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JOURNAL ARTICLE
Zhuo Chen, Yu-Chen Li, Tie-Lin Kong, Yang-Yang Lv, Wei Fa, Shuang Chen
In order to realize the prevailing artificial intelligence technology, memristor-implemented in-memory or neuromorphic computing is highly expected to break the bottleneck of von Neumann computers. Although high-performance memristors have been vigorously developed in labs or in industry, systematic computational investigations on memristors are seldom. Hence, it is urgent to provide theoretical or computational support for the exploration of memristor operating mechanisms or the screening of memristor materials...
May 8, 2024: ACS Applied Materials & Interfaces
#2
JOURNAL ARTICLE
Shengyu Huang, Qimin Ma, Xincheng Liao, Xi Yin, Tuo Shen, Xiaobin Liu, Wenbin Tang, Yusong Wang, Lei Wang, Haiming Xin, Xiaoliang Li, Liu Chang, Zhaohong Chen, Rui Liu, Choulang Wu, Deyun Wang, Guanghua Guo, Feng Zhu
Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains elusive. We examined alterations in indicators linked to mortality outcomes at both the transcriptomic and clinical characteristic levels. At the transcriptomic level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries and endeavored to validate their causal relationships through Mendelian randomization...
May 7, 2024: Scientific Reports
#3
JOURNAL ARTICLE
Jie Wu, Jing Wu, Ru-Li He, Lan Hu, Dong-Feng Liu, Wen-Wei Li
Shewanella oneidensis MR-1 has found widespread applications in pollutant transformation and bioenergy production, closely tied to its outstanding heme synthesis capabilities. However, this significant biosynthetic potential is still unexploited so far. Here, we turned this bacterium into a highly-efficient bio-factory for green synthesis of 5-Aminolevulinic Acid (5-ALA), an important chemical for broad applications in agriculture, medicine, and the food industries. The native C5 pathway genes of S. oneidensis was employed, together with the introduction of foreign anti-oxidation module, to establish the 5-ALA production module, resulting 87-fold higher 5-ALA yield and drastically enhanced tolerance than the wide type...
May 4, 2024: Metabolic Engineering
#4
JOURNAL ARTICLE
Velma K Lopez, Estee Y Cramer, Robert Pagano, John M Drake, Eamon B O'Dea, Madeline Adee, Turgay Ayer, Jagpreet Chhatwal, Ozden O Dalgic, Mary A Ladd, Benjamin P Linas, Peter P Mueller, Jade Xiao, Johannes Bracher, Alvaro J Castro Rivadeneira, Aaron Gerding, Tilmann Gneiting, Yuxin Huang, Dasuni Jayawardena, Abdul H Kanji, Khoa Le, Anja Mühlemann, Jarad Niemi, Evan L Ray, Ariane Stark, Yijin Wang, Nutcha Wattanachit, Martha W Zorn, Sen Pei, Jeffrey Shaman, Teresa K Yamana, Samuel R Tarasewicz, Daniel J Wilson, Sid Baccam, Heidi Gurung, Steve Stage, Brad Suchoski, Lei Gao, Zhiling Gu, Myungjin Kim, Xinyi Li, Guannan Wang, Lily Wang, Yueying Wang, Shan Yu, Lauren Gardner, Sonia Jindal, Maximilian Marshall, Kristen Nixon, Juan Dent, Alison L Hill, Joshua Kaminsky, Elizabeth C Lee, Joseph C Lemaitre, Justin Lessler, Claire P Smith, Shaun Truelove, Matt Kinsey, Luke C Mullany, Kaitlin Rainwater-Lovett, Lauren Shin, Katharine Tallaksen, Shelby Wilson, Dean Karlen, Lauren Castro, Geoffrey Fairchild, Isaac Michaud, Dave Osthus, Jiang Bian, Wei Cao, Zhifeng Gao, Juan Lavista Ferres, Chaozhuo Li, Tie-Yan Liu, Xing Xie, Shun Zhang, Shun Zheng, Matteo Chinazzi, Jessica T Davis, Kunpeng Mu, Ana Pastore Y Piontti, Alessandro Vespignani, Xinyue Xiong, Robert Walraven, Jinghui Chen, Quanquan Gu, Lingxiao Wang, Pan Xu, Weitong Zhang, Difan Zou, Graham Casey Gibson, Daniel Sheldon, Ajitesh Srivastava, Aniruddha Adiga, Benjamin Hurt, Gursharn Kaur, Bryan Lewis, Madhav Marathe, Akhil Sai Peddireddy, Przemyslaw Porebski, Srinivasan Venkatramanan, Lijing Wang, Pragati V Prasad, Jo W Walker, Alexander E Webber, Rachel B Slayton, Matthew Biggerstaff, Nicholas G Reich, Michael A Johansson
During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies, and government entities led by the Centers for Disease Control and Prevention and the US COVID-19 Forecast Hub (https://covid19forecasthub.org). We evaluated approximately 9.7 million forecasts of weekly state-level COVID-19 cases for predictions 1-4 weeks into the future submitted by 24 teams from August 2020 to December 2021...
May 6, 2024: PLoS Computational Biology
#5
JOURNAL ARTICLE
Feifan Yao, Suiqing Zhou, Ruizhi Zhang, Yining Chen, Wei Huang, Kai Yu, Nanmu Yang, Xiangjun Qian, Xiaofeng Tie, Jiali Xu, Yu Zhang, Tasiken Baheti, Jing Xu, Xinzheng Dai, Xiaopei Hao, Liren Zhang, Xuehao Wang, Qing Li
Hepatocellular carcinoma (HCC) is a prevalent malignancy characterized by complex heterogeneity and drug resistance. Resistance to ferroptosis is closely related to the progression of HCC. While HCC tumors vary in their sensitivity to ferroptosis, the precise factors underlying this heterogeneity remain unclear. In this study, we sought to elucidate the mechanisms that contribute to ferroptosis resistance in HCC. Whole-genome CRISPR/Cas9 screen using a subtoxic concentration (IC20) of ferroptosis inducer erastin in the HCC cell line Huh7 revealed TRIM34 as a critical driver of ferroptosis resistance in HCC...
May 2, 2024: Cancer Letters
#6
JOURNAL ARTICLE
Mei-Ling Wang, Cheng-Wei Tie, Jian-Hui Wang, Ji-Qing Zhu, Bing-Hong Chen, Ying Li, Sen Zhang, Lin Liu, Li Guo, Long Yang, Li-Qun Yang, Jiao Wei, Feng Jiang, Zhi-Qiang Zhao, Gui-Qi Wang, Wei Zhang, Quan-Mao Zhang, Xiao-Guang Ni
OBJECTIVE: To develop a multi-instance learning (MIL) based artificial intelligence (AI)-assisted diagnosis models by using laryngoscopic images to differentiate benign and malignant vocal fold leukoplakia (VFL). METHODS: The AI system was developed, trained and validated on 5362 images of 551 patients from three hospitals. Automated regions of interest (ROI) segmentation algorithm was utilized to construct image-level features. MIL was used to fusion image level results to patient level features, then the extracted features were modeled by seven machine learning algorithms...
April 30, 2024: American Journal of Otolaryngology
#7
JOURNAL ARTICLE
Thomas T Miles, Shang-Ju Li, Tija Danzig, Miguel Marrero, Ivelisse Morales, Saleh Babazadeh
BACKGROUND: This study aimed to assess COVID-19 vaccine confidence among healthcare personnel in the safety net sector of the United States and Puerto Rico. This study aimed to examine the extent to which increased knowledge and positive attitudes toward COVID-19 vaccine safety and efficacy were associated with healthcare workers' COVID-19 vaccination status and their recommendation of the vaccine to all patients. METHODS: Online survey data were collected from health care workers working in Free and Charitable Clinics across the United States and Federally Qualified Health Centers in Puerto Rico...
May 3, 2024: BMC Health Services Research
#8
JOURNAL ARTICLE
Ru-Gang Zhu, Shi-Chuang Sun, Yi-Fang Li, Hui Zang, Xiao-Yi Sun, Jie Wei, Li-Feng Song, Tie-Jing Li, Yu-Xiao Wang, Cong Ning, Fei-Fei Shang
This study aimed to compare the effects of pectin and hydrolyzed pectin coating as pre-frying treatments on acrylamide content and quality characteristics of fried potato chips. The hydrolyzed pectin with molecular weight (Mw) of 8.81 ± 0.49 kDa was obtained through partial degradation of pectin (Mw: 747.57 ± 6.73 kDa) using pectinase. Results showed that both pectin and hydrolyzed pectin coating significantly inhibited acrylamide formation and inhibition rates exceeded 90 %...
April 30, 2024: International Journal of Biological Macromolecules
#9
JOURNAL ARTICLE
Yang-Yang Guo, Tie Li, Xiao-Yan Cao, Mao-Xu Zhu
Bloom-induced macroalgal enrichment on the seafloor can substantially facilitate dissolved sulfide (DS) production through sulfate reduction. The reaction of DS with sedimentary reactive iron (Fe) is the main mechanism of DS consumption, which however usually could not effectively prevent DS accumulation caused by pulsed macroalgal enrichment. Here we used incubations to investigate the performance of Fe-rich red soil for buffering of DS produced from macroalgae (Ulva prolifera)-enriched sediment. Based on our results, a combination of red soil additions (6...
April 30, 2024: Marine Pollution Bulletin
#10
JOURNAL ARTICLE
Tie Cheng Sun, Dong Mei Li, Rong Fang Zhang, Dong Mei Wang, Yan Jun Jia
The HLA-A*24:627 allele differs from HLA-A*24:02:01:01 by one nucleotide substitution in codon 172 in exon 2.
May 2024: HLA
#11
JOURNAL ARTICLE
Lijing Zhu, Lisha Sun, Ye Zhang, Xiaoxiao Liu, XueFen Li, Zheng Zhou, Yajuan Cui, Chuan-Xiang Zhou, Tie-Jun Li
Acinic cell carcinoma of the salivary gland (AciCC) is a low-grade carcinoma characterized by the overexpression of the transcription factor nuclear receptor subfamily 4 group A member 3 (NR4A3). AciCC has been the subject of a few molecular research projects. This study delves into AciCC's molecular landscape to identify additional alterations and explore their clinical implications. RNA sequencing and immunohistochemical staining for markers NR4A3/NR4A2, DOG-1, S100, and mammaglobin were utilized on 41 AciCCs and 11 secretory carcinoma (SC) samples...
April 29, 2024: American Journal of Surgical Pathology
#12
JOURNAL ARTICLE
Jie Sheng, Shengkun Jiang, Tie Geng, Zhengqiang Huang, Jiquan Li, Lin Jiang
Polymer-based actuators have gained extensive attention owing to their potential applications in aerospace, soft robotics, etc. However, poor mechanical properties, the inability of multi-stimuli response and programmable deformation, and the costly fabrication procedure have significantly hindered their practical application. Herein, these issues are overcome via a simple and scalable one-step molding method. The actuator is fabricated by hot-pressing commercial unidirectional carbon fiber/epoxy prepregs with a commodity PC membrane...
April 19, 2024: Polymers
#13
JOURNAL ARTICLE
Xiaomin Li, Mykhailo Sakevych, Gentry Atkinson, Vangelis Metsis
Machine learning tasks involving biomedical signals frequently grapple with issues such as limited data availability, imbalanced datasets, labeling complexities, and the interference of measurement noise. These challenges often hinder the optimal training of machine learning algorithms. Addressing these concerns, we introduce BioDiffusion, a diffusion-based probabilistic model optimized for the synthesis of multivariate biomedical signals. BioDiffusion demonstrates excellence in producing high-fidelity, non-stationary, multivariate signals for a range of tasks including unconditional, label-conditional, and signal-conditional generation...
March 22, 2024: Bioengineering
#14
JOURNAL ARTICLE
Dongfang Jiang, Hongmei Liu, Tingting Li, Song Zhao, Keyan Yang, Fuwen Yao, Bo Zhou, Haiping Feng, Sijia Wang, Jiaqi Shen, Jinglan Tang, Yu-Xin Zhang, Yun Wang, Caixia Guo, Tie-Shan Tang
BACKGROUND: Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to various physiological and pathological stimuli. Recently, we have found that the decrement of carboxypeptidase E (CPE) with aging impairs the maturation of brain-derived neurotrophic factor (BDNF) and neurogenesis in the SVZ. However, it remains unknown whether these events occur in the hippocampus, and what the role of CPE is in the adult hippocampal neurogenesis in the context of Alzheimer's disease (AD)...
April 26, 2024: Translational Neurodegeneration
#15
JOURNAL ARTICLE
Hu Li, Jianguo Liu, Litao Zhang, Xingkai Che, Mengjie Zhang, Tie Zhang
Enhalus acoroides, the largest seagrass species in terms of morphology, has been observed to be declining significantly. In an effort to restore seagrass meadows, we conducted a transplantion utilizing dislodged rhizome fragments of E. acoroides as the donor materials. The growth of transplanted seagrass was monitored over a period of three years, and the impact of seagrass recolonization on sedimentary environment was assessed through analysis of sediment microbial diversity. The transplanted plants displayed notable growth, resulting in the successful recolonization of experimental plots by seagrass...
April 25, 2024: Journal of Environmental Management
#16
JOURNAL ARTICLE
Jiani Mo, Yong Liu, Wencong Zhang, Liang Li, Lindi Li, Tianwen Li, Jiahua Mo, Yujiang Chen, Liang Liang, Yuming Zhang, Mo Yang
Primary immune thrombocytopenia (ITP) is linked to specific pathogenic mechanisms, yet its relationship with mitophagy and ferroptosis is poorly understood. This study aimed to identify new biomarkers and explore the role of mitophagy and ferroptosis in ITP pathogenesis. Techniques such as differential analysis, Mfuzz expression pattern clustering, machine learning, gene set enrichment analysis, single-cell RNA sequencing (scRNA-seq) and immune infiltration analysis were employed to investigate the molecular pathways of pivotal genes...
April 26, 2024: British Journal of Haematology
#17
JOURNAL ARTICLE
JinYing Xiang, Bo Liu, Yan Li, Yinying Ren, Yuehan Li, Mi Zhou, Jinyue Yu, Zhengxiu Luo, Enmei Liu, Zhou Fu, Fengxia Ding
OBJECTIVE: Asthma stands as one of the most prevalent chronic respiratory conditions in children, with its pathogenesis tied to the actived antigen presentation by dendritic cells (DCs) and the imbalance within T cell subgroups. This study seeks to investigate the role of the transcription factor EB (TFEB) in modulating the antigen presentation process of DCs and its impact on the differentiation of T cell subgroups. METHODS: Bone marrow dendritic cells (BMDCs) were activated using house dust mites (HDM) and underwent RNA sequencing (RNA-seq) to pinpoint differentially expressed genes...
April 25, 2024: Respiratory Research
#18
MULTICENTER STUDY
Bi Ze, Jin Gao, Xiao-Fen Zhao, Yang-Fang Li, Tie-Song Zhang, Xiao-Mei Liu, Hui Mao, Ming-Cai Qin, Yi Zhang, Yong-Li Yang, Chun-Ye He, Yan Zhao, Kun DU, Lin Liu, Wen-Hao Zhou
Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates. Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity. This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes...
April 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#19
JOURNAL ARTICLE
William C Kerr, Camillia K Lui, Yu Ye, Libo Li, Thomas Greenfield, Katherine J Karriker-Jaffe, Priscilla Martinez
BACKGROUND: Despite substantial declines in underage drinking and binge drinking, alcohol consumption has increased in the past 30 years. This study examined how beverage-specific drinking patterns varied by sex, age, and race and ethnicity from 1979 to 2020. METHODS: Secondary data analysis was conducted on pooled data from the National Alcohol Survey series from 1979 to 2020 of a sample of U.S. adults ages 18 years or older. Total and beverage-specific volume were calculated from graduated frequency questions on reported beverage type, which included beer, wine, and spirits...
April 24, 2024: Alcohol Clin Exp Res (Hoboken)
#20
JOURNAL ARTICLE
Lin-Jian Gu, Li Li, Qian-Nan Li, Ke Xu, Wei Yue, Jing-Yi Qiao, Tie-Gang Meng, Ming-Zhe Dong, Wen-Long Lei, Jia-Ni Guo, Zhen-Bo Wang, Qing-Yuan Sun
Environment factors such as diet and lifestyle can influence the health of both mothers and offspring. However, its transgenerational transmission and underlying mechanisms remain largely unknown. Here, using a maternal lactation-period low-protein diet (LPD) mouse model, we show that maternal LPD during lactation causes decreased survival and stunted growth, significantly reduces ovulation and litter size, and alters the gut microbiome in the female LPD-F1 offspring. The transcriptome of LPD-F1 metaphase II (MII) oocytes shows that differentially expressed genes are enriched in female pregnancy and multiple metabolic processes...
April 22, 2024: Journal of Genetics and Genomics
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