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https://www.readbyqxmd.com/read/29650044/human-amnion-derived-mesenchymal-stem-cells-alleviate-lung-injury-induced-by-white-smoke-inhalation-in-rats
#1
Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong, Zhaofan Xia
BACKGROUND: White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This study aimed to determine the protective effects of human amnion-derived mesenchymal stem cells (hAMSCs) against WSI-induced lung injury in rats. METHODS: hAMSCs were injected into rats via the tail vein 4 h after WSI. At 1, 3, 7, 14, and 28 days after cell injection, hAMSCs labeled with PKH26 in lung, heart, liver, and kidney tissues were observed by fluorescence microscopy...
April 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29642523/tricycloalternarene-analogs-from-a-symbiotic-fungus-aspergillus-sp-d-and-their-antimicrobial-and-cytotoxic-effects
#2
Huawei Zhang, Ziping Zhao, Jianwei Chen, Xuelian Bai, Hong Wang
Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain Aspergillus sp. D from the coastal plant Edgeworthia chrysantha Lindl. led to isolation of one new meroterpenoid, tricycloalternarene 14b ( 1 ), together with four known analogs ( 2 - 5 ), tricycloalternarenes 2b ( 2 ), 3a ( 3 ), 3b ( 4 ), and ACTG-toxin F ( 5 ). Their chemical structures were unambiguously established on the basis of NMR, mass spectrometry, and optical rotation data analysis, as well as by comparison with literature data...
April 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29626540/supramolecular-assembly-of-human-pulmonary-surfactant-protein-sp-d
#3
R Arroyo, A Martin-González, M Echaide, A Jain, W H Brondyk, J Rosenbaum, F Moreno-Herrero, J Perez-Gil
Pulmonary surfactant protein D (SP-D) is a glycoprotein from the collectin family that is a component of the lung surfactant system. It exhibits host defense and immune regulatory functions in addition to contributing to the homeostasis of the surfactant pool within the alveolar airspaces. It is known that the SP-D monomer forms trimers, which further associate into higher order oligomers. However, the pathway and the interactions involved in the assembly of SP-D oligomers are not clearly understood. In the current study, a recombinant form of full-length human SP-D (rhSP-D) has been qualitatively and quantitatively studied by Atomic Force Microscopy (AFM) and electrophoresis, with the aim to understand the conformational diversity and the determinants defining the oligomerization of the protein...
April 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29621540/tgf-beta-inhibits-expression-of-sp-a-sp-b-sp-c-but-not-sp-d-in-human-alveolar-type-ii-cells
#4
Kelly A Correll, Karen E Edeen, Rachel L Zemans, Elizabeth F Redente, Amanda Mikels-Vigdal, Robert J Mason
TGF beta is a multifunctional cytokine that regulates alveolar epithelial cells as well as immune cells and fibroblasts. TGF beta inhibits surfactant protein A, B and C expression in fetal human lung and can inhibit type II cell proliferation induced by FGF7 (KGF). However, little is known about direct effects of TGF beta on adult human type II cells. We cultured alveolar type II cells under air/liquid interface conditions to maintain their state of differentiation with or without TGF beta. TGF beta markedly decreased expression of SP-A, SP-B, SP-C, fatty acid synthase, and the phospholipid transporter ABCA3...
April 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29601229/immunolocalization-of-surfactant-proteins-sp-a-sp-b-sp-c-and-sp-d-in-infantile-labial-glands-and-mucosa
#5
Mechthild Stoeckelhuber, Friedrich Feuerhake, Christoph Schmitz, Klaus-Dietrich Wolff, Marco R Kesting
Surfactant proteins in different glandular structures of the oral cavity display antimicrobial activity for protection of invading microorganisms. Moreover, they are involved in lowering liquid tension in fluids and facilitate secretion flows. Numerous investigations for studying the occurrence of surfactant proteins in glandular tissues were performed using different methods. In the oral cavity, minor salivary glands secrete saliva continuously for the maintenance of a healthy oral environment. For the first time, we could show that infantile labial glands show expression of the surfactant proteins (SP) SP-A, SP-B, SP-C, and SP-D in acinar cells and the duct system in different intensities...
March 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29600055/clarithromycin-mitigates-radiation-pneumonitis-in-patients-with-lung-cancer-treated-with-stereotactic-body-radiotherapy
#6
Atsuya Takeda, Yuichiro Tsurugai, Naoko Sanuki, Tatsuji Enomoto, Masaharu Shinkai, Tomikazu Mizuno, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Yu Hara, Etsuo Kunieda
Background: Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and are used to treat respiratory inflammatory diseases. Radiation pneumonitis has similar pathology to them. Adverse reactions to macrolides are few and self-limited. We thus administered CAM to patients with high-risk factors for radiation pneumonitis, and retrospectively investigated whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29548887/surfactant-proteins-changes-after-acute-hemodynamic-improvement-in-patients-with-advanced-chronic-heart-failure-treated-with-levosimendan
#7
Jeness Campodonico, Massimo Mapelli, Emanuele Spadafora, Stefania Ghilardi, Piergiuseppe Agostoni, Cristina Banfi, Susanna Sciomer
Alveolar-capillary membrane evaluated by carbon monoxide diffusion (DLCO) plays an important role in heart failure (HF). Surfactant Proteins (SPs) have also been suggested as a worthwhile marker. In HF, Levosimendan improves pulmonary hemodynamics and reduces lung fluids but associated SPs and DLCO changes are unknown. Sixty-five advanced HF patients underwent spirometry, cardiopulmonary exercise test (CPET) and SPs determination before and after Levosimendan. Levosimendan caused natriuretic peptide-B (BNP) reduction, peakVO2 increase and VE/VCO2 slope reduction...
March 13, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29529843/clinical-significance-of-nuclear-factor-erythroid-2-related-factor-2-in-patients-with-chronic-obstructive-pulmonary-disease
#8
Wooho Ban, Hyeon Hui Kang, In Kyoung Kim, Jick Hwan Ha, Hyonsoo Joo, Jong Min Lee, Jeong Uk Lim, Sang Haak Lee, Chin Kook Rhee
Background/Aims: Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD status remains unclear. Methods: Patients diagnosed with COPD were recruited from St. Paul's Hospital, The Catholic University of Korea, between July 2009 and May 2012. Patients were classified into two groups according to the severity of their symptoms on initial presentation, a COPD-stable group (n = 25) and a COPD-exacerbation group (n = 30)...
March 13, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29523157/neuromuscular-blockade-is-associated-with-the-attenuation-of-biomarkers-of-epithelial-and-endothelial-injury-in-patients-with-moderate-to-severe-acute-respiratory-distress-syndrome
#9
Peter D Sottile, David Albers, Marc M Moss
BACKGROUND: Neuromuscular blockade (NMB) is a therapy for acute respiratory distress syndrome (ARDS). However, the mechanism by which NMB may improve outcome for ARDS patients remains unclear. We sought to determine whether NMB attenuates biomarkers of epithelial and endothelial lung injury and systemic inflammation in ARDS patients, and whether the association is dependent on tidal volume size and the initial degree of hypoxemia. METHODS: We performed a secondary analysis of patients enrolled in the ARDS network low tidal volume ventilation (ARMA) study...
March 10, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29509998/characterization-of-the-hypersensitive-response-like-cell-death-phenomenon-induced-by-targeting-antiviral-lectin-griffithsin-to-the-secretory-pathway
#10
Bo Min Kim, H C Therese Lotter-Stark, Edward P Rybicki, Rachel K Chikwamba, Kenneth E Palmer
Griffithsin (GRFT) is an antiviral lectin, originally derived from a red alga, which is currently being investigated as a topical microbicide to prevent transmission of human immunodeficiency virus (HIV). Targeting GRFT to the apoplast for production in Nicotiana benthamiana resulted in necrotic symptoms associated with a hypersensitive response (HR)-like cell death, accompanied by H2 O2 generation and increased PR1 expression. Mannose-binding lectins Surfactant protein D (SP-D), cyanovirin-N (CV-N) and human mannose-binding lectin (hMBL) also induce salicylic acid (SA) dependent HR-like cell death in N...
March 6, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29488898/magnetic-field-induced-mixing-of-light-hole-excitonic-states-in-cd-mn-te-cd-mg-te-core-shell-nanowires
#11
Jakub Krzysztof Płachta, Emma Grodzicka, Anna Kaleta, Slawomir Kret, Lech Tomasz Baczewski, Aleksiej Pietruczik, Maciej Wiater, Mateusz Goryca, Tomasz Kazimierczuk, Piotr Kossacki, Grzegorz Karczewski, T Wojtowicz, Piotr Wojnar
A detailed magneto-photoluminescence study of individual (Cd,Mn)Te/(Cd,Mg)Te core/shell nanowires grown by molecular beam epitaxy is performed. First of all, an enhancement of the Zeeman splitting due to sp-d exchange interaction between band carriers and Mn-spins is evidenced in these structures. Then, it is found that the value of this splitting depends strongly on the magnetic field direction with respect to the nanowire axis. The largest splitting is observed when the magnetic field is applied perpendicular and the smallest when it is applied parallel to the nanowire axis...
February 28, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29473039/surfactant-protein-d-in-respiratory-and-non-respiratory-diseases
#12
REVIEW
Grith L Sorensen
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts antimicrobial effects and dampens inflammation through direct microbial interactions and modulation of host cell responses via a series of cellular receptors. However, low protein concentrations, genetic variation, biochemical modification, and proteolytic breakdown can induce decomposition of multimeric SP-D into low-molecular weight forms, which may induce pro-inflammatory SP-D signaling...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29464958/sp-d-exchange-interactions-in-wave-function-engineered-colloidal-cdse-mn-cds-hetero-nanoplatelets
#13
Franziska Muckel, Savas Delikanli, Pedro Ludwig Hernandez Martinez, Tamara Priesner, Severin Lorenz, Julia Ackermann, Manoj Sharma, Hilmi Volkan Demir, Gerd Bacher
In two-dimensional (2D) colloidal semiconductor nanoplatelets, which are atomically flat nanocrystals, the precise control of thickness and composition on the atomic scale allows for the synthesis of heterostructures with well-defined electron and hole wave function distributions. Introducing transition metal dopants with monolayer precision enables tailored magnetic exchange interactions between dopants and band states. Here, we use the absorption based technique of magnetic circular dichroism (MCD) to directly prove exchange coupling of magnetic dopants with the band charge carriers in shell-doped CdSe/Mn:CdS hetero-nanoplatelets...
February 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29445934/serum-surfactant-protein-levels-in-patients-admitted-to-the-hospital-with-acute-copd-exacerbation
#14
Andriana I Papaioannou, Elisavet Konstantelou, Anastasia Papaporfyriou, Konstantinos Bartziokas, Aris Spathis, Petros Bakakos, Stelios Loukides, Nikolaos Koulouris, Spyros Papiris, Konstantinos Kostikas
Surfactant proteins (SPs) have been studied in COPD patients as biomarkers of disease severity and as predictive factors of unfavorable outcomes. The aim of this exploratory study was to evaluate serum levels of SP-A, SP-B, SP-C, and SP-D in patients with COPD both during AECOPD and in stability and to test their possible associations with disease severity and with the development of new exacerbation events. 20 consecutive COPD patients hospitalized for AECOPD were included. Serum SP levels were measured on admission, at discharge, and on stability...
February 14, 2018: Lung
https://www.readbyqxmd.com/read/29440688/unbalanced-inflammatory-reaction-could-increase-tissue-destruction-and-worsen-skin-infectious-diseases-a-comparative-study-of-leishmaniasis-and-sporotrichosis
#15
F N Morgado, L M V de Carvalho, J Leite-Silva, A J Seba, M I F Pimentel, A Fagundes, M F Madeira, M R Lyra, M M Oliveira, A O Schubach, F Conceição-Silva
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425774/a-membrane-type-surfactant-protein-d-sp-d-suppresses-macrophage-mediated-cytotoxicity-in-swine-endothelial-cells
#16
Patmika Jiaravuthisan, Akira Maeda, Chihiro Takakura, Han-Tang Wang, Rieko Sakai, Afifah Mohd Shabri, Pei-Chi Lo, Rei Matsuura, Tasuku Kodama, Hiroshi Eguchi, Hiroomi Okuyama, Shuji Miyagawa
OBJECTIVE: Surfactant protein D (SP-D), which is secreted mainly in the lung, is an oligometric C type lectin that promotes phagocytosis by binding to carbohydrates on microbial surfaces. SP-D can also bind SIRPα, leading to a decrease in cytokine production by monocytes/macrophages. In the present study, we examined the possibility that SP-D suppresses macrophage-mediated xenogeneic cytotoxicity, by creating a membrane-type SP-D. METHODS: The cDNA for the carbohydrate recognition domain (CRD) of human SP-D was switched to that of a membrane-type protein, collectin placenta 1 (CL-P1), with a Flag-tag...
February 6, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29424908/hyperoxia-induces-the-apoptosis-of-alveolar-epithelial-cells-and-changes-of-pulmonary-surfactant-proteins
#17
Y Jin, L-Q Peng, A-L Zhao
OBJECTIVE: To explore the changes of surfactant protein C, D (SP-C, SP-D) and apoptosis of alveolar epithelial cells (AEC) in the lung injury of neonatal rats induced by hyperoxia. MATERIALS AND METHODS: We divided neonatal rats within 24 hours into two groups randomly: the air group (n = 50) and the hyperoxia group (n = 50). Rats in the air group and hyperoxia group were bred conventionally and in tanks with normal pressure and 90% concentration of oxygen, respectively...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29422546/a-comparative-study-of-growth-different-body-weight-trajectories-in-three-species-of-the-genus-eublepharis-and-their-hybrids
#18
Daniel Frynta, Jitka Jančúchová-Lásková, Petra Frýdlová, Eva Landová
An extensive research effort is devoted to the evolution of life-histories and processes underlying the variation in adult body weight; however, in this regard, some animal taxa remain neglected. Here we report rates and timing of growth recorded in two wild-derived populations of a model lizard species, Eublepharis macularius (M, W), other two related species, i.e., E. angramainyu (A) and E. sp. (D), and their between-species hybrids. We detected clear differences among the examined species/populations, which can be interpreted in the terms of "fast - slow" continuum of life-history strategies...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414772/fungal-melanin-stimulates-surfactant-protein-d-mediated-opsonization-of-and-host-immune-response-to-em-aspergillus-fumigatus-em-spores
#19
Sarah Sze Wah Wong, Manjusha Rani, Eswari Dodagatta-Marri, Oumaima Ibrahim-Granet, Uday Kishore, Jagadeesh Bayry, Jean-Paul Latgé, Arvind Sahu, Taruna Madan, Vishukumar Aimanianda
Surfactant protein D (SP-D), a C-type lectin and pattern-recognition soluble factor, plays an important role in immune surveillance to detect and eliminate human pulmonary pathogens. SPD has been shown to protect against infections with the most ubiquitous airborne fungal pathogen, <em>Aspergillus fumigatus</em>, but the fungal surface component(s) interacting with SP-D is unknown. Here, we show that SP-D binds to melanin pigment on the surface of <em>A. fumigatus</em> dormant spores (conidia)...
February 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29393256/clinical-course-of-histologically-proven-multifocal-micronodular-pneumocyte-hyperplasia-in-tuberous-sclerosis-complex-a-case-series-and-comparison-with-lymphangiomyomatosis
#20
Satoshi Konno, Masahiko Shigemura, Takahiro Ogi, Kaoruko Shimizu, Masaru Suzuki, Kichizo Kaga, Yasuhiro Hida, Yoshihiro Matsuno, Masaharu Nishimura
BACKGROUND: Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of tuberous sclerosis complex (TSC). Because of its rarity, no previous study has described the detailed clinical course of this disease. OBJECTIVES: This study aimed to clarify the longitudinal clinical characteristics of subjects with MMPH. METHODS: Nine patients with MMPH diagnosed at Hokkaido University Hospital were retrospectively analyzed...
January 24, 2018: Respiration; International Review of Thoracic Diseases
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