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https://www.readbyqxmd.com/read/28321059/arterial-carboxyhemoglobin-measurement-is-useful-for-evaluating-pulmonary-inflammation-in-subjects-with-interstitial-lung-disease
#1
Yu Hara, Masaharu Shinkai, Soichiro Kanoh, Yuji Fujikura, Bruce K Rubin, Akihiko Kawana, Takeshi Kaneko
Objective The arterial concentration of carboxyhemoglobin (CO-Hb) in subjects with inflammatory pulmonary disease is higher than that in healthy individuals. We retrospectively analyzed the relationship between the CO-Hb concentration and established markers of disease severity in subjects with interstitial lung disease (ILD). Methods The CO-Hb concentration was measured in subjects with newly diagnosed or untreated ILD and the relationships between the CO-Hb concentration and the serum biomarker levels, lung function, high-resolution CT (HRCT) findings, and the uptake in gallium-67 ((67)Ga) scintigraphy were evaluated...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28291742/first-principles-study-of-methane-decomposition-on-b5-step-edge-type-site-of-ru-surface
#2
Ryan Arevalo, Susan Aspera, Mary Clare Escaño, Hiroshi Nakanishi, Hideaki Kasai
Many chemical reactions that produce a wide range of hydrocarbons and alcohols involve the breaking of C-H bonds in methane. In this paper, we analyzed the decomposition of this molecule on the B5 step-edge type site of Ru surface using first principles calculations based on dispersion-corrected density functional theory. Methane was found to be weakly adsorbed on the surface, characterized by the hybridization of its sp states with Ru-d<sub>xz,yz,zz</sub> states. Dissociative adsorption is energetically preferred over molecular methane adsorption, resulting in CH fragment...
March 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28279530/rhamnolipid-aided-biodegradation-of-carbendazim-by-rhodococcus-sp-d-1-characteristics-products-and-phytotoxicity
#3
Naling Bai, Sheng Wang, Rexiding Abuduaini, Meinan Zhang, Xufen Zhu, Yuhua Zhao
We successfully isolated Rhodococcus sp. D-1, an efficient carbendazim-degrading bacterium that degraded 98.20% carbendazim (200ppm) within 5days. Carbendazim was first processed into 2-aminobenzimidazole, converted to 2-hydroxybenzimidazole, and then further mineralized by subsequent processing. After genomic analysis, we hypothesized that D-1 may express a new kind of enzyme capable of hydrolyzing carbendazim. In addition, the effect of the biodegradable biosurfactant rhamnolipid on the rate and extent of carbendazim degradation was assessed in batch analyses...
March 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28278679/a-new-sesquiterpene-lactone-from-fungus-eutypella-sp-d-1
#4
Yue Zhou, Yi-Xin Zhang, Jian-Peng Zhang, Hao-Bing Yu, Xiao-Yu Liu, Xiao-Ling Lu, Bing-Hua Jiao
We isolated and identified a new sesquiterpene lactone which we named eut-Guaiane sesquiterpene (1), along with four cytochalasins from the fungus Eutypella sp. derived from the soil of high latitude of Arctic. The new structure was determined by spectroscopic studies such as 1D and 2D NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. New compound 1 exhibited strong antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus...
February 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28275485/serum-kl-6-and-surfactant-protein-d-as-monitoring-and-predictive-markers-of-interstitial-lung-disease-in-patients-with-systemic-sclerosis-and-mixed-connective-tissue-disease
#5
Hideaki Yamakawa, Eri Hagiwara, Hideya Kitamura, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Koji Okudela, Tae Iwasawa, Tamiko Takemura, Kazuyoshi Kuwano, Takashi Ogura
BACKGROUND: Interstitial lung disease (ILD) is frequent complication of systemic sclerosis (SSc) and mixed connective tissue disease (MCTD). The disease is heterogeneous, and its outcome is unpredictable. Some patients have severe and progressive deterioration of ILD, which is the leading cause of mortality. We aimed to determine whether serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) correlate with SSc/MCTD-associated ILD activity. METHODS: We retrospectively analyzed the medical records of 40 patients with SSc/MCTD-associated ILD: 29 patients with SSc and 11 patients with MCTD...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28224053/understanding-morphological-variability-in-a-taxonomic-context-in-chilean-diplomystids-teleostei-siluriformes-including-the-description-of-a-new-species
#6
Gloria Arratia, Claudio Quezada-Romegialli
Following study of the external morphology and its unmatched variability throughout ontogeny and a re-examination of selected morphological characters based on many specimens of diplomystids from Central and South Chile, we revised and emended previous specific diagnoses and consider Diplomystes chilensis, D. nahuelbutaensis, D. camposensis, and Olivaichthys viedmensis (Baker River) to be valid species. Another group, previously identified as Diplomystes sp., D. spec., D. aff. chilensis, and D. cf. chilensis inhabiting rivers between Rapel and Itata Basins is given a new specific name (Diplomystes incognitus) and is diagnosed...
2017: PeerJ
https://www.readbyqxmd.com/read/28221763/inactivation-clearance-and-functional-effects-of-lung-instilled-short-and-long-silver-nanowires-in-rats
#7
Kian Fan Chung, Joanna Seiffert, Shu Chen, Ioannis G Theodorou, Angela Erin Goode, Bey Fen Leo, Catriona M McGilvery, Farhana Hussain, Coen Wiegman, Christos Rossios, Jie Zhu, Jicheng Gong, Farid Tariq, Vladimir Yufit, Alexander J Monteith, Teruo Hashimoto, Jeremy N Skepper, Mary P Ryan, Junfeng Zhang, Teresa D Tetley, Alexandra E Porter
There is a potential for silver nanowires (AgNWs) to be inhaled, but there is little information on their health effects and their chemical transformation inside the lungs in vivo. We studied the effects of short (S-AgNWs; 1.5 μm) and long (L-AgNWs; 10 μm) nanowires instilled into the lungs of Sprague-Dawley rats. S- and L-AgNWs were phagocytosed and degraded by macrophages; there was no frustrated phagocytosis. Interestingly, both AgNWs were internalized in alveolar epithelial cells, with precipitation of Ag2S on their surface as secondary Ag2S nanoparticles...
February 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28212617/surfactant-protein-d-sp-d-gene-polymorphisms-and-serum-level-as-predictors-of-susceptibility-and-prognosis-of-acute-kidney-injury-in-the-chinese-population
#8
Jiao Liu, Guang Li, Lianghai Li, Zhiyong Liu, Qingshan Zhou, Guirong Wang, Dechang Chen
BACKGROUND: Injury to the kidney epithelial barrier is a characteristic feature of acute kidney injury (AKI). Serum surfactant protein-D (SP-D), a known biomarker of damaged alveolar epithelium, is also secreted by renal tubular epithelial cells. Therefore, the aim of this study was to examine the possible association of SP-D with AKI susceptibility and prognosis. METHODS: In this study, 159 AKI patients and 120 healthy individuals were included. SP-D polymorphisms Thr11Met and Thr160Ala, AKI patient serum SP-D levels at days 1, 3 and 7 and urine KIM-1 levels in both AKI patients and controls were examined...
February 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28187051/kinetics-of-plasma-biomarkers-of-inflammation-and-lung-injury-in-surgical-patients-with-or-without-postoperative-pulmonary-complications
#9
Ary Serpa Neto, Pedro P Z A Campos, Sabrine N T Hemmes, Lieuwe D Bos, Thomas Bluth, Marion Ferner, Andreas Güldner, Markus W Hollmann, Inmaculada India, Thomas Kiss, Rita Laufenberg-Feldmann, Juraj Sprung, Demet Sulemanji, Carmen Unzueta, Marcos F Vidal Melo, Toby N Weingarten, Anita M Tuip-de Boer, Paolo Pelosi, Marcelo Gama de Abreu, Marcus J Schultz
BACKGROUND: Postoperative pulmonary complications (PPCs) are common after major abdominal surgery. The kinetics of plasma biomarkers could improve identification of patients developing PPCs, but the kinetics may depend on intraoperative ventilator settings. OBJECTIVE: To test whether the kinetics of plasma biomarkers are capable of identifying patients who will develop PPCs, and whether the kinetics depend on the intraoperative level of positive end-expiratory pressure (PEEP)...
April 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28185902/lung-remodeling-in-aging-surfactant-protein-d-deficient-mice
#10
Jan Philipp Schneider, Martina Arkenau, Lars Knudsen, Dirk Wedekind, Matthias Ochs
Pulmonary surfactant, a mixture of lipids and proteins at the air-liquid interface of alveoli, prevents the lungs from collapsing due to surface tension. One constituent is surfactant-associated protein-D (SP-D), a protein involved in surfactant homeostasis and innate immunity. Mice deficient in SP-D (SP-D (-/-)) has been described as developing a characteristic phenotype which affects the surfactant system (including changes in the intra-cellular and intra-alveolar surfactant pool, alveolar epithelial type II cells and alveolar macrophages), lung architecture and its inflammatory state (development of an emphysema-like pathology, inflammatory cell infiltration)...
February 7, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28168327/surfactant-protein-d-delays-fas-and-trail-mediated-extrinsic-pathway-of-apoptosis-in-t-cells
#11
Pascal Djiadeu, Lakshmi P Kotra, Neil Sweezey, Nades Palaniyar
Only a few extracellular soluble proteins are known to modulate apoptosis. We considered that surfactant-associated protein D (SP-D), an innate immune collectin present on many mucosal surfaces, could regulate apoptosis. Although SP-D is known to be important for immune cell homeostasis, whether SP-D affects apoptosis is unknown. In this study we aimed to determine the effects of SP-D on Jurkat T cells and human T cells dying by apoptosis. Here we show that SP-D binds to Jurkat T cells and delays the progression of Fas (CD95)-Fas ligand and TRAIL-TRAIL receptor induced, but not TNF-TNF receptor-mediated apoptosis...
February 6, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28163207/expression-of-recombinant-surfactant-protein-sfta3-in-the-human-kidney-cell-line-hek-293t
#12
H Schröder, R Fischer, L Sollfrank, F Paulsen, L Bräuer, M Schicht
Pulmonary surfactant is broadly known to keep the lung dry, clean and open by lowering the surface tension of the fluid-film that lines the alveoli. The surfactant's protein component, the so called surfactant proteins (SPs), make up a multifunctional protein family. In addition to the four "classical" surfactant proteins (SP-A, SP-B, SP-C and SP-D), which possess immunologic as well as surfactant regulatory properties, two novel putative surfactant proteins (SFTA2 and SFTA3) have recently been described. Neither of them shows sequential nor structural similarity with the already known surfactant proteins...
February 3, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28127335/increased-cd11b-and-hypoxia-inducible-factors-1alpha-expressions-in-the-lung-tissue-and-surfactant-protein-d-levels-in-serum-are-related-with-acute-lung-injury-in-severe-malaria-of-c57bl-6-mice
#13
Wike Astrid Cahayani, Eviana Norahmawati, Niniek Budiarti, Loeki Enggar Fitri
BACKGROUND: We aimed to reveal the role of CD11b and hypoxia-inducible factors-1alpha (HIF-1α) expressions on monocytes and alveolar macrophages of lung tissue, and the levels of serum surfactant protein-D (SP-D) in severe malaria-associated acute lung injury (ALI). METHODS: The C57BL/6 mice were divided into control group, renal malaria group (inoculated with 10(6)Plasmodium berghei ANKA), and cerebral malaria group (inoculated with 10(7)P. berghei ANKA). The expressions of CD11b and HIF-1α in lung tissue were observed by immunohistochemistry, and serum SP-D levels were measured by ELISA...
July 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28077805/spin-exciton-interaction-and-related-micro-photoluminescence-spectra-of-znse-mn-dms-nanoribbon
#14
Lipeng Hou, Weichang Zhou, Bingsuo Zou, Yu Zhang, Junbo Han, Xinxin Yang, Zhihong Gong, Jingbo Li, Sishen Xie, Li-Jie Shi
For their spintronic applications the magnetic and optical properties of diluted magnetic semiconductors (DMS) have been studied widely. However, the exact relationships between the magnetic interactions and optical emission behaviors in DMS are not well understood yet due to their complicated microstructural and compositional characters from different growth and preparation techniques. Manganese (Mn) doped ZnSe nanoribbons with high quality were obtained by using the chemical vapor deposition (CVD) method...
March 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28054406/surfactant-protein-d-regulates-murine-testicular-immune-milieu-and-sperm-functions
#15
Sushama Rokade, Uday Kishore, Taruna Madan
PROBLEM: Surfactant protein D (SP-D), a pattern recognition protein that regulates inflammation and immune homoeostasis, is expressed by testicular germ cells under the influence of testosterone. This study investigates the role of SP-D in testicular immune privilege and sperm functions. METHOD OF STUDY: Testicular levels of cytokines and immunoregulatory molecules were evaluated in lipopolysaccharide (LPS)-challenged SP-D gene knockout mice (SP-D(-/-) ). Further, sperm functions were assessed by computer-assisted sperm analyser (CASA) and in vitro capacitation...
January 5, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28011976/genetic-polymorphisms-of-sp-a-sp-b-and-sp-d-and-risk-of-respiratory-distress-syndrome-in-preterm-neonates
#16
Hong-Yu Chang, Fang Li, Feng-Sheng Li, Cheng-Zhong Zheng, Yan-Zhe Lei, Jing Wang
BACKGROUND We examined selected polymorphisms in 3 pulmonary surfactant-associated proteins (SP) for their influence on serum SP levels and risk of respiratory distress syndrome (RDS) in preterm neonates. MATERIAL AND METHODS Premature infants from a Han population were enrolled, including 100 premature infants with RDS (case group) and 120 premature infants without RDS (control group). SNP genotyping for SP-A (+186A/G and +655C/T), SP-B (-18A/C and 1580C/T), and SP-D (Met11ThrT/C and Ala160ThrG/A) used polymerase chain reaction-restriction fragment length polymorphism...
December 24, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27991644/pulmonary-surfactant-protein-sp-d-opsonises-carbon-nanotubes-and-augments-their-phagocytosis-and-subsequent-pro-inflammatory-immune-response
#17
Kirsten M Pondman, Basudev Paudyal, Robert B Sim, Anuvinder Kaur, Lubna Kouser, Anthony G Tsolaki, Lucy A Jones, Carolina Salvador-Morales, Haseeb A Khan, Bennie Ten Haken, Gudrun Stenbeck, Uday Kishore
Carbon nanotubes (CNTs) are increasingly being developed for use in biomedical applications, including drug delivery. One of the most promising applications under evaluation is in treating pulmonary diseases such as tuberculosis. Once inhaled or administered, the nanoparticles are likely to be recognised by innate immune molecules in the lungs such as hydrophilic pulmonary surfactant proteins. Here, we set out to examine the interaction between surfactant protein D (SP-D), a key lung pattern recognition molecule and CNTs, and possible downstream effects on the immune response via macrophages...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/27976836/soluble-thrombomodulin-in-bronchoalveolar-lavage-fluid-is-an-independent-predictor-of-severe-drug-induced-lung-injury
#18
Atsushi Suzuki, Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahiko Ando, Naohiro Watanabe, Tomoki Kimura, Kensuke Kataoka, Toshiki Yokoyama, Koji Sakamoto, Yoshinori Hasegawa
BACKGROUND AND OBJECTIVE: Drug-induced lung injury (DLI) can result from a vast number of agents, and sometimes presents findings similar to those of acute respiratory distress syndrome (ARDS). Previous studies have reported that circulating levels of soluble thrombomodulin (TM) reflect endothelial injuries, which play key roles in the development of ARDS. We hypothesized that endothelial injuries are an important aspect of pathogenesis in severe DLI. The primary aim of this study was to examine the associations between soluble TM and disease severity in DLI patients...
December 15, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27942619/effect-of-co-co-doping-on-the-optical-properties-of-znte-mn-nanocrystals
#19
Alessandra S Silva, Sidney A Lourenço, Marco A T da Silva, Sebastião W da Silva, Paulo C Morais, Noelio O Dantas
We study the effect of Co co-doping on the optical properties of Mn-doped ZnTe nanocrystals (NCs) embedded in a glass matrix. Optical absorption (OA) and crystal field theory strongly indicated the substitutional incorporation of Co(2+) ions into these semiconducting NCs as well as the characteristic transitions of these ions in the visible and near infrared spectral region. Transmission electron microscopy (TEM) images revealed an invariant NC lattice parameter with the incorporation of Mn(2+) and Co(2+) ions...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27913426/depletion-of-circulating-monocytes-suppresses-il-17-and-hmgb1-expression-in-mice-with-lps-induced-acute-lung-injury
#20
Zhilong Jiang, Qianlin Zhou, Chenlin Gu, Dandan Li, Lei Zhu
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an important cause of mortality in critically ill patients. Macrophages play an important role in the pathogenesis of ALI/ARDS. To investigate the role and underlying mechanisms of circulating monocytes and resident alveolar macrophages (AMs) in ALI/ARDS, we depleted circulating monocytes and AMs by clodronate-loaded liposome (CL) in a lipopolysaccharide (LPS)-induced ALI/ARDS mouse model. Our results indicated that depletion of circulating monocytes by intravenous injection of CL 2 days before intratracheal LPS treatment significantly suppressed the acute lung injury in mice with ALI/ARDS, accompanied with significant reduction in neutrophil influx, interleukin-17, monocyte chemoattractant protein 1, high-mobility group box 1 protein, suppressor of cytokine signaling 3, and surfactant protein D (SP-D) in the lungs of 2 days intratracheal LPS-treated mice...
February 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
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