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Jonathan Edward Brammer, Premal Lulla, Garrett Rush Lynch
Approximately 10% of all extra-pulmonary small cell carcinoma (EPSCC) arises in the prostate either as de novo mixed adenocarcinoma with small cell components or a pure small cell carcinoma. Extensive disease carries a median survival of about 10 months in retrospective studies. We present a case managed aggressively with concomitant hormonal and chemotherapy, now 36 months without evidence of disease. At a routine physical, a 55 year male was found to have a 5 cm left upper lobe lung mass, invading his 3rd rib...
December 2011: International Journal of Clinical Oncology
Madhavi Kanuru, Jebakumar J Samuel, Lavanya M Balivada, Gopala K Aradhyam
Calnuc is a novel, highly modular, EF-hand containing, Ca(2+)-binding, Golgi resident protein whose functions are not clear. Using amino acid sequences, we demonstrate that Calnuc is a highly conserved protein among various organisms, from Ciona intestinalis to humans. Maximum homology among all sequences is found in the region that binds to G-proteins. In humans, it is known to be expressed in a variety of tissues, and it interacts with several important protein partners. Among other proteins, Calnuc is known to interact with heterotrimeric G-proteins, specifically with the alpha-subunit...
May 2009: FEBS Journal
Wei-ming Kang, Quan Liao, Yu-pei Zhao, Ya Hu
OBJECTIVE: To study the diagnosis and treatment of solid-pseudopapillary tumor of the pancreas (SPTP). METHODS: The clinical course, surgical treatment, and pathological findings of 13 patients with SPTP were analyzed. RESULTS: SPTP has no specific clinical symptoms. The patients mostly have abdominal pain and space occupying symptoms. Laboratory investigations of some patients showed decreased pancreatic exocrine function and elevated CA242 of tumor markers...
June 2004: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
H Zhou, W Cheng, K Y Lam, G C Chan, P L Khong, P K Tam
Solid-cystic papillary tumor (SCPT) of the pancreas is a rare neoplasm in children. The current study attempted to estimate the incidence and possible pathological origin of the tumor. Clinicopathologic features of the children under the age of 16 years with pancreatic tumors managed in a single institution between January 1993 and November 1999 were reviewed. Representative blocks of SCPT specimens were immunostained for neuron-specific enolase (NSE) chromogrannin, synaptophysin, insulin, glucagon, somatostatin, and gastrin...
November 2001: Pediatric Surgery International
K Y Lam, C Y Lo
The clinico-pathological features of 53 Chinese patients (27 males; 26 females) with pancreatic endocrine tumours were studied. The age range was from 14 to 78 years old (mean: 48 years) with the modal peak in the sixth decade for both sexes. Pancreatic endocrine tumours accounted for 14% of the primary pancreatic tumours operated on in Queen Mary Hospital. The autopsy incidence was 0.11%. Seventy-two per cent (38 cases) of the tumours were clinically functioning, comprising 33 insulinomas, three gastrinomas and two glucagonomas...
February 1997: European Journal of Surgical Oncology
K Y Lam, A C Chan
Two cases of paraganglioma of the urinary bladder are reported. Their immunohistochemical profiles and the clinical features are compared with other cases in the literature. The three pan-endocrine markers (neuron-specific enolase, synaptophysin and chromogrannin) were positive in both cases. Positivity to other neuropeptides (including the present two cases and those in literature) includes adrenocorticotropic hormone (three out of five cases), calcitonin (two out of nine cases), gastrin (two out of six cases), glial fibrillary acidic protein (one out of five cases), glucagon (two out of six cases), serotonin (five out of nine cases), and somatostatin (four out of eight cases)...
September 1993: Australian and New Zealand Journal of Surgery
H J Wu, D J Rozansky, R J Parmer, B M Gill, D T O'Connor
Chromogranin A is the index member of a family of acidic proteins stored and released throughout the neuroendocrine system with peptide hormones and neurotransmitters. To better understand its functional domains, its evolutionary lineage, and the basis of its tissue-specific pattern of expression, we obtained a mouse chromogranin A cDNA and used it to isolate the chromogrannin A gene from the mouse genome. We then characterized the gene's exon/intron structure, and the structure and function of its 5'-regulatory region (promoter/enhancer)...
July 15, 1991: Journal of Biological Chemistry
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