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https://www.readbyqxmd.com/read/29039815/vibration-noise-modeling-for-measurement-while-drilling-system-based-on-fogs
#1
Chunxi Zhang, Lu Wang, Shuang Gao, Tie Lin, Xianmu Li
Aiming to improve survey accuracy of Measurement While Drilling (MWD) based on Fiber Optic Gyroscopes (FOGs) in the long period, the external aiding sources are fused into the inertial navigation by the Kalman filter (KF) method. The KF method needs to model the inertial sensors' noise as the system noise model. The system noise is modeled as white Gaussian noise conventionally. However, because of the vibration while drilling, the noise in gyros isn't white Gaussian noise any more. Moreover, an incorrect noise model will degrade the accuracy of KF...
October 17, 2017: Sensors
https://www.readbyqxmd.com/read/29034841/ppar-%C3%AE-and-wnt-regulate-the-differentiation-of-mscs-into-adipocytes-and-osteoblasts-respectively
#2
Yue Li, Daxiang Jin, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren
Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is well established as a prime inducer of adipogenesis, while the Wnt pathway is regarded as the master moderator of osteogenesis. A theoretical inverse relationship exists between adipogenic and osteogenic lineage commitment and differentiation: the differentiation toward an osteoblast phenotype occurs at the expense of an adipocyte phenotype...
October 12, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29033603/application-of-the-chronic-constriction-injury-of-the-partial-sciatic-nerve-model-to-assess-acupuncture-analgesia
#3
Mu-Jun Zhi, Kun Liu, Zhou-Li Zheng, Xun He, Tie Li, Guang Sun, Meng Zhang, Fu-Chun Wang, Xin-Yan Gao, Bing Zhu
PURPOSE: To validate and explore the application of a rat model of chronic constriction injury to the partial sciatic nerve in investigation of acupuncture analgesia. METHODS: Chronic constriction injury of the sciatic nerve (CCI) and chronic constriction injury of the partial sciatic nerve (CCIp) models were generated by ligating either the sciatic nerve trunk or its branches in rats. Both models were evaluated via paw mechanical withdrawal latency (PMWL), paw mechanical withdrawal threshold (PMWT), nociceptive reflex-induced electromyogram (C-fiber reflex EMG), and dorsal root ganglion immunohistochemistry...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29032031/discovery-of-novel-anti-angiogenesis-agents-part-8-diaryl-thiourea-bearing-1h-indazole-3-amine-as-multi-target-rtks-inhibitors
#4
Ying Sun, Yuanyuan Shan, Chuansheng Li, Ru Si, Xiaoyan Pan, Binghe Wang, Jie Zhang
VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors based on the extensive sequence homology along the kinase domain of angiogenic RTKs. Biological evaluation indicated that these multi-target inhibitors exhibited considerable potential as novel anti-angiogeneic and anticancer agents. Among them, a diaryl thiourea bearing 1H-indazole-3-amine (16a) displayed the most potent RTK inhibition and excellent selectivity...
October 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031059/tying-up-tranylcypromine-novel-selective-histone-lysine-specific-demethylase-1-lsd1-inhibitors
#5
Yue-Yang Ji, Sen-Dong Lin, Yu-Jie Wang, Ming-Bo Su, Wei Zhang, Hendra Gunosewoyo, Fan Yang, Jia Li, Jie Tang, Yu-Bo Zhou, Li-Fang Yu
Aberrant expression of lysine specific histone demethylase 1 (LSD1) has been increasingly associated with numerous cancer cells and several proof-of-concept studies are strongly suggestive of its potential as a druggable target. Tranylcypromine (TCP) is an antidepressant originally known to target the monoamine oxidases A and B (MAO-A and MAO-B), which are structurally related to LSD1. A number of TCP derivatives have been identified as potent LSD1 inhibitors, with a handful of them currently being tested in clinical trials...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29030491/autophagy-is-activated-in-the-ovarian-tissue-of-polycystic-ovary-syndrome
#6
Da Li, Yue You, Fang-Fang Bi, Tie-Ning Zhang, Jiao Jiao, Tian-Ren Wang, Yi-Ming Zhou, Zi-Qi Shen, Xiu-Xia Wang, Qing Yang
The importance of autophagy in polycystic ovary syndrome (PCOS)-related metabolic disorders is increasingly being recognized, but few studies have investigated the role of autophagy in PCOS. Here, transmission electron microscopy demonstrated that autophagy was enhanced in the ovarian tissue from both humans and rats with PCOS. Consistent with this, ovarian granulosa cells from PCOS rats showed increases in the autophagy marker protein light chain 3B (LC3B), whereas levels of the autophagy substrate SQSTM1/p62 were decreased...
October 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28993744/more-stable-ties-or-better-structure-an-examination-of-the-impact-of-co-author-network-on-team-knowledge-creation
#7
Mingze Li, Xiaoli Zhuang, Wenxing Liu, Pengcheng Zhang
This study aims to explore the influence of co-author network on team knowledge creation. Integrating the two traditional perspectives of network relationship and network structure, we examine the direct and interactive effects of tie stability and structural holes on team knowledge creation. Tracking scientific articles published by 111 scholars in the research field of human resource management from the top 8 American universities, we analyze scholars' scientific co-author networks. The result indicates that tie stability changes the teams' information processing modes and, when graphed, results in an inverted U-shape relationship between tie stability and team knowledge creation...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28987818/the-anti-apoptotic-effect-of-fluid-mechanics-preconditioning-by-cells-membrane-and-mitochondria-in-rats-brain-microvascular-endothelial-cells
#8
Shan Tian, Fengping Zhu, Ruiping Hu, Song Tian, Xingxing Chen, Dan Lou, Bing Cao, Qiulei Chen, Bai Li, Fang Li, Yulong Bai, Yi Wu, Yulian Zhu
Exercise preconditioning is a simple and effective way to prevent ischemia. This paper further provided the mechanism in hemodynamic aspects at the cellular level. To study the anti-apoptotic effects of fluid mechanics preconditioning, Cultured rats brain microvascular endothelial cells were given fluid intervention in a parallel plate flow chamber before oxygen glucose deprivation. It showed that fluid mechanics preconditioning could inhibit the apoptosis of endothelial cells, and this process might be mediated by the shear stress activation of Tie-2 on cells membrane surface and Bcl-2 on the mitochondria surface...
October 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28983280/fatigue-and-cognitive-fatigability-in-mild-traumatic-brain-injury-are-correlated-with-altered-neural-activity-during-vigilance-test-performance
#9
Marika C Möller, Love Engström Nordin, Aniko Bartfai, Per Julin, Tie-Qiang Li
INTRODUCTION: Fatigue is the most frequently reported persistent symptom following a mild traumatic brain injury (mTBI), but the explanations for the persisting fatigue symptoms in mTBI remain controversial. In this study, we investigated the change of cerebral blood flow during the performance of a psychomotor vigilance task (PVT) by using pseudo-continuous arterial spin labeling (PCASL) MRI technique to better understand the relationship between fatigability and brain activity in mTBI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28982932/ezh2-deletion-promotes-spermatogonial-differentiation-and-apoptosis
#10
Cheng Jin, Yan Zhang, Zhi-Peng Wang, Xiu-Xia Wang, Tie-Cheng Sun, Xiao-Yu Li, Ji-Xin Tang, Jin-Mei Cheng, Jian Li, Su-Ren Chen, Shou-Long Deng, Yi-Xun Liu
Spermatogenesis is crucial for male fertility and is therefore tightly controlled by a variety of epigenetic regulators. However, the function of enhancer of zeste homolog 2 (EZH2) in spermatogenesis and the molecular mechanisms underlying its activity remain poorly defined. Here, we demonstrate that deleting EZH2 promoted spermatogonial differentiation and apoptosis. EZH2 is expressed in spermatogonia, spermatocytes and round and elongated spermatids from stage 9 to 11 but not in leptotene and zygotene spermatocytes...
November 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28978041/sperm-carried-rnas-play-critical-roles-in-mouse-embryonic-development
#11
Lei Guo, Shi-Bin Chao, Lu Xiao, Zhen-Bo Wang, Tie-Gang Meng, Yuan-Yuan Li, Zhi-Ming Han, Ying-Chun Ouyang, Yi Hou, Qing-Yuan Sun, Xiang-Hong Ou
Recently, numerous studies have reported that the mature sperm contains both coding and non-coding RNAs and the sperm delivers some RNAs to the oocyte at fertilization. However, the functions of the RNAs carried to the oocyte by sperm at fertilization in embryonic development remains a mystery. In this study, the mature spermatozoa were treated with lysolecithin, pronase and RNases (RNase A and RNase H) to remove the sperm-carried RNAs, and then injected into normal mature oocyte. The results showed that after the treatment, the content of the sperm RNAs was decreased by about 90%...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969047/mir-195-5p-is-critical-in-reg%C3%AE-mediated-regulation-of-wnt-%C3%AE-catenin-pathway-in-renal-cell-carcinoma
#12
Shaojun Chen, Longsheng Wang, Xudong Yao, Hui Chen, Chen Xu, Lu Tong, Abdussaboor Shah, Tingmei Huang, Geng Chen, Jiwei Chen, Tie-Long Liu, Xiao-Tao Li, Jun-Hua Zheng, Lei Li
Renal cell carcinoma (RCC) is the most prevalent malignancy of kidney and accounts for approximately 4% of all cancer diagnoses in adults. Previous studies demonstrated microRNA-195-5p (miR-195-5p) as a tumor suppressor which is deregulated in many human cancers. However, the role of miR-195-5p in RCC is largely unknown. In the present study, we demonstrated that miR-195-5p was downregulated and negatively correlated with advanced clinical stage in RCC. Overexpression of miR-195-5p significantly suppressed RCC cells growth in vitro and in vivo, induced apoptosis and enhanced chemosensitivity to sorafenib...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966669/salvianolic-acid-b-and-danshensu-induce-osteogenic-differentiation-of-rat-bone-marrow-stromal-stem-cells-by-upregulating-the-nitric-oxide-pathway
#13
Xinle Zhang, Liyi Zou, Jin Li, Bilian Xu, Tie Wu, Huanqiong Fan, Weiming Xu, Weimin Yao, Yajun Yang, Yuyu Liu, Liao Cui
The aim of the present study was to investigate the effect of salvianolic acid B (Sal B) and danshensu (DSU) on the osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and the mechanisms of the effects. The osteogenic differentiation of MSCs in culture was assessed by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, nitric oxide (NO) production and the mRNA expression levels of osteoprotegerin (OPG) and its ligand by MSCs. MSCs were successfully induced to differentiate into osteoblasts and adipocytes...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962152/study-of-the-association-between-hemorrhage-and-the-position-of-hemorrhagic-stigmata-in-patients-with-esophageal-varices
#14
Shao-Hua Shen, Ying-Di Liu, Xiao Sun, Meng Li, Guo-Hui Sun, Juan Wang, Jiang-Tao Liu, Jun Tie, Jing Yang
The aim of the present study was to investigate the predilection position of hemorrhagic stigmata (HS) in patients with esophageal variceal hemorrhage and provide guidance on endoscopic therapy for esophageal varices. The clinical characteristics, particularly the endoscopic manifestations of HS, in the patients who presented with gastroesophageal variceal hemorrhage and cirrhosis between January 2003 and December 2013 at our hospital were summarized and patients were grouped according to the distance of the lesion site to incisors at 35-40 and ~30 cm...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28959205/furanodiene-induces-extrinsic-and-intrinsic-apoptosis-in-doxorubicin-resistant-mcf-7-breast-cancer-cells-via-nf-%C3%AE%C2%BAb-independent-mechanism
#15
Zhang-Feng Zhong, Hai-Bing Yu, Chun-Ming Wang, Wen-An Qiang, Sheng-Peng Wang, Jin-Ming Zhang, Hua Yu, Liao Cui, Tie Wu, De-Qiang Li, Yi-Tao Wang
Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28957154/concave-lens-like-long-period-fiber-grating-bidirectional-high-sensitivity-bending-sensor
#16
Yun-Shan Zhang, Wei-Gang Zhang, Lei Chen, Yan-Xin Zhang, Song Wang, Lin Yu, Yan-Ping Li, Peng-Cheng Geng, Tie-Yi Yan, Xin-Yu Li, Ling-Xin Kong
A novel bidirectional high-sensitivity fiber-optic bending sensor based on the concave-lens-like long-period fiber grating (CLL-LPFG) is designed and demonstrated. The CLL-LPFG is composed by an array of arc-shaped grating planes, and accordingly, its refractive index modulation serves as a concave lens. As a result, the eigencladding mode of the device gets closer to the device surface than the conventional counterpart. Therefore, the proposed sensor provides a more sensitive result. The experimental results show that the bending sensitivities of the CLL-LPFG reach -32...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28946512/kinetics-and-mechanism-of-ultrasonic-assisted-magnesium-oxide-hydration
#17
Xiaojia Tang, Yixing Nie, Qi Jin, Lin Guo, Jiao Zhao, Tie Li, Yimin Zhu
The kinetics of ultrasonic-assisted magnesium oxide (MgO) hydration was investigated in the present paper. The degree of hydration at different temperature (298-338K) and reaction time (0.25-3h) was determined by thermal gravity analysis (TGA). And the products of the hydration were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectrometer (FT-IR) and Particle Size Distribution analysis (PSD). A coupling model based on characteristic equations for chemical reaction control and inward diffusion control was employed to describe the hydration process...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28946041/a-monoclonal-antibody-based-enzyme-linked-immunosorbent-assay-for-the-determination-of-chlorogenic-acid-in-honeysuckle
#18
Bo Zhang, Tie-Gui Nan, Zhi-Lai Zhan, Li-Ping Kang, Jian Yang, Chang-Jiang-Sheng Lai, Yuan Yuan, Bao-Min Wang, Lu-Qi Huang
The edible flower buds of honeysuckle are traditionally used as herbal medicine or food additives in China. Chlorogenic acid (CGA) serves as the quality control marker of honeysuckle for its high content and antipyretic property. In this paper, a specific monoclonal antibody (mAb2E2) against CGA was produced. After optimization, mAb2E2-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was developed. The concentrations of CGA producing 50% inhibition and the calibration range of the icELISA were 0...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28944660/spin-controlled-multiple-pencil-beams-and-vortex-beams-with-different-polarizations-generated-by-pancharatnam-berry-coding-metasurfaces
#19
Lei Zhang, Shuo Liu, Lianlin Li, Tie Jun Cui
We propose to design coding metasurfaces based on the Pancharatnam-Berry (PB) phase. The proposed PB coding metasurface could control circularly polarized components of incident waves, by encoding geometric phase into the orientation angle of coding particles to generate 1-bit and multibit phase responses. We perform digital convolution operations on scattering patterns of the PB coding metasurface to reach flexible controls of the circularly polarized waves, forming spin-controlled multiple beams with different polarizations in free space, such as pencil beams and vortex beams carrying orbital angular momentum...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28932671/controlling-energy-radiations-of-electromagnetic-waves-via-frequency-coding-metamaterials
#20
Haotian Wu, Shuo Liu, Xiang Wan, Lei Zhang, Dan Wang, Lianlin Li, Tie Jun Cui
Metamaterials are artificial structures composed of subwavelength unit cells to control electromagnetic (EM) waves. The spatial coding representation of metamaterial has the ability to describe the material in a digital way. The spatial coding metamaterials are typically constructed by unit cells that have similar shapes with fixed functionality. Here, the concept of frequency coding metamaterial is proposed, which achieves different controls of EM energy radiations with a fixed spatial coding pattern when the frequency changes...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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