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https://www.readbyqxmd.com/read/29143864/correction-to-cell-type-specific-localization-of-ephs-pairing-with-ephrin-b2-in-the-rat-postnatal-pituitary-gland
#1
Saishu Yoshida, Takako Kato, Naoko Kanno, Naoto Nishimura, Hiroto Nishihara, Kotaro Horiguchi, Yukio Kato
The published online version contains mistakes in Table 1, Table 2 and Fig. 2. See below for the corrected Tables and Figure.
November 16, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29142304/maternal-exposure-to-iodine-excess-throughout-pregnancy-and-lactation-induces-hypothyroidism-in-adult-male-rat-offspring
#2
Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Thiago Pantaleão, Vânia Maria Corrêa da Costa, Maria Tereza Nunes
This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Moreover, the IE-exposed offspring rats presented reduced thyroid hormones levels, morphological alterations in the thyroid follicles, increased thyroid oxidative stress and decreased expression of thyroid differentiation markers (Tshr, Nis, Tg, Tpo, Mct8) and thyroid transcription factors (Nkx2...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142006/characterization-of-neuroendocrine-tumors-in-heterozygous-mutant-menx-rats-a-novel-model-of-invasive-medullary-thyroid-carcinoma
#3
Sara Molatore, Andrea Kügler, Martin Irmler, Tobias Wiedemann, Frauke Neff, Annette Feuchtinger, Johannes Beckers, Mercedes Robledo, Frederico Roncaroli, Natalia S Pellegata
Rats affected by the MENX syndrome spontaneously develop multiple neuroendocrine tumors (NETs) including adrenal, pituitary and thyroid gland neoplasms. MENX was initially reported to be inherited as a recessive trait and affected rats were found to be homozygous for the predisposing Cdkn1b mutation encoding p27. We here report that heterozygous MENX mutant rats (p27+/mut) develop the same spectrum of NETs seen in the homozygous (p27mut/mut) animals but with slower progression. Consequently, p27+/mut rats have a significantly shorter lifespan compared with their wild-type (p27+/+) littermates...
November 15, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29136956/antagonistic-effect-of-oxytocin-and-tacrolimus-combination-on-adipose-tissue-derived-mesenchymal-stem-cells-antagonistic-effect-of-oxytocin-and-tacrolimus-antagonistic-effect-of-oxytocin-and-tacrolimus
#4
Gozde Sir, Bakiye Goker Bagca, Gurkan Yigitturk, Turker Cavusoglu, Cigir Biray Avci, Cumhur Gunduz, Yigit Uyanikgil
Tacrolimus (FK506) is a chemotherapeutic agent, which uses calcineurin pathway via inhibiting the stimulation of T cells to prevent the formation of immune response in the recipient individual in organ transplants. FK506 is mainly metabolized in the liver by cytochrome P450 enzyme system and is known that it has high toxic effects on different cells. Mesenchymal stem cells (MSCs) have recently gained importance since their potential to be used in cellular therapy and tissue regeneration. In some clinical cases, MSCs are transferred into the patient after the organ transplantations in order to support the treatment...
November 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29132721/endocrine-pathology-past-present-and-future
#5
REVIEW
Sylvia L Asa, Ozgur Mete
Endocrine pathology is the subspecialty of diagnostic pathology which deals with the diagnosis and characterisation of neoplastic and non-neoplastic diseases of the endocrine system. This relatively young subspecialty was initially focused mainly on thyroid and parathyroid pathology, with some participants also involved in studies of the pituitary, the endocrine pancreas, and the adrenal glands. However, the endocrine system involves much more than these traditional endocrine organs and the discipline has grown to encompass lesions of the dispersed neuroendocrine cells, including neuroendocrine tumours (NETs) of the lungs, gastrointestinal tract, thymus, breast and prostate, as well as paraganglia throughout the body, not just in the adrenals...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29130118/sox10-positive-cells-emerge-in-the-rat-pituitary-gland-during-late-embryogenesis-and-start-to-express-s100%C3%AE
#6
Hiroki Ueharu, Saishu Yoshida, Naoko Kanno, Kotaro Horiguchi, Naoto Nishimura, Takako Kato, Yukio Kato
In the pituitary gland, S100β-positive cells localize in the neurohypophysis and adenohypophysis but the lineage of the two groups remains obscure. S100β is often observed in many neural crest-derived cell types. Therefore, in this study, we investigate the origin of pituitary S100β-positive cells by immunohistochemistry for SOX10, a potent neural crest cell marker, using S100β-green fluorescence protein-transgenic rats. On embryonic day 21.5, a SOX10-positive cell population, which was also positive for the stem/progenitor cell marker SOX2, emerged in the pituitary stalk and posterior lobe and subsequently expanded to create a rostral-caudal gradient on postnatal day 3 (P3)...
November 13, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29129646/extracellular-volume-depletion-and-resultant-hypotonic-hyponatremia-a-novel-translational-approach
#7
Philip J G M Voets, Roderick P P W M Maas
Although several methods currently exist to determine that a person is hypovolemic, it often remains very challenging to accurately estimate the effective circulating volume or amount of intravascular volume depletion in a non-controlled setting. This depletion of intravascular volume can have many causes and is frequently accompanied by hypotonic hyponatremia as a result of hypovolemia-induced release of arginine vasopressin (AVP) from the posterior pituitary gland. Here, we derive a novel, comprehensible equation that provides a theoretical insight into the complex interrelationship between the degree of isotonic volume depletion and the resultant change in plasma sodium concentration...
November 9, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29118715/differential-regulation-of-thyroid-hormone-metabolism-target-genes-during-non-thyoidal-illness-syndrome-triggered-by-fasting-or-sepsis-in-adult-mice
#8
Klaus N Fontes, Adriana Cabanelas, Flavia F Bloise, Cherley Borba Vieira de Andrade, Luana L Souza, Marianna Wilieman, Isis H Trevenzoli, Lais C Agra, Johnatas D Silva, Christianne Bandeira-Melo, Pedro L Silva, Patricia R M Rocco, Tania M Ortiga-Carvalho
Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the non-thyroidal illness syndrome (NTIS). To date, it is still debated whether NTIS represents an adaptive response or a real hypothyroid state at the tissue level. Moreover, even though it has been considered the same syndrome, we hypothesized that fasting and sepsis induce a distinct set of changes in thyroid hormone metabolism. Herein, we aimed to evaluate the central and peripheral expression of genes involved in the transport (MCT8/Slc16a2 and MCT10/Slc16a10), metabolism (Dio1, Dio2, and Dio3) and action (Thra and Thrb) of TH during NTIS induced by fasting or sepsis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29110720/first-intraindividual-comparison-of-contrast-enhanced-mri-fet-and-dotatoc-pet-in-patients-with-intracranial-meningiomas
#9
Jan Oliver Dittmar, Clemens Kratochwil, Anne Dittmar, Thomas Welzel, Daniel Habermehl, Stefan Rieken, Frederik L Giesel, Uwe Haberkorn, Jürgen Debus, Stephanie E Combs
BACKGROUND: For irradiation treatment planning of meningiomas the use of PET-scans is well established. The most frequently used tracers are either based on amino acids or the somatostatin receptor ligand DOTATOC. Since up to now no inter-institutionally accepted standard PET-tracer has been defined, the aim of this study was to evaluate the influence of these different types of PET-tracers on the GTV-definition. METHODS: Twenty-one patients suffering from intracranial meningiomas underwent CT, MRI, FET- and DOTATOC-PET...
November 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29109870/acute-onset-panhypopituitarism-nearly-missed-by-initial-cosyntropin-testing
#10
Claudine A Blum, Daniel Schneeberger, Matthias Lang, Janko Rakic, Marc Philippe Michot, Beat Müller
Introduction: Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome. Case: A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was vasopressor-nonresponsive. Diabetes insipidus was diagnosed due to polyuria and treated with 4 mg desmopressin...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29106072/regulation-of-continuous-but-complex-expression-pattern-of-six1-during-early-sensory-development
#11
Shigeru Sato, Yasuhide Furuta, Kiyoshi Kawakami
BACKGROUND: In vertebrates, cranial sensory placodes give rise to neurosensory and endocrine structures such as the olfactory epithelium, inner ear and anterior pituitary. We report here the establishment of a transgenic mouse line that expresses Cre recombinase under the control of Six1-21, a major placodal enhancer of the homeobox gene Six1. RESULTS: In the new Cre-expressing line, mSix1-21-NLSCre, the earliest Cre-mediated recombination was induced at embryonic day 8...
November 6, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29104246/relation-among-aromatase-p450-and-tumoral-growth-in-human-prolactinomas
#12
REVIEW
María José García-Barrado, Enrique J Blanco, María Carmen Iglesias-Osma, Marta Carretero-Hernández, Leonardo Catalano-Iniesta, Virginia Sanchez-Robledo, Manuel Carretero, Julio Joaquín Herrero, Sixto Carrero, José Carretero
The pituitary gland is part of hypothalamic-pituitary-gonadal axis, which controls development, reproduction, and aging in humans and animals. In addition, the pituitary gland is regulated mainly by hormones and neurotransmitters released from the hypothalamus and by systemic hormones secreted by target glands. Aromatase P450, the enzyme responsible for the catabolization of aromatizable androgens to estrogens, is expressed in different parts of body, including the pituitary gland. Moreover, aromatase P450 is involved in sexual dimorphism where alteration in the level of aromatase can initiate a number of diseases in both genders...
November 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29103185/trends-in-surgery-hospital-admissions-and-imaging-for-pituitary-adenomas-in-australia
#13
Sjorjina Crowther, R Louise Rushworth, Wayne Rankin, Henrik Falhammar, Liza K Phillips, David J Torpy
PURPOSE: There is a paucity of epidemiological information on treatment and imaging of pituitary adenomas in Australia. METHODS: Australian data on pituitary surgery, hospital admissions for pituitary adenomas, and pituitary imaging on patients 15 years and over were obtained from administrative databases between 2000/2001 and 2014/2015. Changes over time and by age and sex were assessed. RESULTS: In 2014/15 there were 37.7 pituitary procedures/million population, corresponding to a 35...
November 4, 2017: Endocrine
https://www.readbyqxmd.com/read/29100688/bisphenol-a-and-reproductive-hormones-and-cortisol-in-peripubertal-boys-the-inma-granada-cohort
#14
Vicente Mustieles, Olga Ocón-Hernandez, Lidia Mínguez-Alarcón, Cristina Dávila-Arias, Rocío Pérez-Lobato, Irene Calvente, Juan P Arrebola, Fernando Vela-Soria, Soledad Rubio, Russ Hauser, Nicolás Olea, Mariana F Fernández
INTRODUCTION: Bisphenol A (BPA) is a well-known endocrine disrupting compound. Although several studies have investigated the effect of BPA exposure and reproductive hormones in humans, results have been inconsistent. OBJECTIVE: To explore the cross-sectional relationship between bisphenol A (BPA) exposure and reproductive hormones/cortisol among peripubertal boys. MATERIAL AND METHODS: Urinary BPA and serum hormones were assessed in 172 boys belonging to the INMA "Environment and Childhood" Granada birth cohort in their follow-up at 9-11years of age...
October 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29099999/high-fat-simple-carbohydrate-diet-intake-induces-hypothalamic-pituitary-thyroid-axis-dysregulation-in-c57bl-6j-male-mice
#15
Swarnalatha Banavara Nagaraj, Neena Roy, Mahesh Manjunath Gouda, Rajeish Moger, Asha Abraham
Given the association between subclinical hypothyroidism and metabolic syndrome (MetS), we wanted to explore if high fat simple carbohydrate (HFSC) diet affect hypothalamus-pituitary-thyroid axis. One month old male C57BL/6J mice were fed with Control (C) and HFSC (T) feed (n=18 each) respectively for 5 months. T3 showed a significant increase in T(13.5%) compared to age matched C by 5th month.TSH was significantly high (1mo:1.9fold; 3mo:2.66 fold; 5mo:3.5fold) from 1stmonth to 5thmonth in T compared to age matched C...
November 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29097993/s-equol-exerts-estradiol-like-anorectic-action-with-minimal-stimulation-of-estrogen-receptor-%C3%AE-in-ovariectomized-rats
#16
Yuri Nishimura, Kaori Mabuchi, Azusa Takano, Yayoi Hara, Hiroko Negishi, Keiko Morimoto, Tomomi Ueno, Shigeto Uchiyama, Akira Takamata
Chronic estrogen replacement in ovariectomized rats attenuates food intake and enhances c-Fos expression in the suprachiasmatic nucleus (SCN), specifically during the light phase. S-equol, a metabolite of daidzein, has a strong affinity for estrogen receptor (ER)-β and exerts estrogenic activity. The purpose of the present study was to elucidate whether S-equol exerts an estrogen-like anorectic effect by modifying the regulation of the circadian feeding rhythm in ovariectomized rats. Ovariectomized female Wistar rats were divided into an estradiol (E2)-replaced group and cholesterol (vehicle; Veh)-treated group...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29097845/historical-control-background-incidence-of-spontaneous-pituitary-gland-lesions-of-han-wistar-and-sprague-dawley-rats-and-cd-1-mice-used-in-104-week-carcinogenicity-studies
#17
Kaori Isobe, James Baily, Sydney Mukaratirwa, Claudio Petterino, Alys Bradley
The aim of this study was to determine the range and incidences of spontaneous microscopic lesions of the pituitary gland in control Han-Wistar and Sprague-Dawley rats and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the pituitary gland were generally uncommon, excluding cysts/pseudocysts (6.42% in Han-Wistar rats, 5.85% in Sprague-Dawley rats, and 2.08% in CD-1 mice). Primary proliferative lesions were most frequently found in the pars distalis of the pituitary gland...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29095280/primary-hypothyroidism-and-isolated-acth-deficiency-induced-by-nivolumab-therapy-case-report-and-review
#18
REVIEW
Mei Fang Zeng, Li Chen, Hong Ying Ye, Wei Gong, Li Nuo Zhou, Yi Ming Li, Xiao Long Zhao
RATIONALE: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system. PATIENT CONCERNS: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Routine monitoring showed elevated thyroid-stimulating hormone and low free thyroxine after the 6th administration of nivolumab...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093382/prednisolone-responsive-postpartum-igg4-related-hypophysitis
#19
Hisashi Koide, Akina Shiga, Eri Komai, Azusa Yamato, Masanori Fujimoto, Ai Tamura, Takashi Kono, Akitoshi Nakayama, Tomoko Takiguchi, Seiichiro Higuchi, Ikki Sakuma, Hidekazu Nagano, Naoko Hashimoto, Sawako Suzuki, Yasuaki Takeda, Makoto Shibuya, Hiroshi Nishioka, Shozo Yamada, Naoko Inoshita, Norio Ishiwatari, Kentaro Horiguchi, Koutaro Yokote, Tomoaki Tanaka
We herein report the case of a 25-year-old woman who presented with severe headache and visual field defects after childbirth. Magnetic resonance imaging revealed marked swelling of the pituitary gland, and an endocrinological examination revealed panhypopituitarism and diabetes insipidus. An immunohistological analysis of a transsphenoidal biopsy sample of the pituitary gland showed the significant accumulation of an immunogloblin G4 (IgG4)-positive population, leading to the diagnosis of IgG4-related hypophysitis...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29092962/multiple-endocrine-neoplasia-type-1-presenting-with-refractory-seizures
#20
Banshi Lal Kumawat, Chandramohan Sharma, Mohit Janakkumar Shah, Maulik Panchal
We report a case of 29-year-old woman referred to us for management of refractory epilepsy. Under observation, she was detected to have recurrent hypoglycaemia during the episodes of seizures. On investigation, she was found to have hyperinsulinemic hypoglycaemia. Her triple-phase CT scan of abdomen showed neuroendocrine tumour of pancreatic head, with bilateral renal calculi. Screening of other endocrine glands revealed pituitary microadenoma and parathyroid adenoma on imaging, which was also supported by biochemical and hormonal profile...
November 1, 2017: BMJ Case Reports
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