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Dr. Rene

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June 2016: Annals of Intensive Care
Romain Loyon, Emilie Picard, Olivier Mauvais, Lise Queiroz, Virginie Mougey, Jean-René Pallandre, Jeanne Galaine, Patricia Mercier-Letondal, Guillaume Kellerman, Nathalie Chaput, John Wijdenes, Olivier Adotévi, Christophe Ferrand, Pedro Romero, Yann Godet, Christophe Borg
NK cells are critical for innate immunity-mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ. However, the precise influence of inflammatory cytokines on NK cell and CD4 T lymphocyte interactions was never investigated. In this study, we provide evidence that IL-21, a cytokine produced during chronic inflammation or infectious diseases, promotes the differentiation of a specific subset of NK cells coexpressing CD86 and HLA-DR and lacking NKp44...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
J S Logan
No abstract text is available yet for this article.
March 2016: Anatolian Journal of Cardiology
Bogdan Ioncioaia, Ioan Teodor Bud, Mircea Muresan
René Leriche (1879-1955) was a 20(th) century French surgeon generally known in medicine for the syndrome that carries his name, namely the Leriche syndrome in the aorto-iliac occlusive disease. This paper is published to mark the commemoration of 60 year since Leriche's death. Although Dr. Leriche's legacy resides in the domain of vascular medicine, his research enclosed bone pathology and surgical management of pain. Having his surgical training done under professors Mathieu Jaboulay and Antonin Poncet, his friendship and association with Alexis Carrel and William Halsted have contributed to René Leriche's development as a surgeon, researcher and thinker...
2016: Clujul Medical (1957)
Rene J Duquesnoy, Gideon Hönger, Irene Hösli, Marilyn Marrari, Stefan Schaub
This report describes a HLAMatchmaker-based antibody analysis of post-pregnancy sera with antibodies against child-specific HLA-DR epitopes. These sera were reactive in IgG-binding assays with single allele bead (SAB) panels on a Luminex platform. The antibody specificity analysis focused on DRB epitopes that have been recorded in the International HLA Epitope Registry ( as experimentally verified with informative antibodies but we also considered other eplets that predict potential epitopes...
February 2016: Human Immunology
Jorge Román Corona-Rivera, Rafael Nieto-García, Eloy López-Marure, Juan José Cárdenas-Ruiz Velasco, Lucina Bobadilla-Morales, Estrella Lizbeth Mellín-Sánchez, Rafael L Aguirre-Guillén, René O Pérez-Ramírez, Eugenio Zapata-Aldana, Ana K Sandoval-Talamantes, Susana Solís-Ledezma, Alfredo Corona-Rivera, Larissa M Gómez-Ruiz
The aim of our study was to determine the frequency and type of associated congenital anomalies in patients with isolated gastroschisis born at the Dr. Juan I. Menchaca Civil Hospital of Guadalajara (Guadalajara, México), and to explore its possible association with the included outcome variables. One hundred-eight cases with isolated gastroschisis were reviewed from 2009 to 2014. The occurrence of intestinal and extraintestinal associated anomalies (either secondary or primary) was prospectively assessed...
February 2016: American Journal of Medical Genetics. Part A
René Oswaldo Pérez, Juan Carlos Lona, Moisés Quiles, Miguel Ángel Verdugo, Elba Patricia Ascencio, Edith Adriana Benítez
BACKGROUND: Early neonatal sepsis (EOS) is the second leading cause of death in the first week of life. Epidemiology differs in developed and developing countries. AIM: To describe the epidemiology of EOS among newborn patients in a public hospital in western Mexico. METHODS: A prospective cohort study was performed in newborns of Nuevo Hospital Civil de Guadalajara "Dr. Juan I Menchaca". EOS was diagnosed with blood cultures or cultures of cerebrospinal fluid within the first 72 h of life...
August 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Maegan V Prummel, Derek Muradali, Rene Shumak, Vicky Majpruz, Patrick Brown, Hedy Jiang, Susan J Done, Martin J Yaffe, Anna M Chiarelli
PURPOSE: To compare measures of diagnostic accuracy between large concurrent cohorts of women screened with digital computed radiography (CR), direct radiography (DR), and screen-film mammography (SFM). MATERIALS AND METHODS: This study was approved by the University of Toronto Research Ethics Board; informed consent was not required. Three concurrent cohorts of women aged 50-74 years who were screened from 2008-2009 in the Ontario Breast Screening Program with SFM (487,334 screening examinations, 403,688 women), DR (254,758 screening examinations, 220,520 women), or CR (74,140 screening examinations, 64,210 women) were followed for 2 years or until breast cancer diagnosis...
February 2016: Radiology
Philipp Raum, Julia Lamparter, Katharina A Ponto, Tunde Peto, René Hoehn, Andreas Schulz, Astrid Schneider, Philipp S Wild, Norbert Pfeiffer, Alireza Mirshahi
OBJECTIVE: Diabetic retinopathy (DR) is the leading cause of blindness in people of working age. The purpose of this paper is to report the prevalence and cardiovascular associations of diabetic retinopathy and maculopathy (DMac) in Germany. RESEARCH DESIGN AND METHODS: The Gutenberg Health Study (GHS) is a population-based study with 15,010 participants aged between 35 at 74 years from the city of Mainz and the district of Mainz-Bingen. We determined the weighted prevalence of DR and DMac by assessing fundus photographs of persons with diabetes from the GHS data base...
2015: PloS One
Frits Koning, Ranjeny Thomas, Jamie Rossjohn, Rene E Toes
Rheumatoid arthritis (RA) and coeliac disease are inflammatory diseases that both have a strong association with class II HLAs: individuals carrying HLA-DQ2.5 and/or HLA-DQ8 alleles have an increased risk of developing coeliac disease, whereas those carrying HLA-DR shared epitope alleles exhibit an increased risk of developing RA. Although the molecular basis of the association with specific HLA molecules in RA remains poorly defined, an immune response against post-translationally modified protein antigens is a hallmark of each disease...
August 2015: Nature Reviews. Rheumatology
Tamer Akça, Süha Aydın
Prof. Dr. René Leriche was a famous French surgeon who lived between 1879 and 1955. After working as a vascular surgeon in Lyon, he was appointed professor at the University of Strasbourg in 1924 and later the Paris Collége de France in 1937. Leriche had proposed vascular patches as the ideal treatment for obliterated vascular segments and advocated the necessity of sympathectomy in arterial diseases in the 1920s. He defined "Leriche Syndrome" in 1923 which is known by his name and which develops as a result of incomplete obstruction of the aortic bifurcation...
2013: Ulusal Cerrahi Dergisi
Jurgen van Heemst, Tom J W Huizinga, Diane van der Woude, René E M Toes
PURPOSE OF REVIEW: To provide an update on and the context of the recent findings obtained with novel statistical methods on the association of the human leukocyte antigen (HLA) locus with rheumatic diseases. RECENT FINDINGS: Novel single nucleotide polymorphism fine-mapping data obtained for the HLA locus have indicated the strongest association with amino acid positions 11 and 13 of HLA-DRB1 molecule for several rheumatic diseases. On the basis of these data, a dominant role for position 11/13 in driving the association with these diseases is proposed and the identification of causal variants in the HLA region in relation to disease susceptibility implicated...
May 2015: Current Opinion in Rheumatology
Rene J Duquesnoy, Marilyn Marrari, Anat R Tambur, Arend Mulder, Luiz Cláudio Demes da Mata Sousa, Adalberto Socorro da Silva, Semiramis J H do Monte
The International Registry of Antibody-Defined HLA Epitopes ( has been recently established as a tool to understand humoral responses to HLA mismatches. These epitopes can be structurally defined as eplets by three-dimensional molecular modeling and amino acid sequence differences between HLA antigens. A major goal is to identify HLA eplets that have been verified experimentally with informative antibodies. This report addresses class II epitopes encoded by genes in the HLA-D region...
November 2014: Human Immunology
E Drouin, F-R Bataille, M-A Mahé
In August 1883, a Chair of physics was created in Nantes with Dr. Leduc (1853-1939) as the first teacher. Physician and biophysicist, he was a pioneer and visionary in many areas, including the "synthetic biology". Dr. Leduc immediately understood the importance of the discovery of the X-ray by Röntgen in 1896 for medicine. As early as in 1905, he successfully treated cancers with irradiation. In 1935, he was awarded a gold key by the American Congress of Physical Therapy for his accomplishments. The teachings of Dr Leduc largely influenced his student and successor, Dr René Gauducheau's (1881-1968) orientation towards physical and radiological sciences...
November 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
René J Duquesnoy
As important risk factors for transplant rejection and failure, HLA antibodies are now recognized as being specific for epitopes which can be defined structurally with amino acid differences between HLA alleles. Donor-recipient compatibility should therefore be assessed at the epitope rather than the antigen level. HLAMatchmaker is a computer algorithm that considers each HLA antigen as a series of small configurations of polymorphic residues referred to as eplets as essential components of HLA epitopes. It includes epitopes on antigens encoded by all HLA-A, B, C, DR, DQ and DP loci as well as MICA...
June 2014: Transplant Immunology
Julia Lamparter, Philipp Raum, Norbert Pfeiffer, Tunde Peto, René Höhn, Heike Elflein, Philipp Wild, Andreas Schulz, Astrid Schneider, Alireza Mirshahi
AIMS: To evaluate the prevalence of diabetic retinopathy/maculopathy (DR/DMac) and its associations with cardiovascular risk factors (CRF) in participants with prediabetes (PwPD) in a large European cohort within the population-based Gutenberg Health Study (GHS). METHODS: The study was based on a sub-cohort of the GHS (n=5,000, age: 35-74 y). Prediabetes was diagnosed according to HbA1c levels (5.7-6.4%). DR/DMac was graded from fundus photographs. Blood samples and comprehensive questionnaires served for evaluation of laboratory results and CRF...
July 2014: Journal of Diabetes and its Complications
Sunil K Pandya
Charles Morehead studied medicine in Edinburgh and Paris. Among his teachers were George Jardine (1742-1827) (moral philosophy), Professor William Pulteney Alison (1790-1859) (medicine), Pierre Louis (1787-1872) and René Laennec (1781-1826). He joined as Assistant Surgeon in the Bombay Medical Service of the East India Company and was appointed to the staff of Governor Sir Robert Grant (1779-1838). Grant and Morehead founded the Grant Medical College and Sir Jamsetjee Jejeebhoy (1811-1877) Hospital in Bombay...
May 2015: Journal of Medical Biography
Lawrence S Miller, M Elizabeth Sandel
No abstract text is available yet for this article.
December 2013: PM & R: the Journal of Injury, Function, and Rehabilitation
Stephen W Scally, Jan Petersen, Soi Cheng Law, Nadine L Dudek, Hendrik J Nel, Khai Lee Loh, Lakshmi C Wijeyewickrema, Sidonia B G Eckle, Jurgen van Heemst, Robert N Pike, James McCluskey, Rene E Toes, Nicole L La Gruta, Anthony W Purcell, Hugh H Reid, Ranjeny Thomas, Jamie Rossjohn
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04...
November 18, 2013: Journal of Experimental Medicine
Alain Reinberg, Marc Riedel, Eric Brousse, Nadine Le Floc'h, René Clarisse, Benoît Mauvieux, Yvan Touitou, Michael H Smolensky, Michel Marlot, Stéphane Berrez, Mohamed Mechkouri
We investigated the circadian synchronization/desynchronization (by field-study assessment of differences in period, τ, of 16 coexisting and well-documented rhythms) of 30 healthy firemen (FM) exposed to irregular, difficult, and stressful nocturnal work hours who demonstrated excellent clinical tolerance (allochronism). Three groups of FM were studied (A = 12 FM on 24-h duty at the fire station; B = 9 FM on 24-h duty at the emergency call center; C = 9 day-shift administrative FM) of mostly comparable average age, body mass index, career duration, chronotype-morningness/eveningness, and trait of field dependence/independence...
October 2013: Chronobiology International
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