Jarosław Sławek, Anna Roszmann, Piotr Robowski, Mirosława Dubaniewicz, Emilia J Sitek, Krystyna Honczarenko, Agnieszka Gorzkowska, Sławomir Budrewicz, Monika Mak, Monika Gołąb-Janowska, Ewa Koziorowska-Gawron, Marek Droździk, Mateusz Kurzawski, Tomasz Bandurski, Monika Białecka
BACKGROUND: The role of white matter hyperintensities (WMH) and homocysteine (Hcy) and other vascular risk factors in the pathogenesis of Parkinson's disease (PD) dementia (PDD) remains unclear. OBJECTIVE: The aim of the study was to assess the impact of WMH, Hcy and other biochemical and vascular risk factors on PDD. METHODS: A total of 192 patients with PD and 184 age- and sex-matched healthy controls were included. A semistructured interview was used to assess demographic and clinical variables with respect to vascular risk factors (arterial hypertension, diabetes mellitus, atrial fibrillation, ischemic heart disease, obliterative atherosclerosis, hypercholesterolemia, smoking, alcohol intake)...
2013: Neuro-degenerative Diseases