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https://www.readbyqxmd.com/read/27906322/detection-of-gaseous-elemental-mercury-using-a-frequency-doubled-green-diode-laser
#1
Xiutao Lou, Tie Zhang, Hongze Lin, Shiyi Gao, Lianjie Xu, Junnan Wang, Li Wan, Sailing He
We demonstrate a second-harmonic-generation (SHG) based method for the detection of gaseous elemental mercury by using a newly available green diode laser. Multimode ultraviolet radiation at 253.7 nm is generated through a process of SHG. Correlation spectroscopy is introduced into the scheme to guarantee the measurement accuracy. The limit of detection achieved is 0.6 μg/m<sup>3</sup> (0.07 ppb) for 1-m pathlength and 10-s integration time. The measurement accuracy is estimated to be 1.2%. The linear response range is estimated to be 0~60 μg/m<sup>2</sup> (6...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27898654/effect-of-bone-marrow-mesenchymal-stem-cells-on-satellite-cell-proliferation-and-apoptosis-in-immobilization-induced-muscle-atrophy-in-rats
#2
Tie-Shan Li, Hao Shi, Lin Wang, Chuanzhu Yan
BACKGROUND Muscle atrophy due to disuse occurs along with adverse physiological and functional changes, but bone marrow stromal cells (MSCs) may be able to act as muscle satellite cells to restore myofibers. Thus, we investigated whether MSCs could enhance the proliferation of satellite cells and suppress myonuclear apoptosis during immobilization. MATERIAL AND METHODS We isolated, purified, amplified, and identified MSCs. Rats (n=48) were randomized into 3 groups: WB group (n=16), IM-PBS group (n=16), and IM-MSC (n=16)...
November 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27895683/salvage-interstitial-brachytherapy-based-on-computed-tomography-for-recurrent-cervical-cancer-after-radical-hysterectomy-and-adjuvant-radiation-therapy-case-presentations-and-introduction-of-the-technique
#3
Zhong-Shan Liu, Jie Guo, Yang-Zhi Zhao, Xia Lin, Bin Chen, Ming Zhang, Jiang-Ming Li, Xiao-Jun Ren, Bing-Ya Zhang, Tie-Jun Wang
PURPOSE: Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents a new therapeutic technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT). MATERIAL AND METHODS: Sixteen patients with recurrent cervical cancer after radical surgery and adjuvant external-beam radiotherapy (EBRT) were included in this study. These patients underwent high-dose-rate (HDR) interstitial BT with free-hand placement of metal needles guided by real-time 3D-CT...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27894114/hydroxysafflor-yellow-a-promotes-angiogenesis-via-the-angiopoietin-1-tie-2-signaling-pathway
#4
Tangting Chen, Ni Chen, Ningbo Pang, Lamei Xiao, Yongjie Li, Rong Li, Mao Luo, Xin Deng, Meiping Ren, Jianbo Wu, Liqun Wang
BACKGROUND: The flowers of Carthamus tinctorius L. are widely used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of C. tinctorius L. flowers, is known for its multiple biological activities. The present study investigated the effects of HSYA on angiogenesis in vitro and in a mouse hindlimb ischemia model. METHODS: Using human umbilical vein endothelial cells (HUVEC) in vitro and a mouse hindlimb ischemia model in vivo, the angiogenic role of HSYA was evaluated...
November 29, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27890411/effect-of-hydrolysis-of-n2o5-on-nitrate-and-ammonium-formation-in-beijing-china-wrf-chem-model-simulation
#5
Xing Su, Xuexi Tie, Guohui Li, Junji Cao, Rujin Huang, Tian Feng, Xin Long, Ruiguang Xu
Beijing, the capital of China, is a mega city with a population of >20 million. In recent years, the city has experienced heavy air pollution, with particulate matter (PM) being one of its top pollutants. In the last decade, extensive efforts have been made to characterize the sources, properties, and processes of PM in Beijing. Despite progress made by previous studies, there are still some important questions to be answered and addressed. The focus of this research is to study the impact of the heterogeneous hydrolysis of N2O5 on the formation of nitrate (NO3(-)) and ammonium (NH4(+)) in Beijing...
November 24, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27885818/the-impact-of-bevacizumab-in-metastatic-colorectal-cancer-with-an-intact-primary-tumor-results-from-a-large-prospective-cohort-study
#6
Belinda Lee, Hui-Li Wong, Mark Tacey, Jeanne Tie, Rachel Wong, Margaret Lee, Louise Nott, Jeremy Shapiro, Ross Jennens, Natalie Turner, Ben Tran, Sumitra Ananda, Desmond Yip, Gary Richardson, Phillip Parente, Lionel Lim, Greg Stefanou, Matthew Burge, Mahesh Iddawela, Jeremy Power, Peter Gibbs
BACKGROUND: Debate continues regarding the benefits versus risks of initial resection of the primary tumor in metastatic colorectal cancer (mCRC) patients with an asymptomatic primary tumor. Although the benefit of the anti-vascular endothelial growth factor agent bevacizumab alongside first-line chemotherapy in mCRC is established, the impact of bevacizumab on the intact primary tumor (IPT) is less well understood. METHODS: Data from an Australian mCRC registry were used to assess the impact of bevacizumab-based regimens in the presence of an IPT, to see if this differs from effects in resected primary tumor (RPT) patients and to understand the safety profile of bevacizumab in patients with IPT...
November 25, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27876862/in-silico-exploration-for-novel-type-i-inhibitors-of-tie-2-tek-the-performance-of-different-selection-strategy-in-selecting-virtual-screening-candidates
#7
Peichen Pan, Huiyong Sun, Hui Liu, Dan Li, Wenfang Zhou, Xiaotian Kong, Youyong Li, Huidong Yu, Tingjun Hou
The receptor tyrosine kinase Tie-2 is involved in vessel remodeling and maturation, and has been regarded as a potential target for the treatment of various solid tumors. The absence of novel, potent and selective inhibitors severely hampers the understanding of the therapeutic potential of Tie-2. In the present work, we describe the discovery of novel type-I inhibitors of Tie-2 by structure-based virtual screening. Preliminary SAR was also performed based on one active compound, and several novel inhibitors with low micro-molar affinity were discovered...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869212/the-erf-transcription-factor-family-in-cassava-genome-wide-characterization-and-expression-analyses-against-drought-stress
#8
Wei Fan, Meirong Hai, Yunling Guo, Zehong Ding, Weiwei Tie, Xupo Ding, Yan Yan, Yunxie Wei, Yang Liu, Chunlai Wu, Haitao Shi, Kaimian Li, Wei Hu
Cassava (Manihot esculenta) shows strong tolerance to drought stress; however, the mechanisms underlying this tolerance are poorly understood. Ethylene response factor (ERF) family genes play a crucial role in plants responding to abiotic stress. Currently, less information is known regarding the ERF family in cassava. Herein, 147 ERF genes were characterized from cassava based on the complete genome data, which was further supported by phylogenetic relationship, gene structure, and conserved motif analyses...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866193/mixed-aqueous-extract-of-salvia-miltiorrhiza-reduces-blood-pressure-through-inhibition-of-vascular-remodelling-and-oxidative-stress-in-spontaneously-hypertensive-rats
#9
Jing Zhang, Sheng Jun An, Jun Qiu Fu, Pei Liu, Tie Mei Shao, Manli Li, Xue Li, Zhan Jiao, Xi Qing Chai
BACKGROUND/AIMS: Salvia miltiorrhiza (SM) contains four major aqueous active ingredients, which have been isolated, purified and identified as danshensu (DSS), salvianolic acid A (Sal-A), salvianolic acid B (Sal-B) and protocatechuic aldehyde (PAL), totally abbreviated as SABP. Although SM is often used to treat various cardiovascular diseases in traditional Chinese medicine, the efficacy and function of optimal compatibility ratio of SM's active ingredients (SABP) in the prevention and treatment of cardiovascular diseases remain uncertain...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27863391/nordihydroguaiaretic-acid-impairs-prostate-cancer-cell-migration-and-tumor-metastasis-by-suppressing-neuropilin-1
#10
Xin Li, Shengjun Fan, Xueyang Pan, Yilixiati Xiaokaiti, Jianhui Duan, Yundi Shi, Yan Pan, Lu Tie, Xin Wang, Yuhua Li, Xuejun Li
Tumor metastasis is a major cause leading to the deaths of cancer patients. Nordihydroguaiaretic acid (NDGA) is a natural product that has been demonstrated to show therapeutic values in multiple diseases. In this study, we report that NDGA can inhibit cell migration and tumor metastasis via a novel mechanism. NDGA suppresses NRP1 function by downregulating its expression, which leads to attenuated cell motility, cell adhesion to ECM and FAK signaling in cancer cells. Moreover, due to its cross-cell type activity on NRP1 suppression, NDGA also impairs angiogenesis function of endothelial cells and fibronectin assembly by fibroblasts, both of which are critical to promote metastasis...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27861152/rad9a-is-required-for-spermatogonia-differentiation-in-mice
#11
Lin Huang, Zhen-Bo Wang, Shu-Tao Qi, Xue-Shan Ma, Qiu-Xia Liang, Guo Lei, Tie-Gang Meng, Li-Feng Liang, Ye-Xin Xian, Yi Hou, Xiao-Fang Sun, Yong Zhao, Wei-Hua Wang, Qing-Yuan Sun
Spermatogenesis in testes requires precise spermatogonia differentiation. Spermatocytes lacking the Rad9a gene are arrested in pachytene prophase, implying a possible role for RAD9A in spermatogonia differentiation. However, numerous RAD9A-positive pachytene spermatocytes are still observed in mouse testes following Rad9a excision using the Stra8-Cre system, and it is unclear whether Rad9a deletion in spermatogonia interrupts differentiation. Here, we generated a mouse model in which Rad9a was specifically deleted in spermatogonial stem cells (SSCs) using Cre recombinase expression driven by the germ cell-specific Vasa promoter...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851749/the-machado-joseph-disease-deubiquitinase-ataxin-3-regulates-the-stability-and-apoptotic-function-of-p53
#12
Hongmei Liu, Xiaoling Li, Guozhu Ning, Shu Zhu, Xiaolu Ma, Xiuli Liu, Chunying Liu, Min Huang, Ina Schmitt, Ullrich Wüllner, Yamei Niu, Caixia Guo, Qiang Wang, Tie-Shan Tang
As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3) remain elusive, which limits our understanding of its normal cellular function and that of pathogenic mechanism of spinocerebellar ataxia type 3 (SCA3). Here, we identify p53 to be a novel substrate of ATX-3. ATX-3 binds to native and polyubiquitinated p53 and deubiquitinates and stabilizes p53 by repressing its degradation through the ubiquitin (Ub)-proteasome pathway. ATX-3 deletion destabilizes p53, resulting in deficiency of p53 activity and functions, whereas ectopic expression of ATX-3 induces selective transcription/expression of p53 target genes and promotes p53-dependent apoptosis in both mammalian cells and the central nervous system of zebrafish...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27845899/bisdemethoxycurcumin-exerts-pro-apoptotic-effects-in-human-pancreatic-adenocarcinoma-cells-through-mitochondrial-dysfunction-and-a-grp78-dependent-pathway
#13
Haopeng Yang, Shengjun Fan, Yu An, Xin Wang, Yan Pan, Yilixiati Xiaokaiti, Jianhui Duan, Xin Li, Lu Tie, Min Ye, Xuejun Li
Pancreatic cancer is a highly aggressive malignancy, which is intrinsically resistant to current chemotherapies. Herein, we investigate whether bisdemethoxycurcumin (BDMC), a derivative of curcumin, potentiates gemcitabine in human pancreatic cancer cells. The result suggests that BDMC sensitizes gemcitabine by inducing mitochondrial dysfunctions and apoptosis in PANC-1 and MiaPaCa-2 pancreatic cancer cells. Utilizing two-dimensional gel electrophoresis and mass spectrometry, we identify 13 essential proteins with significantly altered expressions in response to gemcitabine alone or combined with BDMC...
November 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27828717/natural-killer-group-2a-expressed-on-both-peripheral-cd3-cd56-nk-cells-and-cd3-cd8-t-cells-plays-a-pivotal-negative-regulatory-role-in-the-progression-of-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#14
Rui-Tian Yi, Ying-Hua Niu, Hong-Li Liu, Tie-Ying Zhang, Yu-Cong Yang, Yu Zhang, Dong-Lin Yin, Tian-Yan Chen, Ying-Ren Zhao
To explore the role of surface receptors natural killer group 2A (NKG2A) and natural killer group 2D (NKG2D) on CD3(+)CD8(+)T cells and CD3(-)CD56(+)NK cells in the progression of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), we measured the expression of NKG2A and NKG2D on the surface of these 2 types of circulating cells by flow cytometry in 3 groups. One group consists of 36 patients with chronic hepatitis B (CHB), another one consists of 22 patients with HBV-related ACLF, and the last one has 12 normal controls (NC)...
November 9, 2016: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/27815024/evaluation-of-coflex-interspinous-stabilization-following-decompression-compared-with-decompression-and-posterior-lumbar-interbody-fusion-for-the-treatment-of-lumbar-degenerative-disease-a-minimum-5-year-follow-up-study
#15
Wei Yuan, Qing-Jun Su, Tie Liu, Jin-Cai Yang, Nan Kang, Li Guan, Yong Hai
Few studies have compared the clinical and radiological outcomes between Coflex interspinous stabilization and posterior lumbar interbody fusion (PLIF) for degenerative lumbar disease. We compared the at least 5-year clinical and radiological outcomes of Coflex stabilization and PLIF for lumbar degenerative disease. Eighty-seven consecutive patients with lumbar degenerative disease were retrospectively reviewed. Forty-two patients underwent decompression and Coflex interspinous stabilization (Coflex group), 45 patients underwent decompression and PLIF (PLIF group)...
November 1, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27811979/a-combination-of-genome-wide-association-and-transcriptome-analysis-reveals-candidate-genes-controlling-harvest-index-related-traits-in-brassica-napus
#16
Kun Lu, Zhongchun Xiao, Hongju Jian, Liu Peng, Cunmin Qu, Minglian Fu, Bin He, Linmei Tie, Ying Liang, Xingfu Xu, Jiana Li
Harvest index (HI), the ratio of seed mass to total biomass of the aboveground plant parts, is an important trait for harvestable yield of crops. Unfortunately, HI of Brassica napus is lower than that of other economically important crops. To identify candidate genes associated with high HI, a genome-wide association study of HI and four HI-related traits was conducted with 520 B. napus accessions cultivated in both Yunnan and Chongqing. We detected 294 single nucleotide polymorphisms significantly associated with the abovementioned traits, including 79 SNPs that affected two or more traits...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27809270/flexible-graphene-electrodes-for-prolonged-dynamic-ecg-monitoring
#17
Cunguang Lou, Ruikai Li, Zhaopeng Li, Tie Liang, Zihui Wei, Mingtao Run, Xiaobing Yan, Xiuling Liu
This paper describes the development of a graphene-based dry flexible electrocardiography (ECG) electrode and a portable wireless ECG measurement system. First, graphene films on polyethylene terephthalate (PET) substrates and graphene paper were used to construct the ECG electrode. Then, a graphene textile was synthesized for the fabrication of a wearable ECG monitoring system. The structure and the electrical properties of the graphene electrodes were evaluated using Raman spectroscopy, scanning electron microscopy (SEM), and alternating current impedance spectroscopy...
November 1, 2016: Sensors
https://www.readbyqxmd.com/read/27808340/exploiting-the-interaction-between-a-semiconductor-nanosphere-and-a-thin-metal-film-for-nanoscale-plasmonic-devices
#18
H Li, Y Xu, J Xiang, X F Li, C Y Zhang, S L Tie, S Lan
The interaction of silicon (Si) nanospheres (NSs) with a thin metal film is investigated numerically and experimentally by characterizing their forward scattering properties. A sharp resonant mode and a zero-scattering dip are found to be introduced in the forward scattering spectrum of a Si NS by putting it on a 50-nm-thick gold film. It is revealed that the sharp resonant mode arises from a new magnetic dipole induced by the electric dipole and its mirror image while the zero-scattering dip originates from the destructive interference between the new magnetic dipole and the original one together with its mirror image...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27806749/the-genomic-characterization-of-enterovirus-d68-from-2011-to-2015-in-beijing-china
#19
Tie Gang Zhang, Hong Quan Li, Ai Hua Li, Meng Chen, Cheng Gong, Ming Luo, Mei Dong, Fang Huang
A retrospective surveillance study on enterovirus D68 was performed in Beijing, China, following the largest and most widespread EV-D68 infection, which occurred in the USA. From January 2011 to July 2015, EV-D68 was identified in 12 individuals with respiratory infections in Beijing, China. The phylogenetic relationships based on the genomic sequence alignment showed that there were two lineages circulating in Beijing from 2011 to 2015. Eight EV-D68 strains belonged to group 1 and four belonged to group 3...
September 2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27800646/examining-the-impact-of-regular-aspirin-use-and-pik3ca-mutations-on-survival-in-stage-2-colon-cancer
#20
Caitlin Murphy, Natalie Turner, Hui-Li Wong, Mathu Sinnathamby, Jeanne Tie, Belinda Lee, Jayesh Desai, Iain Skinner, Michael Christie, Ryan Hutchinson, Sebastian Lunke, Paul Waring, Peter Gibbs, Ben Tran
BACKGROUND: Data suggest aspirin improves survival in CRC harbouring PIK3CA mutations. The impact of aspirin is thought predominantly to be via an anti-inflammatory effect. AIMS: To explore the effect of aspirin use on survival in a real world cohort of Stage 2 colon cancer (CC) patients. METHODS: A prospective CRC database identified patients diagnosed with stage 2 CC between 2000 and 2011. PIK3CA mutation status was determined by next generation sequencing...
November 1, 2016: Internal Medicine Journal
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