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https://www.readbyqxmd.com/read/28738534/high-expression-of-cd47-predicts-adverse-prognosis-in-chinese-patients-and-suppresses-immune-response-in-melanoma
#1
Wenhua Fu, Jisen Li, Wei Zhang, Peng Li
BACKGROUND: Cluster of differentiation 47 (CD47) negatively regulates macrophage phagocytosis and is correlated with adverse survival of multiple cancers. In melanoma patients, especially in Chinese melanoma patients, its prognostic value is unclear. In this study, we aim to study the prognostic value of CD47 in a Chinse melanoma patient cohort and its immunomodulation roles in mouse model. METHOD: 164 melanoma tissue specimens were collected. The expression of CD47 in these clinical samples was examined by immunohistochemistry staining (IHC)...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738530/prenatal-low-level-phenol-exposures-and-birth-outcomes-in-china
#2
Guodong Ding, Caifeng Wang, Angela Vinturache, Shasha Zhao, Rui Pan, Wenchao Han, Limei Chen, Weiye Wang, Tao Yuan, Yu Gao, Ying Tian
Phenolic compounds are among the endocrine disruptors which are widely used in daily life products. Studies in laboratory animals showed reproductive and developmental effects. In spite of widespread exposure to phenols, only few studies examined their effects on human development. This study was designed to investigate the relationship between antenatal phenol exposure and birth outcomes in a Chinese obstetric population. Four hundred ninety-six mother-infant pairs recruited from the Laizhou Wan prospective birth cohort in northern China between 2010 and 2013 were included in the study...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28738487/-circadian-blood-pressure-characteristics-in-hospitalized-unstable-angina-pectoris-patients-with-hypertension
#3
W Zhang, H Zhu, S Y Yao, Y Li, J Liu, H Xue
Objective: To define the characteristic of circadian rhythm of blood pressure in unstable angina pectoris (UAP)patients with hypertension and its effects on the cardiovascular events. Methods: It was a prospective study.Based on coronary angiographic results, 742 consecutive hospitalized UAP patients with hypertension and 89 consecutive hospitalized hypertensive patients were recruited between September 2014 and December 2015 in this study. Clinical data and the results of 24-hour ambulatory blood pressure monitoring (ABPM) were analyzed...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28738466/-a-large-scale-cohort-study-on-aids-in-communities-in-dali-yunnan-province-2014-2015
#4
M Y Xiao, X M Chen, Y L Ma, L R Fu, J Niu, Z J Chen, H Y Li, Q L Wang, L J Song, H B Luo
Objective: To understand HIV incidence in community residents and epidemiological characteristics of newly detected HIV infection cases in Dali, Yunnan province. Methods: A cohort study was conducted among 146 720 community residents who were tested to be HIV negative during 2010-2011, they were followed-up from June 1, 2014 to May 31, 2015. Results: A total of 136 356 community residents received follow up (92.9%). The follow-up time was 0.23-5.40 years (medium: 3.43 years), cumulatively 459 675 person years, and 78 people were found to be HIV positive...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738462/-risk-factors-of-gout-in-jinchang-cohort-a-cox-regression-analysis
#5
C L He, N Cheng, Y M Rong, H Y Li, J S Li, J Ding, X B Hu, H Q Pu, X W Ren, Y N Bai
Objective: To explore the incidence and risk factors of gout in Jinchang cohort and provide scientific evidence for the prevention and control of gout. Methods: People without gout detected by baseline survey in Jinchang cohort were selected as study subjects. All the subjects were followed up through questionnaire interview, physical examination as well as laboratory test from January 24, 2013 to November 24, 2015. Cox regression model was used to analyze the risk factors for gout in Jinchang cohort. In addition, log-linear model was used to analyze the interaction between risk factors...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738456/-cost-effectiveness-of-community-based-treatment-of-chronic-hepatitis-b-in-china
#6
S X Zhang, P C Yang, Y L Cai, Y Lin, Y H Zou
Objective: Since eliminating hepatitis B in China would need considerable public health resources, the economics problem of the strategy of community-based antiviral treatment for chronic hepatitis B (CHB) has become an important issue. The cost-effectiveness and affordability of the strategy were evaluated in this study. Methods: According to the advocacy on eliminating hepatitis B by WHO and the comprehensive protocol of community based prevention of major infectious diseases and the guideline for CHB prevention and treatment in China, the decision analytic Markov model was constructed with the parameters from national surveys or Meta-analysis...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738435/abnormal-placental-cord-insertion-and-adverse-pregnancy-outcomes-results-from-a-prospective-cohort-study
#7
Khadijah I Ismail, Ailish Hannigan, Peter Kelehan, Keelin O'Donoghue, Amanda Cotter
No abstract text is available yet for this article.
July 24, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28738423/continued-statin-prescriptions-after-adverse-reactions-and-patient-outcomes-a-cohort-study
#8
Huabing Zhang, Jorge Plutzky, Maria Shubina, Alexander Turchin
Background: Many patients discontinue statin treatment, often after having a possible adverse reaction. The risks and benefits of continued statin therapy after an adverse reaction are not known. Objective: To examine the relationship between continuation of statin therapy (any prescription within 12 months after an adverse reaction) and clinical outcomes. Design: Retrospective cohort study. Setting: Primary care practices affiliated with 2 academic medical centers...
July 25, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28738421/cardiovascular-disease-among-transgender-adults-receiving-hormone-therapy-a-narrative-review
#9
Carl G Streed, Omar Harfouch, Francoise Marvel, Roger S Blumenthal, Seth S Martin, Monica Mukherjee
Recent reports estimate that 0.6% of adults in the United States, or approximately 1.4 million persons, identify as transgender. Despite gains in rights and media attention, the reality is that transgender persons experience health disparities, and a dearth of research and evidence-based guidelines remains regarding their specific health needs. The lack of research to characterize cardiovascular disease (CVD) and CVD risk factors in transgender populations receiving cross-sex hormone therapy (CSHT) limits appropriate primary and specialty care...
July 25, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28738395/outcomes-of-preoperative-and-postoperative-corticosteroid-therapies-in-myasthenia-gravis
#10
Yun Jing, Xinxin Liu, Lei Yu, Ran Li
AIMS: To compare the long-term outcomes of non-thymomatous myasthenia gravis (MG) patients receiving pre-thymectomy (Pre-CS) or post-thymectomy corticosteroid (Post-CS) therapy. METHODS: In a retrospective cohort study, 41 patients with MG were treated with Pre-CS therapy, and 110 were treated with Post-CS therapy. RESULTS: In the MG cohorts, 9 of 40 patients (22.5%) in the Pre-CS group vs. 28 of 105 patients (26.7%) in the Post-CS group achieved a complete remission (CR) at 1 year, 29...
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28738394/the-contribution-of-adult-hippocampal-neurogenesis-to-the-progression-of-psychiatric-disorders
#11
Rachel A Kohman, Justin S Rhodes
New neurons are continuously formed in the adult hippocampus of the human, nonhuman primate, and rodent throughout life though rates of neurogenesis precipitously decline with age to near zero levels at the end of the natural life span. Since its discovery in the 1960s, a large number of studies have documented numerous environmental and genetic factors which regulate adult neurogenesis. Chief among the positive regulators of neurogenesis are exercise and antidepressant drugs. Chief among the negative regulators of neurogenesis besides age are stress and inflammation...
July 24, 2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28738386/exercise-capacity-impairment-can-predict-postoperative-pulmonary-complications-after-liver-transplantation
#12
Clarissa Bentes de Araújo Magalhães, Ingrid Correia Nogueira, Liegina Silveira Marinho, Elizabeth F Daher, José Huygens P Garcia, Cyntia F G Viana, Pedro Felipe Carvalhedo de Bruin, Eanes Delgado Barros Pereira
BACKGROUND: Postoperative respiratory complications (PRCs) are common after liver transplantation (LT) and contribute significantly to the related morbidity and mortality. OBJECTIVE: The aim of this paper was to determine the incidence of PRCs after LT and the value of simple exercise capacity measures as independent predictors of PRCs. METHODS: We conducted a prospective cohort study of consecutive adults submitted to LT at a University Hospital in Fortaleza Brazil from March 2013 to March 2015...
July 22, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28738364/risk-factors-for-community-acquired-pneumonia-in-adults-a-systematic-review-of-observational-studies
#13
Jordi Almirall, Mateu Serra-Prat, Ignasi Bolíbar, Valentina Balasso
We performed a systematic review of the literature to establish conclusive evidence of risk factors for community-acquired pneumonia (CAP). Observational studies (cross-sectional, case-control, and cohort studies) the primary outcome of which was to assess risk factors for CAP in both hospitalized and ambulatory adult patients with radiologically confirmed pneumonia were selected. The Newcastle-Ottawa Scale specific for cohort and case-control designs was used for quality assessment. Twenty-nine studies (20 case-control, 8 cohort, and 1 cross-sectional) were selected, with 44...
July 25, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28738355/impact-of-renin-angiotensin-aldosterone-system-inhibition-on-serum-potassium-levels-among-peritoneal-dialysis-patients
#14
Silvia Carreira Ribeiro, Ana Elizabeth Figueiredo, Pasqual Barretti, Roberto Pecoits-Filho, Thyago Proença de Moraes
BACKGROUND: The chronic use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker has been associated with hyperkalemia in patients with reduced renal function even after the initiation of hemodialysis. Whether such medications may cause a similar effect in peritoneal dialysis patients is not well established. So, the aim of our study was to analyze the impact of renin-angiotensin-aldosterone inhibitors on the serum levels of potassium in a national cohort of peritoneal dialysis patients...
July 22, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28738314/factors-associated-with-cognitive-impairment-in-a-cohort-of-older-homeless-adults-results-from-the-hope-home-study
#15
Emily Hurstak, Julene K Johnson, Lina Tieu, David Guzman, Claudia Ponath, Christopher T Lee, Christina Weyer Jamora, Margot Kushel
BACKGROUND: We evaluated cognitive function and factors associated with cognitive impairment in a cohort of older homeless adults. We hypothesized that substance use and a history of traumatic brain injury would be associated with cognitive impairment. METHODS: We recruited 350 homeless individuals aged ≥50 years using population-based sampling and conducted structured interviews and neuropsychological testing. We evaluated alcohol use with the Alcohol Use Disorder Identification Test, defining high-severity alcohol use as a total score ≥16 or ≥4 on the alcohol dependency sub-scale...
July 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28738300/paternal-and-maternal-preconception-urinary-phthalate-metabolite-concentrations-and-child-behavior
#16
Carmen Messerlian, David Bellinger, Lidia Mínguez-Alarcón, Megan E Romano, Jennifer B Ford, Paige L Williams, Antonia M Calafat, Russ Hauser, Joseph M Braun
BACKGROUND: Prenatal phthalate exposure has been associated with behavioral problems and lower performance on measures of cognitive ability in children. However, the potential effect of phthalate exposure during the sensitive preconception period is unknown. OBJECTIVES: To estimate the association of maternal and paternal preconception urinary phthalate metabolite concentrations with child behavior and evaluate potential modification by child sex. METHODS: We used data from 166 children (111 singletons, 26 pairs of twins, and 1 set of triplets) born to 134 mothers and 100 fathers participating in a prospective preconception cohort study of subfertile couples from the Massachusetts General Hospital Fertility Center...
July 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28738292/u-shaped-relationship-between-depression-and-body-mass-index-in-the-korean-adults
#17
J-H Lee, S K Park, J-H Ryoo, C-M Oh, J-M Choi, R S McIntyre, R B Mansur, H Kim, S Hales, J Y Jung
BACKGROUND: Although a number of studies have examined the relationship between depression and obesity, it is still insufficient to establish the specific pattern of relationship between depression and body mass index (BMI) categories. Thus, this study was aimed to investigate the relationship between depression and BMI categories. METHODS: A cross-sectional study was conducted for a cohort of 159,390 Korean based on Kangbuk Samsung Health Study (KSHS). Study participants were classified into 5 groups by Asian-specific cut-off of BMI (18...
June 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28738263/prenatal-exposure-to-pm2-5-and-birth-weight-a-pooled-analysis-from-three-north-american-longitudinal-pregnancy-cohort-studies
#18
Maria José Rosa, Ashley Pajak, Allan C Just, Perry E Sheffield, Itai Kloog, Joel Schwartz, Brent Coull, Michelle Bosquet Enlow, Andrea A Baccarelli, Kathi Huddleston, John E Niederhuber, Martha María Téllez Rojo, Robert O Wright, Chris Gennings, Rosalind J Wright
A common practice when analyzing multi-site epidemiological data is to include a term for 'site' to account for unmeasured effects at each location. This practice should be carefully considered when site can have complex relationships with important demographic and exposure variables. We leverage data from three longitudinal North American pregnancy cohorts to demonstrate a novel method to assess study heterogeneity and potential combinability of studies for pooled analyses in order to better understand how to consider site in analyses...
July 21, 2017: Environment International
https://www.readbyqxmd.com/read/28738236/early-predictors-of-study-success-in-a-dutch-advanced-nurse-practitioner-education-program-a-retrospective-cohort-study
#19
Ercolie R Bossema, Tineke H J M Meijs, Jeroen W B Peters
BACKGROUND: Study delay and attrition are major concerns in higher education. They cost time and effort, and threaten the availability of higher qualified professionals. Knowing early what factors contribute to delay and attrition may help prevent this. OBJECTIVE: The aim of this study was to examine whether student characteristics, including a literature study report grade as a proxy of cognitive abilities, predicted study success in a dual advanced nurse practitioner education program...
July 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28738198/stability-of-cognitive-development-during-the-first-five-years-of-life-in-relation-to-heavy-metal-concentrations-in-umbilical-cord-blood-mothers-and-children-s-environmental-health-moceh-birth-cohort-study
#20
Hyungmin Lee, Hyewon Park, Eunhee Ha, Yun-Chul Hong, Mina Ha, Hyesook Park, Bung-Nyun Kim, Soo-Jeong Lee, Kyung Yeon Lee, Ja Hyeong Kim, Kyoung Sook Jeong, Yangho Kim
The objective of this study was to investigate stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood in Korean children. This research is part of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center prospective birth cohort study of pregnant women in Korea who were recruited from 2006 to 2010. We analyzed the complete follow-up data of children who were 5years-old in 2016. We measured lead, mercury, and cadmium levels in the umbilical cord blood of 251 children, and analyzed them, for whom neurodevelopmental data were available...
July 20, 2017: Science of the Total Environment
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