keyword
https://read.qxmd.com/read/38478292/open-versus-closed-suctioning-among-mechanically-ventilated-pediatric-patients-a-randomised-control-trial
#21
JOURNAL ARTICLE
Subhranshu Sekhar Dhal, Rajiv Aggarwal, Hiremath Sagar, Nirmal Kumar Mohakud, Anilkumar Sapare, Sourav Padhee, Manaswinee Sahoo
OBJECTIVES: To compare the difference in efficacy of closed tracheal suction system (CTSS) to open tracheal suction system (OTSS) in reducing incidence of ventilator associated pneumonia (VAP). Also to evaluate their efficacy in stabilizing cardio-respiratory parameters, reducing mortality and duration of intubation. METHODS: This study was a single centre, parallel group, open label, randomized controlled study with an equal allocation (1:1) in pediatric patients requiring mechanical ventilation...
March 13, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38465976/pre-existing-immunocompromising-conditions-and-outcomes-of-acute-covid-19-patients-admitted-for-pediatric-intensive-care
#22
JOURNAL ARTICLE
Courtney M Rowan, Brenna LaBere, Cameron C Young, Laura D Zambrano, Margaret M Newhams, Suden Kucukak, Elizabeth R McNamara, Elizabeth H Mack, Julie C Fitzgerald, Katherine Irby, Aline B Maddux, Jennifer E Schuster, Michele Kong, Heda Dapul, Stephanie P Schwartz, Melania M Bembea, Laura L Loftis, Amanda R Kolmar, Christopher J Babbitt, Ryan A Nofziger, Mark W Hall, Shira J Gertz, Natalie Z Cvijanovich, Matt S Zinter, Natasha B Halasa, Tamara T Bradford, Gwenn E McLaughlin, Aalok R Singh, Charlotte V Hobbs, Kari Wellnitz, Mary A Staat, Bria M Coates, Hillary R Crandall, Mia Maamari, Kevin M Havlin, Adam J Schwarz, Christopher L Carroll, Emily R Levy, Kristin L Moffitt, Angela P Campbell, Adrienne G Randolph, Janet Chou
BACKGROUND: We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care. METHODS: 55 hospitals in 30 U.S. states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients <21 years admitted March 12, 2020-December 30, 2021 to the pediatric intensive care unit (PICU) or high acuity unit for acute COVID-19 were included...
March 11, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38460619/impact-of-prolonged-ischemic-time-on-pediatric-heart-transplantation-outcomes-improved-outcomes-in-the-most-recent-era
#23
JOURNAL ARTICLE
Scott R Auerbach, Adam Arshad, Estela Azeka, Ryan S Cantor, James K Kirklin, Devin Koehl, JonDavid Menteer, David M Peng, William Ravekes, Fawwaz R Shaw, Renata Shih, Jacob Simmonds, Jean Ballweg
BACKGROUND: Impacts of ischemic time (IT) on pediatric heart transplant outcomes are multifactorial. We aimed to analyze the effect of prolonged IT on graft loss after pediatric heart transplantation. We hypothesized that graft survival with prolonged IT has improved across eras. METHODS: Patients <18 years old in the Pediatric Heart Transplant Society database (1993-2019) were included (N=6765) and stratified by diagnosis and era (1993-2004, 2005-2009, and 2010-2019)...
March 7, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38460413/comparison-of-volume-controlled-ventilation-pressure-controlled-ventilation-and-pressure-controlled-ventilation-volume-guaranteed-in-infants-and-young-children-in-the-prone-position-a-prospective-randomized-study
#24
JOURNAL ARTICLE
Chunying Bao, Hongmin Cao, Zhipeng Shen, Yaoqin Hu, Jinjin Huang, Qiang Shu, Qixing Chen
STUDY OBJECTIVE: To explore if the pressure-controlled ventilation (PCV) and pressure-controlled ventilation-volume guaranteed (PCV-VG) modes are superior to volume-controlled ventilation (VCV) in optimizing intraoperative respiratory mechanics in infants and young children in the prone position. DESIGN: A single-center prospective randomized study. SETTING: Children's Hospital, Zhejiang University School of Medicine. PATIENTS: Pediatric patients aged 1 month to 3 years undergoing elective spinal cord detethering surgery...
March 8, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38459440/the-role-of-nutrition-in-analysis-of-risk-factors-and-short-term-outcomes-for-late-onset-necrotizing-enterocolitis-among-very-preterm-infants-%C3%A2-a-nationwide-multicenter-study-in-china
#25
MULTICENTER STUDY
Kun-Yao Hong, Yao Zhu, Fan Wu, Jian Mao, Ling Liu, Rong Zhang, Yan-Mei Chang, Wei Shen, Li-Xia Tang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Zhi Zheng, Xiao-Mei Tong, Xin-Zhu Lin
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze the risk factors for LO-NEC, and the impact of LO-NEC on short-term outcomes in very preterm infants (VPIs) with a focus on nutrition and different onset times. METHOD: Clinical data of VPIs were retrospectively collected from 28 hospitals in seven different regions of China from September 2019 to December 2020...
March 8, 2024: BMC Pediatrics
https://read.qxmd.com/read/38459147/neurosurgical-intervention-for-the-meckel-gruber-syndrome-a-systematic-review
#26
REVIEW
Jefferson Heber Marques Fontes Junior, Silvio Porto Junior, Hugo Nunes Pustilnik, Leonardo de Almeida Leão, Matheus Gomes da Silva da Paz, Taiane Brito Araujo, Fernanda Oliveira Gonçalves de Deus, Tancredo Alcântara, Jules Carlos Dourado, Leonardo Miranda de Avellar
INTRODUCTION: Meckel-Gruber Syndrome (MKS) is an autosomal recessive genetic disorder, notable for its triad of occipital encephalocele, polycystic renal dysplasia, and postaxial polydactyly. Identified by Johann Friederich Meckel in 1822, MKS is categorized as a ciliopathy due to gene mutations. Diagnosis is confirmed by the presence of at least two key features. The condition is incompatible with life, leading to death in the womb or shortly after birth. Recent studies have largely focused on the genetic aspects of MKS, with limited information regarding the impact of neurosurgical approaches, particularly in treating encephaloceles...
March 9, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38458492/review-of-electrical-impedance-tomography-in-the-pediatric-patient
#27
REVIEW
S Cabezudo Ballesteros, P Sanabria Carretero, F Reinoso Barbero
Electrical impedance tomography (EIT) is a new method of monitoring non-invasive mechanical ventilation, at the bedside and useful in critically ill patients. It allows lung monitoring of ventilation and perfusion, obtaining images that provide information on lung function. It is based on the physical principle of impedanciometry or the body's ability to conduct an electrical current. Various studies have shown its usefulness both in adults and in pediatrics in respiratory distress syndrome, pneumonia and atelectasis in addition to pulmonary thromboembolism and pulmonary hypertension by also providing information on pulmonary perfusion, and may be very useful in perioperative medicine; especially in pediatrics avoiding repetitive imaging tests with ionizing radiation...
March 6, 2024: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/38456989/risk-factors-for-infant-hearing-loss-a-meta-analysis
#28
JOURNAL ARTICLE
Yiwei Han, Shangbin Li, Yankun Song, Jingfei Sun, Weichen Yan, Jie Wang, Xiong Gao, Xueying Li, Changjun Ren, Qian Zhao
Hearing loss is a common disability in infants that significantly impacts their cognitive, language, and literacy development. This study aimed to systematically assess the risk factors for the early identification and intervention in infant hearing loss. Databases were searched for meta-analyses of observational studies until November 2023. The quality assessment was performed using the Cochrane risk of bias tool, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to assess the certainty of the evidence...
March 8, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38455752/application-value-of-metagenomics-next-generation-sequencing-in-the-diagnosis-of-respiratory-virus-infection-after-congenital-heart-surgery
#29
JOURNAL ARTICLE
Xiu-Hua Chen, Si-Jia Zhou, Ying-Ying Liu, Hua Cao, Yi-Rong Zheng, Qiang Chen
BACKGROUND: Timely and accurate pathogen diagnosis can be challenging in children who contract a respiratory virus following congenital heart surgery (CHS). This often results in suboptimal drug use and treatment delays. Metagenomics next-generation sequencing (mNGS) is a swift, efficient, and unbiased method for obtaining microbial nucleic acid sequences. This technology holds promise as a comprehensive diagnostic tool, especially for pathogens undetectable by traditional methods. However, the efficacy of mNGS in the context of congenital heart disease infections remains uncertain...
February 29, 2024: Translational Pediatrics
https://read.qxmd.com/read/38455742/myocardial-tissue-expression-of-mrna-and-preoperative-neutrophil-lymphocyte-ratio-in-children-undergoing-congenital-heart-surgery
#30
JOURNAL ARTICLE
Valdano Manuel, Leonardo A Miana, Miriam Helena Fonseca-Alaniz, Gabriel Carrillo Hernan, Davi Freitas Tenório, Celestino Bado, Mariana Lombardi Peres de Carvalho, Matheus Meirelles, João Paulo Mota Telles, Juliano Gomes Penha, Carla Tanamati, Luiz Fernando Caneo, José Eduardo Krieger, Fábio Biscegli Jatene, Marcelo Biscegli Jatene
BACKGROUND: The neutrophil-lymphocyte ratio (NLR) is an easily accessible and inexpensive biomarker that has been shown to predict morbidity and mortality in congenital cardiac surgery. However, its regulatory mechanism remains unclear. This study aims to compare and correlate the tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-10 messenger RNAs (mRNAs) with the NLR in patients with tetralogy of Fallot (ToF) and ventricular septal defect (VSD). METHODS: A prospective translational study was conducted on 10 children with ToF and 10 with VSD, aged between 1 and 24 months...
February 29, 2024: Translational Pediatrics
https://read.qxmd.com/read/38454265/differences-in-possible-risk-factors-treatment-strategies-and-outcomes-of-neonatal-pneumothorax-in-preterm-and-term-infants
#31
JOURNAL ARTICLE
Ümit Ayşe Tandırcıoğlu, Ümran Koral, Nulifer Güzoğlu, Serdar Alan, Didem Aliefendioğlu
OBJECTIVE: The study aimed to compare the risk factors, treatment strategies, and early outcomes of symptomatic neonatal pneumothorax (NP) between preterm and term newborns. MATERIALS AND METHODS: This retrospective cross-sectional study was conducted in a neonatal intensive care unit between 2015 and 2022, consisting of hospitalized neonates with symptomatic NP. The cases were divided into three groups according to their gestational ages: <340/7 (group 1), 340/7-366/7 (group 2), and ≥370/7 weeks (group 3)...
January 2024: Turkish archives of pediatrics
https://read.qxmd.com/read/38453700/programmatic-palliative-care-consultations-in-pediatric-heart-transplant-evaluations
#32
JOURNAL ARTICLE
Erika J Mejia, Rui Xiao, Jennifer K Walter, Chris Feudtner, Kimberly Y Lin, Aaron G DeWitt, Meeta Prasad Kerlin
Guidelines advocate for integrating palliative care into the management of heart failure (HF) and of children with life-limiting disease. The potential impact of palliative care integration into pediatric HF on patient-centered outcomes is poorly understood. The present study sought to assess the association of programmatic implementation of palliative care into the heart transplant evaluation process with hospital-free days (HFD) and end of life (EOL) treatment choices. The study included patients less than 19 years of age who underwent a heart transplant evaluation between February 2012 and April 2020 at a single center...
March 8, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38452183/outcomes-for-pediatric-oncology-and-hematopoietic-stem-cell-transplantation-patients-who-undergo-tracheostomy-placement-a-pediatric-health-information-system-database-cohort-study-2009-2020
#33
JOURNAL ARTICLE
Sinead L Murphy Salem, Jennifer M Perez, Steven J Staffa, Christine N Duncan, Robert J Graham
OBJECTIVES: To describe the epidemiology, surgical complications, and long-term outcomes after tracheostomy in pediatric oncology and/or hematopoietic stem cell transplantation (HSCT) patients in U.S. Children's Hospitals. DESIGN: Retrospective cohort from the Pediatric Health information System (PHIS) database, 2009-2020. SETTING: The PHIS dataset incorporates data from 48 pediatric hospitals in the Children's Hospital Association. PATIENTS: Patients 0-21 years old with an oncologic diagnosis and/or underwent HSCT, received a tracheostomy, and were discharged from hospital between January 1, 2009, and December 31, 2020...
March 7, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38445550/covid-19-infection-in-patients-with-history-of-pediatric-heart-transplant-in-germany-austria-and-switzerland
#34
JOURNAL ARTICLE
Sarah Ulrich, Christian Balmer, Kolja Becker, Josefin Bruhs, Friederike Danne, Volker Debus, Leonie Dewein, Stefano Di-Bernardo, Ulrike Doll, Thilo Fleck, Theodor Tirilomis, Martin Glöckler, Maria Grafmann, Sabine Greil, Urte Grosser, Patrick Saur, Susanne Skrzypek, Michael Steinmetz
COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric heart transplant centers in Germany, Austria and Switzerland to evaluate the risk of a severe COVID-19 infection after pediatric heart transplantation between 02/2020 and 06/2021. Twenty-six subjects (11 male) with a median age of 9...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38445078/prediction-of-bronchopulmonary-dysplasia-in-very-preterm-infants-competitive-risk-model-nomogram
#35
JOURNAL ARTICLE
Andrea Sucasas-Alonso, Sonia Pértega-Díaz, Vanesa Balboa-Barreiro, Fermín García-Muñoz Rodrigo, Alejandro Avila-Alvarez
OBJECTIVE: To develop predictive clinical models of bronchopulmonary dysplasia (BPD) through competing risk analysis. METHODS: Retrospective observational cohort study, including preterm newborns ≤32 weeks gestational age, conducted between January 1, 2013 and September 30, 2022 in a third-level Neonatal Intensive Care Unit in Spain. A prediction study was carried out using competing risk models, where the event of interest was BPD and the competing event was death...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38444466/pulmonary-flow-study-can-predict-in-hospital-prognosis-of-unifocalization-and-corrective-repair-of-pulmonary-atresia-ventricular-septal-defect-with-major-aortopulmonary-collateral-arteries
#36
JOURNAL ARTICLE
Xiaofeng Wang, Zhiyuan Zhu, Zhongyuan Lu, Wenlong Wang, Xu Wang
OBJECTIVES: With the development of perioperative treatment, the results of the unifocalization and corrective repair of pulmonary atresia/ventricular septal defect with major aortopulmonary collateral arteries have been significantly improved. However, the in-hospital recovery is quite different individually. Therefore, it is essential to find prognostic indicators to avoid unsatisfactory recovery. DESIGN: This was a case-control study. SETTING: The study was conducted in the national center for cardiovascular diseases in China...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38441525/nasal-intermittent-positive-pressure-ventilation-during-less-invasive-surfactant-administration-in-preterm-infants-an-open-label-randomized-controlled-study
#37
JOURNAL ARTICLE
Carlo Dani, Marcello Napolitano, Ciro Barone, Angelo Manna, Gabriella Nigro, Gianfranco Scarpelli, Elvira Bonanno, Sara Gatto, Francesco Cavigioli, Carlo Forcellini, Enrico Petoello, Renzo Beghini, Martina Ciarcià, Monica Fusco, Fabio Mosca, Anna Lavizzari, Eloisa Gitto, Letteria Barbuscia, Pasqua Betta, Carmine Mattia, Luigi Corvaglia, Stefania Vedovato, Giovanni Vento, Gianfranco Maffei, Raffaele Falsaperla, Paola Lago, Luca Boni, Gianluca Lista
INTRODUCTION: Approximately half of very preterm infants with respiratory distress syndrome (RDS) fail treatment with nasal continuous positive airway pressure (NCPAP) and need mechanical ventilation (MV). OBJECTIVES: Our aim with this study was to evaluate if nasal intermittent positive pressure ventilation (NIPPV) during less invasive surfactant treatment (LISA) can improve respiratory outcome compared with NCPAP. MATERIALS AND METHODS: We carried out an open-label randomized controlled trial at tertiary neonatal intensive care units in which infants with RDS born at 25+0 -31+6 weeks of gestation between December 1, 2020 and October 31, 2022 were supported with NCPAP before and after surfactant administration and received NIPPV or NCPAP during LISA...
January 22, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38441391/causes-and-management-of-urinary-system-problems-in-children-on-long-term-home-invasive-mechanical-ventilation
#38
REVIEW
Alper Soylu, Salih Kavukcu
Many ventilator-dependent children have comorbid conditions including urinary tract disorders. We aimed to present a focused review of the literature describing the causes and management of urinary system problems in children with long-term home mechanical ventilation. We performed a literature search in PubMed/MEDLINE, Scopus, and Web of Science with keywords "children," "home mechanical ventilation," "urinary system," "urinary tract," "neurogenic bladder," "clean intermittent catheterization," "urinary tract infection," "urolithiasis," and "acute kidney injury...
March 5, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38441360/transitioning-children-using-home-invasive-mechanical-ventilation-from-hospital-to-home-discharge-criteria-disparities-and-ethical-considerations
#39
REVIEW
Jennifer Henningfeld, Annie B Friedrich, Grace Flanagan, Cynthia Griffith, Anna Hughes, Lisa Molkentine, Rebecca Steuart, Stuart Wilkinson, Christopher D Baker
Children using home invasive mechanical ventilation (HIMV), a valuable therapeutic option for chronic respiratory failure, constitute a growing population. Transitioning children using HIMV from hospital to home care is a complex process that requires a multidisciplinary approach involving healthcare professionals, caregivers, and community resources. Medical stability, caregiver competence, and home environment suitability are essential factors in determining discharge readiness. Caregiver education and training play a pivotal role in ensuring safe and effective home care...
March 5, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38440333/factors-in-the-neonatal-period-associated-with-pulmonary-hypertension-at-28%C3%A2-days-of-life-in-broncho-pulmonary-dysplasia
#40
JOURNAL ARTICLE
Nguyen Thi Hai Anh, Tran Minh Dien, Le Thi Ha, Pham Thao Nguyen, Dang Thi Hai Van
Objectives. To identify factors associated with pulmonary hypertension (PH) at 28 days of life in preterm infants with bronchopulmonary dysplasia (BPD). Methods . This observational study included 128 premature infants with BPD between January 2022 and February 2023 from the neonatal intensive care unit of Vietnam National Children's Hospital. Results . PH was observed using echocardiography in 29 patients (22.66%). The prevalence of severe BPD in the PH group (62.07%) was significantly higher than that in the non-PH group (18...
2024: Global Pediatric Health
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