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https://www.readbyqxmd.com/read/28343037/concentration-and-sources-of-atmospheric-nitrous-acid-hono-at-an-urban-site-in-western-china
#1
Ru-Jin Huang, Lu Yang, Junji Cao, Qiyuan Wang, Xuexi Tie, Kin-Fai Ho, Zhenxing Shen, Renjian Zhang, Guohui Li, Chongshu Zhu, Ningning Zhang, Wenting Dai, Jiamao Zhou, Suixin Liu, Yang Chen, Jun Chen, Colin D O'Dowd
Highly time-resolved measurements of nitrous acid (HONO) were carried out with a highly sensitive long path absorption photometer (LOPAP) at an urban site of Xi'an in Western China from 24 July to 6 August 2015 to investigate the atmospheric variations, sources, and formation pathways of HONO. The concentrations of HONO vary from 0.02 to 4.3ppbv with an average of 1.12ppbv for the entire measurement period. The variation trends of HONO and NO2 are very similar and positively correlated which, together with the similar diurnal profiles of HONO/NO2 ratio and HONO, suggest the importance of heterogeneous conversion of HONO from NO2...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28332573/discovery-of-multi-target-receptor-tyrosine-kinase-inhibitors-as-novel-anti-angiogenesis-agents
#2
Jinfeng Wang, Lin Zhang, Xiaoyan Pan, Bingling Dai, Ying Sun, Chuansheng Li, Jie Zhang
Recently, we have identified a biphenyl-aryl urea incorporated with salicylaldoxime (BPS-7) as an anti-angiogenesis agent. Herein, we disclosed a series of novel anti-angiogenesis agents with BPS-7 as lead compound through combining diarylureas with N-pyridin-2-ylcyclopropane carboxamide. Several title compounds exhibited simultaneous inhibition effects against three pro-angiogenic RTKs (VEGFR-2, TIE-2 and EphB4). Some of them displayed potent anti-proliferative activity against human vascular endothelial cell (EA...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317348/-expression-and-significance-of-wingless-type-mmtv-integration-site-family-member-5a-receptor-tyrosine-kinase-like-orphan-receptor-2-in-the-rat-dental-follicle
#3
Wang Liping, Li Boqi, Wang Qi, Tie Xiaomin, Liu Yishan
OBJECTIVE: To observe the expression of wingless-type MMTV integration site family, member 5A (Wnt5A)/receptor tyrosine kinase-like orphan receptor 2 (Ror2) signal in the dental follicle cells during the normal eruption of the teeth as well as to explore the relationship between the expression of dental follicle cells and the formation of mature osteoclasts and eruption of the teeth. METHODS: The mandibulars of 1-13 d old SD rats were separated to observe the growth and develop-ment of the teeth and alveolar bone through hematoxylin-eosin(HE) staining...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28317323/a-functional-snp-regulated-by-mir-196a-3p-in-the-3-utr-of-fgf2-is-associated-with-bone-mineral-density-in-the-chinese-population
#4
Dong-Li Zhu, Yan Guo, Yan Zhang, Shan-Shan Dong, Wen Xu, Ruo-Han Hao, Xiao-Feng Chen, Han Yan, Shui-Yun Yang, Tie-Lin Yang
Previous studies have identified FGF2 as a susceptibility gene for osteoporosis in Caucasians. Evaluating the genetic associations in different ethnicities is necessary. Moreover, elucidating the functional mechanism for the susceptibility loci is important to offer new targets for therapeutic studies. Here, we genotyped ten SNPs in FGF2 and tested for associations with bone mineral density (BMD) in a discovery sample of 1300 Chinese subjects. Nominally significant results were subjected to replication in another sample of 1039 Chinese subjects...
March 19, 2017: Human Mutation
https://www.readbyqxmd.com/read/28300915/onychogryphosis-in-tuberous-sclerosis-complex-an-unusual-feature
#5
Xiang-Chun Han, Li-Qiang Zheng, Tie-Gang Zheng
Onychogryphosis is an acquired nail plate change. It often affects the toenail and is characterized by an opaque, yellow-brownish nail plate that is distorted, grossly thickened, elongated, and partly curved resembling a ram's horn. Tuberous sclerosis complex is a multisystem disorder associated with high rates of mental retardation, autism, cognitive impairment, behavioral problems, or seizures. Nail disease can also be associated, which is a concern to patients due to pain and nail distortion. We reported a typical tuberous sclerosis complex patient with distinctive clinical features of a ram's horn nails, which presented a great challenge to surgical treatment and nail restoration...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28299879/how-accurate-are-medical-oncologists-impressions-of-management-of-metastatic-colorectal-cancer-in-australia
#6
Lewis Au, Natalie Turner, Hui-Li Wong, Kathryn Field, Belinda Lee, David Boadle, Prasad Cooray, Deme Karikios, Suzanne Kosmider, Lara Lipton, Louise Nott, Phillip Parente, Jeanne Tie, Ben Tran, Rachel Wong, Desmond Yip, Jeremy Shapiro, Peter Gibbs
AIM: Current efforts to understand patient management in clinical practice are largely based on clinician surveys with uncertain reliability. The TRACC (Treatment of Recurrent and Advanced Colorectal Cancer) database is a multisite registry collecting comprehensive treatment and outcome data on consecutive metastatic colorectal cancer (mCRC) patients at multiple sites across Australia. This study aims to determine the accuracy of oncologists' impressions of real-word practice by comparing clinicians' estimates to data captured by TRACC...
March 16, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28299345/neutrophils-and-immunity-from-bactericidal-action-to-being-conquered
#7
REVIEW
Tie-Shan Teng, Ai-Ling Ji, Xin-Ying Ji, Yan-Zhang Li
The neutrophil is the major phagocyte and the final effector cell of the innate immunity, with a primary role in the clearance of extracellular pathogens. Using the broad array of cytokines, extracellular traps, and effector molecules as the humoral arm, neutrophils play a crucial role in the host defense against pathogen infections. On the other hand, the pathogen has the capacity to overcome neutrophil-mediated host defense to establish infection causing human disease. Pathogens, such as S. aureus, have the potential to thwart neutrophil chemotaxis and phagocytosis and thereby succeed in evading killing by neutrophils...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28296728/a-meta-analysis-comparing-the-outcomes-of-ligasure-small-jaw-versus-clamp-and-tie-technique-or-harmonic-focus-scalpel-in-thyroidectomy
#8
COMPARATIVE STUDY
Lei Zhang, Namei Li, Xuemei Yang, Jie Chen
BACKGROUND: LigaSure (LS) Small Jaw is a surgical hemostasis equipment that is newly introduced in thyroid surgery. The objective of this study is to assess the short-term efficacy and safety outcomes of LS Small Jaw compared with clamp-and-tie technique or Harmonic Focus Scalpel in thyroidectomy. METHODS: A literature search was performed in the PubMed and Embase databases (until June 12, 2016) that reported the comparisons between LS Small Jaw and other techniques in thyroidectomy...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28289045/efficacy-and-safety-of-lapatinib-and-trastuzumab-for-her2-positive-breast-cancer-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#9
Zhi-Qiao Xu, Yan Zhang, Ning Li, Pei-Jie Liu, Ling Gao, Xin Gao, Xiao-Jing Tie
OBJECTIVES: The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary mechanisms of action and synergistic antitumour actively in models of HER2-positive breast cancer. However, the efficacy of trastuzumab in combination with lapatinib remains controversial. Therefore, we conducted this meta-analysis to compare combination treatment with lapatinib and trastuzumab to trastuzumab or lapatinib alone in the treatment of HER2-positive breast cancer...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28275732/a-three-degree-horizon-of-peace-in-the-military-alliance-network
#10
Weihua Li, Aisha E Bradshaw, Caitlin B Clary, Skyler J Cranmer
States form defensive military alliances to enhance their security in the face of potential or realized interstate conflict. The network of these international alliances is increasingly interconnected, now linking most of the states in a complex web of ties. These alliances can be used both as a tool for securing cooperation and to foster peace between direct partners. However, do indirect connections-such as the ally of an ally or even further out in the alliance network-result in lower probabilities of conflict? We investigate the extent to which military alliances produce peace between states that are not directly allied...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28272483/snp-snp-interactions-between-wnt4-and-wnt5a-were-associated-with-obesity-related-traits-in-han-chinese-population
#11
Shan-Shan Dong, Wei-Xin Hu, Tie-Lin Yang, Xiao-Feng Chen, Han Yan, Xiang-Ding Chen, Li-Jun Tan, Qing Tian, Hong-Wen Deng, Yan Guo
Considering the biological roles of WNT4 and WNT5A involved in adipogenesis, we aimed to investigate whether SNPs in WNT4 and WNT5A contribute to obesity related traits in Han Chinese population. Targeted genomic sequence for WNT4 and WNT5A was determined in 100 Han Chinese subjects and tag SNPs were selected. Both single SNP and SNP × SNP interaction association analyses with body mass index (BMI) were evaluated in the 100 subjects and another independent sample of 1,627 Han Chinese subjects. Meta-analyses were performed and multiple testing corrections were carried out using the Bonferroni method...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272417/effects-of-the-tlr4-signaling-pathway-on-apoptosis-of-neuronal-cells-in-diabetes-mellitus-complicated-with-cerebral-infarction-in-a-rat-model
#12
Chao Li, Li-He Che, Tie-Feng Ji, Lei Shi, Jin-Lu Yu
This study aims to explore the effects of the TLR4 signaling pathway on the apoptosis of neuronal cells in rats with diabetes mellitus complicated with cerebral infarction (DMCI). A DMCI model was established with 40 Sprague Dawley rats, which were assigned into blank, sham, DM + middle cerebral artery occlusion (MCAO) and DM + MCAO + TAK242 groups. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were measured. A TUNEL assay was applied for detecting cell apoptosis, and Western blotting was used for detecting the expression of TLR4, TNF-α, IL-1β and apoptosis-related proteins...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28258568/aquaporins-in-cardiovascular-system
#13
Lu Tie, Di Wang, Yundi Shi, Xuejun Li
Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28251080/clinical-results-of-non-descemet-stripping-endothelial-keratoplasty
#14
Tao Zhang, Shao-Wei Li, Tie-Hong Chen, Jing-Liang He, Yan-Wei Kang, Fang-Qi Lyu, Jian-Hua Ning, Chang Liu
AIM: To investigate the impact of non-Descemet stripping endothelial keratoplasty (non-DSEK) on graft rejection rate, and its overall procedural effectiveness in patients. METHODS: Non-DSEK was performed on 65 eyes of 64 patients, and the procedural outcomes, including rejection episodes, failure and dislocation of the grafts, best corrected visual acuity (BCVA), endothelial cell density (ECD), and other complications, were analyzed retrospectively. RESULTS: Of the 65 eyes, 63 recovered from bullous keratopathy with a clear cornea...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28248096/a-three-dimensional-molecular-perovskite-ferroelectric-3-ammoniopyrrolidinium-rbbr3
#15
Qiang Pan, Zhi-Bo Liu, Yuan-Yuan Tang, Peng-Fei Li, Rong-Wei Ma, Ru-Yuan Wei, Yi Zhang, Yu-Meng You, Heng-Yun Ye, Ren-Gen Xiong
It is known that CH3NH3PbI3 is particularly promising for next-generation solar devices; therefore, molecular perovskite structures have recently received extraordinary attention from the academic community because of their potential in producing unique physical properties. However, although great efforts have been made, molecular ferroelectrics with three-dimensional (3D) perovskite structures are still rare. So far, reported perovskite-like molecular ferroelectrics are basically one- or two-dimensional, significantly deviating from the inorganic perovskite ferroelectrics...
March 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28242773/adipose-specific-deletion-of-kif5b-exacerbates-obesity-and-insulin-resistance-in-a-mouse-model-of-diet-induced-obesity
#16
Ju Cui, Jing Pang, Ya-Jun Lin, Huan Gong, Zhen-He Wang, Yun-Xuan Li, Jin Li, Zai Wang, Ping Jiang, Da-Peng Dai, Jian Li, Jian-Ping Cai, Jian-Dong Huang, Tie-Mei Zhang
Recent studies have shown that KIF5B (conventional kinesin heavy chain) mediates glucose transporter type 4 translocation and adiponectin secretion in 3T3-L1 adipocytes, suggesting an involvement of KIF5B in the homeostasis of metabolism. However, the in vivo physiologic function of KIF5B in adipose tissue remains to be determined. In this study, adipose-specific Kif5b knockout (F-K5bKO) mice were generated using the Cre-LoxP strategy. F-K5bKO mice had similar body weights to controls fed on a standard chow diet...
February 27, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28237907/pathology-targeted-cell-delivery-via-injectable-micro-scaffold-capsule-mediated-by-endogenous-tgase
#17
Chunxiao Qi, Yaqian Li, Patrick Badger, Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Yan Shi, Tie Xia, Jiahong Dong, Chenyu Huang, Yanan Du
Targeted cell delivery to lesion sites via minimally invasive approach remains an unmet need in regenerative medicine to endow satisfactory therapeutic efficacy and minimized side-effects. Here, we rationally designed a pathology-targeted cell delivery strategy leveraging injectable micro-scaffolds as cell-loading capsule and endogenous tissue transglutaminase (TGase) at lesion site as adhesive. Up-regulated TGase post-liver injury catalyzed chemical bonding between the glutamine and lysine residues on liver surface and micro-scaffolds both ex vivo and in vivo, facilitating sufficient adhesion on the pathological liver...
February 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28220881/use-of-selective-serotonin-reuptake-inhibitors-in-the-first-trimester-and-risk-of-cardiovascular-related-malformations-a-meta-analysis-of-cohort-studies
#18
Tie-Ning Zhang, Shan-Yan Gao, Zi-Qi Shen, Da Li, Cai-Xia Liu, Hai-Chen Lv, Yuan Zhang, Ting-Ting Gong, Xin Xu, Chao Ji, Qi-Jun Wu
The relationship between selective serotonin-reuptake inhibitors (SSRIs) use during first trimester and cardiovascular-related malformations of infants is still uncertain. Therefore, we conducted this systematic review and meta-analysis to assess the aforementioned association. A systematic literature review identified studies for cohort studies about SSRIs use and cardiovascular-related malformations in PubMed and Web of Science. We summarized relative risk (RRs) and 95% confidence intervals (CIs) of cardiovascular-related malformations using random-effects model, and heterogeneity and publication-bias analyses were conducted...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216250/biotransfomation-of-cyperenoic-acid-by-cunninghamella-elegans-as-3-2028-and-the-potent-anti-angiogenic-activities-of-its-metabolites
#19
Yu Chen, Jin-Long Tian, Jing-Shuai Wu, Tie-Min Sun, Li-Na Zhou, Shao-Jiang Song, Song You
Cyperenoic acid (1) is one of the major sesquiterpenes isolated from Croton crassifolius, which exhibited potent anti-angiogenic activity. Traditional structural modification of 1 is difficult to perform by chemical technology due to the remarkable stability of the patchoulane skeleton. In order to overcome chemical synthesis difficulties and obtain structurally diverse derivations, microbial transformation of 1 by using Cunninghamella elegans AS 3.2028 was studied for the first time. Five new hydroxylated products 2-6 were obtained...
February 16, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28212323/low-intensity-extracorporeal-shock-wave-therapy-enhances-brain-derived-neurotrophic-factor-expression-through-perk-atf4-signaling-pathway
#20
Bohan Wang, Hongxiu Ning, Amanda B Reed-Maldonado, Jun Zhou, Yajun Ruan, Tie Zhou, Hsun Shuan Wang, Byung Seok Oh, Lia Banie, Guiting Lin, Tom F Lue
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but its mechanisms are not well understood. Previously, we found that Li-ESWT increased the expression of brain-derived neurotrophic factor (BDNF). Here we assessed the underlying signaling pathways in Schwann cells in vitro and in penis tissue in vivo after nerve injury. The result indicated that BDNF were significantly increased by the Li-ESWT after nerve injury, as well as the expression of BDNF in Schwann cells (SCs, RT4-D6P2T) in vitro...
February 16, 2017: International Journal of Molecular Sciences
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