keyword
MENU ▼
Read by QxMD icon Read
search

invasive pulmonary aspergillosis

keyword
https://www.readbyqxmd.com/read/27913978/case-series-study-of-invasive-pulmonary-aspergillosis
#1
Ana I Aller-García, Carmen Castro-Méndez, Ana Alastruey-Izquierdo, Elena M Marín-Martínez, Ismail Zakariya-Yousef Breval, Carmen Couto-Caro, Juan C López-Marín, Nicolás Peña-Griñán, Maite Ruiz de Pipaon, Ana M Romero-Mejías, Estrella Martín-Mazuelos
Diagnosis of invasive pulmonary aspergillosis (IPA) is challenging. The objective of the study was to assess the value of microbiological tests to the diagnosis of IPA in the absence of non-specific radiological data. A retrospective study of 23 patients with suspicion of IPA and positivity of some microbiological diagnostic tests was performed. These tests included conventional microbiological culture, detection of Aspergillus galactomannan (GM) antigen and in some patients (1 → 3)-β-D-glucan (BDG) and Aspergillus fumigatus DNA using the LightCycler(®) SeptiFast test...
December 2, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27900022/conversion-of-aspergilloma-to-chronic-necrotizing-pulmonary-aspergillosis-following-treatment-with-sunitinib-a-case-report
#2
Yeon Wook Kim, Hyun Woo Lee, Jaeyoung Cho, Han-Sol Choi, Jungsil Lee, Sung Soo Park, Eun Young Heo, Kwang Nam Jin, Deog Kyeom Kim
Semi-invasive or invasive aspergillosis occurring following chemotherapy with sunitinib is a rare condition with unknown incidence and prognosis. Here, we report a case involving a 59-year-old male who had a history of underlying stable aspergilloma and was newly diagnosed with metastatic renal cell carcinoma. Following surgical resection for renal cell carcinoma and adjuvant chemotherapy with sunitinib for 8 months, the patient presented with hemoptysis. Chest computed tomography revealed an increased soft tissue mass and air crescent sign of the underlying aspergilloma, combined with consolidation and bronchial artery hypertrophy around the lesion...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889954/invasive-pulmonary-aspergillosis-in-a-patient-with-metastatic-non-small-cell-lung-cancer-after-treatment-with-gefitinib
#3
Sejeong Park, Soyoung Park, Hana Choi, Ji Young Park, Hyo Seok Lim, Myung Jae Park, Si-Young Kim
No abstract text is available yet for this article.
November 25, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27889253/blood-and-tissue-distribution-of-posaconazole-in-a-rat-model-of-invasive-pulmonary-aspergillosis
#4
E Cendejas-Bueno, A Forastiero, I Ruiz, E Mellado, J Gavaldà, A Gomez-Lopez
Posaconazole is the recommended prophylactic agent in patients at high risk of invasive fungal infection, since adequate drug levels seem to be reached in target sites despite the relatively low levels detected in blood. The objective of this study is to obtain pharmacokinetic (PK) information associated to blood and tissue distribution of posaconazole in an animal model of invasive pulmonary aspergillosis. The PK parameters in lung samples were systematically higher than in serum. After multiple-dose administration of posaconazole, a significant accumulation of the drug was evident in lung tissue...
October 11, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27887809/an-estimation-of-burden-of-serious-fungal-infections-in-france
#5
J-P Gangneux, M-E Bougnoux, C Hennequin, C Godet, J Chandenier, D W Denning, B Dupont
OBJECTIVE OF THE STUDY: An estimation of burden of serious fungal diseases in France is essential data to inform public health priorities on the importance of resources and research needed on these infections. In France, precise data are available for invasive fungal diseases but estimates for several other diseases such as chronic and immunoallergic diseases are by contrast less known. MATERIALS AND METHODS: A systematic literature search was conducted using the Web of Science Platform...
November 22, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27842866/reviewing-the-importance-and-evolution-of-fungal-infections-and-potential-antifungal-resistance-in-haematological-patients
#6
REVIEW
Alessandro Busca, Anna Maria Tortorano, Livio Pagano
There is a growing body of evidence supporting the emergence of azole resistance in Aspergillus and Candida spp. and this may be of particular concern due to the potential implications in the management of invasive fungal infections occurring in immunocompromised hosts. The aim of present review was to describe the magnitude of the problem, summarising the epidemiology and potential impact of yeast and mould antifungal resistance in patients with haematological malignancies. The first cases of triazole-resistant Aspergillus fumigatus isolates were reported in 1997 in patients receiving itraconazole...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27836224/-infectious-events-during-the-course-of-autoimmune-diseases-treated-with-rituximab-a-retrospective-study-of-93%C3%A2-cases
#7
M Catroux, M Lauda-Maillen, M Pathe, A-C De Boisgrollier de Ruolz, F Cazenave-Roblot, P Roblot, O Souchaud-Debouverie
OBJECTIVE: Describe the occurring infections in patients treated with rituximab for an autoimmune disease. METHODS: Retrospective and monocentric study of 93 adult patients treated with rituximab for autoimmune indications over a nine years period. RESULTS: Thirty-eight patients suffered from a total of 95 infections. Out of them, 18 patients (19 %) had had at least an infectious episode triggering a hospital admission and/or intravenous treatment...
November 8, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27826887/diagnosis-of-invasive-pulmonary-aspergillosis
#8
E Swoboda-Kopeć, M Sikora, K Piskorska, M Gołaś, I Netsvyetayeva, D Przybyłowska, E Mierzwińska-Nastalska
Culturing strains from clinical samples is the main method to diagnose invasive pulmonary aspergillosis. Detecting the galactomannan antigen in serum samples is an auxiliary examination. The goal of this study was to determine the frequency with which Aspergillus fumigatus was cultured in clinical samples taken from patients hospitalized in the the Infant Jesus Teaching Hospital in Warsaw, Poland, in the period of 2013-2014. Specimens from the respiratory tract and blood were cultured for mycological and serological assessments...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27826143/application-of-a-low-molecular-weight-antifungal-protein-from-penicillium-chrysogenum-paf-to-treat-pulmonary-aspergillosis-in-mice
#9
Zoltán Palicz, Tamás Gáll, Éva Leiter, Sándor Kollár, Ilona Kovács, Kornél Miszti-Blasius, István Pócsi, László Csernoch, Péter Szentesi
PAF, a small antifungal protein from Penicillium chrysogenum, inhibits the growth of several pathogenic filamentous fungi, including members of the Aspergillus genus. PAF has been proven to have no toxic effects in vivo in mice by intranasal application. To test its efficacy against invasive pulmonary aspergillosis (IPA), experiments were carried out in mice suffering from IPA. Adult mice were immunosuppressed and then infected with Aspergillus fumigatus. After stable infection, the animals were inoculated with PAF intranasally at a concentration of 2...
November 9, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27816904/aspergillus-serology-have-we-arrived-yet
#10
Malcolm D Richardson, Iain D Page
Aspergillosis presents in various clinical forms, among them chronic pulmonary aspergillosis, which is a spectrum of disease entities including aspergilloma, chronic cavitary pulmonary aspergillosis, and chronic fibrosing pulmonary aspergillosis. Aspergillus also contributes to fungal allergy and sensitization. Analysis of the immune response to Aspergillus and its antigens is an integral part of the diagnosis of these diseases. Over the past half century, the techniques used to determine antibody titers have evolved from testing for precipitating and agglutinating antibodies by agar gel double diffusion and immunolectrophoresis to enzyme-linked immunosorbent assays using recombinant proteins as capture antigens...
November 5, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27799353/posaconazole-loaded-leukocytes-as-a-novel-treatment-strategy-targeting-invasive-pulmonary-aspergillosis
#11
Shane R Baistrocchi, Mark J Lee, Melanie Lehoux, Benjamin Ralph, Brendan D Snarr, Robert Robitaille, Donald C Sheppard
BACKGROUND:  Impaired delivery of antifungals to hyphae within necrotic lesions is thought to contribute to therapeutic failure in invasive pulmonary aspergillosis (IPA). We hypothesized that transfusion of leukocytes loaded ex-vivo with the lipophilic antifungal posaconazole could improve delivery of antifungals to the sites of established infection and improve outcome in experimental IPA. METHODS:  The HL-60 leukemia cell line was differentiated to a neutrophil-like phenotype (dHL-60 cells) then exposed to a range of posaconazole concentrations...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27796076/emergency-management-of-life-threatening-haemoptysis-due-to-invasive-pulmonary-aspergillosis-in-a-sarcoidosis-patient
#12
Florentina Popescu, Mathias Lutz, Maninder Singh Kalkat, Dincer Aktuerk
No abstract text is available yet for this article.
October 30, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27795351/genotyping-of-aspergillus-fumigatus-reveals-compartmentalization-of-genotypes-in-disseminated-disease-after-invasive-pulmonary-aspergillosis
#13
Pilar Escribano, Patricia Muñoz, Pedro Montilla, Belén Padilla, Emilio Bouza, Jesús Guinea
Invasive pulmonary aspergillosis disseminated to distant organs (IPAd) is uncommon (1, 2) and has traditionally been considered a monomicrobial infection caused by a single A. fumigatus clone present both in the lower respiratory tract and at distant sites (3, 4).….
October 26, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27794529/bronchiectasis-and-aspergillus-how-are-they-linked
#14
Anthony De Soyza, Stefano Aliberti
Bronchiectasis is a chronic airway infection syndrome, distinct from cystic fibrosis that is rising in prevalence and is associated with significant morbidity and mortality. It can be caused by many etiologies including post-infectious effects or be seen in common lung diseases such as chronic obstructive pulmonary disease (COPD) or severe asthma. Bronchiectasis is associated with many Aspergillus-associated syndromes: allergic bronchopulmonary aspergillosis (ABPA) may complicate asthma, thus leading to bronchiectasis as part of the diagnostic criteria of ABPA or can complicate preexisting bronchiectasis due to another etiology...
October 28, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27789254/estimating-the-burden-of-invasive-and-serious-fungal-disease-in-the-united-kingdom
#15
Matthew Pegorie, David W Denning, William Welfare
BACKGROUND: The burden of fungal disease in the UK is unknown. Only limited data are systematically collected. We have estimated the annual burden of invasive and serious fungal disease. METHODS: We used several estimation approaches. We searched and assessed published estimates of incidence, prevalence or burden of specific conditions in various high risk groups. Studies with adequate internal and external validity allowed extrapolation to estimate current UK burden...
October 24, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27784492/-reversed-halo-sign-chest-ct-findings-in-5-patients-and-cause-analysis
#16
M Lu, Y H Chen, X Han, W Yang, J Zhang, X Zhu, H Zhu, B He, B Z Sun, W Z Yao
Objective: To describe diseases that may present with the reversed halo sign (RHS) on high-resolution CT, and therefore to improve the recognition of this thoracic radiological feature. Methods: We retrospectively reviewed the HRCT scans and medical records of 5 patients who presented with RHS on chest CT from Peking University Third Hospital. With "reversed halo sign, fairy ring, atoll sign" as the Chinese and English keywords, 420 cases from the literatures were also reviewed through PubMed, Wanfang and CNKI databases until August 2015...
October 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27783381/increased-mortality-in-hematological-malignancy-patients-with-acute-respiratory-failure-from-undetermined-etiology-a-groupe-de-recherche-en-r%C3%A3-animation-respiratoire-en-onco-h%C3%A3-matologique-grrr-oh-study
#17
Adrien Contejean, Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Michael Darmon, Mercé Jourdain, Anne Renault, Benoît Schlemmer, Elie Azoulay
BACKGROUND: Acute respiratory failure (ARF) is the most frequent complication in patients with hematological malignancies and is associated with high morbidity and mortality. ARF etiologies are numerous, and despite extensive diagnostic workflow, some patients remain with undetermined ARF etiology. METHODS: This is a post-hoc study of a prospective multicenter cohort performed on 1011 critically ill hematological patients. Relationship between ARF etiology and hospital mortality was assessed using a multivariable regression model adjusting for confounders...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27777981/extrapulmonary-aspergillus-infection-in-patients-with-card9-deficiency
#18
Nikolaus Rieber, Roel P Gazendam, Alexandra F Freeman, Amy P Hsu, Amanda L Collar, Janyce A Sugui, Rebecca A Drummond, Chokechai Rongkavilit, Kevin Hoffman, Carolyn Henderson, Lily Clark, Markus Mezger, Muthulekha Swamydas, Maik Engeholm, Rebecca Schüle, Bettina Neumayer, Frank Ebel, Constantinos M Mikelis, Stefania Pittaluga, Vinod K Prasad, Anurag Singh, Joshua D Milner, Kelli W Williams, Jean K Lim, Kyung J Kwon-Chung, Steven M Holland, Dominik Hartl, Taco W Kuijpers, Michail S Lionakis
Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital immunodeficiency. We studied the clinical, genetic, histological, and immunological features of 2 unrelated patients without known immunodeficiency who developed extrapulmonary invasive aspergillosis at the ages of 8 and 18. One patient died at age 12 with progressive intra-abdominal aspergillosis. The other patient had presented with intra-abdominal candidiasis at age 9, and developed central nervous system aspergillosis at age 18 and intra-abdominal aspergillosis at age 25...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27761457/the-role-of-galactomannan-testing-to-diagnose-invasive-pulmonary-aspergillosis-in-critically-ill-patients
#19
COMMENT
Maya Hites, Eduardo Wilfrido Goicoechea Turcott, Fabio Silvio Taccone
No abstract text is available yet for this article.
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27761456/improving-diagnostic-accuracy-for-invasive-pulmonary-aspergillosis-in-the-intensive-care-unit
#20
COMMENT
Katerina Kaziani, Elli Mitrakou, George Dimopoulos
No abstract text is available yet for this article.
September 2016: Annals of Translational Medicine
keyword
keyword
70832
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"