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Cacna1c glutamate

Juan R Bustillo, Veena Patel, Thomas Jones, Rex Jung, Nattida Payaknait, Clifford Qualls, Jose M Canive, Jingyu Liu, Nora Irma Perrone-Bizzozero, Vince D Calhoun, Jessica A Turner, Charles Gasparovic
BACKGROUND: The proton magnetic resonance spectroscopy ((1)H-MRS) signals from glutamate (or the combined glutamate and glutamine signal-Glx) have been found to be greater in various brain regions in people with schizophrenia. Recently, the Psychiatric Genetics Consortium reported that several common single-nucleotide polymorphisms (SNPs) in glutamate-related genes confer increased risk of schizophrenia. Here, we examined the relationship between presence of these risk polymorphisms and brain Glx levels in schizophrenia...
2017: Frontiers in Psychiatry
Merlin G Butler, Austen B McGuire, Humaira Masoud, Ann M Manzardo
A large body of genetic data from schizophrenia-related research has identified an assortment of genes and disturbed pathways supporting involvement of complex genetic components for schizophrenia spectrum and other psychotic disorders. Advances in genetic technology and expanding studies with searchable genomic databases have led to multiple published reports, allowing us to compile a master list of known, clinically relevant, or susceptibility genes contributing to schizophrenia. We searched key words related to schizophrenia and genetics from peer-reviewed medical literature sources, authoritative public access psychiatric websites and genomic databases dedicated to gene discovery and characterization of schizophrenia...
March 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Gerald A Higgins, Ari Allyn-Feuer, Edward Barbour, Brian D Athey
AIM: A regulatory network in the human brain mediating lithium response in bipolar patients was revealed by analysis of functional SNPs from genome-wide association studies (GWAS) and published gene association studies, followed by epigenome mapping. METHODS: An initial set of 23,312 SNPs in linkage disequilibrium with lead SNPs, and sub-threshold GWAS SNPs rescued by pathway analysis, were studied in the same populations. These were assessed using our workflow and annotation by the epigenome roadmap consortium...
2015: Pharmacogenomics
John I Nurnberger, Daniel L Koller, Jeesun Jung, Howard J Edenberg, Tatiana Foroud, Ilaria Guella, Marquis P Vawter, John R Kelsoe
IMPORTANCE: Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders. OBJECTIVE: To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS). DATA SOURCES: Four independent data sets with individual genome-wide data available in July 2011 along with all data sets contributed to the Psychiatric Genomics Consortium Bipolar Group by May 2012...
June 2014: JAMA Psychiatry
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