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Serum chromogranin A

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https://www.readbyqxmd.com/read/29102861/an-isolated-metachronous-metastasis-to-the-adrenal-gland-from-a-pancreatic-neuroendocrine-tumor-a-case-report
#1
Yasunaru Sakuma, Naohiro Sata, Kazuhiro Endo, Yoshikazu Yasuda, Shinichiro Yokota, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyoshi Fukushima, Shoko Asakawa, Yuuki Kawarai Shimada, Chieko Kawarai Lefor, Alan Kawarai Lefor
INTRODUCTION: Pancreatic neuroendocrine tumors are rare. Treatment includes aggressive local management of the primary lesion and metastases, and systemic somatostatin. This is the first report of an isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor that presented 90 months after the primary tumor. PRESENTATION OF CASE: The patient presented as a 53yo man with a left upper quadrant mass and synchronous metastases to the spleen and liver (pancreatic neuroendocrine tumor T4N0M1, Stage IV), which were resected (CD56-, synaptophysin+, chromogranin+, Ki-67<1%)...
October 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29099942/phase-1-study-of-high-specific-activity-i-131-mibg-for-metastatic-and-or-recurrent-pheochromocytoma-or-paraganglioma
#2
Richard B Noto, Daniel A Pryma, Jessica Jensen, Tess Lin, Nancy Stambler, Thomas Strack, Vivien Wong, Stanley J Goldsmith
Context: There are no approved therapies for the treatment of metastatic and/or recurrent pheochromocytoma or paraganglioma (PPGL) in the United States. Objective: To determine the maximum tolerated dose (MTD) of high-specific-activity I-131 meta-iodobenzylguanidine (MIBG) for the treatment of metastatic and/or recurrent PPGL. Design: Phase 1, dose escalating study to determine the MTD via a standard 3+3 design; escalating by 37 MBq/kg starting at 222 MBq/kg...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29063171/-neuroendocrine-prostate-cancer
#3
S Tritschler, R Erdelkamp, C Stief, M Hentrich
Neuroendocrine prostate cancer (NEPC) mostly occurs as a treatment-emergent adaptive response under the pressure of intensive androgen deprivation treatment (t-NEPC). Approximately 30-40% of patients with metastatic castration-resistant prostate cancer (mCRPC) also have neuroendocrine involvement. In contrast primary small cell prostate cancer is very rare (<1%). A t‑NEPC should be clinically suspected in patients who have particularly aggressive mCRPC but a disproportionately low prostate-specific antigen (PSA) level and elevated neuroendocrine tumor markers, such as chromogranin A and neuron-specific enolase...
November 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#4
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28974776/associations-between-snps-and-immune-related-circulating-proteins-in-schizophrenia
#5
Man K Chan, Jason D Cooper, Stefanie Heilmann-Heimbach, Josef Frank, Stephanie H Witt, Markus M Nöthen, Johann Steiner, Marcella Rietschel, Sabine Bahn
Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia. However, despite the convergence of evidence, direct links between the genetic and proteomic findings are still lacking for schizophrenia. We investigated associations between single nucleotide polymorphisms (SNPs) from the custom-made PsychArray and the expression levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 matched controls...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28949141/glycobiomarker-fucosylated-short-form-secretogranin-iii-levels-are-increased-in-the-serum-of-patients-with-small-cell-lung-carcinoma
#6
Akira Togayachi, Jun Iwaki, Hiroyuki Kaji, Hideki Matsuzaki, Atsushi Kuno, Yoshitoshi Hirao, Masaharu Nomura, Masayuki Noguchi, Yuzuru Ikehara, Hisashi Narimatsu
Secretogranin III (SgIII) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins are expressed in endocrine and neuroendocrine cells and subsequently processed into bioactive hormones. Although granin-derived peptide expression is correlated with neuroendocrine carcinomas, little is known about SgIII. We previously identified SgIII by a comparative glycoproteomics approach for elucidation of glycobiomarker candidates in lung carcinoma. Here, we examined the expression, secretion, and glycosylation of SgIII to identify novel biomarkers of small cell lung carcinoma (SCLC)...
September 26, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28939160/hepatocellular-carcinoma-with-neuroendocrine-differentiation-a-case-report
#7
Jiajie G Lu, M Aabid Farukhi, Donna Mayeda, Samuel W French
Hepatocellular carcinoma with neuroendocrine differentiation, where tumor cells stain for both hepatocellular and neuroendocrine markers, is extremely rare. We report a case of a 65-year-old man who presented with a 14-cm rapidly growing mass in the right lobe of his liver with local extension into the gallbladder and portal vein. Serum AFP was 4625ng/mL. Liver biopsy showed a poorly differentiated neoplasm with cells showing nuclear pleomorphism, high nuclear/cytoplasmic ratio, and numerous mitoses. The tumor cells stain for AFP, glutamine synthase, arginase, and glypican-3...
September 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28875556/melatonin-alleviates-weanling-stress-in-mice-involvement-of-intestinal-microbiota
#8
Wenkai Ren, Peng Wang, Jiameng Yan, Gang Liu, Benhua Zeng, Tarique Hussain, Can Peng, Jie Yin, Bie Tan, Tiejun Li, Hong Wei, Guoqiang Zhu, Russel J Reiter, Yulong Yin
Melatonin influences intestinal microbiota, and the pathogenesis of various diseases. This study was conducted to explore whether melatonin alleviates weanling stress through intestinal microbiota in a weanling mouse model. Melatonin supplementation in weanling mice (provided in the drinking water at a dosage of 0.2mg/ml for 2 weeks) significantly improved body weight gain (1.4±0.03 g/day in melatonin group vs. 1.2±0.06 g/day in control group) and intestinal morphology [i.e., villus length (258.1±12.2 um in melatonin group vs...
September 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28815093/a-case-of-hyperparathyroidism-due-to-a-large-intrathyroid-parathyroid-adenoma-with-recurrent-episodes-of-acute-pancreatitis
#9
Kazunori Kageyama, Noriko Ishigame, Aya Sugiyama, Akiko Igawa, Takashi Nishi, Satoko Morohashi, Hiroshi Kijima, Makoto Daimon
We report a case of a 66-year-old woman who developed hyperparathyroidism due to a large intrathyroid parathyroid adenoma with episodes of acute pancreatitis. She had previously been treated for acute pancreatitis twice. Serum calcium was 12.4 mg/dL, and intact parathyroid hormone was 253 pg/dL. Ultrasonography and computed tomography of the neck with contrast enhancement revealed a soft tissue mass (28 mm transverse diameter) within the left lobe of the thyroid. (99m)Tc-MIBI scintigraphy demonstrated focal accumulation due to increased radiotracer uptake in the left thyroid lobe...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28806264/18f-fdg-pet-ct-of-brown-adipose-tissue-hyperactivation-associated-with-pregnancy-and-paraganglioma
#10
Anna Margherita Maffione, Lucia Rampin, Sotirios Chondrogiannis, Maria Cristina Marzola, Patrick M Colletti, Domenico Rubello
This 32-year-old woman presented with pregnancy-related arterial hypertension unresponsive to antihypertensive therapy. During cesarean delivery, a lobulated retroperitoneal mass was discovered. F-FDG PET/CT performed 18 days postpartum demonstrated the hyperactive retroperitoneal mass and extensive hyperactivated brown adipose tissue. The mass was surgically removed, revealing a para-aortic multicentric paraganglioma. After surgery, blood pressure normalized, and serum chromogranin A and urinary metanephrines normalized...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28804908/influence-of-abiraterone-acetate-on-neuroendocrine-differentiation-in-chemotherapy-naive-metastatic-castration-resistant-prostate-cancer
#11
Baijun Dong, Liancheng Fan, Yanqing Wang, Chenfei Chi, Xiaowei Ma, Rui Wang, Wen Cai, Xiaoguang Shao, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Xiaonan Kang, Lixin Zhou, Wei Xue
BACKGROUND: To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted an analysis in 115 chemotherapy-naïve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone-specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment...
May 2017: Prostate
https://www.readbyqxmd.com/read/28756619/prostate-carcinoma-with-amphicrine-features-further-refining-the-spectrum-of-neuroendocrine-differentiation-in-tumours-of-primary-prostatic-origin
#12
Susan Prendeville, Issam Al-Bozom, Eva Compérat, Joan Sweet, Andrew J Evans, Mohamed Ben-Gashir, Ozgur Mete, Theodorus H van der Kwast, Michelle R Downes
OBJECTIVE: The current WHO classification categorises high grade neuroendocrine (NE) carcinomas of the prostate into small cell and large cell types. A distinct form of carcinoma demonstrating synchronous dual exocrine and NE differentiation, termed amphicrine carcinoma, has been described at various other sites, primarily within the gastrointestinal tract. In this study, we describe the clinicopathologic features of a series of metastatic prostatic carcinomas with amphicrine features...
July 30, 2017: Histopathology
https://www.readbyqxmd.com/read/28723285/case-244-systemic-amyloidosis-a-complication-of-waldenstr%C3%A3-m-macroglobulinemia
#13
Maja Hrabak-Paar, Marko Kralik
History A 68-year-old man was admitted to the hospital for work-up because of generalized fatigue, anorexia, chronic diarrhea, and weight loss. Laboratory work-up revealed an erythrocyte sedimentation rate of 58 mm/h (reference range, 3-23 mm/h), a hemoglobin level of 14.1 g/dL (reference range, 13.8-17.5 g/dL), a leukocyte count of 8.1 × 10(9)/L (reference range, [3.4-9.7] × 10(9)/L), a platelet count of 223 × 10(9)/L (reference range, [158-424] × 10(9)/L), an alkaline phosphatase level of 85 U/L (1.42 μkat/L) (normal level, <142 U/L [2...
August 2017: Radiology
https://www.readbyqxmd.com/read/28697655/functional-ulnar-nerve-paraganglioma-first-documented-occurrence-in-the-extremity-with-hitherto-undescribed-associated-extensive-glomus-cell-hyperplasia-and-tumorlet-formation
#14
Louis Tsun Cheung Chow, Michael Ho Ming Chan, Simon Kwok Chuen Wong
Extra-adrenal paraganglioma has never been described in the extremities. A 34-year-old woman complained of an enlarging mass in the right forearm for 18 months. Imaging showed a circumscribed vascular tumor attached to the ulnar nerve; biopsy revealed features of paraganglioma. The resected tumor consisted of zellballen pattern of chief cells staining positively for chromogranin with surrounding S100-positive sustentacular cells. The chief cells contained many neurosecretory granules and mitochondria, whereas the sustentacular cells contained a large amount of rough endoplasmic reticulum and some microfilaments...
July 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28605448/efficacy-of-peptide-receptor-radionuclide-therapy-for-functional-metastatic-paraganglioma-and-pheochromocytoma
#15
COMPARATIVE STUDY
Grace Kong, Simona Grozinsky-Glasberg, Michael S Hofman, Jason Callahan, Amichay Meirovitz, Ofra Maimon, David A Pattison, David J Gross, Rodney J Hicks
Purpose: Treatment options for unresectable paraganglioma (PGL)/pheochromocytoma (PCC), especially with uncontrolled secondary hypertension (HTN), are limited. Preliminary studies with peptide receptor radionuclide therapy (PRRT) suggest efficacy, but data on HTN control and survival are lacking. We assessed PRRT outcomes in such patients from two referral centers. Methods: Twenty consecutive patients (13 men; age range, 21 to 77 years) with high somatostatin receptor (SSTR) expression treated with 177Lu-DOTA-octreotate, nine with radiosensitizing chemotherapy, were retrospectively reviewed...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28585679/diagnostic-value-of-selected-biochemical-markers-in-the-detection-of-recurrence-of-medullary-thyroid-cancer-comparison-of-calcitonin-procalcitonin-chromogranin-a-and-carcinoembryonic-antigen
#16
Kosma Woliński, Jarosław Kaznowski, Aleksandra Klimowicz, Adam Maciejewski, Dagny Łapińska-Cwojdzińska, Edyta Gurgul, Adrian D Car, Marta Fichna, Paweł Gut, Maria Gryczyńska, Marek Ruchała
INTRODUCTION: Medullary thyroid cancer (MTC) is a malignancy of the thyroid gland, which derives from parafollicular C cells. Periodic measurement of biochemical markers of MTC remains a crucial part of patient follow-up and disease monitoring. The aim of the study was to compare the diagnostic value of four selected markers - calcitonin (Ct), procalcitonin (PCT), chromogranin A (CgA), and carcinoembryonic antigen (CEA). METHODS: Patients with histopathologically confirmed MTC hospitalised in a single department between January 2015 and December 2015 were included in the study...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28561881/reference-limits-for-chromogranin-a-cyfra-21-1-ca-125-ca-19-9-and-carcinoembryonic-antigen-in-patients-with-chronic-kidney-disease
#17
Gustav Mikkelsen, Arne Åsberg, Maria E Hultström, Knut Aasarød, Gunhild G Hov
BACKGROUND: Patients with chronic kidney disease (CKD) may have increased plasma concentrations of some tumor markers even when no cancer is present. Previous studies have indicated that plasma concentrations of chromogranin A (CGA), cytokeratin 19 fragments (CYFRA 21-1), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are higher in patients with CKD but without cancer, than in healthy individuals, and this can make interpretation of results more complicated...
May 27, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28559773/neuroendocrine-testicular-tumors-a-systematic-review-and-meta-analysis
#18
REVIEW
Mseddi M Amine, Bouzguenda Mohamed, Hadjslimane Mourad, Hamza Majed, Charfi Slim, Bouassida Mehdi, Mnif Hela, Rebai Nouri, Kallel Rim, Boudaouara Tahya, Mhiri M Nabil
PURPOSE: The purpose of this study is to study the main epidemiological, clinical, para clinical, pathological, therapeutic, and evolutionary features of patients with testicular neuroendocrine tumors (TNET). MATERIALS AND METHODS: Nine case series and sixteen case reports were identified by searching PubMed database and qualified for inclusion in this study. We added the data of one case treated in the department of urology in Habib Bourguiba Hospital in Sfax, to the published cases...
April 2017: Current Urology
https://www.readbyqxmd.com/read/28553179/peptide-receptor-radionuclide-therapy-with-177-lu-dotatate-for-metastatic-neuroendocrine-tumor-occurring-in-association-with-multiple-endocrine-neoplasia-type-1-and-cushing-s-syndrome
#19
Chinna Naik, Sandip Basu
Neuroendocrine tumor (NET) occurring in association with other endocrine syndromes forms a distinct entity. The aim was to assess the therapy response profile of the routine peptide receptor radionuclide therapy (PRRT) in this relatively uncommon but clinically challenging subgroup of patients. A retrospective analysis was undertaken from the case records from those who were treated with (177)Lu-DOTATATE for metastatic NET. In addition to assessing the therapeutic efficacy, emphasis was also given to study lesional sites and scan pattern...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28533888/neuroprotective-effects-of-melatonin-administration-against-chronic-immobilization-stress-in-rats
#20
Asmaa Ms Gomaa, Heba M Galal, Amal T Abou-Elgait
Chronic stress can impair brain functions and play a well-known role in the development of stress-related disorders such as anxiety. Melatonin (Mel) is a neurohormone which regulate several physiological processes including mood and behavior. This experimental study was designed to evaluate the effect of Mel on chronic immobilization stress (CIS) for 6 weeks in rats and to elucidate its possible underlying mechanisms. Twenty-eight adult male Wistar albino rats were divided into four equal groups: the control group, the Mel-treated group which was injected daily with Mel (10 mg/kg/day; IP) for 6 weeks, the stressed group which was subjected to CIS protocol daily for 6 weeks, and the Mel-treated stressed group which was injected with Mel and concurrently exposed to CIS protocol for 6 weeks...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
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