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https://www.readbyqxmd.com/read/29234369/bufei-yishen-granules-combined-with-acupoint-sticking-therapy-suppress-inflammation-in-chronic-obstructive-pulmonary-disease-rats-via-jnk-p38-signaling-pathway
#1
Yange Tian, Ya Li, Jiansheng Li, Suxiang Feng, Suyun Li, Jing Mao, Yang Xie, Xuefang Liu, Haoran Dong, Wanchun Zheng, Minghang Wang
The present study was initiated to explore the mechanism of the effects of Bufei Yishen granules combined with acupoint sticking therapy (Shu-Fei Tie) on inflammation regulated by c-Jun N-terminal kinase (JNK) and p38 MAPK signaling in COPD rats. Seventy-two rats were divided into healthy control (Control), Model, Bufei Yishen (BY), acupoint sticking (AS), Bufei Yishen + acupoint sticking (BY + AS), and aminophylline (APL) groups (n = 12 each). COPD rats were exposed to cigarette smoke and bacteria and were given the various treatments from weeks 9 through 20; all animals were sacrificed at the end of week 20...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29219439/strongly-asymmetric-spectroscopy-in-plasmon-exciton-hybrid-systems-due-to-interference-induced-energy-repartitioning
#2
Si-Jing Ding, Xiaoguang Li, Fan Nan, Yu-Ting Zhong, Li Zhou, Xudong Xiao, Qu-Quan Wang, Zhenyu Zhang
Recent intense effort has been devoted to exploring different manifestations of resonant excitations of strongly coupled plasmons and excitons, but so far such studies have been limited to situations where the Fano- or Rabi-type spectra are largely symmetric at zero detuning. Using a newly developed full quantum mechanical model, here we reveal the existence of a highly asymmetric spectroscopic regime for both the Rabi splitting and transparency dip. The asymmetric nature is inherently tied to the non-negligible exciton absorbance and is caused by substantial interference-induced energy repartitioning of the resonance peaks...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29216466/the-spatiotemporal-transmission-of-dengue-and-its-driving-mechanism-a-case-study-on-the-2014-dengue-outbreak-in-guangdong-china
#3
Guanghu Zhu, Jianpeng Xiao, Bing Zhang, Tao Liu, Hualiang Lin, Xing Li, Tie Song, Yonghui Zhang, Wenjun Ma, Yuantao Hao
Dengue transmission is a complex spatiotemporal process with hidden interactions between hosts, vectors, and viruses as well as environment. This study aims to identify the transmission patterns and the driving mechanism that contributed to the dengue epidemics occurred in Guangdong Province of China in 2014. Based on the city-specific epidemiological, meteorological, demographic and geographic data, we first performed wavelet analysis and then integrated the key dynamics (i.e., mosquito population dynamics, human movement, virus transmission, and parameter estimation) into a transmission model...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29212039/comprehensive-mapping-of-pluripotent-stem-cell-metabolism-using-dynamic-genome-scale-network-modeling
#4
Sriram Chandrasekaran, Jin Zhang, Zhen Sun, Li Zhang, Christian A Ross, Yu-Chung Huang, John M Asara, Hu Li, George Q Daley, James J Collins
Metabolism is an emerging stem cell hallmark tied to cell fate, pluripotency, and self-renewal, yet systems-level understanding of stem cell metabolism has been limited by the lack of genome-scale network models. Here, we develop a systems approach to integrate time-course metabolomics data with a computational model of metabolism to analyze the metabolic state of naive and primed murine pluripotent stem cells. Using this approach, we find that one-carbon metabolism involving phosphoglycerate dehydrogenase, folate synthesis, and nucleotide synthesis is a key pathway that differs between the two states, resulting in differential sensitivity to anti-folates...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29211704/histone-deacetylase-hdac-inhibitor-suberoylanilide-hydroxamic-acid-saha-induces-apoptosis-in-prostate-cancer-cell-lines-via-the-akt-foxo3a-signaling-pathway
#5
Xuan-Yan Shi, Wei Ding, Tie-Qiu Li, Yi-Xiong Zhang, Shan-Chao Zhao
BACKGROUND Histone deacetylase (HDAC) inhibitors are emerging as a new class of anti-cancer drugs that promote cancer cell apoptosis, and include suberoylanilide hydroxamic acid (SAHA). The aim of this study was to investigate the mechanism of SAHA-induced apoptosis in human prostate cancer cell lines, DU145 and PC-3. MATERIAL AND METHODS Cell lines, DU145 and PC-3, were studied before and after treatment with SAHA. The effects of SAHA treatment on cell proliferation were studied using the MTT cell proliferation assay...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29209873/99mtc-rituximab-as-a-tracer-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-a-single-center-analysis
#6
Jiwei Wang, Tie Fan, Yingjian He, Xue Chen, Zhaoqing Fan, Yuntao Xie, Tianfeng Wang, Jinfeng Li, Tao Ouyang
PURPOSE: This study aimed to determine the long-term prognosis of breast cancer patients with 99mTc-rituximab for sentinel lymph node biopsy (SLNB). METHODS: A total of 2947 patients with negative sentinel lymph nodes (SLNs) omitting axillary lymph node dissection (ALND), treated between June 2005 and December 2013, were retrospectively analyzed. SLNB was performed prior to adjuvant therapy. RESULTS: After a median follow-up of 62 months, 22 cases of axillary recurrence (AR) were observed...
December 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29208956/pol%C3%AE-o-glcnacylation-governs-genome-integrity-during-translesion-dna-synthesis
#7
Xiaolu Ma, Hongmei Liu, Jing Li, Yihao Wang, Yue-He Ding, Hongyan Shen, Yeran Yang, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, Meng-Qiu Dong, Ping Xu, Tie-Shan Tang, Caixia Guo
DNA polymerase η (Polη) facilitates translesion DNA synthesis (TLS) across ultraviolet (UV) irradiation- and cisplatin-induced DNA lesions implicated in skin carcinogenesis and chemoresistant phenotype formation, respectively. However, whether post-translational modifications of Polη are involved in these processes remains largely unknown. Here, we reported that human Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase upon DNA damage. Abrogation of this modification results in a reduced level of CRL4CDT2-dependent Polη polyubiquitination at lysine 462, a delayed p97-dependent removal of Polη from replication forks, and significantly enhanced UV-induced mutagenesis even though Polη focus formation and its efficacy to bypass across cyclobutane pyrimidine dimers after UV irradiation are not affected...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29207683/non-coding-rna-a-potential-biomarker-and-therapeutic-target-for-sepsis
#8
REVIEW
Tie-Ning Zhang, Da Li, Jing Xia, Qi-Jun Wu, Ri Wen, Ni Yang, Chun-Feng Liu
Sepsis, a syndrome of physiologic, pathologic, and biochemical abnormalities caused by an altered systemic host response to infection, has become the main cause of death among patients admitted to the intensive care units. Recently, genome-wide expression analysis revealed that over 80% of the essential genetic elements were altered in critically ill patients. Notably, non-coding RNAs, including microRNAs, long non-coding RNAs and circular RNAs, have been proven to play essential roles in innate immunity, mitochondrial dysfunction and organ dysfunction...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29183964/regulation-of-blood-testis-barrier-assembly-in-vivo-by-germ-cells
#9
Xiao-Yu Li, Yan Zhang, Xiu-Xia Wang, Cheng Jin, Yu-Qian Wang, Tie-Cheng Sun, Jian Li, Ji-Xin Tang, Alia Batool, Shou-Long Deng, Su-Ren Chen, C Yan Cheng, Yi-Xun Liu
The assembly of the blood-testis barrier (BTB) during postnatal development is crucial to support meiosis. However, the role of germ cells in BTB assembly remains unclear. Herein, KitW/KitWV mice were used as a study model. These mice were infertile, failing to establish a functional BTB to support meiosis due to c-Kit mutation. Transplantation of undifferentiated spermatogonia derived from normal mice into the testis of KitW/KitWV mice triggered functional BTB assembly, displaying cyclic remodeling during the epithelial cycle...
November 28, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29183824/zika-virus-infection-in-travelers-returning-from-countries-with-local-transmission-guangdong-china-2016
#10
Haimei Jia, Meng Zhang, Maoyu Chen, Zhiwen Yang, Jiansen Li, Guo Huang, Dawei Guan, Xiaoli Cen, Lijie Zhang, Qiwen Feng, Jianron Yi, De Wu, Haojie Zhong, Huilai Ma, Tie Song
BACKGROUND: Zika virus (ZIKV) is a mosquito-borne virus spreading rapidly in the Americas, Africa, and Asia. No indigenous ZIKV infection had been seen in China. We monitored ZIKV infection among travelers returning to Enping county from ZIKV transmitting countries from 1 March to 10 April 2016. METHODS: We analyzed data including interviews; conducted laboratory test on blood, urine, saliva, conjunctival swab or semen specimens for evidence of ZIKV infection; evaluated household for presence of Aedes mosquitoes or larvae...
November 25, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29181323/a-new-interpretation-and-quantitative-method-for-diplopia-test-304-cases-of-ocular-motor-nerve-palsy-for-clinical-test-and-verify
#11
Ling-Yun Zhou, Tie-Juan Liu, Xue-Mei Li, Chang Su, Xiao-Jie Ji, Ming Zhao
We introduce a new interpretation and quantitative method for computerized diplopia test. By comparing this new method to the Hess screen test, we validate its applicability among 304 patients with ocular motor nerve palsy. This new method shows great assistant value as the Hess screen test in making accurate diagnosis and quantitative evaluation the severity of diplopia. Furthermore, it is more convenient and suitable for daily clinical use.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29175152/transplantation-of-human-umbilical-cord-blood-mononuclear-cells-attenuated-ischemic-injury-in-mcao-rats-via-inhibition-of-nf-%C3%AE%C2%BAb-andnlrp3inflammasome
#12
Lu Liu, Juan Cen, Yong Man, Jianbin Li, Dahuan Zhang, Fei Wang, Jinhua Li, Ji Ma, Xiaoming Wang, Biansheng Ji
Accumulated evidences displayed that transplantation of stem cells may be a promising approach for the treatment of neurological disorders. However, the underlying mechanisms remain to be well elucidated. Moreover, some investigators can not reproduce similar results as the previous. The present results showed that transplantation of fresh human umbilical cord blood mononuclear cells (cbMNCs) attenuated ischemic damage in middle cerebral artery occlusion (MCAO) rats, accompanied with improvement of neurologic deficits, learning and memory function...
November 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/29172978/application-of-the-fda-biosimilar-extrapolation-framework-to-make-off-label-determinations
#13
Edward Li, Ernesto Lobaina
BACKGROUND: The FDA's extrapolation framework allows for a biosimilar to obtain licensure for indications that were not explicitly studied in the context of a clinical trial by extending conclusions from studies in 1 population to make inferences in other populations. Within routine clinical care, drugs and biologics are routinely used for medically accepted off-label indications. The appropriateness of these products for off-label indications are typically curated by compendia and guidelines, which have established processes and criteria for reviewing and evaluating the evidence to make such determinations...
December 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29170554/mechanotransduction-modulated-fibrotic-microniches-reveal-the-contribution-of-angiogenesis-in-liver-fibrosis
#14
Longwei Liu, Zhifeng You, Hongsheng Yu, Lyu Zhou, Hui Zhao, Xiaojun Yan, Dulei Li, Bingjie Wang, Lu Zhu, Yuzhou Xu, Tie Xia, Yan Shi, Chenyu Huang, Wei Hou, Yanan Du
The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid endothelial cells (LSECs) and hepatic stellate cells (HSCs). We investigated how the mechanical properties of their substrates affect the formation of capillary-like structures and how they relate to the progression of angiogenesis during liver fibrosis. Differences in cell response in the FμNs were synonymous of the early and late stages of liver fibrosis...
December 2017: Nature Materials
https://www.readbyqxmd.com/read/29168231/a-newly-hybrid-anchoring-balloon-for-direct-peroral-cholangioscopy-using-an-ultraslim-upper-endoscope
#15
Jian Li, Shao-Ju Guo, Jing-Chao Zhang, Hong-Yan Wang, Kai Li, She-Hui Niu
OBJECTIVES: Large impacted or residual invisible common bile duct (CBD) stones after mechanical lithotripsy are challenging. We aimed to evaluate the feasibility and success rate of a new hybrid anchoring balloon-guided direct peroral cholangioscopy (POC) for these conditions, using an ultraslim endoscope. METHODS: Sixty-five patients with large or residual invisible CBD stones for direct POC from July 2012 to July 2016 were identified, including 6 cases in whom an additional interventional procedure was required...
November 23, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29164214/withapubesides-a-d-natural-inducible-nitric-oxide-synthase-inos-inhibitors-from-physalis-pubescens
#16
Gui-Yang Xia, Tie Yao, Bing-Yang Zhang, Yang Li, Ning Kang, Shi-Jie Cao, Li-Qin Ding, Li-Xia Chen, Feng Qiu
Four new steroid glycosides, withapubesides A-D (1-4), were isolated from the stems of Physalis pubescens L. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were deduced by single-crystal X-ray diffraction and ECD data analysis, respectively. Compound 3 has shown significant inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with an IC50 value of 12.8 μM and moderate cytostatic activity against human carcinoma cells (786-O, C4-2B, 22Rvl, A375 and A375S2) with IC50 values in the range of 3...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29163882/rapid-and-precise-determination-of-zero-field-splittings-by-terahertz-time-domain-electron-paramagnetic-resonance-spectroscopy
#17
Jian Lu, I Ozge Ozel, Carina A Belvin, Xian Li, Grigorii Skorupskii, Lei Sun, Benjamin K Ofori-Okai, Mircea Dincă, Nuh Gedik, Keith A Nelson
Zero-field splitting (ZFS) parameters are fundamentally tied to the geometries of metal ion complexes. Despite their critical importance for understanding the magnetism and spectroscopy of metal complexes, they are not routinely available through general laboratory-based techniques, and are often inferred from magnetism data. Here we demonstrate a simple tabletop experimental approach that enables direct and reliable determination of ZFS parameters in the terahertz (THz) regime. We report time-domain measurements of electron paramagnetic resonance (EPR) signals associated with THz-frequency ZFSs in molecular complexes containing high-spin transition-metal ions...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29159497/correction-to-superior-biomechanical-properties-and-tying-time-with-the-modified-prusik-knot-and-wittstein-suture-loop-to-the-krackow-stitch
#18
Chih-Kai Hong, Cheng-Li Lin, Jui-Ming Yang, Chien-An Shih, Yi-Chuan Chou, Ming-Long Yeh, Chen-Hao Chiang, Wei-Ren Su
Due to an error during the production process, the legend.
November 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29150676/severe-pollution-in-china-amplified-by-atmospheric-moisture
#19
Xuexi Tie, Ru-Jin Huang, Junji Cao, Qiang Zhang, Yafang Cheng, Hang Su, Di Chang, Ulrich Pöschl, Thorsten Hoffmann, Uli Dusek, Guohui Li, Douglas R Worsnop, Colin D O'Dowd
In recent years, severe haze events often occurred in China, causing serious environmental problems. The mechanisms responsible for the haze formation, however, are still not well understood, hindering the forecast and mitigation of haze pollution. Our study of the 2012-13 winter haze events in Beijing shows that atmospheric water vapour plays a critical role in enhancing the heavy haze events. Under weak solar radiation and stagnant moist meteorological conditions in winter, air pollutants and water vapour accumulate in a shallow planetary boundary layer (PBL)...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29149871/near-work-outdoor-activity-and-myopia-in-children-in-rural-china-the-handan-offspring-myopia-study
#20
Zhong Lin, Tie Ying Gao, Balamurali Vasudevan, Kenneth J Ciuffreda, Yuan Bo Liang, Vishal Jhanji, Su Jie Fan, Wei Han, Ning Li Wang
BACKGROUND: The near work and outdoor activity are the most important environmental risk factors for myopia. However, data from Chinese rural children are relatively rare and remain controversial. Therefore, the purpose of this study was to evaluate the relationship of both near work and outdoor activities with refractive error in rural children in China. METHODS: In this cross-sectional study, 572 (65.1%) of 878 children (6-18 years of age) were included from the Handan Offspring Myopia Study (HOMS)...
November 17, 2017: BMC Ophthalmology
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