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https://www.readbyqxmd.com/read/27860312/cytochrome-p450-26a1-modulates-natural-killer-cells-in-mouse-early-pregnancy
#1
Chao-Yang Meng, Zhong-Yin Li, Wen-Ning Fang, Zhi-Hui Song, Dan-Dan Yang, Dan-Dan Li, Ying Yang, Jing-Pian Peng
Cytochrome P450 26A1 (CYP26A1) has a spatiotemporal expression pattern in the uterus, with a significant increase in mRNA and protein levels during peri-implantation. Inhibiting the function or expression of CYP26A1 can cause pregnancy failure, suggesting an important regulatory role of CYP26A1 in the maintenance of pregnancy. However, little is known about the exact mechanism involved. In this study, using a pCR3.1-cyp26a1 plasmid immunization mouse model and a Cyp26a1-MO (Cyp26a1-specific antisense oligos) knockdown mouse model, we report that the number of Dolichos biflorus agglutinin (DBA) lectin-positive uterine natural killer (uNK) cells was reduced in pCR3...
November 17, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27815424/activating-kir2ds4-is-expressed-by-uterine-nk-cells-and-contributes-to-successful-pregnancy
#2
Philippa R Kennedy, Olympe Chazara, Lucy Gardner, Martin A Ivarsson, Lydia E Farrell, Shiqiu Xiong, Susan E Hiby, Francesco Colucci, Andrew M Sharkey, Ashley Moffett
Tissue-specific NK cells are abundant in the pregnant uterus and interact with invading placental trophoblast cells that transform the maternal arteries to increase the fetoplacental blood supply. Genetic case-control studies have implicated killer cell Ig-like receptor (KIR) genes and their HLA ligands in pregnancy disorders characterized by failure of trophoblast arterial transformation. Activating KIR2DS1 or KIR2DS5 (when located in the centromeric region as in Africans) lower the risk of disorders when there is a fetal HLA-C allele carrying a C2 epitope...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27736914/induced-human-decidual-nk-like-cells-improve-utero-placental-perfusion-in-mice
#3
Ricardo C Cavalli, Ana Sofia Cerdeira, Elizabeth Pernicone, Henri A Korkes, Suzanne D Burke, Augustine Rajakumar, Ravi I Thadhani, Drucilla J Roberts, Manoj Bhasin, S Ananth Karumanchi, Hernan D Kopcow
Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral artery remodeling is associated with decreased placental perfusion, increased uterine artery resistance, and obstetric complications such as preeclampsia and intrauterine growth restriction. Ex vivo manipulation of human peripheral blood NK (pNK) cells by a combination of hypoxia, TGFß-1 and 5-aza-2'-deoxycytidine yields cells with phenotypic and in vitro functional similarities to dNK cells, called idNK cells...
2016: PloS One
https://www.readbyqxmd.com/read/27699222/maternal-obesity-drives-functional-alterations-in-uterine-nk-cells
#4
Sofie Perdu, Barbara Castellana, Yoona Kim, Kathy Chan, Lauren DeLuca, Alexander G Beristain
Over one-fifth of North American women of childbearing age are obese, putting these women at risk for a variety of detrimental chronic diseases. In addition, obesity increases the risk for developing major complications during pregnancy. The mechanisms by which obesity contributes to pregnancy complications and loss remain unknown. Increasing evidence indicates that obesity results in major changes to adipose tissue immune cell composition and function; whether or not obesity also affects immune function in the uterus has not been explored...
July 21, 2016: JCI Insight
https://www.readbyqxmd.com/read/27628753/regulation-of-apoptotic-pathways-during-endometriosis-from-the-molecular-basis-to-the-future-perspectives
#5
Vaclav Vetvicka, Antonio Simone Laganà, Francesca Maria Salmeri, Onofrio Triolo, Vittorio Italo Palmara, Salvatore Giovanni Vitale, Vincenza Sofo, Milena Králíčková
PURPOSE: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. This may provoke a breakdown in the peritoneal cavity homeostasis, with the consequent processes of immune alteration, documented by peripheral mononuclear cells recruitment and secretion of inflammatory cytokines in early phases and of angiogenic and fibrogenic cytokines in the late stages of the disease...
November 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27517034/paternal-hla-c-and-maternal-killer-cell-immunoglobulin-like-receptor-genotypes-in-the-development-of-autism
#6
Moriya Gamliel, Karen L Anderson, Richard P Ebstein, Nurit Yirmiya, David Mankuta
Killer-cell immunoglobulin-like receptors (KIRs) are a family of cell surface proteins found on natural killer cells, which are components of the innate immune system. KIRs recognize MHC class I proteins, mainly HLA-C and are further divided into two groups: short-tailed 2/3DS activating receptors and long-tailed 2/3DL inhibitory receptors. Based on the Barker Hypothesis, the origins of illness can be traced back to embryonic development in the uterus, and since KIR:HLA interaction figures prominently in the maternal-fetal interface, we investigated whether specific KIR:HLA combinations may be found in autism spectrum disorders (ASD) children compared with their healthy parents...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27446091/human-circulating-and-tissue-resident-cd56-bright-natural-killer-cell-populations
#7
REVIEW
Janine E Melsen, Gertjan Lugthart, Arjan C Lankester, Marco W Schilham
Two human natural killer (NK) cell subsets are usually distinguished, displaying the CD56(dim)CD16(+) and the CD56(bright)CD16(-/+) phenotype. This distinction is based on NK cells present in blood, where the CD56(dim) NK cells predominate. However, CD56(bright) NK cells outnumber CD56(dim) NK cells in the human body due to the fact that they are predominant in peripheral and lymphoid tissues. Interestingly, within the total CD56(bright) NK cell compartment, a major phenotypical and functional diversity is observed, as demonstrated by the discovery of tissue-resident CD56(bright) NK cells in the uterus, liver, and lymphoid tissues...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27433816/the-evaluation-of-alteration-of-elam-1-expression-in-the-endometriosis-patients
#8
Hoda Bahrami, Reza Roozafzoon, Zinat Ghanbari, Neda Jegargooshe, Parvaneh Jafari, Mohammad Nazari, Saeed Heidari-Keshel
BACKGROUND: As a definition, Endometriosis is a commonly encountered gynecological disease; as endometrial glandular and stromal cells existing in the outside of the uterus. In spite of several studies on endometriosis, its molecular mechanism and pathogenesis nevertheless have been not completely illuminated. Role of ELAM-1 gene in mediating the adhesion of tumor cells to endothelial cells by binding to ELAM-1 ligands expressed by eosinophils, neutrophils, monocytes, natural killer cell effectors T-lymphocyte cell, and cancer (progenitor/stem) cells is well studied...
July 19, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27040357/endogenous-tweak-is-critical-for-regulating-the-function-of-mouse-uterine-natural-killer-cells-in-an-immunological-model-of-pregnancy-loss
#9
Xuefeng Qi, Mingzhu Lei, Lijuan Qin, Mengjie Xie, Dandan Zhao, Jingyu Wang
Uterine natural killer (uNK) cells are the most abundant lymphocyte population in the feto-maternal interface during early gestation, and uNK cells play a significant role in the establishment and maintenance of pregnancy-related vascularization, as well as in tolerance to the fetus. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible molecule (Fn14), are involved in preventing local cytotoxicity and counterbalancing the cytotoxic function of uNK cells...
May 2016: Immunology
https://www.readbyqxmd.com/read/26992687/ly49-knockdown-in-mice-results-in-aberrant-uterine-crypt-formation-and-impaired-blastocyst-implantation
#10
Lucy Leon, Allison M Felker, Vanessa R Kay, Megan M Tu, Andrew P Makrigiannis, B Anne Croy
Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49(KD) uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility...
March 2016: Placenta
https://www.readbyqxmd.com/read/26985000/the-transcription-factor-nfil3-is-essential-for-normal-placental-and-embryonic-development-but-not-for-uterine-natural-killer-unk-cell-differentiation-in-mice
#11
Mackenzie L Redhead, Nathália A Portilho, Allison M Felker, Shuhiba Mohammad, Danielle L Mara, B Anne Croy
Mice ablated for the gene encoding the transcription factor Nfil3 lack peripheral natural killer (NK) cells but retain tissue-resident NK cells, particularly in mucosal sites, including virgin uterus. We undertook a time course histological study of implantation sites from syngeneically (Nfil3(-/-)) and allogeneically (BALB/c) mated Nfil3(-/-) females. We also examined implantation sites from Rag2(-/-)Il2rg(-/-) females preconditioned by adoptive transfer of Nfil3(-/-) marrow or uterine cell suspensions to identify the Nfil3(-/-) pregnancy aberrations that could be attributed to nonlymphoid cells...
May 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/26925058/the-residual-innate-lymphoid-cells-in-nfil3-deficient-mice-support-suboptimal-maternal-adaptations-to-pregnancy
#12
Selma Boulenouar, Jean-Marc Doisne, Amanda Sferruzzi-Perri, Louise M Gaynor, Jens Kieckbusch, Elisa Balmas, Hong Wa Yung, Shagayegh Javadzadeh, Léa Volmer, Delia A Hawkes, Keli Phillips, Hugh J M Brady, Abigail L Fowden, Graham J Burton, Ashley Moffett, Francesco Colucci
Uterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in humans and mice. We have recently characterized the composition of uterine ILCs (uILCs), some of which require the transcription factor NFIL3, but the extent to which NFIL3-dependent cells support successful reproduction in mice is unknown. By mating Nfil3 (-/-) females with wild-type males, here we show the effects of NFIL3 deficiency in maternal cells on both the changes in uILCs during pregnancy and the downstream consequences on reproduction...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26782366/uterine-leukocyte-function-and-dysfunction-a-hypothesis-on-the-impact-of-endometriosis
#13
REVIEW
Kirstin L Parkin, Asgerally T Fazleabas
Endometriosis is a chronic inflammatory disease characterized by the growth of endometrial glands and stroma outside of the uterus. The disease affects approximately 10-15% of women of reproductive age and presents with clinical symptoms of pelvic pain and infertility. Changes in the leukocyte populations within the ectopic tissue and eutopic endometrium have been reported, and data suggest these alterations contribute to the pathology and symptoms of the disease. In this review, we discussed differences when comparing uterine NK cells and regulatory T cells within the eutopic endometrium between patients with endometriosis and healthy patients, and how these differences relate to implantation failure and/or decreased clearance of menstrual tissue in patients with the disease...
March 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/26759962/multi-parameter-flow-cytometric-analysis-of-uterine-immune-cell-fluctuations-over-the-murine-estrous-cycle
#14
Kerrilyn R Diener, Sarah A Robertson, John D Hayball, Erin L Lousberg
Investigating immune cell populations within various reproductive tissues commonly utilises flow cytometric methods. With advances in fluorophore technology and equipment capabilities, multiple cell types from a single tissue sample can be identified by using different combinations of cell surface markers to distinguish specific cell populations. Here a protocol optimized for mouse uterine tissue was used to show the proportional changes in dendritic cells, monocyte/macrophages, T and B cells, NK and NK T cells, and the granulocytes, neutrophils and eosinophils at each of the four stages of the estrous cycle...
February 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/26711346/disrupted-pi3k-p110%C3%AE-signaling-dysregulates-maternal-immune-cells-and-increases-fetal-mortality-in-mice
#15
Jens Kieckbusch, Elisa Balmas, Delia A Hawkes, Francesco Colucci
Maternal immune cells are an integral part of reproduction, but how they might cause pregnancy complications remains elusive. Macrophages and their dual function in inflammation and tissue repair are thought to play key yet undefined roles. Altered perinatal growth underpins adult morbidity, and natural killer (NK) cells may sustain fetal growth by establishing the placental blood supply. Using a mouse model of genetic inactivation of PI3K p110δ, a key intracellular signaling molecule in leukocytes, we show that p110δ regulates macrophage dynamics and NK-cell-mediated arterial remodeling...
December 29, 2015: Cell Reports
https://www.readbyqxmd.com/read/26710086/assessment-of-maternal-vascular-remodeling-during-pregnancy-in-the-mouse-uterus
#16
Jens Kieckbusch, Louise M Gaynor, Francesco Colucci
The placenta mediates the exchange of factors such as gases and nutrients between mother and fetus and has specific demands for supply of blood from the maternal circulation. The maternal uterine vasculature needs to adapt to this temporary demand and the success of this arterial remodeling process has implications for fetal growth. Cells of the maternal immune system, especially natural killer (NK) cells, play a critical role in this process. Here we describe a method to assess the degree of remodeling of maternal spiral arteries during mouse pregnancy...
December 5, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26569331/immune-mechanisms-linking-obesity-and-preeclampsia
#17
REVIEW
Frank T Spradley, Ana C Palei, Joey P Granger
Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal morbidity and mortality in developing countries and its pervasiveness is increasing within developed countries including the USA. However, the mechanisms mediating the pathogenesis of this maternal disorder and its rising prevalence are far from clear. A major theory with strong experimental evidence is that placental ischemia, resulting from inappropriate remodeling and widening of the maternal spiral arteries, stimulates the release of soluble factors from the ischemic placenta causing maternal endothelial dysfunction and hypertension...
November 12, 2015: Biomolecules
https://www.readbyqxmd.com/read/26370728/menstrual-blood-contains-immune-cells-with-inflammatory-and-anti-inflammatory-properties
#18
Samira Hosseini, Fazel Shokri, Reihaneh Tokhmechy, Elham Savadi-Shiraz, Mahmood Jeddi-Tehrani, Marjaneh Rahbari, Amir-Hassan Zarnani
AIM: Successful pregnancy requires balanced regulation of immune cells at the feto-maternal interface. Systemic monitoring of the immune system cannot precisely outline local immune status in the uterus. In this survey, endometrial immune milieu was investigated using a non-invasive method of analysis of menstrual blood (MB). The results were compared with peripheral blood (PB). METHOD: PB and MB of healthy fertile women (n = 15) were collected simultaneously on the second day of their menstrual cycle...
November 2015: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/26335175/bentamapimod-jnk-inhibitor-as602801-induces-regression-of-endometriotic-lesions-in-animal-models
#19
Stephen S Palmer, Melis Altan, Deborah Denis, Enrico Gillio Tos, Jean-Pierre Gotteland, Kevin G Osteen, Kaylon L Bruner-Tran, Selvaraj G Nataraja
Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites. Current endocrine therapies address the estrogenic aspect of disease and offer some relief from pain but are associated with significant side effects. Immune dysfunction is also widely believed to be an underlying contributor to the pathogenesis of this disease. This study evaluated an inhibitor of c-Jun N-terminal kinase, bentamapimod (AS602801), which interrupts immune pathways, in 2 rodent endometriosis models...
January 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26308138/aggressive-mll-gene-rearranged-cd7-cd56-myeloid%C3%A2-%C3%A2-natural-killer-cell-precursor-acute-leukaemia-with-extramedullary-relapse-in-the-uterus-and-breast
#20
LETTER
Gwyneth Soon, Shir Ying Lee, Shi Wang
No abstract text is available yet for this article.
October 2015: Pathology
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