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https://www.readbyqxmd.com/read/29166579/the-tcr-takes-some-immune-responsibility
#1
Ashley A Viehmann Milam, Paul M Allen
In this issue of Immunity, Van Braeckel-Budimmir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infection is dominated by a Vβ8.1 T cell response. Mice lacking Vβ8.1 T cells fail to mount a pathogenic response, thus showing that the TCR locus can be an Immune response (Ir) gene.
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166502/outcomes-of-long-term-treatments-of-type-i-hereditary-angioedema-in-a-turkish-family
#2
Gulsen Akoglu, Belgin Kesim, Gokhan Yildiz, Ahmet Metin
BACKGROUND: Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks. OBJECTIVE: We aimed to investigate the clinical and genetic features of a family with angioedema attacks. METHODS: The medical history, clinical features and C1-INH gene mutation of a Turkish family were investigated and outcomes of long-term treatments were described. RESULTS: Five members had experienced recurrent swellings on the face and extremities triggered by trauma...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166467/paula-coutinho-s-outstanding-contribution-to-the-definition-of-machado-joseph-disease
#3
Bruno Carniatto Marques Garcia, Francisco Manoel Branco Germiniani, Paula Marques, Jorge Sequeiros, Hélio Afonso Ghizoni Teive
Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is the most common form of autosomal dominant ataxia in the world. Paula Coutinho, a highly-regarded Portuguese neurologist worldwide, had a seminal participation in the definition of this disease, more than 40 years ago.
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166465/cross-cultural-adaptation-to-brazilian-portuguese-of-the-waterloo-footedness-questionnaire-revised-wfq-r-brazil
#4
Monike Barros Camargos, Andressa da Silva Palmeira, Emerson Fachin-Martins
Post-stroke hemiparesis causes compensated postures, which can modify the footedness established before the impairment. Recently, a paresis severity-modulated dominance hypothesis stated that measures to detect footedness become crucial to float new ideas for neurorehabilitation strategies. The Waterloo Footedness Questionnaire-Revised (WFQ-R) represents the most acceptable measure but it had not yet been cross-culturally adapted for Portuguese spoken in Brazil. Our aim was to cross-culturally adapt the WFQ-R to Brazilian Portuguese, verifying its reliability...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166384/neanderthal-hunting-strategies-inferred-from-mortality-profiles-within-the-abric-roman%C3%A3-sequence
#5
Juan Marín, Palmira Saladié, Antonio Rodríguez-Hidalgo, Eudald Carbonell
Ungulate mortality profiles are commonly used to study Neanderthal subsistence strategies. To assess the hunting strategies used by Neanderthals, we studied the ages at death of the cervids and equids found in levels E, H, I, Ja, Jb, K, L and M of the Abric Romaní sequence. These levels date between 43.2 ± 1.1 ka BP (14C AMS) and 54.5 ± 1.7 ka BP (U-series). The degree of eruption and development of the teeth and their wear stages were used to determine the ages of these animals at death, and mortality profiles were constructed using these data...
2017: PloS One
https://www.readbyqxmd.com/read/29166338/use-of-organs-from-hepatitis-c-virus-positive-donors-for-uninfected-recipients-a-potential-cost-effective-approach-to-save-lives
#6
Patrick B Trotter, Dominic M Summers, Ines Ushiro-Lumb, Matthew Robb, J Andrew Bradley, James Powell, Christopher J E Watson, James Neuberger
BACKGROUND: Organs from hepatitis C virus (HCV) seropositive (HCVpos) individuals are seldom used for transplantation because of the risk of disease transmission. Because transmitted HCV is now amenable to effective treatment we estimated the potential impact of using HCVpos deceased donor organs for transplantation. METHODS: The Potential Donor Audit (PDA) of patients (<80years) dying in UK critical care units and the UK Transplant Registry (UKTR) was searched to identify HCVpos potential and proceeding deceased donors...
November 22, 2017: Transplantation
https://www.readbyqxmd.com/read/29166178/changes-of-dominant-spoilage-bacteria-and-biogenic-amines-of-taihu-white-prawn-exopalaemon-modestus-during-ice-storage
#7
Lihui Du, Xiaoran Fan, Fang Liu, Qi Zhou, Jian Yuan, Xingrong Ju
The microbiological and chemical changes in Taihu white prawn (Exopalaemon modestus) during ice storage were evaluated. For the microbiological changes, total viable counts were obtained. PCR coupled with denatured gradient gel electrophoresis was then performed to investigate the changes in microflora. For the chemical changes, total volatile basic nitrogen was determined and biogenic amines were detected. The initial total viable count was 6.2 log CFU/g, which increased to 7.1 log CFU/g after storage at 0°C for 10 days...
November 22, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29166176/microbiological-quality-assessment-of-game-meats-at-retail-in-japan
#8
Hiroshi Asakura, Jun Kawase, Tetsuya Ikeda, Mioko Honda, Yoshimasa Sasaki, Masashi Uema, Hidenori Kabeya, Hiromu Sugiyama, Shizunobu Igimi, Shinji Takai
In this study, we examined the prevalence of Shiga toxin-producing Escherichia coli and Salmonella spp. and the distribution of indicator bacteria in 248 samples of game meats (120 venison and 128 wild boar) retailed between November 2015 and March 2016 in Japan. No Salmonella spp. were detected in any of the samples, whereas Shiga toxin-producing Escherichia coli serotype OUT:H25 (stx2d(+), eae(-)) was isolated from one deer meat sample, suggesting a possible source for human infection. Plate count assays indicated greater prevalence of coliforms and E...
November 22, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29166167/kinship-and-incest-avoidance-drive-patterns-of-reproductive-skew-in-cooperatively-breeding-birds
#9
Christina Riehl
Social animals vary in how reproduction is divided among group members, ranging from monopolization by a dominant pair (high skew) to equal sharing by cobreeders (low skew). Despite many theoretical models, the ecological and life-history factors that generate this variation are still debated. Here I analyze data from 83 species of cooperatively breeding birds, finding that kinship within the breeding group is a powerful predictor of reproductive sharing across species. Societies composed of nuclear families have significantly higher skew than those that contain unrelated members, a pattern that holds for both multimale and multifemale groups...
December 2017: American Naturalist
https://www.readbyqxmd.com/read/29166108/a-simple-molecular-orbital-treatment-of-current-distributions-in-quantum-transport-through-molecular-junctions
#10
Sin-Mu Jhan, Bih-Yaw Jin
A simple molecular orbital treatment of local current distributions inside single molecular junctions is developed in this paper. Using the first-order perturbation theory and nonequilibrium Green's function techniques in the framework of Hückel theory, we show that the leading contributions to local current distributions are directly proportional to the off-diagonal elements of transition density matrices. Under the orbital approximation, the major contributions to local currents come from a few dominant molecular orbital pairs which are mixed by the interactions between the molecule and electrodes...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166068/pure-rotational-h2-thermometry-by-ultrabroadband-coherent-anti-stokes-raman-spectroscopy
#11
Trevor L Courtney, Alexis Bohlin, Brian D Patterson, Christopher J Kliewer
Coherent anti-Stokes Raman spectroscopy (CARS) is a sensitive technique for probing highly luminous flames in combustion applications to determine temperatures and species concentrations. CARS thermometry has been demonstrated for the vibrational Q-branch and pure-rotational S-branch of several small molecules. Practical advantages of pure-rotational CARS, such as multi-species detection, reduction of coherent line mixing and collisional narrowing even at high pressures, and the potential for more precise thermometry, have motivated experimental and theoretical advances in S-branch CARS of nitrogen (N2), for example, which is a dominant species in air-fed combustion processes...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166054/modeling-super-resolution-sers-using-a-t-matrix-method-to-elucidate-molecule-nanoparticle-coupling-and-the-origins-of-localization-errors
#12
Charles W Heaps, George C Schatz
A computational method to model diffraction-limited images from super-resolution surface-enhanced Raman scattering microscopy is introduced. Despite significant experimental progress in plasmon-based super-resolution imaging, theoretical predictions of the diffraction limited images remain a challenge. The method is used to calculate localization errors and image intensities for a single spherical gold nanoparticle-molecule system. The light scattering is calculated using a modification of generalized Mie (T-matrix) theory with a point dipole source and diffraction limited images are calculated using vectorial diffraction theory...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166032/combined-cononsolvency-and-temperature-effects-on-adsorbed-pnipam-microgels
#13
Sebastian Backes, Patrick Krause, Weronika Tabaka, Marcus U Witt, Regine von Klitzing
The present study adresses the multi-responsive behavior of Poly(N-isopropylacrylamide) (PNIPAM) microgels adsorbed to interfaces. The microgels react to changes in temperature by shrinking in aqueous solution above their volume phase transition temperature (VPTT). Additionally, they shrink in mixtures of water and ethanol, although both individual liquids are good solvents for PNIPAM. The combination of this so-called cononsolvency effect and the temperature response of adsorbed microgels is studied by atomic force microscopy (AFM)...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29165998/characterization-of-natural-organic-substances-potentially-hindering-rt-pcr-based-virus-detection-in-large-volumes-of-environmental-water
#14
Akihiko Hata, Manami Inaba, Hiroyuki Katayama, Hiroaki Furumai
Quantitative detection of pathogenic viruses in the environmental water is essential for the assessment of water safety. It is known that some of natural organic substances interfere with virus detection processes, i.e., nucleic acid extraction and reverse transcription-PCR. Such substances are carried over into a sample after virus concentration. In this study, inhibitory substances in coastal water samples were characterized in view of their effects on efficiency of virus detection and property as organic matters...
November 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29165801/sex-and-rank-affect-how-infant-rhesus-macaques-look-at-faces
#15
Annika Paukner, Emily M Slonecker, Ashley M Murphy, Lauren J Wooddell, Amanda M Dettmer
We investigated how differences in infant sex and mothers' dominance status affect infant rhesus macaques' (Macaca mulatta) interest in visually exploring emotional facial expressions. Thirty-eight infants were presented with animated avatars of macaque facial expressions during the first month of life. Sons of high-ranking mothers looked more at faces, especially the eye region, than sons of low-ranking mothers, but no difference in looking duration was found for daughters. Males looked significantly more at eyes than females, but this effect was reversed in infants who were reared without mothers in a primate nursery facility...
November 22, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29165631/instrumental-variables-estimation-under-a-structural-cox-model
#16
Torben Martinussen, Ditte Nørbo Sørensen, Stijn Vansteelandt
Instrumental variable (IV) analysis is an increasingly popular tool for inferring the effect of an exposure on an outcome, as witnessed by the growing number of IV applications in epidemiology, for instance. The majority of IV analyses of time-to-event endpoints are, however, dominated by heuristic approaches. More rigorous proposals have either sidestepped the Cox model, or considered it within a restrictive context with dichotomous exposure and instrument, amongst other limitations. The aim of this article is to reconsider IV estimation under a structural Cox model, allowing for arbitrary exposure and instruments...
November 20, 2017: Biostatistics
https://www.readbyqxmd.com/read/29165627/health-literacy-and-patient-outcomes-in-chronic-kidney-disease-a-systematic-review
#17
Dominic M Taylor, Simon Fraser, Chris Dudley, Gabriel C Oniscu, Charles Tomson, Rommel Ravanan, Paul Roderick
Background: Limited health literacy affects 25% of people with chronic kidney disease (CKD), and may reduce self-management skills resulting in poorer clinical outcomes. By disproportionately affecting people with low socio-economic status and non-white ethnicity, limited health literacy may promote health inequity. Methods: We performed a systematic review of quantitative studies of health literacy and clinical outcomes among adults with CKD. Results: A total of 29 studies (13 articles; 16 conference abstracts) were included...
November 20, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165577/quantitative-mri-brain-in-congenital-adrenal-hyperplasia-in-vivo-assessment-of-the-cognitive-and-structural-impact-of-steroid-hormones
#18
Emma A Webb, Lucy Elliott, Dominic Carlin, Martin Wilson, Kirsty Hall, Jennifer Netherton, Julie Reed, Tim G Barrett, Vijay Salwani, Jon D Clayden, Wiebke Arlt, Nils Krone, Andrew C Peet, Amanda G Wood
Context: Brain white matter hyper-intensities are seen on routine clinical imaging in 46% of adults with congenital adrenal hyperplasia (CAH). The extent and functional relevance of these abnormalities have not been studied using quantitative MRI analysis. Objective: To examine white matter microstructure, neural volumes and CNS metabolites in CAH due to 21-hydroxylase deficiency (21OHD) and to determine whether identified abnormalities are associated with cognition, glucocorticoid and androgen exposure...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165401/systematic-overview-of-bacopa-monnieri-l-wettst-dominant-poly-herbal-formulas-in-children-and-adolescents
#19
REVIEW
James D Kean, Luke A Downey, Con Stough
Background: The Ayurvedic medicinal system employs a holistic approach to health, utilising the synergistic properties of organic resources. Research into the Ayurvedic herb Bacopa monnieri (L.) Wettst. (B.monnieri) has reported improvements in cognitive outcomes in child and adult populations. The aim of current review is to systematically assess and critically summarize clinical trials investigating B.monnieri-dominant poly-herbal formulas and their effects on the cognition, memory, learning, and behaviour in children and adolescents...
November 22, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29165321/interfacial-rheology-of-model-particles-at-liquid-interfaces-and-its-relation-to-bicontinuous-pickering-emulsions
#20
Job H J Thijssen, Jan Vermant
Interface-dominated materials are commonly encountered in both science and technology, and typical examples include foams and emulsions. Conventionally stabilised by surfactants, emulsions can also be stabilised by micron-sized particles. These so-called Pickering-Ramsden (PR) emulsions have received substantial interest, as they are model arrested systems, rather ubiquitous in industry and promising templates for advanced materials. The mechanical properties of the particle-laden liquid-liquid interface, probed via interfacial rheology, have been shown to play an important role in the formation and stability of PR emulsions...
November 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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