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https://www.readbyqxmd.com/read/28212323/low-intensity-extracorporeal-shock-wave-therapy-enhances-brain-derived-neurotrophic-factor-expression-through-perk-atf4-signaling-pathway
#1
Bohan Wang, Hongxiu Ning, Amanda B Reed-Maldonado, Jun Zhou, Yajun Ruan, Tie Zhou, Hsun Shuan Wang, Byung Seok Oh, Lia Banie, Guiting Lin, Tom F Lue
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but its mechanisms are not well understood. Previously, we found that Li-ESWT increased the expression of brain-derived neurotrophic factor (BDNF). Here we assessed the underlying signaling pathways in Schwann cells in vitro and in penis tissue in vivo after nerve injury. The result indicated that BDNF were significantly increased by the Li-ESWT after nerve injury, as well as the expression of BDNF in Schwann cells (SCs, RT4-D6P2T) in vitro...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212317/an-auction-based-spectrum-leasing-mechanism-for-mobile-macro-femtocell-networks-of-iot
#2
Xin Chen, Lei Xing, Tie Qiu, Zhuo Li
The Internet of Things (IoT) is a vision of the upcoming society. It can provide pervasive communication between two or more entities using 4G-LTE (Long Term Evolution) communication technology. In 4G-LTE networks, there are two important problems: helping manage the spectrum demands of IoT devices and achieving much more revenue with the limited resource. This paper proposes a pricing framework to investigate the spectrum leasing in mobile heterogeneous networks with single macrocell and multiple femtocells...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28202293/therapeutic-hypothermia-attenuates-brain-edema-in-a-pig-model-of-cardiac-arrest-possible-role-of-the-angiopoietin-tie-2-system
#3
Jiebin Li, ChunSheng Li, Wei Yuan, JunYuan Wu, Jie Li, ZhenHua Li, YongZhen Zhao
OBJECTIVE: This study aimed to clarify whether therapeutic hypothermia protects against cerebral edema following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a porcine model via regulating the angiopoietin-Tie-2 ligand-receptor system. METHODS: Male pigs were randomized into the therapeutic hypothermia group, the normothermia group or the sham control group. CA was induced in pigs by untreated ventricular fibrillation for 8min. Brain edema was determined by measuring the cerebral cortical water content at 24h after the return of spontaneous circulation (ROSC)...
February 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28180282/ataxin-3-promotes-genome-integrity-by-stabilizing-chk1
#4
Yingfeng Tu, Hongmei Liu, Xuefei Zhu, Hongyan Shen, Xiaolu Ma, Fengli Wang, Min Huang, Juanjuan Gong, Xiaoling Li, Yun Wang, Caixia Guo, Tie-Shan Tang
No abstract text is available yet for this article.
February 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28178195/overexpression-of-skp2-inhibits-the-radiation-induced-bystander-effects-of-esophageal-carcinoma
#5
Xiao-Chun Wang, Tie-Jun Zhang, Zi-Jian Guo, Chang-Yan Xiao, Xiao-Wen Ding, Fang Fang, Wen-Tao Sheng, Xu Shu, Jue Li
BACKGROUND: To investigate the effects of S-phase kinase protein 2 (SKP2) expression on the radiation induced bystander effect (RIBE) in esophageal cancer (EC) cells. MATERIALS AND METHODS: Western blot was used to detect the levels of SKP2, Rad51, and Ku70 in EC cells. Positive transfection, RNAi, micronucleus (MN), and γ-H2AX focus formation assay were used to investigate the effects of SKP2 on RIBE induced by irradiated cells. RESULTS: We found a significant negative correlation between SKP2 expression and MN frequency (p < 0...
February 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28177882/time-trends-in-the-prevalence-and-epidemiological-characteristics-of-neural-tube-defects-in-liaoning-province-china-2006-2015-a-population-based-study
#6
Tie-Ning Zhang, Ting-Ting Gong, Yan-Ling Chen, Qi-Jun Wu, Yuan Zhang, Cheng-Zhi Jiang, Jing Li, Li-Li Li, Chen Zhou, Yan-Hong Huang
To evaluate the time trends in the prevalence of neural tube defects and all their subtypes as well as to identify the epidemiological characteristics of these malformations documented in the Liaoning Province of northeast China from 2006 to 2015. This was a population-based observational study using data from 3,248,954 live births as well as from 6217 cases of neural tube defects, 1,600 cases of anencephaly, 2,029 cases of spina bifida, 404 cases of encephalocele, and 3,008 cases of congenital hydrocephalus from 14 cities in Liaoning Province from 2006 to 2015...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28164408/her2-somatic-mutations-are-associated-with-poor-survival-in-her2-negative-breast-cancers
#7
Tonghui Wang, Ye Xu, Shuyan Sheng, Hua Yuan, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
It is well documented that HER2 overexpression/amplification is associated with the poor survival in breast cancer patients. However, it is largely unknown whether HER2 somatic mutations are associated with the survival in HER2-negative breast cancer patients. Here, we identified HER2 somatic mutations in tumors from 1,348 unselected breast cancer patients by sequencing the entire HER2 coding region. All these mutations were tested for in corresponding blood samples to determine whether they were somatic or germline mutations...
February 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28161957/effect-of-surface-charge-on-the-nanofriction-and-its-velocity-dependence-in-an-electrolyte-based-on-lateral-force-microscopy
#8
Dalei Jing, Yunlu Pan, Dayong Li, Xuezeng Zhao, Bharat Bhushan
The nanofriction between a silicon nitride probe and both a silicon wafer and an octadecyltrichlorosilane (OTS)-coated surface is studied in saline solution by using lateral force microscopy (LFM). The effects of surface charge on the nanofriction in an electrolyte as well as its velocity dependence are studied, while the surface charge at the solid-liquid interface is adjusted by changing the pH value of the electrolyte. The results show that the nanofrictional behavior between the probe and the samples in an electrolyte depends strongly on the surface charge at the solid-liquid interface...
February 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28150722/mir-27a-rs895819-is-involved-in-increased-atrophic-gastritis-risk-improved-gastric-cancer-prognosis-and-negative-interaction-with-helicobacter-pylori
#9
Qian Xu, Tie-Jun Chen, Cai-Yun He, Li-Ping Sun, Jing-Wei Liu, Yuan Yuan
MiR-27a rs895819 is a loop-stem structure single nucleotide polymorphism affecting mature miR-27a function. In this study, we performed a comprehensive analysis about the association of rs895819 with gastric cancer risk and prognosis, atrophic gastritis risk, as well as the interactions with environmental factors. A total of 939 gastric cancer patients, 1,067 atrophic gastritis patients and 1,166 healthy controls were screened by direct sequencing and MALDI-TOF-MS. The association of rs895819 with clinical pathological parameters and prognostic survival in 357 gastric cancer patients was also been analyzed...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28107822/does-training-improve-diagnostic-accuracy-and-inter-rater-agreement-in-applying-the-berlin-radiographic-definition-of-acute-respiratory-distress-syndrome-a-multicenter-prospective-study
#10
Jin-Min Peng, Chuan-Yun Qian, Xiang-You Yu, Ming-Yan Zhao, Shu-Sheng Li, Xiao-Chun Ma, Yan Kang, Fa-Chun Zhou, Zhen-Yang He, Tie-He Qin, Yong-Jie Yin, Li Jiang, Zhen-Jie Hu, Ren-Hua Sun, Jian-Dong Lin, Tong Li, Da-Wei Wu, You-Zhong An, Yu-Hang Ai, Li-Hua Zhou, Xiang-Yuan Cao, Xi-Jing Zhang, Rong-Qing Sun, Er-Zhen Chen, Bin Du
BACKGROUND: Poor inter-rater reliability in chest radiograph interpretation has been reported in the context of acute respiratory distress syndrome (ARDS), although not for the Berlin definition of ARDS. We sought to examine the effect of training material on the accuracy and consistency of intensivists' chest radiograph interpretations for ARDS diagnosis. METHODS: We conducted a rater agreement study in which 286 intensivists (residents 41.3%, junior attending physicians 35...
January 20, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28102408/bottom-up-synthesis-of-nitrogen-doped-porous-carbon-scaffolds-for-lithium-and-sodium-storage
#11
Hongling Lu, Renpeng Chen, Yi Hu, Xiaoqi Wang, Yanrong Wang, Lianbo Ma, Guoyin Zhu, Tao Chen, Zuoxiu Tie, Zhong Jin, Jie Liu
Here we report an effective bottom-up solution-phase process for the preparation of nitrogen-doped porous carbon scaffolds (NPCSs), which can be employed as high-performance anode materials for both lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). The as-obtained NPCSs show favorable features for electrochemical energy storage such as high specific surface area, appropriate pore size distribution (3.9 nm in average), large pore volume (1.36 cm(3) g(-1)), nanosheet-like morphology, a certain degree of graphitization, enlarged interlayer distance (0...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28100475/effects-of-obesity-and-exercise-on-testicular-leptin-signal-transduction-and-testosterone-biosynthesis-in-male-mice
#12
Xuejie Yi, Haining Gao, Dequan Chen, Donghui Tang, Wanting Huang, Tao Li, Tie Ma, Bo Chang
To explore the role of the testicular leptin and JAK-STAT(LEP-JAK-STAT) pathway in testosterone biosynthesis during juvenile stages and exercise for weight loss, male C57BL/6J mice were randomly divided into normal-diet (ND) and high-fat diet (HFD) groups. After 10 weeks, mice in the HFD group were further divided randomly into obese control (OC), obese moderate-volume exercise (OME), and obese high-volume exercise (OHE) groups. Mice in the OME group were provided with 2 h/day, 6 days/week swimming exercise for 8 weeks and mice in the OHE group underwent twice the amount of daily exercise intervention as the OME group...
January 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28096330/spectroscopic-evidence-for-bulk-band-inversion-and-three-dimensional-massive-dirac-fermions-in-zrte5
#13
Zhi-Guo Chen, R Y Chen, R D Zhong, John Schneeloch, C Zhang, Y Huang, Fanming Qu, Rui Yu, Q Li, G D Gu, N L Wang
Three-dimensional topological insulators (3D TIs) represent states of quantum matters in which surface states are protected by time-reversal symmetry and an inversion occurs between bulk conduction and valence bands. However, the bulk-band inversion, which is intimately tied to the topologically nontrivial nature of 3D Tis, has rarely been investigated by experiments. Besides, 3D massive Dirac fermions with nearly linear band dispersions were seldom observed in TIs. Recently, a van der Waals crystal, ZrTe5, was theoretically predicted to be a TI...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28086897/application-of-the-analytic-hierarchy-approach-to-the-risk-assessment-of-zika-virus-disease-transmission-in-guangdong-province-china
#14
Xing Li, Tao Liu, Lifeng Lin, Tie Song, Xiaolong Du, Hualiang Lin, Jianpeng Xiao, Jianfeng He, Liping Liu, Guanghu Zhu, Weilin Zeng, Lingchuan Guo, Zheng Cao, Wenjun Ma, Yonghui Zhang
BACKGROUND: An international spread of Zika virus (ZIKV) infection has attracted global attention in 2015. The infection also affected Guangdong province, which is located in southern China. Multiple factors, including frequent communication with South America and Southeast Asia, suitable climate (sub-tropical) for the habitat of Aedes species, may increase the risk of ZIKV disease transmission in this region. METHODS: An analytic hierarchy process (AHP) method was used to develop a semi-quantitative ZIKV risk assessment model...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28076997/surgical-treatment-of-severe-multilevel-circumferential-compressive-myelopathy-of-the-cervical-spine-is-circumferential-procedure-necessary
#15
Xiao-Kang Liu, Hao Li, Jian-Guang Xu, Er-Zhu Yang, Tie-Sheng Hou, Bing-Fang Zeng, Xiao-Feng Lian
OBJECTIVE: To determine the necessity of circumferential decompression and fusion in patients with severe multilevel cervical spondylotic myelopathy with circumferential cord compression. METHODS: This prospective study involved 51 patients with severe multilevel circumferential cervical myelopathy underwent two-stage circumferential procedure between July 2008 and June 2010. VAS scores, satisfaction surveys and JOA scores and imaging studies were obtained. Twenty-three patients (45...
January 11, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28074479/gdf8-inhibits-bone-formation-and-promotes-bone-resorption-in-mice
#16
Yu-Si Chen, Qi Guo, Li-Juan Guo, Ting Liu, Xian-Ping Wu, Zhang-Yuan Lin, Hong-Bo He, Tie-Jian Jiang
Growth Differentiation Factor 8 (GDF8), also called myostatin, is a member of the transforming growth factor (TGF)-β super-family. As a negative regulator of skeletal muscle growth, GDF8 is also associated with bone metabolism. However, the function of GDF8 in bone metabolism is not fully understood. Our study aimed to investigate the role of GDF8 in bone metabolism, both in vitro and in vivo. Our results showed that GDF8 had a negative regulatory effect on primary mouse osteoblasts, and promoted receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro...
January 11, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28073275/highly-efficient-retention-of-polysulfides-in-sea-urchin-like-carbon-nanotube-nanopolyhedra-superstructures-as-cathode-material-for-ultralong-life-lithium-sulfur-batteries
#17
Tao Chen, Baorui Cheng, Guoyin Zhu, Renpeng Chen, Yi Hu, Lianbo Ma, Hongling Lv, Yanrong Wang, Jia Liang, Zuoxiu Tie, Zhong Jin, Jie Liu
Despite high theoretical energy density, the practical deployment of lithium-sulfur (Li-S) batteries is still not implemented because of the severe capacity decay caused by polysulfide shuttling and the poor rate capability induced by low electrical conductivity of sulfur. Herein, we report a novel sulfur host material based on "sea urchin"-like cobalt nanoparticle embedded and nitrogen-doped carbon nanotube/nanopolyhedra (Co-NCNT/NP) superstructures for Li-S batteries. The hierarchical micromesopores in Co-NCNT/NP can allow efficient impregnation of sulfur and block diffusion of soluble polysulfides by physical confinement, and the incorporation of embedded Co nanoparticles and nitrogen doping (∼4...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28073028/multiplexed-detection-of-lung-cancer-biomarkers-in-patients-serum-with-cmos-compatible-silicon-nanowire-arrays
#18
Anran Gao, Xun Yang, Jing Tong, Lin Zhou, Yuelin Wang, Jianlong Zhao, Hongju Mao, Tie Li
In this work, a real-time assay for highly sensitive, label-free, multiplexed electrical detection of lung cancer biomarkers was developed by using silicon nanowire field-effect (SiNW-FET) devices. Highly responsive SiNW arrays were fabricated using a CMOS-compatible anisotropic self-stop etching technique with mass reproducibility and low cost character. The SiNW nanosensor was integrated with PDMS microfluidic device, which allows rapid analyte delivery, makes the analysis to be conducted using exceedingly small samples and enables potential multiplexed detection...
January 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28068898/integrated-mrna-and-microrna-analysis-identifies-genes-and-small-mirna-molecules-associated-with-transcriptional-and-post-transcriptional-level-responses-to-both-drought-stress-and-re-watering-treatment-in-tobacco
#19
Qiansi Chen, Meng Li, Zhongchun Zhang, Weiwei Tie, Xia Chen, Lifeng Jin, Niu Zhai, Qingxia Zheng, Jianfeng Zhang, Ran Wang, Guoyun Xu, Hui Zhang, Pingping Liu, Huina Zhou
BACKGROUND: Drought stress is one of the most severe problem limited agricultural productivity worldwide. It has been reported that plants response to drought-stress by sophisticated mechanisms at both transcriptional and post-transcriptional levels. However, the precise molecular mechanisms governing the responses of tobacco leaves to drought stress and water status are not well understood. To identify genes and miRNAs involved in drought-stress responses in tobacco, we performed both mRNA and small RNA sequencing on tobacco leaf samples from the following three treatments: untreated-control (CL), drought stress (DL), and re-watering (WL)...
January 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28068599/discovery-of-novel-anti-angiogenesis-agents-part-6-multi-targeted-rtk-inhibitors
#20
Lin Zhang, Yuanyuan Shan, Chuansheng Li, Ying Sun, Ping Su, Jinfeng Wang, Lisha Li, Xiaoyan Pan, Jie Zhang
Angiogenesis is modulated by a multitude of pro-angiogenic factors including VEGFR-2, Tie-2, and EphB4. Moreover, their crosstalk also had been well elaborated. We have identified several diarylurea-based VEGFR-2 inhibitors as potential anti-angiogenesis agents. As a continuation to our previous research, two series of diaryl malonamide and diaryl thiourea derivatives have been developed as multiplex VEGFR-2/Tie-2/EphB4 inhibitors. Interestingly, the biological evaluation indicated that several compounds bearing trifluoromethyl or trifluoromethoxyl exhibited promising multiplex inhibition against angiogenesis-related VEGFR-2, Tie-2, and EphB4...
January 2, 2017: European Journal of Medicinal Chemistry
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