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https://www.readbyqxmd.com/read/28651368/risk-of-recurrence-in-pituitary-neuroendocrine-tumors-a-prospective-study-using-a-five-tiered-classification
#1
Gérald Raverot, Emmanuelle Dantony, Julie Beauvy, Alexandre Vasiljevic, Sara Mikolasek, Françoise Borson-Chazot, Emmanuel Jouanneau, Pascal Roy, Jacqueline Trouillas
Background: Most pituitary neuroendocrine tumors (PitNET) show benign behavior, but a significant number are invasive, recur or resist to medical treatment. Based on a retrospective case-control study we recently proposed a classification of PitNETs of prognostic relevance. This prospective study aims to test the value of this classification in an independent patient cohort. Methods: The cohort included patients of a single center operated upon a PitNET. Using a grading system based on invasion on MRI, immunocytochemical profile (ICC), Ki-67, mitotic index, and p53 positivity, tumors were classified...
June 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28651338/evaluation-of-the-impact-of-tumor-hpv-status-on-outcome-in-patients-with-locally-advanced-unresectable-head-and-neck-squamous-cell-carcinoma-hnscc-receiving-cisplatin-5-fluorouracil-with-or-without-docetaxel-a-subset-analysis-of-eortc-24971-study
#2
A Psyrri, C Fortpied, G Koutsodontis, M Avgeris, C Kroupis, N Goutas, J Menis, L Herman, L Giurgea, E Remenar, M Degardin, I S Pateras, J A Langendijk, C van Herpen, A Awada, J R Germà-Lluch, H R Kienzer, L Licitra, J B Vermorken
Background: EORTC 24971 was a phase III trial demonstrating superiority of induction regimen TPF over PF, in terms of progression-free (PFS) and overall survival (OS) in locoregionally advanced unresectable HNSCC. We conducted a retrospective analysis of prospectively collected data aiming to evaluate whether only HPV(-) patients (pts) benefit from adding docetaxel to PF, in which case de-intensifying induction treatment in HPV(+) pts could be considered. Methods: Pre-therapy tumor biopsies (blocks or slides) were assessed for high-risk HPV by p16 immunohistochemistry, PCR and qPCR...
June 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28651336/safety-and-efficacy-of-a-repositionable-and-fully-retrievable-aortic-valve-used-in-routine-clinical-practice-the-respond-study
#3
Volkmar Falk, Jochen Wöhrle, David Hildick-Smith, Sabine Bleiziffer, Daniel J Blackman, Mohamed Abdel-Wahab, Ulrich Gerckens, Axel Linke, Hüseyin Ince, Peter Wenaweser, Dominic J Allocco, Keith D Dawkins, Nicolas M Van Mieghem
Aims: RESPOND is a prospective, open-label, single-arm study evaluating the outcomes following transcatheter aortic valve implantation (TAVI) with the repositionable and fully retrievable Lotus Valve used in routine clinical practice for the treatment of patients with aortic valve stenosis. Methods and results: RESPOND enrolled 1014 patients at sites across Europe, New Zealand, and Latin America; 996 patients received a Lotus Valve (mean age: 80.8 years; 50.8% female; Society of Thoracic Surgeons score: 6...
June 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28651311/outcomes-of-very-elderly-%C3%A2-80-years-critical-ill-patients-in-a-medical-intensive-care-unit-of-a-tertiary-hospital-in-korea
#4
Seung Hun Lee, Tae Won Lee, Sunmi Ju, Jung-Wan Yoo, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Jong Deog Lee, Ho Cheol Kim
Background/Aims: This study evaluated clinical characteristics and outcomes in very elderly (≥ 80 years of age) critical-ill patients admitted to a medical intensive care unit (MICU) in a regional single tertiary hospital. Methods: We retrospectively evaluated prospectively collected data in the MICU for the period of December 2011 to May 2014. Patients were divided into ≥ 80 and < 80 years of age and clinical characteristics and outcomes were compared among these patients...
June 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651262/relationship-of-radiographic-osteoarthritis-severity-with%C3%A2-treatment-outcomes-after-imaging-guided-knee%C3%A2-injections-a-prospective-outcomes-study
#5
Ivan Miletic, Christoph Agten, Reto Sutter, Christian Pfirrmann, Cynthia Peterson
Introduction To be able to predict which patients are more likely to have a positive treatment outcome, the purpose of this study is 1: To compare outcomes after intra-articular corticosteroid knee injections with the Kellgren and Lawrence (KL) 5 and 3 grading systems for knee osteoarthritis, the Osteoarthritis Research Society International (OARSI) grading system and actual joint space measurements; and 2: To compare the reliability of these grading systems. Materials and Methods Knee radiographs of 117 patients who received intra-articular corticosteroid injections were independently evaluated by two radiologists blinded to the outcome...
June 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28651247/a-prospective-comparison-of-selective-multiparametric-magnetic-resonance-imaging-fusion-targeted-and-systematic-transrectal-ultrasound-guided-biopsies-for-detecting-prostate-cancer-in-men-undergoing-repeated-biopsies
#6
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Ingegerd Balslev, Henrik S Thomsen
INTRODUCTION: The aim of the study was to compare the prostate cancer (PCa) detection rate of systematic transrectal ultrasound-guided biopsies (TRUS-bx) and multiparametric-MRI targeted biopsies (mp-MRI-bx) in a repeat biopsy setting and evaluate the clinical significance following an "MRI-targeted-only" approach. MATERIALS AND METHODS: Patients with prior negative biopsies underwent prostatic multiparametric-MRI that was scored using the Prostate Imaging Reporting and Data System (PI-RADS) classification...
June 27, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28651188/hyperhomocysteinaemia-is-an-independent-risk-factor-for-peripheral-arterial-disease-in-a-chinese-han-population
#7
Dan Rong, Jie Liu, Xin Jia, Daniah Al-Nafisee, Senhao Jia, Guoyi Sun, Yue Li, Weihang Lu, Haifeng Li, Hongpeng Zhang, Xiaohui Ma, Jiang Xiong, Xiaoping Liu, Raouf A Khalil, Wei Guo
BACKGROUND AND AIMS: Hyperhomocysteineamia (HHcy) has long been suggested as a risk factor for atherosclerosis. However, the association between HHcy and peripheral arterial disease (PAD) is still controversial. There is a lack of research on this topic in the Chinese population. This study aims to provide further results. METHODS: 240 PAD patients and 240 control subjects were evaluated for both serum total homocysteine levels and ankle brachial indexes (ABIs)...
May 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28651158/prospective-validation-of-a-lymphocyte-infiltration-prognostic-test-in-stage-iii-colon-cancer-patients-treated-with-adjuvant-folfox
#8
Jean-François Emile, Catherine Julié, Karine Le Malicot, Come Lepage, Josep Tabernero, Enrico Mini, Gunnar Folprecht, Jean-Luc Van Laethem, Stéphanie Dimet, Camille Boulagnon-Rombi, Marc-Antoine Allard, Frédérique Penault-Llorca, Jaafar Bennouna, Pierre Laurent-Puig, Julien Taieb
BACKGROUND: The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use. PATIENTS AND METHODS: According to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study...
June 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28651149/incidence-of-ovarian-endometrioma-among-women-with-peritoneal-endometriosis-with-and-without-a-history-of-hormonal-contraceptive-use
#9
Shahryar K Kavoussi, Kate C Odenwald, Sawsan As-Sanie, Dan I Lebovic
OBJECTIVE(S): To determine if, among women with peritoneal endometriosis, the incidence of ovarian endometrioma at first laparoscopy differs between those with and without a history of hormonal contraceptive use. STUDY DESIGN: Retrospective case-control study of women who were patients at a fertility center and had first laparoscopy from 2009 through 2015 showing, at minimum, evidence of peritoneal endometriosis (n=136). Chart review was conducted for history of prior birth control use as well as operative and pathology notes of surgeries...
June 20, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28651115/ten-year-results-of-applying-an-original-scoring-system-for-addressing-adjuvant-therapy-use-after-breast-conserving-surgery-for-ductal-carcinoma-in-situ-of-the-breast
#10
Massimiliano Gennaro, Maria Carmen De Santis, Luigi Mariani, Salvatore Lo Vullo, Vera Cappelletti, Roberto Agresti, Umberto Cortinovis, Biagio Paolini, Serena Di Cosimo, Maria Luisa Carcangiu, Maria Grazia Daidone, Laura Lozza
PURPOSE: Although large-scale randomised clinical trials have established that radiotherapy (RT) - alone or combined with hormonal therapy (HT) - is effective in reducing the risk of ipsilateral breast tumour recurrence (IBTR), overall survival does not seem to be improved by adjuvant therapies. We sought to ascertain whether specific criteria can be adopted to avoid RT with an acceptable rate of IBTR after breast-conserving surgery (BCS) achieving tumour-free margins. PATIENTS AND METHODS: This non-randomised prospective study concerned the outcome of patients who underwent BCS for ductal carcinoma in situ (DCIS) and were prospectively assessed by means of an established scoring system based on width of free margins in association with age <40, presence of comedonecrosis, high grade, ER negativity and HER2 positivity, to orient the use of any adjuvant therapies...
June 23, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28651102/childhood-stress-and-birth-timing-among-african-american-women-cortisol-as-biological-mediator
#11
Shannon L Gillespie, Lisa M Christian, Angela D Alston, Pamela J Salsberry
Preterm birth (PTB) occurs among 1:11U.S. white women and 1:7.5 African American women and is a significant driver of racial disparities in infant mortality. Maternal stress is the most common clinical phenotype underlying spontaneous PTB. Specific patterns of stress and biological mediators driving PTB remain unclear. We examined the effect of childhood stress on birth timing among African American women and evaluated maternal cortisol elevation as a biological mediator. A prospective observational design was employed, with a single study visit at 28-32 weeks gestation and medical record review...
June 15, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28650950/neurobiologic-correlates-of-attention-and-memory-deficits-following-critical-illness-in-early-life
#12
Raisa M Schiller, Hanneke IJsselstijn, Marlous J Madderom, André B Rietman, Marion Smits, Arno F J van Heijst, Dick Tibboel, Tonya White, Ryan L Muetzel
OBJECTIVES: Survivors of critical illness in early life are at risk of long-term-memory and attention impairments. However, their neurobiologic substrates remain largely unknown. DESIGN: A prospective follow-up study. SETTING: Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands. PATIENTS: Thirty-eight school-age (8-12 yr) survivors of neonatal extracorporeal membrane oxygenation and/or congenital diaphragmatic hernia with an intelligence quotient greater than or equal to 80 and a below average score (z score ≤ -1...
June 23, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28650914/associations-of-rotational-shift-work-and-night-shift-status-with-hypertension-a-systematic-review-and-meta-analysis
#13
Sandhya Manohar, Charat Thongprayoon, Wisit Cheungpasitporn, Michael A Mao, Sandra M Herrmann
BACKGROUND: The reported risks of hypertension (HTN) in rotating shift and night shift workers are controversial. The objective of this meta-analysis was to assess the association between shift work status and HTN. METHODS: A literature search was performed using MEDLINE, EMBASE and Cochrane Database from inception through October 2016. Studies that reported odds ratios (OR) comparing the risk of HTN in shift workers were included. A prespecified subgroup analysis by rotating shift and night shift statuses were also performed...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28650912/the-effect-of-vasodilator-%C3%AE-blockers-on-renal-function-in-hypertensive-patients
#14
Lawrence H Kwon, Karan Wats, Clive Rosendorff
BACKGROUND: Not only is there a limited number of studies on the effects of vasodilator β-blocker (VBB) therapy on kidney function - specifically, glomerular filtration rate (GFR), serum creatinine (sCr) and proteinuria - but of those that have been reported, the results are mixed. This meta-analysis seeks to assess the efficacy of VBBs on selected renal parameters in hypertensive patients. METHODS: We conducted a meta-analysis of any prospective trial that provided both baseline and follow-up of at least 4 weeks of VBB therapy - carvedilol, labetalol, dilevalol, nebivolol and celiprolol in patients with hypertension...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28650904/pediatric-procedural-sedation-using-the-combination-of-ketamine-and-propofol-outside-of-the-emergency-department-a-report-from-the-pediatric-sedation-research-consortium
#15
Jocelyn R Grunwell, Curtis Travers, Anne G Stormorken, Patricia D Scherrer, Corrie E Chumpitazi, Jana A Stockwell, Mark G Roback, Joseph Cravero, Pradip P Kamat
OBJECTIVES: Outcomes associated with a sedative regimen comprised ketamine + propofol for pediatric procedural sedation outside of both the pediatric emergency department and operating room are underreported. We used the Pediatric Sedation Research Consortium database to describe a multicenter experience with ketamine + propofol by pediatric sedation providers. DESIGN: Prospective observational study of children receiving IV ketamine + propofol for procedural sedation outside of the operating room and emergency department using data abstracted from the Pediatric Sedation Research Consortium during 2007-2015...
June 23, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28650903/thigh-ultrasound-monitoring-identifies-decreases-in-quadriceps-femoris-thickness-as-a-frequent-observation-in-critically-ill-children
#16
Frederic V Valla, David K Young, Muriel Rabilloud, Uvaraj Periasami, Manoj John, Florent Baudin, Carole Vuillerot, Aurélie Portefaix, Deborah White, Jenna A Ridout, Rosan Meyer, Bénédicte Gaillard Le Roux, Etienne Javouhey, Nazima Pathan
OBJECTIVES: Significant muscle wasting develops in critically ill adults, with subsequent worse outcomes. In the pediatric setting, occurrence and effects of muscle wasting are undescribed; this is in part due to a lack of validated, objective methods for assessing muscle wasting. A single measurement of quadriceps femoris thickness has failed to show consistent reproducibility. We hypothesized that averaging repeated measurements could afford good reproducibility to allow for quadriceps femoris thickness decline detection and monitoring...
June 23, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28650897/ultrasonographic-evaluation-of-the-urethral-rhabdosphincter-morphology-in-female-patients-with-urodynamic-stress-incontinence
#17
Dimitrios Zacharakis, Themos Grigoriadis, Eleni Pitsouni, Ekaterini Domali, Athanasios Protopapas, Stavros Athanasiou
OBJECTIVES: During the last 2 decades, ultrasonography has been proposed for the morphologic evaluation of the urethral rhabdosphincter. The aims of this study were to evaluate the feasibility of a simple sonographic technique for the assessment of the urethral rhabdosphincter morphology by using a 2-dimensional (2D) transvaginal transducer and to evaluate any associations between the sonographic parameters of rhabdosphincter morphology with the presence of urodynamic stress incontinence (USI)...
July 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28650882/diagnostic-utility-of-intraoperative-neurophysiological-monitoring-for-intramedullary-spinal-cord-tumors-systematic-review-and-meta-analysis
#18
Tej D Azad, Arjun V Pendharkar, Viet Nguyen, James Pan, Ian D Connolly, Anand Veeravagu, Rita Popat, John K Ratliff, Gerald A Grant
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: The aim of this study was to systematically evaluate the diagnostic utility of intraoperative neurophysiological monitoring (IONM) for detecting postoperative injury in resection of intramedullary spinal cord tumors (IMSCT). SUMMARY OF BACKGROUND DATA: Surgical management of IMSCT can involve key neurological and vascular structures. IONM aims to assess the functional integrity of susceptible elements in real time...
June 23, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28650879/novel-angular-measures-of-cervical-deformity-account-for-upper-cervical-compensation-and-sagittal-alignment
#19
Themistocles S Protopsaltis, Renaud Lafage, Shaleen Vira, Daniel Sciubba, Alex Soroceanu, Kojo Hamilton, Justin Smith, Peter G Passias, Gregory Mundis, Robert Hart, Frank Schwab, Eric Klineberg, Christopher Shaffrey, Virginie Lafage, Christopher Ames
STUDY DESIGN: This is a retrospective review of a prospective multicenter database. OBJECTIVE: This study introduces 2 new cervical alignment measures accounting for both cervical deformity (CD) and upper cervical compensation. SUMMARY OF BACKGROUND DATA: Current descriptions of CD like the C2-C7 sagittal vertical axis (cSVA) do not account for compensatory mechanisms such as C0-C2 lordosis and pelvic tilt, which makes surgical planning difficult...
June 23, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28650850/systemic-aminoglycosides-induced-vestibulotoxicity-in-humans
#20
Ruth Van Hecke, Vincent Van Rompaey, Floris L Wuyts, Laura Leyssens, Leen Maes
OBJECTIVES: This systematic review aimed to investigate the prevalence and characteristics of vestibular adverse effects of aminoglycoside (AG) therapy in humans and to analyze objective vestibular tests for the detection of AG-induced vestibulotoxicity. DESIGN: PubMed, Cochrane Database, Web of Science, and reference lists of all included studies were screened by two independent researchers. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed...
June 23, 2017: Ear and Hearing
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