keyword
https://read.qxmd.com/read/38537241/pre-incisional-local-infiltration-with-levobupivacaine-in-laparoscopic-cholecystectomy-a-randomized-and-clinical-trial
#1
JOURNAL ARTICLE
Jorge Herrador-Benito, Javier Páramo-Zunzunegui, Gil Rodríguez-Caravaca, Manuel Durán-Poveda
OBJECTIVE: Laparoscopic cholecystectomy (LC), despite its minimally invasive nature, requires effective control of post-operative pain. The use of local anesthetics (LA) has been studied, but the level of evidence is low, and there is little information on important parameters such as health-related quality of life (HRQoL) or return to work. The objective of the study was to evaluate the efficacy of 0.50% levobupivacaine infiltration of incisional sites in reducing POP after LC. METHODS: This was a prospective, randomized, double-blind study...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537230/the-value-of-endoscopic-duodenal-papilloplasty-with-titanium-clip-in-improving-post-operative-complications-of-choledocholithiasis
#2
JOURNAL ARTICLE
Xuan Zhao, Lihong Shi, Jinchen Wang, Siming Guo, Sumin Zhu
OBJECTIVE: To investigate the value of endoscopic duodenal papillary sphincterotomy combined with balloon dilatation in the treatment of duodenal papilloplasty with titanium clip after choledocholithiasis in post-operative complications. MATERIALS AND METHODS: One hundred and twenty-five patients (69 males and 56 females) with a median age of 65 (32-81) years were included. The treatment plan was randomly divided into Group A (n = 59) and Group B (n = 66) according to the random number table...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#3
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38537182/diagnostic-and-prognostic-efficacy-of-optic-nerve-sheath-diameter-in-patients-with-dysnatremia
#4
JOURNAL ARTICLE
Berika Kavaz Kuru, Ahmet Baydın, Metin Ocak, İskender Aksoy
AIM: This study aimed to investigate the diagnostic and prognostic value of optic nerve sheath diameter (ONSD) measurement in patients with dysnatremia. MATERIAL AND METHODS: This prospective clinical study included patients aged ≥18 years who were diagnosed with dysnatremia on admission to the emergency department. RESULTS: The present study included 65 patients (35 with hypernatremia [hypernatremia group] and 30 with hyponatremia [hyponatremia group]) and 14 healthy volunteers (control group)...
February 13, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537085/long-term-survival-outcomes-of-robotic-total-gastrectomy-for-locally-advanced-proximal-gastric-cancer-a-prospective-study
#5
JOURNAL ARTICLE
Qing Zhong, Yi-Hui Tang, Zhi-Yu Liu, Zhi-Quan Zhang, Qi-Chen He, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Chao-Hui Zheng, Chang-Ming Huang
BACKGROUND: Robotic gastrectomy is a safe and feasible approach for gastric cancer (GC); however, its long-term oncological efficacy remains unclear. We evaluated the long-term survival outcomes and recurrence patterns of patients with locally advanced proximal GC who underwent robotic total gastrectomy (RTG). METHODS: This prospective study (FUGES-014 study) enrolled 48 patients with locally advanced proximal GC who underwent RTG between March 2018 and February 2020 at a tertiary referral teaching hospital...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537077/nomogram-for-predicting-difficult-total-laparoscopic-hysterectomy-a-multi-institutional-retrospective-model-development-and-validation-study
#6
JOURNAL ARTICLE
Yin Chen, Jiahong Jiang, Min He, Kuiyan Zhong, Shuai Tang, Li Deng, Yanzhou Wang
BACKGROUND: Total laparoscopic hysterectomy (TLH) is the most commonly performed gynecological surgery. However, the difficulty of the operation varies depending on the patient and surgeon. Subsequently, patient's outcomes and surgical efficiency are affected. We aimed to develop and validate a pre-operative nomogram to predict the operative difficulty in patients undergoing TLH. METHODS: This retrospective study included 663 patients with TLH from XXX Hospital and 102 patients from YYY Hospital in Chongqing, China...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537056/perioperative-outcomes-and-long-term-survival-of-cryosurgery-on-unresectable-pancreatic-cancer-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Kang Xue, Xiaofeng Liu, Xiaolin Xu, Li Wang, Bole Tian
BACKGROUND: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumor size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited. MATERIALS AND METHODS: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537049/macular-perfusion-changes-in-people-administered-two-types-of-covid-19-vaccines-optical-coherence-tomography-angiography-study
#8
JOURNAL ARTICLE
Zeynep Serikoglu Akbas, Tuna Ozan, Ceyhun Arici
PURPOSE: To evaluate macular chorioretinal flow changes on optical coherence tomography angiography, in participants who received inactivated and messenger RNA (mRNA) vaccines to prevent Coronavirus disease 2019 (COVID-19). METHODS: In this prospective cohort study, healthy participants who received two doses of an inactivated COVID-19 vaccine (CoronaVac) and then one dose of an mRNA vaccine (BNT162b2) were examined before and after each vaccination. Ophthalmologic examination and imaging with optical coherence tomography angiography were performed during each visit...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38537046/evaluation-of-early-ocular-discomfort-after-glaucoma-surgery-trabeculectomy-versus-ahmed-glaucoma-valve-implantation
#9
JOURNAL ARTICLE
Ricardo Y Abe, Douglas R Yamamoto, Fernanda Maria Silveira Souto, José Paulo Cabral Vasconcellos, Vital Paulino Costa
PURPOSE: This study aims to compare the initial ocular discomfort symptoms resulting from trabeculectomy and Ahmed glaucoma valve implantation surgeries. METHODS: A prospective comparative study was conducted. The evaluation of ocular discomfort employed a questionnaire designed to identify the frequency and severity of distinct symptoms: ocular pain, general discomfort, tearing, foreign body sensation, and burning. This questionnaire was administered prior to surgery as a baseline, and subsequently at 7, 30, and 90 days post-surgery...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38537008/impact-of-anthro-metabolic-indices-and-gestational-weight-gain-on-maternal-and-neonatal-outcomes-a-prospective-observational-study
#10
JOURNAL ARTICLE
Esra Keles, Leyla Kaya, Neşe Yakşi, Zahide Kaya, Önder Tosun
OBJECTIVE: The aim of this study was to examine the relationship of anthro-metabolic indices on maternal and neonatal outcomes. METHODS: This prospective observational study was conducted on healthy mother-baby pairs between January 1, 2023 and July 1, 2023. Detailed sociodemographic information was collected through an interview with the mother. Clinical, biochemical, obstetric, fetal, and neonatal outcomes were abstracted from hospital medical records. Anthropometric measurements were obtained from the examination of mother-baby pairs...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#11
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536799/pubertal-timing-a-life-course-pathway-linking-early-life-risk-to-adulthood-cardiometabolic-health
#12
JOURNAL ARTICLE
Maria E Bleil, Bradley M Appelhans, Steven E Gregorich, Robert A Hiatt, Glenn I Roisman, Cathryn Booth-LaForce
OBJECTIVE: To evaluate a series of prospective life course models testing whether the timing of pubertal development is a pathway through which prepubertal risk factors may influence adulthood cardiometabolic health. METHODS: Subjects were 655 female participants in the NICHD Study of Early Child Care and Youth Development (SECCYD) and recent SECCYD 30-year follow-up, the Study of Health in Early and Adult Life (SHINE). Prepubertal risk factors included maternal menarcheal age, child race/ethnicity, child health status indicators, and child adversity indicators...
2024: PloS One
https://read.qxmd.com/read/38536784/muscle-strength-during-pregnancy-and-postpartum-in-adolescents-and-adults
#13
JOURNAL ARTICLE
Maria Luiza da Silva Santos, Sabrina Gabrielle Gomes Fernandes Macêdo, Juliana Fernandes, Catherine M Pirkle, Saionara M A Câmara
Adolescent childbirth is associated with worse physical function over the long-term. Differential loss of muscle strength during pregnancy and postpartum for adolescents compared to adults may be one explanation for this, but research examining these differences is lacking. The objective of this study as to assess hand grip strength and hip adduction muscle strength in adolescents and adults during pregnancy and postpartum. A prospective cohort study was carried out with adolescent (13 to 18 years) and adult (23 to 28 years) primigravid women...
2024: PloS One
https://read.qxmd.com/read/38536762/the-impact-of-musculoskeletal-ill-health-on-quality-of-life-and-function-after-critical-care-a-multicentre-prospective-cohort-study
#14
JOURNAL ARTICLE
O D Gustafson, E B King, M M Schlussel, A Arnold, C Wade, P S Nicol, M J Rowland, H Dawes, M A Williams
Physical disability is a common component of post-intensive care syndrome, but the importance of musculoskeletal health in this population is currently unknown. We aimed to determine the musculoskeletal health state of intensive care unit survivors and assess its relationship with health-related quality of life; employment; and psychological and physical function. We conducted a multicentre prospective cohort study of adults admitted to intensive care for > 48 h without musculoskeletal trauma or neurological insult...
March 27, 2024: Anaesthesia
https://read.qxmd.com/read/38536739/a-scoping-review-of-the-mechanisms-underlying-developmental-anesthetic-neurotoxicity
#15
JOURNAL ARTICLE
Matthew Thomas Borzage, Bradley S Peterson
Although anesthesia makes painful or uncomfortable diagnostic and interventional health care procedures tolerable, it may also disrupt key cellular processes in neurons and glia, harm the developing brain, and thereby impair cognition and behavior in children. Many years of studies using in vitro, animal behavioral, retrospective database studies in humans, and several prospective clinical trials in humans have been invaluable in discerning the potential toxicity of anesthetics. The objective of this scoping review was to synthetize the evidence from preclinical studies for various mechanisms of toxicity across diverse experimental designs and relate their findings to those of recent clinical trials in real-world settings...
March 27, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38536712/transformer-based-2d-3d-medical-image-registration-for-x-ray-to-ct-via-anatomical-features
#16
JOURNAL ARTICLE
Feng Qu, Min Zhang, Weili Shi, Wei He, Zhengang Jiang
BACKGROUND: 2D/3D medical image registration is one of the key technologies for surgical navigation systems to perform pose estimation and achieve accurate positioning, which still remains challenging. The purpose of this study is to introduce a new method for X-ray to CT 2D/3D registration and conduct a feasibility study. METHODS: In this study, a 2D/3D affine registration method based on feature point detection is investigated. It combines the morphological and edge features of spinal images to accurately extract feature points from the images, and uses graph neural networks to aggregate anatomical features of different points to increase the local detail information...
February 2024: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://read.qxmd.com/read/38536701/the-milan-score-a-novel-manometric-tool-for-a-more-efficient-diagnosis-of-gastro-esophageal-reflux-disease
#17
JOURNAL ARTICLE
Stefano Siboni, Marco Sozzi, Ivan Kristo, Sara Boveri, Benjamin D Rogers, Nicola De Bortoli, Anthony Hobson, Brian E Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan L Ivy, Garrett Greenan, Takahiro Masuda, Roberto Penagini, Benedetta Barcella, Marina Coletta, Dimitrios Theodorou, Tania Triantafyllou, Chiara Facchini, Vincent Tee, Luigi Bonavina, Lorenzo Cusmai, Sebastian F Schoppmann, Edoardo Savarino, Emanuele Asti, C Prakash Gyawali
OBJECTIVE: A definitive diagnosis of gastroesophageal reflux disease (GERD) depends on endoscopic and/or pH-study criteria. However, high resolution manometry (HRM) can identify factors predicting GERD, such as ineffective esophageal motility (IEM), esophago-gastric junction contractile integral (EGJ-CI), evaluating esophagogastric junction (EGJ) type and straight leg raise (SLR) maneuver response. We aimed to build and externally validate a manometric score (Milan Score) to stratify the risk and severity of the disease in patients undergoing HRM for suspected GERD...
March 27, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38536666/non-cancerous-complications-in-htlv-1-carriers
#18
REVIEW
Akihiro Ohmoto, Shigeo Fuji
INTRODUCTION: Human T-cell leukemia virus type 1 (HTLV-1) carriers may develop adult T-cell leukemia (ATL), or HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The evidence is limited regarding other diseases potentially associated with HTLV-1, such as HTLV-1-associated autoimmune diseases. AREA COVERED: We summarized the available information on complications associated with HTLV-1 infection. EXPERT OPINION: Previous studies showed that HTLV-1 carriers have an increased incidence of collagen diseases including Sjögren's syndrome, as well as dysthyroidism, diabetes mellitus, and atherosclerosis...
March 27, 2024: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/38536653/validation-of-a-patient-specific-finite-element-analysis-framework-for-identification-of-growing-rod-failure-regions-in-early-onset-scoliosis-patients
#19
JOURNAL ARTICLE
Daksh Jayaswal, Manoj Kodigudla, Amey Kelkar, Vijay Goel, Vivek Palepu
PURPOSE: Growing rods are the gold-standard for treatment of early onset scoliosis (EOS). However, these implanted rods experience frequent fractures, requiring additional surgery. A recent study by the U.S. Food and Drug Administration (FDA) identified four common rod fracture locations. Leveraging this data, Agarwal et al. were able to correlate these fractures to high-stress regions using a novel finite element analysis (FEA) framework for one patient. The current study aims to further validate this framework through FEA modeling extended to multiple patients...
March 27, 2024: Spine Deformity
https://read.qxmd.com/read/38536647/differences-in-injury-profiles-between-female-and-male-athletes-across-the-participant-classification-framework-a-systematic-review-and-meta-analysis
#20
Natalie J Hardaker, Patria A Hume, Stacy T Sims
BACKGROUND: Female sex is a significant determinant of anterior cruciate ligament (ACL) injury. It is not understood if sex is a key determinant of other sports-related injuries. OBJECTIVE: The aim of this systematic review was to identify where differences in injury profiles are most apparent between the sexes in all sports across the six-tiered participant classification framework. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the 'implementing PRISMA in Exercise, Rehabilitation, Sport medicine and SporTs science'(PERSiST) guidance...
March 27, 2024: Sports Medicine
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