good level of all main World scientific languages such as French, German, and English. Besides his main profession, he was also interested in Ottoman urological medicine around the conquer of Istanbul and allocated them a space in his books in 1930s...
March 18, 2024: Journal of Medical Biography
#7
JOURNAL ARTICLE
Büşra Köksal, Rümeysa Bilginer Kartal, Ufuk Saim Gunay, Hakan Durmaz, Ahu Arslan Yıldız, Ümit Hakan Yıldız
The rapid manufacturing of biocomposite scaffold made of saturated-Poly(ε-caprolactone) (PCL) and unsaturated Polyester (PE) blends with gelatin and modified gelatin (NCO-Gel) is demonstrated. Polyester blend-based scaffold are fabricated with and without applying potential in the melt electrowriting system. Notably, the applied potential induces phase separation between PCL and PE and drives the formation of PE rich spots at the interface of electrowritten fibers. The objective of the current study is to control the phase separation between saturated and unsaturated polyesters occurring in the melt electro-writing process and utilization of this phenomenon to improve efficiency of biofunctionalization at the interface of scaffold via Aza-Michael addition reaction...
March 15, 2024: International Journal of Biological Macromolecules
#8
JOURNAL ARTICLE
Ö Zeynep Güner Yılmaz, Anıl Yılmaz, Serdar Bozoglu, Nilgun Karatepe, Saime Batirel, Ali Sahin, Fatma Seniha Güner
Single-walled carbon nanotubes (SWCNTs) outperform other materials due to their high conductivity, large specific surface area, and chemical resistance. They have numerous biomedical applications, including the magnetization of the SWCNT (mSWCNT). The drug loading and release properties of see-through pectin hydrogels doped with SWCNTs and mSWCNTs were evaluated in this study. The active molecule in the hydrogel structure is allantoin, and calcium chloride serves as a cross-linker. In addition to mixing, absorption, and swelling techniques, drug loading into carbon nanotubes was also been studied...
March 5, 2024: ACS Omega
#9
JOURNAL ARTICLE
Saim Jung, Joon Sung Shin, Sun Hyung Lee, Sungwon Lee, Jaehyun Kim, Kyung-Lak Son, Bong-Jin Hahm, Chan-Woo Yeom
OBJECTIVE: This study aimed to develop and validate the Korean version of the Somatic Symptom Disorder-B Criteria Scale (SSD-12) in outpatients at a psychiatric clinic and assess its diagnostic accuracy. METHODS: A total of 207 patients completed SSD-12. For the diagnostic accuracy of SSD-12, the somatic symptom disorder (SSD) section of the structured clinical interview for DSM-5 disorders-research version (SCID-5-RV) was used. The SSD-12 construct and concurrent validity were assessed by examining the correlations with Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), PHQ-15, 5-level EQ-5D version (EQ-5D-5L), and World Health Organization Quality of Life Brief Version (WHOQOL-BREF)...
February 2024: Psychiatry Investigation
#10
JOURNAL ARTICLE
Yeşim Aslan Kanmaz, Barış Can Güzel, Saime Betül Baygeldi, Meryem Karan
BACKGROUND: Morphometric measurements help to understand the skull morphology in different animal species, detect skull deformations and figure out their causes. OBJECTIVES: The aim of this study is to make a three-dimensional (3D) modelling of the badger skull using computed tomography, to show its anatomical structures and to reveal the morphometric measurement values. METHODS: Skull measurements were carried out using a digital calliper at 27 measurement points based on metric measurement points...
March 2024: Veterinary Medicine and Science
#11
JOURNAL ARTICLE
Yunju Yin, Saiming Gong, Mengmeng Han, Jingzun Wang, Hanjing Shi, Xianji Jiang, Liu Guo, Yehui Duan, Qiuping Guo, Qinghua Chen, Fengna Li
This study was conducted to explore the regulatory mechanism of leucine (Leu) on lipid metabolism of finishing pigs. Twenty-four Duroc × Landrace × Large cross pigs with an average body weight of 68.33 ± 0.97 kg were randomly allocated into 3 treatment groups with 8 replicates per group (1 pig per replicate). The dietary treatments were as follows: control group (CON), 0.25% Leu group and 0.50% Leu group. The experimental period was 42 d. The results showed as follows...
March 2024: Animal Nutrition
#12
JOURNAL ARTICLE
Ismail Mese, Rahsan Karaci, Ceylan Altintas Taslicay, Cengizhan Taslicay, Gur Akansel, Saime Fusun Domac
BACKGROUND AND PURPOSE: <p>The aim of the study was to investigate the question: Can MRI radiomics analysis of the periaqueductal gray region elucidate the pathophysiological mechanisms underlying various migraine subtypes, and can a machine learning model using these radiomics features accurately differentiate between migraine patients and healthy individuals, as well as between migraine subtypes, including atypical cases with overlapping symptoms?</p>. METHODS: <p>The study analyzed initial MRI images of individuals taken after their first migraine diagnosis, and additional MRI scans were acquired from healthy subjects...
January 30, 2024: Ideggyógyászati Szemle
#13
JOURNAL ARTICLE
Rauf Melekoglu, Seyma Yasar, Cemil Colak, Murat Kasap, Umran Karabulut Dogan, Saim Yologlu, Ercan Yilmaz, Sherif Shazly
Placenta accreta spectrum (PAS) presents a significant obstetric challenge, associated with considerable maternal and fetal-neonatal morbidity and mortality. Nevertheless, it is imperative to acknowledge that a noteworthy subset of PAS cases remains undetected until the time of delivery, thereby contributing to an augmented incidence of morbidity among the affected individuals. The delayed identification of PAS not only hinders timely intervention but also exacerbates the associated health risks for both the maternal and fetal outcomes...
February 2, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Prutha Jinwala, Rajesh Patidar, Shashank Bansal, Vikas Asati, S P Shrivastava, Aditya Elhence, Swati Patel, P G Chitalkar
Prutha Jinwala T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) in adolescents and young adults (AYAs) is a clinically aggressive malignancy and life-threatening at diagnosis. Intensive chemotherapy protocols, inspired by the Berlin-Frankfurt-Münster (BFM) regimen, along with central nervous system (CNS) prophylaxis, have achieved a 75 to 85% 5-year disease-free survival rate. However, in cases of marrow and CNS relapses, second-line chemotherapy is usually ineffective. This study aimed to assess the safety and efficacy of the BFM 2002 protocol and to correlate clinical profiles and prognostic factors with survival outcomes in AYA T-ALL/LBL patients...
October 2023: South Asian Journal of Cancer
#15
MULTICENTER STUDY
Emel Okulu, Ibrahim Murat Hirfanoglu, Mehmet Satar, Omer Erdeve, Esin Koc, Ferda Ozlu, Mahmut Gokce, Didem Armangil, Gaffari Tunc, Nihal Demirel, Sezin Unal, Ramazan Ozdemir, Mehmet Fatih Deveci, Melek Akar, Melike Kefeli Demirel, Merih Çetinkaya, Halime Sema Can Buker, Belma Saygılı Karagöl, Deniz Yaprak, Abdullah Barıs Akcan, Ayse Anik, Fatma Narter, Sema Arayici, Egemen Yildirim, Ilke Mungan Akin, Ozlem Sahin, Ozgul Emel Bulut Ozdemir, Fahri Ovali, Mustafa Ali Akin, Yalcin Celik, Aysen Orman, Sinan Uslu, Hilal Ozkan, Nilgun Koksal, Ayhan Tastekin, Mehmet Gunduz, Ayse Engin Arisoy, Resat Gurpinar, Rahmi Ors, Huseyin Altunhan, Ramazan Kececi, Hacer Yapicioglu Yildizdas, Demet Terek, Mehmet Ates, Sebnem Kader, Mehmet Mutlu, Kıymet Çelik, Ebru Yucesoy, Mustafa Kurthan Mert, Selvi Gulasi, Kazım Kucuktasci, Didem Arman, Berna Hekimoglu, Nazlı Dilay Gultekin, Hasan Tolga Celik, Dilek Kahvecioglu, Can Akyildiz, Erdal Taşkın, Nukhet Aladag Ciftdemir, Saime Sundus Uygun, Tugba Barsan Kaya, Arzu Akdag, Aslan Yilmaz
BACKGROUND: Hypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and short- and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the standard care for HIE of infants ≥36 weeks gestational age (GA), as it has been demonstrated to reduce the rates of mortality, and adverse neurodevelopmental outcomes. This study aims to determine the incidence of HIE in our country, to assess the TH management in infants with HIE, and present short-term outcomes of these infants...
2023: PloS One
#16
JOURNAL ARTICLE
Saim Mahmood Khan, Jawairya Muhammad Hussain
No abstract text is available yet for this article.
December 6, 2023: Annals of Palliative Medicine
#17
JOURNAL ARTICLE
Tyler J Dunn, Erin Holmes, Yi Yang, John P Bentley, Saim Kashmiri, Sujith Ramachandran
BACKGROUND: Despite a number of states in the U.S. enacting medical marijuana policies, there is currently a lack of research outlining the role that individual-level factors play in predicting medical marijuana use, especially regarding use and misuse of prescription pain relievers. The overall aim of this study was to assess the prevalence of medical marijuana use in the U.S. and to identify clinical, social, and demographic predictors. METHODS: A retrospective secondary database analysis was conducted utilizing five years of the National Survey on Drug Use and Health (NSUDH)...
December 2023: Explor Res Clin Soc Pharm
#18
JOURNAL ARTICLE
Medine Yılmaz, Gülçin Uyanık, Gamze Ağartıoğlu Kundakçı, Media Subaşı Baybuğa, Birsen Altay, Dilek Cingil, Ayşe Berivan Bakan, Betül Aktaş, Cantürk Çapık, Saime Erol, Şenay Pehlivan, Gülfer Fidan
Social participation is important in terms of active aging and quality of life during old age. This cross-sectional study aimed to determine the social participation of older adults in rural and urban areas in Turkey. Related factors were similarly identified. The sample comprised 1,224 people over the age of 60, with a mean of 69.78 ± 7.48 years. Among the participants, 61.4% live in urban areas. The data were collected in family health centers through face-to-face interview and the Interview Form, Social Participation Assessment Form, and Social Participation Dimension of the Turkish Version of the Aging Module of the World Health Organization Quality of Life (WHOQOL) Scale...
November 26, 2023: Journal of Aging & Social Policy
#19
JOURNAL ARTICLE
Kübra Esin, Saime Batirel, Gözde Ülfer, Pakize Yigit, Nevin Sanlier
Background and Objectives : Irisin is an adipo-myokine with potential metabolic effects in the body, and its association with childhood obesity is still controversial. This study aimed to investigate the relationship between serum irisin levels and anthropometric parameters, body composition, metabolic profiles, leptin, and adiponectin in obese and normal-weight children. Methods : The study sample consisted of a total of 80 children aged 6-10, including 44 obese children (BMI ≥ 97th percentile) and 36 normal-weight children...
November 5, 2023: Medicina
#20
JOURNAL ARTICLE
Tetsuya Yoshizaki, Yoshinobu Yamamoto, Tomoya Sako, Yasuaki Kitamura, Takayuki Ose, Tsukasa Ishida, Atsushi Ikeda, Ryusuke Ariyoshi, Mineo Iwatate, Fumiaki Kawara, Shinwa Tanaka, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama
BACKGROUND AND AIMS: Perforation during esophageal endoscopic submucosal dissection (ESD) typically results from electrical damage. However, there are cases in which perforation occurs due to segmental absence of intestinal musculature (SAIM) without iatrogenic muscular injury. We investigated the occurrence rate and clinical course of SAIM during esophageal ESD. METHODS: We conducted a retrospective review of esophageal ESDs performed between 2013 and 2019 in 10 centers in Japan...
November 10, 2023: Gastrointestinal Endoscopy
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