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Gluten and parkinson

Andrew McKeon, Vanda A Lennon, Sean J Pittock, Thomas J Kryzer, Joseph Murray
OBJECTIVE: To report neurologic phenotypes and their etiologies determined among 68 patients with either (1) celiac disease (CD) or (2) no CD, but gliadin antibody positivity (2002-2012). METHODS: Neurologic patients included both those with the CD-prerequisite major histocompatibility complex class II human leukocyte antigen (HLA)-DQ2/DQ8 haplotype, and those without. The 3 groups were as follows: group 1 (n = 44), CD or transglutaminase (Tg)-2/deamidated gliadin immunoglobulin (Ig)A/IgG detected; group 2 (n = 15), HLA-DQ2/DQ8 noncarriers, and gliadin IgA/IgG detected; and group 3 (n = 9), HLA-DQ2/DQ8 carriers, and gliadin IgA/IgG detected...
November 11, 2014: Neurology
Tran H Tran
PURPOSE OF REVIEW: To summarize the recent advances in celiac disease in children. RECENT FINDINGS: New clues to the pathogenesis of celiac disease continue to emerge that may implicate the role of microbiome changes, antirotavirus VP7 antibodies, and the Parkinson's disease seven gene in celiac disease. Updated guidelines in pediatrics no longer support biopsies in all patients with celiac disease who have been identified by serology, clinical signs, and genetics...
October 2014: Current Opinion in Pediatrics
Robert K Naviaux
The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. The resulting metabolic mismatch between available resources and functional capacity produces a cascade of changes in cellular electron flow, oxygen consumption, redox, membrane fluidity, lipid dynamics, bioenergetics, carbon and sulfur resource allocation, protein folding and aggregation, vitamin availability, metal homeostasis, indole, pterin, 1-carbon and polyamine metabolism, and polymer formation...
May 2014: Mitochondrion
Péter Vörös, Erna Sziksz, Leonóra Himer, Anna Onody, Domonkos Pap, Klára Frivolt, Beáta Szebeni, Rita Lippai, Hajnalka Győrffy, Andrea Fekete, Ferenc Brandt, Kriszta Molnár, Gábor Veres, András Arató, Tivadar Tulassay, Adám Vannay
Recently, it has been suggested that the gene called Parkinson's disease 7 (PARK7) might be an upstream activator of hypoxia-inducible factor (HIF)-1α, which plays a major role in sustaining intestinal barrier integrity. Furthermore, PARK7 has been proposed to participate in the Toll-like receptor (TLR)-dependent regulation of the innate immune system. Our aim was to investigate the involvement of PARK7 in the pathogenesis of coeliac disease (CD). Duodenal biopsy specimens were collected from 19 children with untreated CD, five children with treated CD (maintained on gluten-free diet), and ten children with histologically normal duodenal biopsies...
September 2013: Virchows Archiv: An International Journal of Pathology
José Fidel Baizabal-Carvallo, Joseph Jankovic
Movement disorders have been known to be associated with a variety of autoimmune diseases, including Sydenham's chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, systemic lupus erythematosus, antiphospholipid syndrome, gluten sensitivity, paraneoplastic and autoimmune encephalopathies. Tremors, dystonia, chorea, ballism, myoclonus, parkinsonism, and ataxia may be the initial and even the only presentation of these autoimmune diseases. Although antibodies directed against various cellular components of the central nervous system have been implicated, the pathogenic mechanisms of these autoimmune movement disorders have not yet been fully elucidated...
July 2012: Movement Disorders: Official Journal of the Movement Disorder Society
Peter R Holt
BACKGROUND: Intestinal malabsorption in the elderly is infrequent, and clinical features are muted so that the diagnosis is often missed. Physiologic changes with aging are restricted to altered absorption of calcium and perhaps zinc and magnesium; however, achlorhydria can lead to impaired absorption of vitamin B(12), folic acid, and calcium. METHODS AND RESULTS: Small bowel bacterial overgrowth occurs more commonly in elderly than in younger patients, accompanying gastric hypochlorhydria, altered intestinal motor activity, or diseases such as Parkinson's disease...
2007: Digestive Diseases
Masafumi Ihara, Fumi Makino, Hideyuki Sawada, Takahiro Mezaki, Kotaro Mizutani, Hiroshi Nakase, Makoto Matsui, Hidekazu Tomimoto, Shun Shimohama
OBJECTIVE: Gluten sensitivity is associated with multiple neurological abnormalities including gluten ataxia, motor neuron disease-like neuropathy, small fiber type neuropathy, cognitive impairment, and even parkinsonism. We investigated whether or not gluten sensitivity is involved in Japanese patients with idiopathic cerebellar ataxia with extracerebellar presentation. PATIENTS OR MATERIALS: Fourteen patients with idiopathic cerebellar ataxia with extracerebellar presentation (autonomic instability, parkinsonism, or pyramidal dysfunction in varying combinations) were screened for anti-gliadin antibodies (AGA) to analyze for the presence or absence of gluten sensitivity...
2006: Internal Medicine
Maciej Ostrowski, Magdalena Izdebska, Alina Grzanka, Agnieszka Zuryń, Dariusz Grzanka
Transglutaminase 2 (TG-ase 2) is one of the enzymes which catalyzes the deamination and transacylation of proteins. The transfer of a glutamine acyl residue to a lysine amine group of the acceptor protein is one of the posttranslational covalent modifications regulating some polypeptide activities. The control of protein oligomerization by TG-ase 2 is a cause of the formation of detergent-insoluble macromolecular aggregates. These inclusions are present in degenerating cells during, for example, Alzheimer's and Parkinson's disease...
2005: Postȩpy Higieny i Medycyny Doświadczalnej
Salil Manek, Mark F. Lew
Determining the precise cause of gait dysfunction in adults is often difficult because of the multifactorial nature of the disorder. Additionally, elderly patients have other comorbidities that further complicate their diagnosis. A proper history and physical examination, however, often allow the clinician to arrive at the correct diagnosis. Once a diagnosis is reached, appropriate therapeutic decisions can be made. Patients presenting with Parkinsonism need a thorough evaluation to rule out potentially reversible conditions, such as normal pressure hydrocephalus...
March 2003: Current Treatment Options in Neurology
M Hadjivassiliou, A Gibson, G A Davies-Jones, A J Lobo, T J Stephenson, A Milford-Ward
BACKGROUND: Antigliadin antibodies are a marker of untreated coeliac disease but can also be found in individuals with normal small-bowel mucosa. Because neurological dysfunction is a known complication of coeliac disease we have investigated the frequency of antigliadin antibodies, as a measure of cryptic gluten sensitivity, and coeliac disease in neurological patients. METHODS: Using ELISA, we estimated serum IgG and IgA antigliadin antibodies in 147 neurological patients who were divided into two groups...
February 10, 1996: Lancet
M M Singh, S R Kay
In studying the relationships between anticholinergic-neuroleptic interactions and the nosological and prognostic distinctions in schizophrenia, we have shown that these distinctions have clinicopathological meaning. The countertherapeutic anticholinergic effects seemed to be particularly evident in the good outcome, schizophreniform cases and differentiated between the three diagnostic subtypes. Such effects were most conspicuous in the catatonics who also had the most favorable prognosis, while the paranoids differed from others in not only showing the least anticholinergic effects but also in not conforming to the relationship between these effects and prognosis...
1978: Neuropsychobiology
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