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https://www.readbyqxmd.com/read/29899426/efficacy-of-two-different-dosages-of-levofloxacin-in-curing-helicobacter-pylori-infection-a-prospective-single-center-randomized-clinical-trial
#1
Huo-Ye Gan, Tie-Li Peng, You-Ming Huang, Kai-Hua Su, Lin-Li Zhao, Li-Ya Yao, Rong-Jiao Yang
Bismuth + proton pump inhibitor (PPI) + amoxicillin + levofloxacin is one of the bismuth quadruple therapy regimens widely used for the eradication of H. pylori infection. The recommended dosage of levofloxacin is 500 mg once daily or 200 mg twice daily to eradicate H. pylori infection. The aim of the present open-label, randomized control trial was to compare the effectiveness, safety, and compliance of different dosages of levofloxacin used to cure Helicobacter pylori infection. Eligible patients were randomly assigned to receive esomeprazole, amoxicillin, colloidal bismuth pectin and levofloxacin 500 mg once/day (group A) or levofloxacin 200 mg twice/day (group B) for 14 days...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29897576/the-therapeutic-effect-of-yinhuangerchen-mixture-on-avian-infectious-laryngotracheitis
#2
Tie Zhang, Jian Chen, Chunguang Wang, Wanyu Shi, Dinggang Li
The study was conducted to investigate the effect of Yinhuangerchen mixture (YM) on Avian infectious laryngotracheitis (AILT) induced by artificial infection and provide a scientific basis for its clinical application. A total of 200 chickens were challenged with infectious laryngotracheitis virus (ILTV). At 72 h post-challenge, the chickens were treated with different doses of YM or the Chinese herbal medicine Houyanjing powder. The relative expression of ILTV, the pathological changes of trachea, and the number of SIgA-secreting cells were detected...
June 8, 2018: Poultry Science
https://www.readbyqxmd.com/read/29896195/cholesterol-crystal-mediated-inflammation-is-driven-by-plasma-membrane-destabilization
#3
Fei Shu, Jiahuan Chen, Xiaojie Ma, Yunzhou Fan, Li Yu, Wencheng Zheng, Matthias W Amrein, Tie Xia, Yan Shi
Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated early in life, it progresses to plaque formation and form cell accumulation. A culprit in this cascade is the deposition of cholesterol crystals (CC). The involvement of smaller crystals in the early stage of atherosclerotic changes may be critical to the long-term pathological development. How these small crystals initiate the pro-inflammatory events is under study. We report here an unexpected mechanism that microscopic CC interact with cellular membrane in a phagocytosis-independent manner...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29889110/intraoperative-neural-monitoring-in-endoscopic-thyroidectomy-via-bilateral-areola-approach
#4
Daqi Zhang, Qingfeng Fu, Gianlorenzo Dionigi, Tie Wang, Jingwei Xin, Jiao Zhang, Gaofeng Xue, Hongbo Li, Hui Sun
OBJECTIVE: The aim of this report was dual: (a) to describe the step by step standardized intraoperative neural monitoring (IONM) procedure for recurrent laryngeal nerve (RLN) and external branch of the superior laryngeal nerve focusing on percutaneous IONM method, and (b) evaluation and outcomes of intermittent IONM in 237 endoscopic thyroidectomy via bilateral areolar approach cases. MATERIALS AND METHODS: A 10-mm curved incision is made along the margin of the right areola at the 2 to 4 o'clock position for the 30-degree endoscope...
June 7, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29869055/pyruvate-kinase-m2-increases-angiogenesis-neurogenesis-and-functional-recovery-mediated-by-upregulation-of-stat3-and-focal-adhesion-kinase-activities-after-ischemic-stroke-in-adult-mice
#5
Dongdong Chen, Ling Wei, Zhi-Ren Liu, Jenny J Yang, Xiaohuan Gu, Zheng Z Wei, Li-Ping Z Liu, Shan Ping Yu
Ischemic stroke remains a serious threat to human life. Generation of neuronal and vascular cells is an endogenous regenerative mechanism in the adult brain, which may contribute to tissue repair after stroke. However, the regenerative activity is typically insufficient for significant therapeutic effects after brain injuries. Pyruvate kinase isoform M2 (PKM2) is a key regulator for energy metabolism. PKM2 also has nonmetabolic roles involving regulations of gene expression, cell proliferation, and migration in cancer cells as well as noncancerous cells...
June 4, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29861775/the-comprehensive-therapy-of-electroacupuncture-promotes-regeneration-of-nerve-fibers-and-motor-function-recovery-in-rats-after-spinal-cord-injury
#6
Yi-Fan Li, Tie Li, Da-Wei Zhang, Hui Xue, Dong Chen, Chen Li, Fu-Chun Wang
The present study aimed to evaluate the role of the combination treatment of methylprednisolone (MP) and electroacupuncture (EA) in regeneration of nerve fibers and functional recovery in rats with spinal cord injury (SCI). Female Wistar rats were used for an SCI model by using a weight-drop hammer at levels T10 (spinal cord segment corresponding to the 10th thoracic vertebra). Four groups received different treatments for the study: SCI control, MP, MP and EA, and Sham. The growth of nerve fibers was examined by counting fluorescein positive nerve fibers...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29859977/distinct-roles-of-nmdar-and-mglur5-in-light-exposure-reversal-of-feedforward-synaptic-strength-in-v1-of-juvenile-mice-after-binocular-vision-deprivation
#7
Xiaoxiu Tie, Shuo Li, Yilin Feng, Biqin Lai, Sheng Liu, Bin Jiang
In the visual cortex, sensory deprivation causes global augmentation of the amplitude of AMPA receptor-mediated miniature EPSCs in layer 2/3 pyramidal cells and enhancement of NMDA receptor-dependent LTP in cells activated in layer 4, effects that are both rapidly reversed by light exposure. Layer 2/3 pyramidal cells receive both feedforward input from layer 4 and intra-cortical lateral input from the same layer, LTP is mainly induced by the former input. Whether feedforward excitatory synaptic strength is affected by visual deprivation and light exposure, how this synaptic strength correlates with the magnitude of LTP in this pathway, and the underlying mechanism have not been explored...
May 31, 2018: Neuroscience
https://www.readbyqxmd.com/read/29850566/rapamycin-inhibits-the-growth-and-collagen-production-of-fibroblasts-derived-from-human-urethral-scar-tissue
#8
Delai Fu, Jian Yin, Shanlong Huang, Hecheng Li, Zhaolun Li, Tie Chong
Rapamycin can inhibit fibroblast proliferation, collagen accumulation, and urethral stricture in rabbits. Transforming growth factor-beta-1 (TGF- β 1) signaling, with downstream recruitment of Smad2, is known to promote fibrosis. This in vitro study examined the effects of rapamycin on fibroblasts derived from human urethral scar tissue (FHUS) and investigated the possible mechanism with respect to regulation of TGF- β 1 signaling. FHUS were cultured from urethral scar tissues collected from four patients with urethral stricture...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29850486/exposure-to-nitrogen-oxide-in-the-first-trimester-and-risk-of-cardiovascular-related-malformations-a-dose-response-meta-analysis-of-observational-studies
#9
REVIEW
Tie-Ning Zhang, Da Li, Qi-Jun Wu, Jing Xia, Ri Wen, Xing-Chen Chen, Ni Yang, Yan-Ling Chen, Yan-Hong Huang, Chun-Feng Liu
Nitrogen oxide (NO x ) is produced during combustion at high temperature, which is a major constituent of air pollutants. Recent studies suggested inconsistent results on the association between NO x exposure and cardiovascular-related malformations. We aimed to assess aforementioned association in pregnant women in the first trimester and cardiovascular-related malformations of infants. A systematic literature review identified studies for observational studies about NO x exposure and cardiovascular-related malformation in PubMed...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29850338/initial-stage-primary-intraosseous-squamous-cell-carcinoma-derived-from-odontogenic-keratocyst-with-unusual-keratoameloblastomatous-change-of-the-maxilla-a-case-report-and-literature-discussion
#10
Kentaro Kikuchi, Fumio Ide, Shota Takizawa, Seiji Suzuki, Hideaki Sakashita, Tie-Jun Li, Kaoru Kusama
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm derived from odontogenic epithelial remnants in the central jaw bone. Most PIOSCCs originate from odontogenic cysts with a nonkeratinized epithelial lining, especially from radicular/residual and dentigerous cysts. There have been few reports of PIOSCCs derived from the odontogenic keratocyst (OKC), particularly those describing pathological features at the initial stage. The diagnosis of PIOSCC is difficult and based on exclusion of other carcinomas, including metastatic tumors from other primary sites...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29805660/association-between-5-lipoxygenase-expression-and-malignant-behaviors-and-poor-prognosis-in-esophageal-squamous-cell-carcinoma
#11
Chun-Ying Bai, Jun-Yi Zhang, Tie-Wei Shi, Yu-Qin Bai, Bing-Li Wu, Ze-Peng Du, Zhi-Yong Wu, Xiu-E Xu, Shao-Hong Wang, Jian-Yi Wu, Rui-Yun Te, Jing-Yi Zhang, Li-Yan Xu, En-Min Li
5-lipoxygenase (5-LO) catalyzes the first step of arachidonic acid metabolism to inflammatory mediator leukotrienes. The present study assessed 5-LO expression in esophageal squamous cell carcinoma (ESCC) tissue specimens for associations with clinicopathological and survival data from patients, then explored 5-LO activity in ESCC cells in vitro . 5-LO expression was detected in tissue microarrays containing 297 ESCC samples using immunohistochemistry. Kaplan-Meier curves were used to analyze the survival significance of 5-LO expression and relative risk was evaluated using the multivariate Cox proportional hazards model...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29805347/hesperidin-a-plant-flavonoid-accelerated-the-cutaneous-wound-healing-in-streptozotocin-induced-diabetic-rats-role-of-tgf-%C3%A3-smads-and-ang-1-tie-2-signaling-pathways
#12
Wenbin Li, Amit D Kandhare, Anwesha A Mukherjee, Subhash L Bodhankar
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot ulcers. Methods: Diabetes was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.) in Sprague Dawley rats (180-220 g) and wounds were created on the dorsal surface of the hind paw of rats...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29799735/brown-carbon-aerosol-in-urban-xi-an-northwest-china-the-composition-and-light-absorption-properties
#13
Ru-Jin Huang, Lu Yang, Jun-Ji Cao, Yang Chen, Qi Chen, Yongjie Li, Jing Duan, Chongshu Zhu, Wenting Dai, Kai Wang, Chunshui Lin, Haiyan Ni, Joel Christopher Corbin, Yunfei Wu, Renjian Zhang, Xuexi Tie, Thorsten Hoffmann, Colin O'Dowd, Uli Dusek
Light-absorbing organic carbon (i.e., brown carbon or BrC) in the atmospheric aerosol has significant contribution to light absorption and radiative forcing. However, the link between BrC optical properties and chemical composition remains poorly constrained. In this study, we combine spectrophotometric measurements and chemical analyses of BrC samples collected from July 2008 to June 2009 in urban Xi'an, Northwest China. Elevated BrC was observed in winter (5 times higher than in summer), largely due to increased emissions from wintertime domestic biomass burning...
May 25, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29770673/-global-burden-and-challenges-of-parasitic-diseases-in-africa
#14
Li Yi-Ting, Ren Guang-Hui, Liang You-Sheng, Yang Kun, Sun Le-Ping, Li Shi-Zhu, Lü Shan, Jia Tie-Wu
Parasitic diseases are common infectious diseases closely related to poverty, which are mainly endemic in the tropical and subtropical regions. Africa is the major epidemic area of parasitic diseases, and the global burden of malaria and schistosomiasis is over 85% in Africa. This paper reviews the disease burden, regional distribution and control strategies of the main parasitic diseases in Africa, in order to promote the prevention and control of parasitic diseases in this area.
April 17, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29766244/copy-number-of-arsr-reporter-plasmid-determines-its-arsenite-response-and-metal-specificity
#15
Yun Fang, Chunjie Zhu, Xingjuan Chen, Yan Wang, Meiying Xu, Guoping Sun, Jun Guo, Jinnon Yoo, Cuijuan Tie, Xin Jiang, Xianqiang Li
The key component in bacteria-based biosensors is a transcriptional reporter employed to monitor induction or repression of a reporter gene corresponding to environmental change. In this study, we made a series of reporters in order to achieve highly sensitive detection of arsenite. From these reporters, two biosensors were developed by transformation of Escherichia coli DH5α with pLHPars9 and pLLPars9, consisting of either a high or low copy number plasmid, along with common elements of ArsR-luciferase fusion and addition of two binding sequences, one each from E...
May 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29765378/epithelial-c5ar1-signaling-enhances-uropathogenic-escherichia-coli-adhesion-to-human-renal-tubular-epithelial-cells
#16
Yun Song, Kun-Yi Wu, Weiju Wu, Zhao-Yang Duan, Ya-Feng Gao, Liang-Dong Zhang, Tie Chong, Malgorzata A Garstka, Wuding Zhou, Ke Li
Recent work in a murine model of ascending urinary tract infection has suggested that C5a/C5aR1 interactions play a pathogenic role in the development of renal infection through enhancement of bacterial adhesion/colonization to renal tubular epithelial cells (RTECs). In the present study, we extended these observations to human. We show that renal tubular epithelial C5aR1 signaling is involved in promoting uropathogenic Escherichia coli (UPEC) adhesion/invasion of host cells. Stimulation of primary cultures of RTEC with C5a resulted in significant increases in UPEC adhesion/invasion of the RTEC...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29762525/electronic-magnetic-half-metallic-and-mechanical-properties-of-a-new-equiatomic-quaternary-heusler-compound-yrhtige-a-first-principles-study
#17
Yilin Han, Yang Wu, Tingzhou Li, R Khenata, Tie Yang, Xiaotian Wang
We apply First-principles theory to study the electronic structure as well as the magnetic and mechanical characteristics of YRhTiGe, a newly-designed Y-based quaternary equiatomic Heusler compound. This compound is half-metallic in nature with a ferromagnetic ground state. The total magnetic moment of YRhTiGe is 2 μB and it obeys the Slater-Pauling rule, Mt = Zt - 18, where Mt and Zt are the total magnetic moment and total number of valence electrons, respectively. The magnetic and half-metallic behaviors at its equilibrium and strained lattice constants have been discussed in detail...
May 15, 2018: Materials
https://www.readbyqxmd.com/read/29751287/chemical-profiling-in-moutan-cortex-after-sulfuring-and-desulfuring-processes-reveals-further-insights-into-the-quality-control-of-tcms-by-nontargeted-metabolomic-analysis
#18
Zhi-Lai Zhan, Ai-Ping Deng, Li-Ping Kang, Jin-Fu Tang, Tie-Gui Nan, Tong Chen, Ya-Li He, Lan-Ping Guo, Lu-Qi Huang
As a traditional processing method, sulfuring has been used in the processing of many traditional Chinese medicines (TCMs). Desulfuring, which has emerged in recent years, is a new method applied to sulfured herbs so they can comply with regulations regarding residual SO2 . Due to the chemical transformations and the residual SO2 in the herbs, both sulfuring and desulfuring have negative effects on the safety and therapeutic effects of TCMs, and Moutan Cortex is one of the TCMs most susceptible to these effects...
May 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29746219/feasibility-of-continuous-intraoperative-neural-monitoring-during-transoral-endoscopic-thyroidectomy-vestibular-approach-in-a-porcine-model
#19
Daqi Zhang, Shijie Li, Gianlorenzo Dionigi, Tie Wang, Jiao Zhang, Gaofeng Xue, Hui Sun
BACKGROUND: Experimental study to evaluate feasibility of continuous intraoperative neural monitoring (C-IONM) in transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS: Duroc-Landrace pigs were orally intubated with electromyogram endotracheal tube. Automatic periodic stimulation (APS) electrode was allocated in the operative field through the 5-mm ports. APS was then repose on vagal nerve (VN) with different approaches: (1) median, that is, between sternothyroid and thyroid gland; and (2) lateral, that is, between sternocleidomastoid and sternothyroid...
May 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29744974/ring-compression-suture-for-controlling-post-partum-hemorrhage-during-cesarean-section
#20
Guang-Tai Li, Xiao-Fan Li, Yun-He Zhang, Yue Si, Guang-Rui Li, Hong-Mei Xu
AIM: To avoid complications associated with uterine compression sutures, we devised a ring compression suture (RCS). METHODS: The RCS was performed on 12 patients with post-partum hemorrhage (PPH) during cesarean section. The suture was inserted 0.5 cm below the attachment point of the uterosacral ligament into the uterine cavity and pushed downward through the cervical canal into the vagina. The other end of the stitch was threaded through the lower abdominal wall, from the inside of the abdomen cavity to the outside of the abdominal wall, emerging at the external surface of the lower abdomen 2 cm lateral to the ventral median line and 1 cm above the symphysis pubis...
May 10, 2018: Journal of Obstetrics and Gynaecology Research
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