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https://www.readbyqxmd.com/read/29464958/sp-d-exchange-interactions-in-wave-function-engineered-colloidal-cdse-mn-cds-hetero-nanoplatelets
#1
Franziska Muckel, Savas Delikanli, Pedro Ludwig Hernandez Martinez, Tamara Priesner, Severin Lorenz, Julia Ackermann, Manoj Sharma, Hilmi Volkan Demir, Gerd Bacher
In two-dimensional (2D) colloidal semiconductor nanoplatelets, which are atomically flat nanocrystals, the precise control of thickness and composition on the atomic scale allows for the synthesis of heterostructures with well-defined electron and hole wave function distributions. Introducing transition metal dopants with monolayer precision enables tailored magnetic exchange interactions between dopants and band states. Here, we use the absorption based technique of magnetic circular dichroism (MCD) to directly prove exchange coupling of magnetic dopants with the band charge carriers in shell-doped CdSe/Mn:CdS hetero-nanoplatelets...
February 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29445934/serum-surfactant-protein-levels-in-patients-admitted-to-the-hospital-with-acute-copd-exacerbation
#2
Andriana I Papaioannou, Elisavet Konstantelou, Anastasia Papaporfyriou, Konstantinos Bartziokas, Aris Spathis, Petros Bakakos, Stelios Loukides, Nikolaos Koulouris, Spyros Papiris, Konstantinos Kostikas
Surfactant proteins (SPs) have been studied in COPD patients as biomarkers of disease severity and as predictive factors of unfavorable outcomes. The aim of this exploratory study was to evaluate serum levels of SP-A, SP-B, SP-C, and SP-D in patients with COPD both during AECOPD and in stability and to test their possible associations with disease severity and with the development of new exacerbation events. 20 consecutive COPD patients hospitalized for AECOPD were included. Serum SP levels were measured on admission, at discharge, and on stability...
February 14, 2018: Lung
https://www.readbyqxmd.com/read/29440688/unbalanced-inflammatory-reaction-could-increase-tissue-destruction-and-worsen-skin-infectious-diseases-a-comparative-study-of-leishmaniasis-and-sporotrichosis
#3
F N Morgado, L M V de Carvalho, J Leite-Silva, A J Seba, M I F Pimentel, A Fagundes, M F Madeira, M R Lyra, M M Oliveira, A O Schubach, F Conceição-Silva
The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425774/a-membrane-type-surfactant-protein-d-sp-d-suppresses-macrophage-mediated-cytotoxicity-in-swine-endothelial-cells
#4
Patmika Jiaravuthisan, Akira Maeda, Chihiro Takakura, Han-Tang Wang, Rieko Sakai, Afifah Mohd Shabri, Pei-Chi Lo, Rei Matsuura, Tasuku Kodama, Hiroshi Eguchi, Hiroomi Okuyama, Shuji Miyagawa
OBJECTIVE: Surfactant protein D (SP-D), which is secreted mainly in the lung, is an oligometric C type lectin that promotes phagocytosis by binding to carbohydrates on microbial surfaces. SP-D can also bind SIRPα, leading to a decrease in cytokine production by monocytes/macrophages. In the present study, we examined the possibility that SP-D suppresses macrophage-mediated xenogeneic cytotoxicity, by creating a membrane-type SP-D. METHODS: The cDNA for the carbohydrate recognition domain (CRD) of human SP-D was switched to that of a membrane-type protein, collectin placenta 1 (CL-P1), with a Flag-tag...
February 6, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29424908/hyperoxia-induces-the-apoptosis-of-alveolar-epithelial-cells-and-changes-of-pulmonary-surfactant-proteins
#5
Y Jin, L-Q Peng, A-L Zhao
OBJECTIVE: To explore the changes of surfactant protein C, D (SP-C, SP-D) and apoptosis of alveolar epithelial cells (AEC) in the lung injury of neonatal rats induced by hyperoxia. MATERIALS AND METHODS: We divided neonatal rats within 24 hours into two groups randomly: the air group (n = 50) and the hyperoxia group (n = 50). Rats in the air group and hyperoxia group were bred conventionally and in tanks with normal pressure and 90% concentration of oxygen, respectively...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29422546/a-comparative-study-of-growth-different-body-weight-trajectories-in-three-species-of-the-genus-eublepharis-and-their-hybrids
#6
Daniel Frynta, Jitka Jančúchová-Lásková, Petra Frýdlová, Eva Landová
An extensive research effort is devoted to the evolution of life-histories and processes underlying the variation in adult body weight; however, in this regard, some animal taxa remain neglected. Here we report rates and timing of growth recorded in two wild-derived populations of a model lizard species, Eublepharis macularius (M, W), other two related species, i.e., E. angramainyu (A) and E. sp. (D), and their between-species hybrids. We detected clear differences among the examined species/populations, which can be interpreted in the terms of "fast - slow" continuum of life-history strategies...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414772/fungal-melanin-stimulates-surfactant-protein-d-mediated-opsonization-of-and-host-immune-response-to-em-aspergillus-fumigatus-em-spores
#7
Sarah Sze Wah Wong, Manjusha Rani, Eswari Dodagatta-Marri, Oumaima Ibrahim-Granet, Uday Kishore, Jagadeesh Bayry, Jean-Paul Latgé, Arvind Sahu, Taruna Madan, Vishukumar Aimanianda
Surfactant protein D (SP-D), a C-type lectin and pattern-recognition soluble factor, plays an important role in immune surveillance to detect and eliminate human pulmonary pathogens. SPD has been shown to protect against infections with the most ubiquitous airborne fungal pathogen, <em>Aspergillus fumigatus</em>, but the fungal surface component(s) interacting with SP-D is unknown. Here, we show that SP-D binds to melanin pigment on the surface of <em>A. fumigatus</em> dormant spores (conidia)...
February 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29393256/clinical-course-of-histologically-proven-multifocal-micronodular-pneumocyte-hyperplasia-in-tuberous-sclerosis-complex-a-case-series-and-comparison-with-lymphangiomyomatosis
#8
Satoshi Konno, Masahiko Shigemura, Takahiro Ogi, Kaoruko Shimizu, Masaru Suzuki, Kichizo Kaga, Yasuhiro Hida, Yoshihiro Matsuno, Masaharu Nishimura
BACKGROUND: Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of tuberous sclerosis complex (TSC). Because of its rarity, no previous study has described the detailed clinical course of this disease. OBJECTIVES: This study aimed to clarify the longitudinal clinical characteristics of subjects with MMPH. METHODS: Nine patients with MMPH diagnosed at Hokkaido University Hospital were retrospectively analyzed...
January 24, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29368450/frequency-dependent-airway-hyperresponsiveness-in-a-mouse-model-of-emphysema-and-allergic-inflammation
#9
Kentaro Tamura, Koichiro Matsumoto, Satoru Fukuyama, Keiko Kan-O, Yumiko Ishii, Ken Tonai, Miyoko Tatsuta, Aimi Enokizu, Hiromasa Inoue, Yoichi Nakanishi
Asthma and chronic obstructive pulmonary disease (COPD), chronic airway inflammatory diseases characterized by airflow limitation, have different etiologies and pathophysiologies. Asthma-COPD Overlap (ACO) has recently been used for patients with mixed asthma and COPD. The pathophysiological mechanisms of ACO have not been clearly understood due to the lack of an appropriate murine model. To investigate its pathophysiology, we examined a murine model by allergen challenge in surfactant protein-D (SP-D)-deficient mice that spontaneously developed pulmonary emphysema...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29368146/irritant-induced-asthma-to-hypochlorite-in-mice-due-to-impairment-of-the-airway-barrier
#10
Sofie Van Den Broucke, Lore Pollaris, Greetje Vande Velde, Erik Verbeken, Benoit Nemery, Jeroen Vanoirbeek, Peter Hoet
Inhalation of commonly present irritants, such as chlorine and chlorine derivatives, can cause adverse respiratory effects, including irritant-induced asthma (IIA). We hypothesize that due to airway barrier impairment, exposure to hypochlorite (ClO-) can result in airway hypersensitivity. C57Bl/6 mice received an intra-peritoneal (i.p.) injection of the airway damaging agent naphthalene (NA, 200 mg/kg body weight) or vehicle (mineral oil, MO). In vivo micro-computed tomography (CT) images of the lungs were acquired before and at regular time points after the i...
January 24, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29324810/course-of-sp-d-ykl-40-ccl18-and-ca-15-3-in-adult-patients-hospitalised-with-community-acquired-pneumonia-and-their-association-with-disease-severity-and-aetiology-a-post-hoc-analysis
#11
Simone M C Spoorenberg, Stefan M T Vestjens, G P Voorn, Coline H M van Moorsel, Bob Meek, Pieter Zanen, Ger T Rijkers, Willem Jan W Bos, Jan C Grutters
BACKGROUND AND AIM: SP-D, YKL-40, CCL18 and CA 15-3 are pulmonary markers that have been extensively investigated in different chronic pulmonary diseases. However, in acute pulmonary diseases, such as community-acquired pneumonia (CAP), little is known about the course of these markers and their relationship with the aetiological agent. The aim of this study was to investigate the course of these four markers in CAP and to study influence of disease severity, aetiology and antibiotic use prior to admission on their course...
2018: PloS One
https://www.readbyqxmd.com/read/29324056/cardiopulmonary-effects-induced-by-occupational-exposure-to-titanium-dioxide-nanoparticles
#12
Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang, Guang Jia
Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO2) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-TiO2 and to identify biomarkers associated with exposure. A cross-sectional study was conducted in a nano-TiO2 manufacturing plant in eastern China. Exposure assessment and characterization of TiO2 particles were performed in a packaging workshop...
January 11, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29311495/fluorescent-imaging-analysis-for-distribution-of-fluorescent-dye-labeled-or-encapsulated-liposome-in-monocrotaline-induced-pulmonary-hypertension-model-rat
#13
Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo
Pulmonary hypertension (PH) is a life-threatening lung disease. Despite the availability of several approved drugs, the development of a new treatment method is needed because of poor prognosis. Tissue selective drug delivery systems can avoid the adverse effects of current therapy and enhance efficacy. We evaluated the possibility of delivering drugs to the lungs of a PH rat model using fluorescence dye-labeled nanosized liposomes. To evaluate the tissue distribution following systemic exposure, fluorescent dye-labeled, 40-180 nm liposomes with and without polyethylene glycol (PEG) were intravenously administered to a monocrotaline-induced PH (MCT) rat model and tissue fluorescence was measured...
January 6, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29300863/changes-in-orchid-populations-and-endophytic-fungi-with-rainfall-and-prescribed-burning-in-pterostylis-revoluta-in-victoria-australia
#14
N U Jasinge, T Huynh, A C Lawrie
Background and Aims: Wildfires are common in seasonally dry parts of the world with a Mediterranean climate. Prescribed burning is used to reduce fuel load and fire risk, but often without reliable information on its effects. This study investigated the effects of prescribed burns in different seasons on Pterostylis revoluta, an autumn-flowering Australian terrestrial orchid, and its orchid mycorrhizal fungi (OMFs) to find the least damaging season for a prescribed burn. Methods: Burns were conducted mid-season in spring and summer 2011 and autumn and winter 2012...
January 2, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29282698/elevated-surfactant-protein-levels-and-increased-flow-of-cerebrospinal-fluid-in-cranial-magnetic-resonance-imaging
#15
Stefan Schob, Alexander Weiß, Alexey Surov, Julia Dieckow, Cindy Richter, Mandy Pirlich, Diana Horvath-Rizea, Wolfgang Härtig, Karl-Titus Hoffmann, Matthias Krause, Ulf Quäschling
Surfactant proteins (SPs) are a multifunctional group of proteins, responsible for the regulation of rheological properties of body fluids, host defense, and cellular waste clearance. Their concentrations are changed in cerebrospinal fluid (CSF) of patients suffering from communicating hydrocephalus. Hydrocephalic conditions are accompanied by altered CSF flow dynamics; however, the association of CSF-SP concentrations and CSF flow has not yet been investigated. Hence, the aim of this study was to evaluate the association between SP concentrations in the CSF and marked CSF flow phenomena at different anatomical landmarks of CSF spaces...
December 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29278744/quantification-of-surfactant-proteins-in-tears-of-patients-suffering-from-dry-eye-disease-compared-to-healthy-subjects
#16
Andreas Posa, Friedrich Paulsen, Richard Dietz, Fabian Garreis, Ralph Sander, Martin Schicht, Saadettin Sel, Michael Scholz, Christian M Hammer, Lars Bräuer
PURPOSE: To quantify and compare the amounts of surfactant proteins SP-A, SP-B, SP-C and SP-D in the tear fluid collected from patients with dry eye syndrome and from individuals with a healthy ocular surface. METHODS: Schirmer strips were used to collect tear fluid from both eyes of 241 volunteers (99 men, 142 women; age range: 18-87 years). Dry eye syndrome was diagnosed by ophthalmologists in 125 patients, whereas the healthy control group comprised 116 individuals...
December 24, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29277064/reduced-serum-club-cell-protein-as-a-pulmonary-damage-marker-for-chronic-fine-particulate-matter-exposure-in-chinese-population
#17
Yanhua Wang, Huawei Duan, Tao Meng, Meili Shen, Qianpeng Ji, Jie Xing, Qingrong Wang, Ting Wang, Yong Niu, Tao Yu, Zhong Liu, Hongbing Jia, Yuliang Zhan, Wen Chen, Zhihu Zhang, Wenge Su, Yufei Dai, Xuchun Zhang, Yuxin Zheng
BACKGROUND: Exposure to fine particulate matter (PM2.5) pollution is associated with increased morbidity and mortality from respiratory diseases. However, few population-based studies have been conducted to assess the alterations in circulating pulmonary proteins due to long-term PM2.5 exposure. METHODS: We designed a two-stage study. In the first stage (training set), we assessed the associations between PM2.5 exposure and levels of pulmonary damage markers (CC16, SP-A and SP-D) and lung function in a coke oven emission (COE) cohort with 558 coke plant workers and 210 controls...
December 21, 2017: Environment International
https://www.readbyqxmd.com/read/29246207/plasma-surfactant-protein-d-as-a-diagnostic-biomarker-for-acute-respiratory-distress-syndrome-validation-in-us-and-korean-cohorts
#18
Jinkyeong Park, Maria Pabon, Augustine M K Choi, Ilias I Siempos, Laura E Fredenburgh, Rebecca M Baron, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Chi-Min Park, Gee Young Suh
BACKGROUND: Acute respiratory distress syndrome (ARDS) is potentially underrecognized by clinicians. Early recognition and subsequent optimal treatment of patients with ARDS may be facilitated by usage of biomarkers. Surfactant protein D (SP-D), a marker of alveolar epithelial injury, has been proposed as a potentially useful biomarker for diagnosis of ARDS in a few studies. We tried to validate the performance of plasma SP-D levels for diagnosis of ARDS. METHODS: We conducted a retrospective analysis using data from three (two in USA and one in Korea) prospective biobank cohorts involving 407 critically ill patients admitted to medical intensive care unit (ICU)...
December 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29191953/surfactant-protein-d-is-a-causal-risk-factor-for-copd-results-of-mendelian-randomisation
#19
Ma'en Obeidat, Xuan Li, Stephen Burgess, Guohai Zhou, Nick Fishbane, Nadia N Hansel, Yohan Bossé, Philippe Joubert, Ke Hao, David C Nickle, Maarten van den Berge, Wim Timens, Michael H Cho, Brian D Hobbs, Kim de Jong, Marike Boezen, Rayjean J Hung, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H Beaty, Kathleen C Barnes, Peter D Paré, Don D Sin
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these variants affected lung tissue gene expression in 1037 individuals. A Mendelian randomisation framework was then applied, whereby serum SP-D-associated variants were tested for association with COPD risk in 11 157 cases and 36 699 controls and with 11 years decline of lung function in the 4061 individuals...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29168349/bioactive-pimarane-diterpenes-from-the-arctic-fungus-eutypella-sp-d-1
#20
Xiaoli Wang, Kunlai Sun, Bin Wang
Two new pimarane diterpenes, libertellenone M (1) and libertellenone N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. D-1 derived from high-latitude soil of the Arctic. The structures of these compounds were determined by spectroscopic data as well as experimental and calculated electronic circular dichroism (ECD) analysis. Antimicrobial and cytotoxic activities of the isolated compounds were evaluated. Compound 3 exhibited weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Vibrio vulnificus, each with MIC values of 16 μg/mL...
November 23, 2017: Chemistry & Biodiversity
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