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https://www.readbyqxmd.com/read/28644880/o-glcnacylation-mediates-the-control-of-cytosolic-phosphoenolpyruvate-carboxykinase-activity-via-pgc1%C3%AE
#1
Pedro Latorre, Luis Varona, Carmen Burgos, José A Carrodeguas, Pascual López-Buesa
PGC1α is a coactivator of many transcription factors and cytosolic phosphoenolpyruvate carboxykinase (PCK1) is a key enzyme for gluconeogenesis. PGC1α interacts with the transcription factor PPARγ to stimulate PCK1 expression and thus de novo glucose synthesis. These proteins are not only important for central energy metabolism but also for supplying intermediates for other metabolic pathways, including lipidogenesis and protein synthesis and might therefore be important factors in the ethiopathogenesis of metabolic disorders like diabetes but also in other pathologies like cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28643820/does-wealth-make-health-cherchez-la-renal-replacement-therapy
#2
COMMENT
Maria D Sanchez-Niño, Alberto Ortiz
In this issue of CKJ, McQuarrie et al. have explored the relationship between socioeconomic status and outcomes among Scottish patients with a renal biopsy diagnosis of primary glomerulonephritis. Patients in the lower socioeconomic category had a twofold higher risk of death. No significant differences were observed on progression to end-stage renal disease (ESRD) requiring renal replacement therapy (RRT), suggesting that overall medical management was appropriate for all socioeconomic categories. The findings are significant since they come from an ethnically homogeneous population with free access to healthcare; they also relate to a specific aetiology of chronic kidney disease (CKD) expected to be less dependent on unhealthy lifestyles than other more frequent aetiologies that dominate studies of CKD in general, such as diabetic or hypertensive nephropathy...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28642328/leukocyte-diversity-in-resolving-and-nonresolving-mechanisms-of-cardiac-remodeling
#3
REVIEW
Bochra Tourki, Ganesh Halade
In response to myocardial infarction (MI), time-dependent leukocyte infiltration is critical to program the acute inflammatory response. Post-MI leukocyte density, residence time in the infarcted area, and exit from the infarcted injury predict resolving or nonresolving inflammation. Overactive or unresolved inflammation is the primary determinant in heart failure pathology post-MI. Here, our review describes supporting evidence that the acute inflammatory response also guides the generation of healing and regenerative mediators after cardiac damage...
June 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28640857/glucose-dysregulation-and-response-to-common-anti-diabetic-agents-in-the-fatzo-pco-mouse
#4
Richard G Peterson, Charles Van Jackson, Karen M Zimmerman, Jorge Alsina-Fernandez, M Dodson Michael, Paul J Emmerson, Tamer Coskun
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of these two strains and the selective inbreeding for obesity, insulin resistance and hyperglycemia has resulted in an inbred strain exhibiting obesity in the presumed presence of an intact leptin pathway. Routinely used rodent models for obesity and diabetes research have a monogenic defect in leptin signaling that initiates obesity. Given that obesity and its sequelae in humans are polygenic in nature and not associated with leptin signaling defects, the FATZO mouse may represent a more translatable rodent model for study of obesity and its associated metabolic disturbances...
2017: PloS One
https://www.readbyqxmd.com/read/28634206/papers-of-note-in-science-translational-medicine9-394
#5
Leslie K Ferrarelli
This week's articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer.
June 20, 2017: Science Signaling
https://www.readbyqxmd.com/read/28633442/continuous-glucose-monitoring-in-female-nod-mice-reveals-daily-rhythms-and-a-negative-correlation-with-body-temperature
#6
Ron Korstanje, Jennifer L Ryan, Holly S Savage, Bonnie L Lyons, Kevin G Kane, Stacey J Sukoff Rizzo
Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment impacting behavior and measurements. In the current study we measured blood glucose and body temperature at 10-second intervals for 12 weeks in a cohort of NOD/ShiLtJ female mice using wireless telemetry. This allowed us, for the first time, to obtain a high-resolution profile of the circadian rhythm of these two parameters and the onset of hyperglycemic development in real time...
June 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/28631813/high-fat-diet-attenuates-hyperglycemia-body-composition-changes-and-bone-loss-in-male-streptozotocin-induced-type-1-diabetic-mice
#7
Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, Katherine J Motyl
There is a growing and alarming prevalence of obesity and the metabolic syndrome in type I diabetic patients (T1DM), particularly in adolescence. In general, low bone mass, higher fracture risk and increased marrow adipose tissue (MAT) are features of diabetic osteopathy in insulin deficient subjects. On the other hand, type 2 diabetes (T2DM) is associated with normal or high bone mass, a greater risk of peripheral fractures and no change in MAT. Therefore, we sought to determine the effect of weight gain on bone turnover in insulin deficient mice...
June 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28631105/stent-fracture-is-associated-with-a-higher-mortality-in-patients-with-type-2-diabetes-treated-by-implantation-of-a-second-generation-drug-eluting-stent
#8
Zhen Ge, Zhi-Zhong Liu, Jing Kan, Jun-Jie Zhang, Sui-Ji Li, Nai-Liang Tian, Fei Ye, Xue-Song Qian, Song Yang, Meng-Xuan Chen, Tanveer S Rab, Shao-Liang Chen
Type 2 diabetes correlates with clinical events after the implantation of a second-generation drug-eluting stent (DES). The rate and prognostic value of stent fracture (SF) in patients with diabetes who underwent DES implantation remain unknown. A total of 1160 patients with- and 2251 without- diabetes, who underwent surveillance angiography at 1 year after DES implantation between June 2004 and August 2014, were prospectively studied. The primary endpoints included the incidence of SF and a composite major adverse cardiac event [MACE, including myocardial infarction (MI), cardiac death, and target-vessel revascularization (TVR)] at 1-year follow-up and at the end of follow-up for overall patients, and target lesion failure [TLF, including cardiac death, target vessel myocardial infarction (TVMI) and target lesion revascularization (TLR)] at the end of study for SF patients...
June 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28629897/a-unified-pathophysiological-construct-of-diabetes-and-its-complications
#9
REVIEW
Stanley S Schwartz, Solomon Epstein, Barbara E Corkey, Struan F A Grant, James R Gavin Iii, Richard B Aguilar, Mary E Herman
Advances in understanding diabetes mellitus (DM) through basic and clinical research have helped clarify and reunify a disease state fragmented into numerous etiologies and subtypes. It is now understood that a common pathophysiology drives the diabetic state throughout its natural history and across its varied clinical presentations, a pathophysiology involving metabolic insults, oxidative damage, and vicious cycles that aggravate and intensify organ dysfunction and damage. This new understanding of the disease requires that we revisit existing diagnostics and treatment approaches, which were built upon outmoded assumptions...
June 16, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28627597/significance-of-dynamic-changes-in-gastric-smooth-muscle-cell-apoptosis-pi3k-akt-mtor-and-ampk-mtor-signaling-in-a-rat-model-of-diabetic-gastroparesis
#10
Mo-Han Zhang, Jing-Zhi Jiang, Ying-Lan Cai, Li-Hua Piao, Zheng Jin
The aim of the present study was to investigate the significance of cell apoptosis, the phosphoinositide-3-kinase (PI3K)-protein kinase B (AKT)-mammalian target of rapamycin (mTOR) pathway, and the 5' adenosine monophosphate-activated protein kinase (AMPK)‑mTOR pathways in the process of diabetic gastroparesis. Changes in gastric smooth muscle cells of diabetic rats with induced gastroparesis were examined. The diabetic rat model was established by dividing animals into a normal control group and diabetic model groups examined at 2, 4 and 6 weeks...
June 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28626953/translation-and-validation-of-the-insulin-treatment-appraisal-scale-in-hong-kong-primary-care-patients
#11
K P Lee
AIM: Patients with type 2 diabetes mellitus (DM) often delay the initiation or titration of insulin treatment due to psychological factors. This phenomenon is referred to as psychological insulin resistance (PIR). The insulin treatment appraisal scale (ITAS) is a 20-item instrument for assessing PIR. A previous Chinese version of the ITAS (C-ITAS) was found to be subject to problems arising from its translation. The present study aimed to translate and validate this instrument, which will facilitate research and aid in counselling in a clinical setting...
June 19, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28622406/building-bridges-to-address-health-disparities-in-puerto-rico-the-salud-para-pi%C3%A3-ones-project
#12
Enid J García-Rivera, Princess Pacheco, Marielis Colón, Mary Helen Mays, Maricruz Rivera, Verónica Munet-Díaz, María Del R González, María Rodríguez, Rebecca Rodríguez, Astrid Morales
Over the past several decades, Puerto Ricans have faced increased health threats from chronic diseases, particularly diabetes and hypertension. The patient-provider relationship is the main platform for individual disease management, whereas the community, as an agent of change for the community's health status, has been limited in its support of individual health. Likewise, traditional research approaches within communities have placed academic researchers at the center of the process, considering their knowledge was of greater value than that of the community...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28620387/notch-regulates-macrophage-mediated-inflammation-in-diabetic-wound-healing
#13
Andrew S Kimball, Amrita D Joshi, Anna E Boniakowski, Matthew Schaller, Jooho Chung, Ronald Allen, Jennifer Bermick, William F Carson, Peter K Henke, Ivan Maillard, Steve L Kunkel, Katherine A Gallagher
Macrophages are essential immune cells necessary for regulated inflammation during wound healing. Recent studies have identified that Notch plays a role in macrophage-mediated inflammation. Thus, we investigated the role of Notch signaling on wound macrophage phenotype and function during normal and diabetic wound healing. We found that Notch receptor and ligand expression are dynamic in wound macrophages during normal healing. Mice with a myeloid-specific Notch signaling defect (DNMAML(floxed)Lyz2(Cre+) ) demonstrated delayed early healing (days 1-3) and wound macrophages had decreased inflammatory gene expression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28619097/adipose-tissue-derived-stromal-vascular-fraction-in-regenerative-medicine-a-brief-review-on-biology-and-translation
#14
REVIEW
Pablo Bora, Anish S Majumdar
Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs). Recently, both SVF and ADSCs have gained wide-ranging translational significance in regenerative medicine. Initially used for cosmetic breast enhancement, this mode of treatment has found use in many diseases involving immune disorders, tissue degeneration, and ischaemic conditions. In this review, we try to address several important aspects of this field, outlining the biology, technology, translation, and challenges related to SVF- and ADSC-based therapies...
June 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28616360/current-advancements-and-strategies-in-tissue-engineering-for-wound-healing-a-comprehensive-review
#15
REVIEW
Jasmine Ho, Claire Walsh, Dominic Yue, Alan Dardik, Umber Cheema
Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review of current literature has identified common themes and strategies that are proving successful within the field: The delivery of cells, mainly mesenchymal stem cells, within scaffolds of the native matrix is one such strategy...
June 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28611007/using-social-media-to-deliver-weight-loss-programming-to-young-adults-design-and-rationale-for-the-healthy-body-healthy-u-hbhu-trial
#16
Melissa A Napolitano, Jessica A Whiteley, Meghan N Mavredes, Jamie Faro, Loretta DiPietro, Laura L Hayman, Charles J Neighbors, Samuel Simmens
BACKGROUND: The transitional period from late adolescence to early adulthood is a vulnerable period for weight gain, with a twofold increase in overweight/obesity during this life transition. In the United States, approximately one-third of young adults have obesity and are at a high risk for weight gain. PURPOSE: To describe the design and rationale of a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsored randomized, controlled clinical trial, the Healthy Body Healthy U (HBHU) study, which compares the differential efficacy of three interventions on weight loss among young adults aged 18-35years...
June 10, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28607430/liraglutide-improves-liver-microvascular-dysfunction-in-cirrhosis-evidence-from-translational-studies
#17
Fernanda Cristina de Mesquita, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Raquel Maeso-Díaz, Sergi Vila, Diana Hide, Martí Ortega-Ribera, José Luís Rosa, Juan Carlos García-Pagán, Jaime Bosch, Jarbas Rodrigues de Oliveira, Jordi Gracia-Sancho
Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide on HSC phenotype and hepatic microvascular function using diverse pre-clinical models of CLD. Human and rat HSC were in vitro treated with liraglutide, or vehicle, and their phenotype, viability and proliferation were evaluated. In addition, liraglutide or vehicle was administered to rats with CLD...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28601616/fructose-rich-diet-and-insulin-action-in-female-rat-heart-estradiol-friend-or-foe
#18
REVIEW
Maja Bundalo, Snjezana Romic, Snezana Tepavcevic, Mojca Stojiljkovic, Aleksandra Stankovic, Maja Zivkovic, Goran Koricanac
Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation...
June 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28600363/a-self-efficacy-education-programme-on-foot-self-care-behaviour-among-older-patients-with-diabetes-in-a-public-long-term-care-institution-malaysia-a-quasi-experimental-pilot-study
#19
Siti Khuzaimah Ahmad Sharoni, Hejar Abdul Rahman, Halimatus Sakdiah Minhat, Sazlina Shariff Ghazali, Mohd Hanafi Azman Ong
OBJECTIVE: A pilot self-efficacy education programme was conducted to assess the feasibility, acceptability and potential impact of the self-efficacy education programme on improving foot self-care behaviour among older patients with diabetes in a public long-term care institution. METHOD: A prequasi-experimental and postquasi-experimental study was conducted in a public long-term care institution in Selangor, Malaysia. Patients with diabetes aged 60 years and above who fulfilled the selection criteria were invited to participate in this programme...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28598798/level-of-internet-use-among-greek-adolescents-with-type-1-diabetes
#20
Katerina Daniilidou, Panagiota Triantafyllou, Maria Resta, Meropi Dimitriadou, Athanasios Christoforidis
Background Compulsive Internet use has emerged as a contemporary addictive behavior. Our aim was to investigate the reasons for Greek adolescents with type 1 diabetes mellitus (T1DM) and their families to use the Internet and additionally to investigate the level of Internet use and its associations to demographic, socio-economic parameters and glycemic control. Methods Patients with T1DM, aged >12 years and their parents were recruited during their regular visits to the Pediatric Diabetes Clinic. A similar group of healthy children, age- and sex-matched served as a control group...
June 9, 2017: International Journal of Adolescent Medicine and Health
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