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https://www.readbyqxmd.com/read/29025303/serum-surfactant-protein-d-as-a-marker-for-bronchopulmonary-dysplasia
#1
Suja Vinod, Andrew Gow, Barry Weinberger, Debra Potak, Mark Hiatt, Shaku Chandra, Thomas Hegyi
BACKGROUND: Lung epithelial cells express surfactant protein D (SP-D), a calcium-dependent lectin that plays an important role in antibody-independent pulmonary host defense. Previous studies have shown that it is found in the peripheral circulation in patients with pulmonary disease, likely because of translocation into the blood when lung epithelial barriers are disrupted by inflammation or acute injury. In adults, serum SP-D levels are biomarkers for the progression and severity of chronic lung disease...
October 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29021828/endurance-exercise-training-decreased-serum-levels-of-surfactant-protein-d-and-improved-aerobic-fitness-of-obese-women-with-type-2-diabetes
#2
Sajjad Rezaei, Mahdieh Molanouri Shamsi, Mehdi Mahdavi, Azadeh Jamali, Jonato Prestes, Ramires Alsamir Tibana, James Wilfred Navalta, Fabrício Azevedo Voltarelli
BACKGROUND: Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defense. To find the relationship between exercise training and SP-D in diabetes, we examined the possible effects of a 10-week endurance exercise-training program on serum levels of SP-D, leptin, lipid profile and insulin resistance in obese women with type-2 diabetes mellitus (T2DM). METHODS: Twenty-two obese women with T2DM were randomly assigned to either exercise training (ET) or control (C) group...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28986143/validation-of-calcaneus-trabecular-microstructure-measurements-by-hr-pqct
#3
Louis M Metcalf, Enrico Dall'Ara, Margaret A Paggiosi, John R Rochester, Nicolas Vilayphiou, Graham J Kemp, Eugene V McCloskey
OBJECTIVE: Assessment of calcaneus microstructure using high-resolution peripheral quantitative computed tomography (HR-pQCT) might be used to improve fracture risk predictions or to assess responses to pharmacological and physical interventions. To develop a standard clinical protocol for the calcaneus, we validated calcaneus trabecular microstructure measured by HR-pQCT against 'gold-standard' micro-CT measurements. METHODS: Ten human cadaveric feet were scanned in situ using HR-pQCT (isotropic 82μm voxel size) at 100, 150 and 200ms integration times, and at 100ms integration time following removal of the calcaneus from the foot (ex vivo)...
October 3, 2017: Bone
https://www.readbyqxmd.com/read/28972165/surfactant-protein-a-downregulates-epidermal-growth-factor-receptor-by-mechanisms-different-from-those-of-surfactant-protein-d
#4
Yoshihiro Hasegawa, Motoko Takahashi, Shigeru Ariki, Atsushi Saito, Yasuaki Uehara, Rina Takamiya, Koji Kuronuma, Hirofumi Chiba, Yuji Sakuma, Hiroki Takahashi, Yoshio Kuroki
We recently reported that the lectin surfactant protein D (SP-D) suppresses epidermal growth factor receptor (EGFR) signaling by interfering with ligand-binding to EGFR through an interaction between the carbohydrate recognition domain (CRD) of SP-D and N-glycans of EGFR. Here, we report that surfactant protein A (SP-A) also suppresses EGF signaling in A549 human lung adenocarcinoma cells and in CHOK1 cells stably expressing human EGFR and that SP-A inhibits the proliferation and motility of the A549 cells...
September 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28967518/gymnocranius-obesus-a-new-large-eye-seabream-from-the-coral-triangle
#5
Wei-Jen Chen, Ryohei Miki, Philippe Borsa
Two previously recorded new species of the large-eye seabream genus Gymnocranius (Gymnocranius sp. D and Gymnocranius sp. E) remain undescribed. Here we describe Gymnocranius sp. E as Gymnocranius obesus sp. nov. This new species is morphologically distinct from all other known species under Gymnocranius by the following combination of characters: relatively deep body, with ratio of standard length to body depth 2.2-2.4; protruding large eye, with eye diameter about equal to or slightly larger than inter-orbital width; caudal fin moderately forked; no blue spots or wavy blue lines on cheek and snout in adults; fourth transversal dark bar on flank running from the sixth spine of the dorsal fin to the origin of the anal fin; anal, caudal and dorsal fins drab with yellowish to yellow margins...
September 26, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28960651/surfactant-protein-d-multimerization-and-gene-polymorphism-in-copd-and-asthma
#6
Dalia Fakih, Zeina Akiki, Kirsten Junker, Myrna Medlej-Hashim, Mirna Waked, Pascale Salameh, Uffe Holmskov, Hasnaa Bouharoun-Tayoun, Soulaima Chamat, Grith L Sorensen, Rania Jounblat
BACKGROUND AND OBJECTIVE: A structural single nucleotide polymorphism rs721917 in the surfactant protein D (SP-D) gene, known as Met11Thr, was reported to influence the circulating levels and degree of multimerization of SP-D and was associated with both COPD and atopy in asthma. Moreover, disease-related processes are known to degrade multimerized SP-D, however, the degree of the protein degradation in these diseases is not clarified. We aimed to determine the distribution of multimerized (high molecular weight (HMW)) and non-multimerized (low molecular weight (LMW)) species of serum SP-D and their correlation with genetic polymorphisms and presence of disease in Lebanese COPD and asthmatic patients...
September 28, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28947028/serum-surfactant-protein-d-predicts-the-outcome-of-patients-with-idiopathic-pulmonary-fibrosis-treated-with-pirfenidone
#7
Kimiyuki Ikeda, Masanori Shiratori, Hirofumi Chiba, Hirotaka Nishikiori, Keiki Yokoo, Atsushi Saito, Yoshihiro Hasegawa, Koji Kuronuma, Mitsuo Otsuka, Gen Yamada, Hiroki Takahashi
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal pulmonary disease with poor prognosis. Pirfenidone, the first antifibrotic drug, suppresses the decline in forced vital capacity (FVC) and improves prognosis in some, but not all, patients with IPF; therefore, an indicator for identifying improved outcomes in pirfenidone therapy is desirable. This study aims to clarify whether baseline parameters can be predictors of disease progression and prognosis in patients with IPF treated with pirfenidone...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28945872/serum-surfactant-protein-d-as-a-biomarker-for-measuring-lung-involvement-in-obese-type-2-diabetic-patients
#8
Carolina López-Cano, Albert Lecube, Marta García-Ramírez, Xavier Muñoz, Enric Sánchez, Asunción Seminario, Marta Hernández, Andreea Ciudin, Liliana Gutiérrez, Cristina Hernández, Rafael Simó
Context: Lung impairment is a new target for late diabetic complications. Biomarkers that could facilitate the identification of patients requiring functional respiratory tests have not been reported. Objective: The aim of this study is to examine whether serum surfactant protein D (SP-D) and A (SP-A) could be useful biomarkers of lung damage in obese patients with type 2 diabetes without known lung disease. Design and Setting: A case-control study conducted in an ambulatory obesity unit...
September 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28943927/measurement-of-exhaled-nitric-oxide-and-serum-surfactant-protein-d-levels-for-monitoring-radiation-pneumonitis-following-thoracic-radiotherapy
#9
Hideya Yamazaki, Norihiro Aibe, Satoaki Nakamura, Naomi Sasaki, Gen Suzuki, Ken Yoshida, Kei Yamada, Masahiko Koizumi, Taichiro Arimoto, Yoshinobu Iwasaki, Yoshiko Kaneko, Koichi Takayama
The present study aimed to examine the role of exhaled nitric oxide (eNO) and serum surfactant protein D (SP-D) level in the determination of radiation pneumonitis (RP) after thoracic radiotherapy (RT). The study included 34 treatments for 33 patients, including 16 three-dimensional conformal and 18 stereotactic body RT treatments. eNO levels were measured prior to RT, immediately subsequent to RT, every week during the RT course and at 1, 3, 6, 9 and 12 months following the treatment. The therapy reduced the eNO from 24...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943558/the-serum-level-of-kl-6-is-associated-with-the-risk-of-insulin-resistance-and-new-onset-diabetes-mellitus-the-tanno-sobetsu-study
#10
Hiroshi Akasaka, Hirofumi Ohnishi, Yoshifumi Narita, Masami Kameda, Takayuki Miki, Hiroki Takahashi, Wari Yamamoto, Hitoshi Sohma, Naoya Masumori, Tetsuji Miura
Objective Inflammatory cytokines generated in visceral fat have been shown to contribute to the development of insulin resistance. The involvement of pulmonary inflammation in insulin resistance remains unclear, but smoking is known to be a risk factor for diabetes as well as chronic obstructive pulmonary disease. We herein examined the hypothesis that increased serum levels of lung interstitial injury biomarkers (SP-A, SP-D and KL-6) are associated with the risk of diabetes development. Methods For cross-sectional and longitudinal analyses, we enrolled 750 apparently healthy non-diabetic subjects who received annual examinations in 2011 or 2012 in the Tanno-Sobetsu cohort...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28937231/pulmonary-surfactant-and-bacterial-lipopolysaccharide-the-interaction-and-its-functional-consequences
#11
M Kolomaznik, Z Nova, A Calkovska
The respiratory system is constantly exposed to pathogens which enter the lungs by inhalation or via blood stream. Lipopolysaccharide (LPS), also named endotoxin, can reach the airspaces as the major component of the outer membrane of Gram-negative bacteria, and lead to local inflammation and systemic toxicity. LPS affects alveolar type II (ATII) cells and pulmonary surfactant and although surfactant molecule has the effective protective mechanisms, excessive amount of LPS interacts with surfactant film and leads to its inactivation...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28881145/secondhand-tobacco-smoke-and-severity-in-wheezing-children-nasal-oxidant-stress-and-inflammation
#12
Ozge Yilmaz, Ahmet Turkeli, Ece Onur, Sema Bilge, Hasan Yuksel
OBJECTIVES: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. METHODS: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment...
September 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28878025/gallbladder-derived-surfactant-protein-d-regulates-gut-commensal-bacteria-for-maintaining-intestinal-homeostasis
#13
Hana Sarashina-Kida, Hideo Negishi, Junko Nishio, Wataru Suda, Yuki Nakajima, Mika Yasui-Kato, Keiko Iwaisako, Sujin Kang, Nobuyasu Endo, Hideyuki Yanai, Masataka Asagiri, Hiroshi Kida, Masahira Hattori, Atsushi Kumanogoh, Tadatsugu Taniguchi
The commensal microbiota within the gastrointestinal tract is essential in maintaining homeostasis. Indeed, dysregulation in the repertoire of microbiota can result in the development of intestinal immune-inflammatory diseases. Further, this immune regulation by gut microbiota is important systemically, impacting health and disease of organ systems beyond the local environment of the gut. What has not been explored is how distant organs might in turn shape the microbiota via microbe-targeted molecules. Here, we provide evidence that surfactant protein D (SP-D) synthesized in the gallbladder and delivered into intestinal lumen binds selectively to species of gut commensal bacteria...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28875146/importance-of-serial-changes-in-biomarkers-in-idiopathic-pulmonary-fibrosis
#14
Akihiko Sokai, Kiminobu Tanizawa, Tomohiro Handa, Kumiko Kanatani, Takeshi Kubo, Kohei Ikezoe, Yoshinari Nakatsuka, Shinsaku Tokuda, Toru Oga, Toyohiro Hirai, Sonoko Nagai, Kazuo Chin, Michiaki Mishima
The clinical significance of serial changes in serum biomarkers in patients with idiopathic pulmonary fibrosis (IPF) remains to be established. This retrospective study was conducted to clarify the associations of serial changes in serum Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) with changes in physiological indices and overall mortality in IPF. The study subjects were 75 patients with IPF. The 6 month change in serum KL-6 was significantly correlated with changes in the percentage of the predicted forced vital capacity (FVC % pred) and the percentage of the predicted diffusing capacity of the lung for carbon monoxide (% DLCO), while the 6 month change in serum SP-D was correlated only with % DLCO...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28868809/color-tuning-in-garnet-oxides-the-role-of-tetrahedral-coordination-geometry-for-3%C3%A2-d-metal-ions-and-ligand-metal-charge-transfer-band-gap-manipulation
#15
Anupam Bhim, Sourav Laha, Jagannatha Gopalakrishnan, Srinivasan Natarajan
We explored garnet-structured oxide materials containing 3d transition-metal ions (e.g., Co(2+) , Ni(2+) , Cu(2+) , and Fe(3+) ) for the development of new inorganic colored materials. For this purpose, we synthesized new garnets, Ca3 Sb2 Ga2 ZnO12 (I) and Ca3 Sb2 Fe2 ZnO12 (II), that were isostructural with Ca3 Te2 Zn3 O12 . Substitution of Co(2+) , Ni(2+) , and Cu(2+) at the tetrahedral Zn(2+) sites in I and II gave rise to brilliantly colored materials (different shades of blue, green, turquoise, and red)...
September 4, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28836844/behavioral-and-physiologic-changes-in-holstein-steers-experimentally-infected-with-mannheimia-haemolytica
#16
Nicole L Eberhart, Jennifer M Storer, Marc Caldwell, Arnold M Saxton, Peter D Krawczel
OBJECTIVE To evaluate changes in behavior and surfactant protein (SP) A and D concentrations in serum and bronchoalveolar lavage fluid (BALF) samples of calves experimentally infected with Mannheimia haemolytica. ANIMALS Twelve 4- to 5-month-old Holstein steers. PROCEDURES Calves were divided into 2 treatment groups and instrumented with a data logger to collect behavioral data. After 10 days of acclimation, calves were experimentally inoculated with 3 × 10(9) CFUs to 5 × 10(9) CFUs of M haemolytica suspended in approximately 5 mL of PBS solution (infected calves; n = 6) or 5 mL of PBS solution without M haemolytica (control calves; 6) through a catheter into the right accessory lung lobe...
September 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28828358/biomarkers-for-the-acute-respiratory-distress-syndrome-how-to-make-the-diagnosis-more-precise
#17
REVIEW
M Isabel García-Laorden, José A Lorente, Carlos Flores, Arthur S Slutsky, Jesús Villar
The acute respiratory distress syndrome (ARDS) is an acute inflammatory process of the lung caused by a direct or indirect insult to the alveolar-capillary membrane. Currently, ARDS is diagnosed based on a combination of clinical and physiological variables. The lack of a specific biomarker for ARDS is arguably one of the most important obstacles to progress in developing novel treatments for ARDS. In this article, we will review the current understanding of some appealing biomarkers that have been measured in human blood, bronchoalveolar lavage fluid (BALF) or exhaled gas that could be used for identifying patients with ARDS, for enrolling ARDS patients into clinical trials, or for better monitoring of patient's management...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28814734/dipole-orientation-analysis-without-optical-simulation-application-to-thermally-activated-delayed-fluorescence-emitters-doped-in-host-matrix
#18
Takeshi Komino, Yuji Oki, Chihaya Adachi
The dipole orientation of guest emitters doped into host matrices is usually investigated by angular dependent photoluminescence (PL) measurements, which acquire an out-of-plane PL radiation pattern of the guest-host thin films. The PL radiation patterns generated by these methods are typically analysed by optical simulations, which require expertise to perform and interpret in the simulation. In this paper, we developed a method to calculate an orientational order parameter S without the use of full optical simulations...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805192/temperature-dependent-magnetic-compton-profiles-and-first-principles-strategies-of-quaternary-half-heusler-alloy-co1-x-cu-x-mnsb-0%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-x%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-0-8
#19
Kishor Kumar, Alpa Dashora, N L Heda, H Sakurai, N Tsuji, M Itou, Y Sakurai, B L Ahuja
Temperature dependent experimental Compton profiles of quaternary alloys Co1-x Cu x MnSb (x  =  0.0, 0.2, 0.6 and 0.8) when decomposed into constituent profiles show that the sp-electron spin polarization is antiferromagnetically coupled to Mn-3d moments. The orbital magnetic moments derived from combination of magnetic Compton profiles (MCPs) and magnetization measurements are found to be small. Moreover, the first-principles full potential-linearized augmented plane wave (FP-LAPW) calculations have been performed to validate the experimental investigations of spin moments and half-Heusler properties...
August 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28791362/correlation-analysis-of-surfactant-protein-a-and-surfactant-protein-d-with-lung-function-in-exhaled-breath-condensate-from-lung-cancer-patients-with-and-without-copd
#20
Xuefeng Lin, Zhenlin Wu, Yichu Fan, Mingyou Chi, Xiaodong Wang, Xun Zhang, Daqiang Sun
Pulmonary surfactant protein A (SP‑A) and pulmonary surfactant protein D (SP‑D) are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to determine the correlation between SP‑A, SP‑D and lung function in patients with COPD. A total of 60 patients with lung cancer undergoing unilateral lobectomy were selected and divided into three groups, including a non‑COPD group (n=20), a COPD treatment group (n=20) and a COPD control group (n=20)...
October 2017: Molecular Medicine Reports
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