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https://www.readbyqxmd.com/read/28641719/surfactant-protein-d-inhibits-interleukin-12p40-production-by-macrophages-through-the-sirp%C3%AE-rock-erk-signaling-pathway
#1
Rui Yamaguchi, Arisa Sakamoto, Takatoshi Yamamoto, Yasuji Ishimaru, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguchi
OBJECTIVE: Interleukin (IL)-12 has a pivotal profibrotic role in the development of idiopathic pulmonary fibrosis (IPF). Medical research trials based on IPF registry databases have actively recruited patients. Surfactant protein D (SP-D) is a useful biomarker in patients with IPF. SP-D binds to signal regulatory protein α (SIRPα), which acts as an inhibitory receptor, and this SP-D/SIRPα interaction may have an anti-inflammatory effect. Accordingly, the inhibitory effect of SP-D on IL-12p40 production by lipopolysaccharide (LPS)-stimulated macrophages was investigated...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28620154/influence-of-donor-lung-surfactant-a-and-b-protein-expression-on-the-development-of-primary-graft-dysfunction-after-lung-transplantation-a-pilot-study
#2
Asmae Belhaj, Carine Boven, Laurence Dewachter, Maria Ruiz Patino, Youri Sokolow, Benoît Rondelet
BACKGROUND Primary graft dysfunction (PGD) is responsible of high early mortality in lung transplanted patients. We measured the rate of surfactant proteins in the organ donor, and we observed the occurrence of lung PGD in the recipient. The co-relation between these two parameters was evaluated. MATERIAL AND METHODS In this pilot study, we prospectively collected blood samples and lung biopsies in thirteen donors at the time of recovery of organs before preservation. Gene expression of SP-A, SP-B, SP-D, and CC16 was evaluated by real-time quantitative PCR...
June 16, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28615099/-hyperoxia-modulates-the-expressions-of-c-ebp%C3%AE-and-pulmonary-surfactant-proteins-in-aecii-of-premature-rats
#3
Yanmin Lu, Hongyan Lu, Jiangyan Liu, Ming Chang, Qiuxia Wang, Wei Tang
Objective To explore the effect of hyperoxia on the expressions of CCAAT enhancer binding protein α (C/EBPα) and pulmonary surfactant proteins (SP-A, SP-B, SP-C, SP-D) and their correlations in primary type II alveolar epithelial cells (AECIIs) from premature rats. Methods AECIIs were divided into an air control group and a hyperoxia model group. The cells of the two groups were respectively exposed toair and 950 mL/L O2. The cells were harvested at 24, 48, and 72 hours after exposure. Inverted phase-contrast microscope was used to observe morphological changes of the cells...
June 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28610627/multiple-biomarkers-predict-disease-severity-progression-and-mortality-in-copd
#4
Rachel L Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E Miller, Ruth Tal-Singer, Russell P Bowler
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by multiple subtypes and variable disease progression. Blood biomarkers have been variably associated with subtype, severity, and disease progression. Just as combined clinical variables are more highly predictive of outcomes than individual clinical variables, we hypothesized that multiple biomarkers may be more informative than individual biomarkers to predict subtypes, disease severity, disease progression, and mortality...
June 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28610019/four-new-species-of-i-callibaetis-i-eaton-ephemeroptera-baetidae-nymphal-description-of-i-callibaetis-i-i-abaetetuba-i-fasciatus-pictet-and-keys-for-south-american-species-of-i-callibaetis-i
#5
Paulo Vilela Cruz, Frederico Falcão Salles, Neusa Hamada
The first phylogenetic study of Callibaetis Eaton indicated an unrevealed diversity in this genus, including four new species named as Callibaetis sp. A, B, C and D, and the undescribed nymph of Callibaetis (Abaetetuba) fasciatus (Pictet). Given that neither the nymph of C. (Ab.) fasciatus nor the four new species received a proper description, the objective of this study is to describe them. The nymph of C. (Ab.) fasciatus differs from the others species in the subgenus by the presence of one row of setae on basal part of inner-dorsal row of maxilla and metanotum without spines; Callibaetis sp...
April 5, 2017: Zootaxa
https://www.readbyqxmd.com/read/28591049/impact-of-serum-sp-a-and-sp-d-levels-on-comparison-and-prognosis-of-idiopathic-pulmonary-fibrosis-a-systematic-review-and-meta-analysis
#6
Kai Wang, Qing Ju, Jing Cao, Wenze Tang, Jian Zhang
BACKGROUND AND OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis in general; however, it is heterogeneous to detect relative biomarkers for predicting the disease progression. Serum biomarkers can be conveniently collected to detect and help to differentially diagnose IPF and predict IPF prognosis. This meta-analysis aimed to evaluate the use of serum surfactant proteins A and D (SP-A and SP-D) for differential diagnosis and prognosis of IPF. METHODS: Relevant articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases and reviewed by 2 independent readers...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28591009/surfactant-proteins-a-and-d-attenuate-lps-induced-apoptosis-in-primary-intestinal-epithelial-cells-iecs
#7
Linlin Zhang, Qinghe Meng, Natesh Yepuri, Guirong Wang, Xiuming Xi, Robert N Cooney
INTRODUCTION: SP-A/D KO mice with sepsis demonstrate more severe lung, kidney and gut injury/apoptosis than WT controls. We hypothesize SP-A and SP-D directly regulate LPS-induced P38 MAPK activation and gut apoptosis during sepsis. METHODS: Primary IECs were established from SP-A/D KO or C57BL/6 WT mice, stimulated with LPS and harvested at 24 h. IECs from WT mice were treated with SP-A, SP-D or vehicle for 20 h, then LPS for 24 h. Apoptosis, cleaved caspase-3 levels and the ratio of BAX/Bcl-2 were assayed...
June 6, 2017: Shock
https://www.readbyqxmd.com/read/28585516/salivary-sp-d-may-be-a-biomarker-reflecting-small-airway-inflammation-and-asthma-exacerbation
#8
S Okazaki, H Murai, S Kidoguchi, E Nomura, N Itoh, N Hashimoto, T Hamada, A Kawakita, M Yasutomi, Y Ohshima
BACKGROUND AND OBJECTIVE: Background: Noninvasive and child-friendly biomarkers are important tools for understanding the various phenotypes of childhood asthma. Objective: The aim of this study was to examine the usefulness of salivary surfactant protein (SP)-D in assessing the pathophysiology of childhood asthma. METHODS: We measured salivary concentrations of SP-D and forced oscillation technique (FOT) indexes in 19 healthy controls and 21 asthmatic children...
June 6, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28566647/potential-use-of-polyvinyl-acetate-polyvinylpyrrolidone-mixture-for-the-development-of-atenolol-sustained-release-matrix-tablets-optimization-of-formulation-through-in-vitro-in-vivo-assessment-study
#9
Ali Saeed Owayez, Galal Mahmoud Abd El-Ghany, Irhan Ibrahim Abu Hashim
The objective of this study was to develop sustained release matrix tablets of atenolol (AT) using different concentrations of polyvinyl acetate-polyvinylpyrrolidone mixture (KSR) (20, 30, or 40%) with various types of fillers such as spray dried lactose (SP.D.L), avicel pH 101 (AV), and emcompress (EMS). The physical characteristics of the prepared tablets were evaluated. Characterization of the optimized formulation was performed using Fourier transform (FT)-IR spectroscopy and differential scanning calorimetry (DSC)...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28489417/a-semiquantitative-ct-grading-system-for-evaluating-therapeutic-response-in-pulmonary-alveolar-proteinosis
#10
Sayoko Tokura, Masanori Akira, Tomohisa Okuma, Ryushi Tazawa, Toru Arai, Chikatoshi Sugimoto, Akiko Matsumuro, Masaki Hirose, Toshinori Takada, Koh Nakata, Haruyuki Ishii, Yasunori Kasahara, Masayuki Hojo, Shinya Ohkouchi, Yoshiko Tsuchihashi, Masanori Yokoba, Ryosuke Eda, Hideaki Nakayama, Takahito Nei, Konosuke Morimoto, Yasuyuki Nasuhara, Masahito Ebina, Toshio Ichiwata, Koichiro Tatsumi, Etsuro Yamaguchi, Yoshikazu Inoue
RATIONALE: A useful semi-quantitative method of using CT images to evaluate therapeutic response in pulmonary alveolar proteinosis (PAP) has not been established, although the extent score or grading score of ground-glass opacities has been used. OBJECTIVES: The purpose of this study was to establish a semi-quantitative method for evaluating therapeutic response in PAP. METHODS: CT scans obtained within one month before and after the therapy from 32 patients with PAP who participated in a multicenter phase 2 trial of GM-CSF inhalation therapy were evaluated by two chest radiologists independently...
May 10, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28464801/surfactant-protein-d-predicts-prognosis-of-interstitial-lung-disease-induced-by-anticancer-agents-in-advanced-lung-cancer-a-case-control-study
#11
Kota Nakamura, Motoyasu Kato, Takehito Shukuya, Keita Mori, Yasuhito Sekimoto, Hiroaki Ihara, Ryota Kanemaru, Ryo Ko, Rina Shibayama, Ken Tajima, Ryo Koyama, Naoko Shimada, Osamu Nagashima, Fumiyuki Takahashi, Shinichi Sasaki, Kazuhisa Takahashi
BACKGROUND: Interstitial lung diseases induced by anticancer agents (ILD-AA) are rare adverse effects of anticancer therapy. However, prognostic biomarkers for ILD-AA have not been identified in patients with advanced lung cancer. Our aim was to analyze the association between serum biomarkers sialylated carbohydrate antigen Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D), and clinical characteristics in patients diagnosed with ILD-AA. METHODS: Between April 2011 and March 2016, 1224 advanced lung cancer patients received cytotoxic agents and epidermal growth factor receptor tyrosine kinase inhibitors at Juntendo University Hospital and Juntendo University Urayasu Hospital...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28442012/-preoperatiove-airway-bacterial-colonization-the-missing-link-between-non-small-cell-lung-cancer-following-lobectomy-and-postoperative-pneumonia
#12
Ke Gao, Yutian Lai, Jian Huang, Yifan Wang, Xiaowei Wang, Guowei Che
BACKGROUND: Surgical procedure is the main method of treating lung cancer. Meanwhile, postoperative pneumonia (POP) is the major cause of perioperative mortality in lung cancer surgery. The preoperative pathogenic airway bacterial colonization is an independent risk factor causing postoperative pulmonary complications (PPC). This cross-sectional study aimed to explore the relationship between preoperative pathogenic airway bacterial colonization and POP in lung cancer and to identify the high-risk factors of preoperative pathogenic airway bacterial colonization...
April 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28409939/band-resolved-double-photoemission-spectroscopy-on-correlated-valence-electron-pairs-in-metals
#13
Andreas Trützschler, Michael Huth, Cheng-Tien Chiang, Robin Kamrla, Frank O Schumann, Jürgen Kirschner, Wolf Widdra
Correlated valence electrons in Ag and Cu are investigated using double photoemission spectroscopy driven by a high-order harmonic light source. Electron pairs consisting of two d electrons as well as pairs with one sp and one d electron are resolved in the two-dimensional energy spectrum. Surprisingly, the intensity ratio of sp-d to d-d pairs from Ag is 3 times higher than in the self-convoluted density of states. Our results directly show the band-resolved configurations of electron pairs in solids and emphasize a band-dependent picture for electron correlation even in these paradigmatic metals...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28385654/surfactant-protein-d-a-sensitive-predictor-for-efficiency-of-preoperative-pulmonary-rehabilitation
#14
Jian Huang, Yutian Lai, Ke Gao, Yifan Wang, Heng Du, Jianhua Su, Guowei Che, Xudong Zhou
BACKGROUND: Surfactant Protein D (SP-D) as a lung-derived biomarker for inflammatory lung disease is being studied in depth. Meanwhile, the Pre-operative Rehabilitation Program (PRP) has been proposed as an effective treatment to reduce the incidence of Post-operative Pulmonary Complications (PPCs) and further improve quality of life. However, the relationship between serum SP-D levels and PRP remains unclear. This study aimed to explore the correlation between these two phenomena and validate the feasibility of using preoperative serum SP-D levels to predict or assess the effectiveness of PRP...
April 3, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28382887/morphology-and-molecular-characterization-of-demidospermus-spirophallus-n-sp-d-prolixus-n-sp-monogenea-dactylogyridae-and-a-redescription-of-d-anus-in-siluriform-catfish-from-brazil
#15
L Franceschini, A C Zago, M I Müller, C J Francisco, R M Takemoto, R J da Silva
The present study describes Demidospermus spirophallus n. sp. and Demidospermus prolixus n. sp. (Monogenea, Dactylogyridae) from the siluriform catfish Loricaria prolixa Isbrücker & Nijssen, 1978 (Siluriformes, Loricariidae) from the state of São Paulo, Brazil, supported by morphological and molecular data. In addition, notes on the circumscription of the genus with a redescription of Demisdospermus anus are presented. Demidospermus spirophallus n. sp. differed from other congeners mainly because of the morphology of the male copulatory organ (MCO), which exhibited 2½ counterclockwise rings, a tubular accessory piece with one bifurcated end and a weakly sclerotized vagina with sinistral opening...
April 6, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28370220/impact-of-anti-tumor-necrosis-factor-%C3%AE-agents-on-serum-levels-of-kl-6-and-surfactant-protein-d-in-patients-with-psoriasis
#16
Mitsuha Hayashi, Koichi Yanaba, Yoshinori Umezawa, Akihiko Asahina, Hidemi Nakagawa
We longitudinally examined the influence of anti-tumor necrosis factor (TNF)-α treatment on serum levels of KL-6 and surfactant protein-D (SP-D). The study group comprised 22 patients with psoriasis treated with infliximab or adalimumab and with no history of interstitial lung disease (ILD). KL-6 and SP-D levels were measured in serum samples. Twelve of the 22 patients (55%) showed at least a 20% increase in KL-6 levels compared with baseline. Of these 12 patients, none exhibited any signs of ILD on chest computed tomography and nine who showed an increase in KL-6 levels (75%) showed at least a 20% increase in SP-D levels...
March 31, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28367508/alterations-of-the-murine-gut-microbiome-in-allergic-airway-disease-are-independent-of-surfactant-protein-d
#17
Kenneth K Barfod, Michael Roggenbuck, Suzan Al-Shuweli, Dalia Fakih, Søren J Sørensen, Grith L Sørensen
BACKGROUND: SP-D is an important host defense lectin in innate immunity and SP-D deficient mice show several abnormal immune effects and are susceptible to allergen-induced airway disease. At the same time, host microbiome interactions play an important role in the development of allergic airway disease, and alterations to gut microbiota have been linked to airway disease through the gut-lung axis. Currently, it is unknown if the genotype (Sftpd-/- or Sftpd+/+) of the standard SP-D mouse model can affect the host microbiota to such an degree that it would overcome the cohousing effect on microbiota and interfere with the interpretation of immunological data from the model...
March 2017: Heliyon
https://www.readbyqxmd.com/read/28355256/the-usefulness-of-monomeric-periostin-as-a-biomarker-for-idiopathic-pulmonary-fibrosis
#18
Shoichiro Ohta, Masaki Okamoto, Kiminori Fujimoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Hiroshi Ishii, Keiichi Akasaka, Junya Ono, Ayami Kamei, Yoshinori Azuma, Hisako Matsumoto, Yukie Yamaguchi, Michiko Aihara, Takeshi Johkoh, Atsushi Kawaguchi, Masao Ichiki, Hironori Sagara, Jun-Ichi Kadota, Masayuki Hanaoka, Shin-Ichiro Hayashi, Shigeru Kohno, Tomoaki Hoshino, Kenji Izuhara
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study...
2017: PloS One
https://www.readbyqxmd.com/read/28321059/arterial-carboxyhemoglobin-measurement-is-useful-for-evaluating-pulmonary-inflammation-in-subjects-with-interstitial-lung-disease
#19
Yu Hara, Masaharu Shinkai, Soichiro Kanoh, Yuji Fujikura, Bruce K Rubin, Akihiko Kawana, Takeshi Kaneko
Objective The arterial concentration of carboxyhemoglobin (CO-Hb) in subjects with inflammatory pulmonary disease is higher than that in healthy individuals. We retrospectively analyzed the relationship between the CO-Hb concentration and established markers of disease severity in subjects with interstitial lung disease (ILD). Methods The CO-Hb concentration was measured in subjects with newly diagnosed or untreated ILD and the relationships between the CO-Hb concentration and the serum biomarker levels, lung function, high-resolution CT (HRCT) findings, and the uptake in gallium-67 ((67)Ga) scintigraphy were evaluated...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28291742/first-principles-study-of-methane-decomposition-on-b5-step-edge-type-site-of-ru-surface
#20
Ryan Lacdao Arevalo, Susan Meñez Aspera, Mary Clare Sison Escaño, Hiroshi Nakanishi, Hideaki Kasai
Many chemical reactions that produce a wide range of hydrocarbons and alcohols involve the breaking of C-H bonds in methane. In this paper, we analyzed the decomposition of this molecule on the B5 step-edge type site of Ru surface using first principles calculations based on dispersion-corrected density functional theory. Methane was found to be weakly adsorbed on the surface, characterized by the hybridization of its sp states with Ru-d xz,yz,zz states. Dissociative adsorption is energetically preferred over molecular methane adsorption, resulting in CH fragment...
March 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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