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Chromogranin A

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https://www.readbyqxmd.com/read/29033257/chromogranin-a-is-not-a-biomarker-of-mastocytosis
#1
Pahul Hanjra, Chyi-Chia R Lee, Irina Maric, Melody Carter, Ana Olivera, Dean D Metcalfe, Hirsh D Komarow
No abstract text is available yet for this article.
October 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29032398/analysis-of-mir-96-and-mir-133a-expression-in-gastrointestinal-neuroendocrine-neoplasms
#2
Rakesh Mandal, Heather Hardin, Rebecca Baus, William Rehrauer, Ricardo V Lloyd
Grading of gastrointestinal neuroendocrine neoplasms (GI-NENs) relies mainly on mitotic activity and Ki-67 proliferation index. It is often difficult to predict metastatic potential of these neoplasms. Recent studies have shown that GI-NENs express a wide spectrum of microRNAs. We examined two microRNAs (miR-96 and miR-133a) that were recently identified in GI-NENs to determine if they could assist in evaluating the biological behavior of these neoplasms. A tissue microarray (TMA) was constructed with 51 primary GI-NENs, mainly from the small intestine and metastatic tumors from the same cases, including liver metastases (N = 20) and lymph node metastases (N = 33)...
October 14, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/29028155/a-parallel-reaction-monitoring-mass-spectrometric-method-for-analysis-of-potential-csf-biomarkers-for-alzheimer-s-disease
#3
Gunnar Brinkmalm, Simon Sjödin, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow
PURPOSE: The aim of this study was to develop and evaluate a parallel reaction monitoring mass spectrometry (PRM-MS) assay consisting of a panel of potential protein biomarkers in cerebrospinal fluid (CSF). EXPERIMENTAL DESIGN: Thirteen proteins were selected based on their association with neurodegenerative diseases and involvement in synaptic function, secretory vesicle function, or innate immune system. CSF samples were digested and 2-3 peptides per protein were quantified using stable isotope-labeled peptide standards...
October 13, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#4
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29018988/circulating-chromogranin-a-and-its-fragments-as-diagnostic-and-prognostic-disease-markers
#5
REVIEW
Angelo Corti, Fabrizio Marcucci, Tiziana Bachetti
Chromogranin A (CgA), a secretory protein released in the blood by neuroendocrine cells and neurons, is the precursor of various bioactive fragments involved in the regulation of the cardiovascular system, metabolism, innate immunity, angiogenesis, and tissue repair. After the original demonstration that circulating CgA can serve as a biomarker for a wide range of neuroendocrine tumors, several studies have shown that increased levels of CgA can be present also in the blood of patients with cardiovascular, gastrointestinal, and inflammatory diseases with, in certain cases, important diagnostic and prognostic implications...
October 10, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28992396/alcohol-feeding-in-mice-promotes-colonic-hyperpermeability-and-changes-in-colonic-organoid-stem-cell-fate
#6
Christopher B Forsyth, Maliha Shaikh, Faraz Bishehsari, Garth Swanson, Robin M Voigt, Hemraj Dodiya, Peter Wilkinson, Beata Samelco, Shiwen Song, Ali Keshavarzian
BACKGROUND: Alcohol increases intestinal permeability to pro-inflammatory microbial products that promote liver disease, even after a period of sobriety. We sought to test the hypothesis that alcohol affects intestinal stem cells using an in vivo model and ex vivo organoids generated from jejunum and colon from mice fed chronic alcohol. METHODS: Mice were fed a control or an alcohol diet. Intestinal permeability, liver steatosis/inflammation, and stool short chain fatty acids (SCFA) were measured...
October 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28984419/diagnosis-of-pediatric-neuroblastoma-by-urine-cytology-a-case-report
#7
Shiori Nishikawa, Hiroshi Noguchi, Takako Tokumitsu, Akinobu Ohno, Sayaka Moriguchi-Goto, Kazunari Maekawa, Yujiro Asada, Hiroshi Moritake, Mariko Kinoshita, Ai Yamada, Kazunari Takamura, Yuichiro Sato
Neuroblastomas are embryonal tumors arising from the neuronal crest cells of the synaptic nervous system. Findings from aspiration cytology have been reported, but there have been no reports of urine cytology findings. Here, we report a case of pediatric neuroblastoma characterized by urine cytology. A 2-year-old boy presented with abdominal pain, nausea, and loss of appetite. Computed tomography revealed a large tumor in the left suprarenal region with massive infiltration into the kidney. Urinary cytology showed highly cellular clusters composed of small, round, atypical cells with little cytoplasm and high nuclear/cytoplasmic ratio; nuclear molding was also noted in some places...
October 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28982917/gastric-spindle-cell-neuroendocrine-tumor-mimicking-gastrointestinal-stromal-tumor-unique-morphology-and-diagnostic-pitfall
#8
Alexandria A Lee, Nishant Poddar, Muhammad B Hammami, Jula Veerapong, Dengfeng Cao, Jin-Ping Lai
Gastric neuroendocrine tumors (GNETs) with spindle cell morphology are extremely rare. We present a case of a 49-year-old female patient with a history of systemic lupus erythematosus, Sjogren's syndrome, and gastroesophageal reflux disease. She was initially thought to have a spindle cell gastrointestinal stromal tumor per histological studies of the fundic polypectomy samples. Immunohistochemically, the tumor cells were negative for CD117, and CD34, but positive for chromogranin, synaptophysin, and CD56 with a 6% Ki-67 index, consistent with a spindle cell-type well differentiated neuroendocrine tumor, World Health Organization (WHO) Grade 2...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28981685/role-of-the-neuroendocrine-antimicrobial-peptide-catestatin-in-innate-immunity-and-pain
#9
Zeyu Deng, Changshui Xu
Catestatin (CST) is a neuroendocrine peptide which is derived from the chromogranin A. It has been demonstrated that CST can affect a wide range of processes, such as innate immunity, inflammatory and autoimmune reactions, and several homeostatic regulations. Furthermore, CST is positive against several kinds of bacterial strains at micromolecular range, which shows its antimicrobial activity. Recently, the role of CST in acute and chronic pain has attracted much attention. In this review, we discussed the latest research findings of CST and its role in innate immunity and pain...
August 22, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28980281/evaluating-the-effects-of-cardiac-resynchronization-therapy-on-pathophysiological-pathways-of-heart-failure-using-surrogate-biomarkers
#10
Hamza Sunman, Adem Özkan, Hikmet Yorgun, Uğur Canpolat, Erdem Karabulut, Tülin Bayrak, Ergün Barış Kaya, Lale Tokgözoğlu, Necla Özer, Asuman Özkara, Kudret Aytemir, Ali Oto
BACKGROUND: Several studies have investigated the effects of cardiac resynchronization therapy (CRT) on heart failure (HF), but none have evaluated the pathophysiological pathways involved in a single group of patients. Therefore, this study aims to assess the long-term effects of CRT on six different pathophysiological pathways involved in the process of HF by the use of surrogate biomarkers. METHODS: In a group 44 patients with HF, six groups of biomarkers were measured, both at baseline and 1 year after CRT implantation: Inflammation (interleukin [IL]-4, IL-6, tumor necrosis factor [TNF]-α, high sensitive C-reactive protein [hsCRP]); oxidative stress (myeloperoxidase, oxidized low-density lipoprotein [oxLDL], uric acid); extracellular matrix (ECM) remodeling (matrix metalloproteinase [MMP]-2 and -9, galectin-3, procollagen III N-terminal propeptide [prokol-3NT]); neurohormonal pathways (endothelin-1, chromogranin-A); myocyte injury (troponin T, creatine kinase MB fraction [CK-MB]), myocyte stress (B-type natriuretic peptide [BNP])...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28980225/merkel-cell-carcinoma-of-the-buccal-mucosa-and-lower-lip
#11
Mohammed N Islam, Hardeep Chehal, Molly Housley Smith, Sarah Islam, Indraneel Bhattacharyya
Merkel cell carcinoma (MCC) is an uncommon relatively aggressive neuroendocrine dermal neoplasm first described in 1972 as a tumor of the sun exposed skin. Although most MCC affect the skin of the head and neck, rare primarily oral mucosal cases have been documented. Merkel cells are nondendritic neuroendocrine cells that are found not only in the skin but also the oral mucosa and give rise to MCC. Neuroendocrine cells may be found as aggregates in organs or as diffuse or isolated cells within organs and their epithelial lining...
October 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28980157/expression-of-the-cholecystokinin-b-receptor-in-neoplastic-gastric-cells
#12
Patricia Mjønes, Ivar S Nordrum, Øystein Sørdal, Liv Sagatun, Reidar Fossmark, Arne Sandvik, Helge L Waldum
Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus, cholecystokinin-B receptor (CCKBR) becomes of interest. The aim of our study was to explore whether CCKBR is expressed in stomach cancers. Thirty-seven tumors from 19 men and 18 women diagnosed with either adenocarcinoma or neuroendocrine neoplasm (NENs) were included in this study...
October 4, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28979624/-central-neurocytomas-clinical-and-radiopathological-correlations-about-12-cases
#13
Fayçal Abbad, Souad Sellami, Fe Hazmiri, Najat El Idriss Ganouni, Said Ait Benali, Mouna Khouchani, Hanane Rais
Central neurocytomas are defined as neoplasms composed of round, uniform cells, with neural immunophenotypic profile and low proliferation index. They account for 0.5% of intracranial tumors. They usually occur near the foramen of Monro and can cause obstructive hydrocephaly. We conducted a retrospective data collection from records of 12 patients with central neurocytomas in the Anatomopathological Laboratory at the Mohammed VI University Hospital, Marrakech, between January 2006 and June 2015. This study aimed to report and describe the radiopathological features of this rare histologic type...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28975588/glycosylated-chromogranin-a-potential-role-in-the-pathogenesis-of-heart-failure
#14
REVIEW
Anett H Ottesen, Geir Christensen, Torbjørn Omland, Helge Røsjø
PURPOSE OF REVIEW: Endocrine and paracrine factors influence the cardiovascular system and the heart by a number of different mechanisms. The chromogranin-secretogranin (granin) proteins seem to represent a new family of proteins that exerts both direct and indirect effects on cardiac and vascular functions. The granin proteins are produced in multiple tissues, including cardiac cells, and circulating granin protein concentrations provide incremental prognostic information to established risk indices in patients with myocardial dysfunction...
October 3, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28974776/associations-between-snps-and-immune-related-circulating-proteins-in-schizophrenia
#15
Man K Chan, Jason D Cooper, Stefanie Heilmann-Heimbach, Josef Frank, Stephanie H Witt, Markus M Nöthen, Johann Steiner, Marcella Rietschel, Sabine Bahn
Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia. However, despite the convergence of evidence, direct links between the genetic and proteomic findings are still lacking for schizophrenia. We investigated associations between single nucleotide polymorphisms (SNPs) from the custom-made PsychArray and the expression levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 matched controls...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28972818/neuron-specific-enolase-as-an-immunohistochemical-marker-is-better-than-its-reputation
#16
Patricia Mjønes, Liv Sagatun, Ivar S Nordrum, Helge L Waldum
The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being a cytosolic marker may be useful in this setting. NSE is by many considered nonspecific, due to the finding of this marker in tumors considered not to be of neuroendocrine origin. Our aim was to determine whether this is true and whether NSE is more specific than previously realized. We examined 178 tumors (carcinomas and NENs) from breast, lung, stomach, and kidney using immunohistochemistry with the following markers: chromogranin A, synaptophysin, CD56, secretagogin, and NSE...
September 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28960456/primary-large-cell-neuroendocrine-carcinoma-of-the-skin-an-under-recognized-entity-and-a-mimic-of-metastatic-disease
#17
Ian Marie Lano, Daniel Rayson, Thomas Arnason, Noreen M G Walsh
Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62 year old woman with a cutaneous papule on the mid-chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Mucin production was absent...
September 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28956082/enteroendocrine-k-and-l-cells-in-healthy-and-type-2-diabetic-individuals
#18
Tina Jorsal, Nicolai A Rhee, Jens Pedersen, Camilla D Wahlgren, Brynjulf Mortensen, Sara L Jepsen, Jacob Jelsing, Louise S Dalbøge, Peter Vilmann, Hazem Hassan, Jakob W Hendel, Steen S Poulsen, Jens J Holst, Tina Vilsbøll, Filip K Knop
AIMS/HYPOTHESIS: Enteroendocrine K and L cells are pivotal in regulating appetite and glucose homeostasis. Knowledge of their distribution in humans is sparse and it is unknown whether alterations occur in type 2 diabetes. We aimed to evaluate the distribution of enteroendocrine K and L cells and relevant prohormone-processing enzymes (using immunohistochemical staining), and to evaluate the mRNA expression of the corresponding genes along the entire intestinal tract in individuals with type 2 diabetes and healthy participants...
September 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/28951733/chromofungin-ameliorates-the-progression-of-colitis-by-regulating-alternatively-activated-macrophages
#19
Nour Eissa, Hayam Hussein, Laëtitia Kermarrec, Jasmine Grover, Marie-Hélène Et Metz-Boutigue, Charles N Bernstein, Jean-Eric Ghia
Ulcerative colitis (UC) is characterized by a functional dysregulation of alternatively activated macrophage (AAM) and intestinal epithelial cells (IECs) homeostasis. Chromogranin-A (CHGA) secreted by neuroendocrine cells is implicated in intestinal inflammation and immune dysregulation. CHGA undergoes proteolytic processing to generate CHGA-derived peptides. Chromofungin (CHR: CHGA47-66) is a short CHGA-derived peptide encoded by CHGA Exon-IV and is involved in innate immune regulation, but the basis is poorly investigated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28949141/glycobiomarker-fucosylated-short-form-secretogranin-iii-levels-are-increased-in-the-serum-of-patients-with-small-cell-lung-carcinoma
#20
Akira Togayachi, Jun Iwaki, Hiroyuki Kaji, Hideki Matsuzaki, Atsushi Kuno, Yoshitoshi Hirao, Masaharu Nomura, Masayuki Noguchi, Yuzuru Ikehara, Hisashi Narimatsu
Secretogranin III (SgIII) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins are expressed in endocrine and neuroendocrine cells and subsequently processed into bioactive hormones. Although granin-derived peptide expression is correlated with neuroendocrine carcinomas, little is known about SgIII. We previously identified SgIII by a comparative glycoproteomics approach for elucidation of glycobiomarker candidates in lung carcinoma. Here, we examined the expression, secretion, and glycosylation of SgIII to identify novel biomarkers of small cell lung carcinoma (SCLC)...
September 26, 2017: Journal of Proteome Research
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