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https://www.readbyqxmd.com/read/28059636/the-effects-of-adequate-iodine-supply-on-the-incidence-of-iodine-induced-thyroid-disorders-in-slovenia
#1
Vid Bajuk, Katja Zaletel, Edvard Pirnat, Sergej Hojker, Simona Gaberšček
BACKGROUND: We aimed to establish the changes in the incidence and characteristics of iodine-induced hyperthyroidism (II-Hyper) and iodine-induced hypothyroidism (II-Hypo) in the two-year period before and the ten-year period after the increase in mandatory salt iodization from the previous 10 mg of potassium iodide to 25 mg per kg in 1999. Furthermore, we aimed at determining the duration of treatment in II-Hyper patients, since no data regarding severity and treatment of II-Hyper with respect to iodine supply are available...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27936680/novel-barley-1%C3%A2-3-1%C3%A2-4-%C3%AE-glucan-endohydrolase-alleles-confer-increased-enzyme-thermostability
#2
Juanita C Lauer, Kuok Yap, Suong Cu, Rachel A Burton, Jason K Eglinton
Barley (1→3,1→4)-β-glucan endohydrolases (β-glucanases; EI and EII) are primarily responsible for hydrolyzing high molecular weight (1→3,1→4)-β-glucans (β-glucan) during germination. Incomplete endosperm modification during malting results in residual β-glucan that can contribute to increased wort viscosity and beer chill haze. Four newly identified forms of EI and EII and the reference enzymes EI-a and EII-a were expressed in Escherichia coli, and the recombinant proteins were characterized for enzyme kinetics and thermostability...
January 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27896786/construction-of-efficient-streptococcus-zooepidemicus-strains-for-hyaluoronic-acid-production-based-on-identification-of-key-genes-involved-in-sucrose-metabolism
#3
Xuzhen Zhang, Man Wang, Tuanjie Li, Lixia Fu, Wei Cao, Hao Liu
Biosynthesis of polysaccharide hyaluoronic acid (HA) by Streptococcus zooepidemicus is a carbon-intensive process. The carbon flux and factor(s) restricting HA yield were not well understood. Here, we investigated the function of genes involved in sucrose metabolism and identified targets limiting HA yield, which were exploited to construct efficient S. zooepidemicus strains for HA production. The sucrose uptake was addressed by deletion of scrA and scrB, which encodes sucrose-PTS permease and sucrose-6-phosphate hydrolase, respectively...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27862457/a-pts-eii-mutant-library-in-group-a-streptococcus-identifies-a-promiscuous-man-family-pts-transporter-influencing-sls-mediated-hemolysis
#4
Ganesh S Sundar, Emrul Islam, Kanika Gera, Yoann Le Breton, Kevin S McIver
The Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive human pathogen that must adapt to unique host environments in order to survive. Links between sugar metabolism and virulence have been demonstrated in GAS, where mutants in the phosphoenolpyruvate-dependent phosphotransferase system (PTS) exhibited Streptolysin S (SLS)-mediated hemolysis during exponential growth. This early onset hemolysis correlated with an increased lesion size and severity in a murine soft tissue infection model when compared with parental M1T1 MGAS5005...
November 8, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27776158/both-iic-and-iid-components-of-mannose-phosphotransferase-system-are-involved-in-the-specific-recognition-between-immunity-protein-pedb-and-bacteriocin-receptor-complex
#5
Wanli Zhou, Guohong Wang, Chunmei Wang, Fazheng Ren, Yanling Hao
Upon exposure to exogenous pediocin-like bacteriocins, immunity proteins specifically bind to the target receptor of the mannose phosphotransferase system components (man-PTS IIC and IID), therefore preventing bacterial cell death. However, the specific recognition of immunity proteins and its associated target receptors remains poorly understood. In this study, we constructed hybrid receptors to identify the domains of IIC and/or IID recognized by the immunity protein PedB, which confers immunity to pediocin PA-1...
2016: PloS One
https://www.readbyqxmd.com/read/27717246/exercise-induced-inspiratory-symptoms-in-school-children
#6
Frederik Buchvald, Lue Drasbaek Phillipsen, Thomas Hjuler, Kim G Nielsen
BACKGROUND AND AIMS: Exercise-induced inspiratory symptoms (EIIS) have multiple causes, one of which is exercise-induced laryngeal obstruction (EILO). There is limited knowledge regarding EIIS in children, both in primary care practices and in pediatric asthma clinics. The aim of this study was to describe the feasibility of a diagnostic methodology and its results in a cohort of children with EIIS referred to our tertiary pediatric pulmonary center. METHODS: This study analyzed consecutively collected data in children from East Denmark and Greater Copenhagen referred during a 3½ years period...
November 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27703139/experimental-determination-of-excitonic-band-structures-of-single-walled-carbon-nanotubes-using-circular-dichroism-spectra
#7
Xiaojun Wei, Takeshi Tanaka, Yohei Yomogida, Naomichi Sato, Riichiro Saito, Hiromichi Kataura
Experimental band structure analyses of single-walled carbon nanotubes have not yet been reported, to the best of our knowledge, except for a limited number of reports using scanning tunnelling spectroscopy. Here we demonstrate the experimental determination of the excitonic band structures of single-chirality single-walled carbon nanotubes using their circular dichroism spectra. In this analysis, we use gel column chromatography combining overloading selective adsorption with stepwise elution to separate 12 different single-chirality enantiomers...
October 5, 2016: Nature Communications
https://www.readbyqxmd.com/read/27651018/how-is-inflammatory-bowel-disease-managed-in-spanish-gastroenterology-departments-the-results-of-the-gestiona-eii-survey
#8
Manuel Barreiro-de Acosta, Federico Argüelles-Arias, Joaquín Hinojosa, Francisco Javier Júdez Gutiérrez, Jose Maria Tenías Burillo
INTRODUCTION: Not all national health centers include specialized units or clinicians devoted to inflammatory bowel disease. The goal of the survey was to gain an insight into the management of this disease within Spanish gastroenterology departments via a survey among their members. MATERIAL AND METHODS: An online survey was conducted in February and March 2015, among SEPD members (2017 clinician members), who were split into three categories: heads of department, general gastroenterologists, and experts in this disease...
October 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27647522/high-resolution-impedance-manometry-parameters-enhance-the-esophageal-motility-evaluation-in-non-obstructive-dysphagia-patients-without-a-major-chicago-classification-motility-disorder
#9
D A Carlson, T Omari, Z Lin, N Rommel, K Starkey, P J Kahrilas, J Tack, J E Pandolfino
BACKGROUND: High-resolution impedance manometry (HRIM) allows evaluation of esophageal bolus retention, flow, and pressurization. We aimed to perform a collaborative analysis of HRIM metrics to evaluate patients with non-obstructive dysphagia. METHODS: Fourteen asymptomatic controls (58% female; ages 20-50) and 41 patients (63% female; ages 24-82), 18 evaluated for dysphagia and 23 for reflux (non-dysphagia patients), with esophageal motility diagnoses of normal motility or ineffective esophageal motility, were evaluated with HRIM and a global dysphagia symptom score (Brief Esophageal Dysphagia Questionnaire)...
September 20, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27598795/resilience-moderates-the-relationship-between-emotional-intelligence-and-clinical-communication-ability-among-chinese-practice-nursing-students-a-structural-equation-model-analysis
#10
Linghua Kong, Yun Liu, Guopeng Li, Yueyan Fang, Xiaofei Kang, Ping Li
OBJECTIVE: To examine the positive association between emotional intelligence and clinical communication ability among practice nursing students, and to determine whether resilience plays a moderating role in the relationship between emotional intelligence and clinical communication ability among Chinese practice nursing students. METHODS: Three hundred and seventy-seven practice nursing students from three hospitals participated in this study. They completed questionnaires including the Emotional Intelligence Inventory (EII), Connor-Davidson Resilience Scale (CD-RISC-10), and Clinical Communication Ability Scale (CCAS)...
November 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27571867/-not-available
#11
María Josefa Martínez Gómez, Cristóbal Melián Fernández, María Romeo Donlo
La enfermedad inflamatoria intestinal (EII) es una patología crónica que cursa en brotes. En los últimos años se ha visto un aumento de la incidencia, sobre todo en edades más tempranas. La malnutrición se encuentra frecuentemente asociada a esta patología, por tanto, es de vital importancia una intervención nutricional adecuada, especialmente en pacientes pediátricos, que intente asegurar no solo un óptimo crecimiento, sino también una mejoría de la clínica. Nuestro objetivo será actualizar, según la evidencia publicada, el conocimiento del papel de la nutrición en la enfermedad y en el tratamiento de la misma...
July 12, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27492717/exercise-inducible-laryngeal-obstruction-diagnostics-and-management
#12
Ola Drange Røksund, John-Helge Heimdal, Hege Clemm, Maria Vollsæter, Thomas Halvorsen
Obstruction of the central airways is an important cause of exercise-induced inspiratory symptoms (EIIS) in young and otherwise healthy individuals. This is a large, heterogeneous and vastly understudied group of patients. The symptoms are too often confused with those of asthma. Laryngoscopy performed as symptoms evolve during increasing exercise is pivotal, since the larynx plays an important role in symptomatology for the majority. Abnormalities vary between patients, and laryngoscopic findings are important for correct treatment and handling...
July 18, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27403306/gastric-malt-lymphoma-analysis-of-a-series-of-consecutive-patients-over-20-years
#13
Joana Moleiro, Sara Ferreira, Pedro Lage, A Dias Pereira
INTRODUCTION AND AIMS: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Helicobacter pylori (HP) infection. Our aim was to evaluate demographic, clinical and endoscopic characteristics of gastric MALT lymphoma patients, as well as to analyse response to treatment and factors that affect complete remission (CR) and relapse. We also assessed the long-term prognosis. METHODS: The study involved a retrospective evaluation of consecutive patients admitted with gastric MALT lymphoma (1993-2013)...
June 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27322278/fabrication-of-a-micro-needle-array-electrode-by-thermal-drawing-for-bio-signals-monitoring
#14
Lei Ren, Qing Jiang, Keyun Chen, Zhipeng Chen, Chengfeng Pan, Lelun Jiang
A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method...
2016: Sensors
https://www.readbyqxmd.com/read/27096802/immunohistochemical-evaluation-of-apoptosis-and-proliferation-in-the-mucous-membrane-of-selected-uterine-regions-in-pre-pubertal-bitches-exposed-to-low-doses-of-zearalenone
#15
E Stopa, I Babińska, Ł Zielonka, M Gajęcki, M Gajęcka
Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This paper describes a 42-day experiment performed on clinically healthy female dogs aged approximately 70 days, with estimated body weight of 8 kg...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27052615/haemophilus-parainfluenzae-as-a-marker-of-the-upper-respiratory-tract-microbiota-changes-under-the-influence-of-preoperative-prophylaxis-with-or-without-postoperative-treatment-in-patients-with-lung-cancer
#16
Urszula Kosikowska, Anna Biernasiuk, Paweł Rybojad, Renata Łoś, Anna Malm
BACKGROUND: Haemophili are representative microbiota of the upper respiratory tract. The aim of this study was to assess the effects of perioperative antimicrobial prophylaxis and/or postoperative treatment on Haemophilus parainfluenzae prevalence, and antimicrobial sensitivity in short-term hospitalized patients with lung cancer who underwent surgery. RESULTS: Samples were collected from 30 short-term hospitalized patients with lung cancer and from 65 healthy people...
April 6, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/26931657/poultry-feed-based-on-protein-hydrolysate-derived-from-chrome-tanned-leather-solid-waste-creating-value-from-waste
#17
Rubina Chaudhary, Anupama Pati
Leather industry generates huge amount of chrome-containing leather solid waste which creates major environment problems to tanners worldwide. Chrome-tanned leather solid waste is primarily chromium complex of collagen protein. The presence of chromium limits its protein application in animal feed industry. The purified protein hydrolysate with zero chromium could be used in poultry feed. In this study, an attempt has been made to assess performance of poultry with purified protein hydrolysate as a feed derived from chrome-tanned leather waste as partial replacement of soyabean meal as a sole source of protein for growing broiler chickens...
April 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26927391/over-expression-of-1-3-1-4-%C3%AE-d-glucanase-isoenzymes-eii-gene-results-in-decreased-1-3-1-4-%C3%AE-d-glucan-content-and-increased-starch-level-in-barley-grains
#18
Ning Han, Chenglong Na, Yuqiong Chai, Jianshu Chen, Zhongbo Zhang, Bin Bai, Hongwu Bian, Yuhong Zhang, Muyuan Zhu
BACKGROUND: High content of (1,3;1,4)-β-D-glucan of barley grains is regarded as an undesirable factor affecting malting potential, brewing yield and feed utilization. Production of thermostable bacterial (1,3;1,4)-β-glucanase in transgenic barley grain or the supplementation exogenous bacterial (1,3;1,4)-β-glucanase have been used to improve malt and feed quality. The aim of this study was to investigate the effect of over-expression of an endogenous (1,3;1,4)-β-glucanase on β-glucan content and grain composition in barley...
March 1, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/25771933/unexpected-finding-of-feline-specific-giardia-duodenalis-assemblage-f-and-cryptosporidium-felis-in-asymptomatic-adult-cattle-in-northern-spain
#19
Guillermo A Cardona, Aida de Lucio, Begoña Bailo, Lourdes Cano, Isabel de Fuentes, David Carmena
Giardia duodenalis and Cryptosporidium spp. are common enteric protozoan parasites in production animals, including cattle. Typically, both the clinical outcome of these infections and the distribution of G. duodenalis assemblages and Cryptosporidium species are age-dependent, with the occurrence of diarrhoeal disease being mainly associated with young animals and sub-clinical, low intensity infections being predominantly found in adult animals. To investigate the prevalence and genetic diversity of G. duodenalis and Cryptosporidium spp...
April 30, 2015: Veterinary Parasitology
https://www.readbyqxmd.com/read/25761459/immunogenicity-and-efficacy-of-flagellin-envelope-fusion-dengue-vaccines-in-mice-and-monkeys
#20
Ge Liu, Langzhou Song, David W C Beasley, Robert Putnak, Jason Parent, John Misczak, Hong Li, Lucia Reiserova, Xiangyu Liu, Haijun Tian, Wenzhe Liu, Darlene Labonte, Lihua Duan, Youngsun Kim, Linda Travalent, Devin Wigington, Bruce Weaver, Lynda Tussey
The envelope (E) protein of flaviviruses includes three domains, EI, EII, and EIII, and is the major protective antigen. Because EIII is rich in type-specific and subcomplex-specific neutralizing epitopes and is easy to express, it is particularly attractive as a recombinant vaccine antigen. VaxInnate has developed a vaccine platform that genetically links vaccine antigens to bacterial flagellin, a Toll-like receptor 5 ligand. Here we report that tetravalent dengue vaccines (TDVs) consisting of four constructs, each containing two copies of EIII fused to flagellin (R3...
May 2015: Clinical and Vaccine Immunology: CVI
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