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https://www.readbyqxmd.com/read/28802693/diversity-of-tissue-resident-nk-cells
#1
REVIEW
Hui Peng, Zhigang Tian
Although natural killer (NK) cells were initially named for their spontaneous tumor-killing capacity, their concept has been greatly expanded with more than 40 years of extensive investigation. Currently, NK cells are known as a heterogeneous population of innate lymphoid cell (ILC) family, consisting of different subsets with unique phenotypic and functional features. Recent studies have shown that tissue-resident NK (trNK) cells, which are distinct from conventional NK (cNK) cells, preferentially distribute in non-lymphoid tissues, such as the liver, uterus, salivary gland, and adipose...
August 9, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28695287/the-role-of-kir-and-hla-interactions-in-pregnancy-complications
#2
REVIEW
Francesco Colucci
Combinations of KIR and HLA genes associate with pregnancy complications as well as with many other clinical scenarios. Understanding how certain KIR and HLA genes influence the biology of a disease is, however, a formidable challenge. These are the two most variable gene families in the human genome. Moreover, the biology of a disease is best understood by studying the cells of the affected tissue. Natural Killer (NK) cells express KIR and are the most abundant leukocytes in the uterus. Most of our knowledge of NK cells is based on what we have learned from cells isolated from blood, but these are different from their tissue resident counterparts, including uterine NK (uNK) cells...
July 10, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28633489/effects-of-early-pregnancy-on-uterine-lymphocytes-and-endometrial-expression-of-immune-regulatory-molecules-in-dairy-heifers1
#3
Sreelakshmi Vasudevan, Manasi M Kamat, Sadhat S Walusimbi, Joy L Pate, Troy L Ott
Natural killer (NK) cells are essential for establishment of human and rodent pregnancies. The function of these and other cytotoxic T cells (CTL) is controlled by stimulatory and inhibitory signaling. A role for cytotoxic cells during early pregnancy in cattle has not been described, but regulation of their function at the fetal-maternal interface is thought to be critical for conceptus survival. The hypothesis that the relative abundance of CTL and expression of inhibitory signaling molecules is increased by the conceptus during early pregnancy was tested...
June 19, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28620462/immunoprofiling-of-human-uterine-mast-cells-identifies-three-phenotypes-and-expression-of-er%C3%AE-and-glucocorticoid-receptor
#4
Bianca De Leo, Arantza Esnal-Zufiaurre, Frances Collins, Hilary O D Critchley, Philippa T K Saunders
Background: Human mast cells (MCs) are long-lived tissue-resident immune cells characterised by granules containing the proteases chymase and/or tryptase. Their phenotype is modulated by their tissue microenvironment. The human uterus has an outer muscular layer (the myometrium) surrounding the endometrium, both of which play an important role in supporting a pregnancy. The endometrium is a sex steroid target tissue consisting of epithelial cells (luminal, glandular) surrounded by a multicellular stroma, with the latter containing an extensive vascular compartment as well as fluctuating populations of immune cells that play an important role in regulating tissue function...
2017: F1000Research
https://www.readbyqxmd.com/read/28578177/the-impact-of-uterine-immaturity-on-obstetrical-syndromes-during%C3%A2-adolescence
#5
Ivo Brosens, Joanne Muter, Caroline E Gargett, Patrick Puttemans, Giuseppe Benagiano, Jan J Brosens
Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28507070/limited-colonization-undermined-by-inadequate-early-immune-responses-defines-the-dynamics-of-decidual-listeriosis
#6
Gabrielle Rizzuto, Elisa Tagliani, Priyanka Manandhar, Adrian Erlebacher, Anna I Bakardjiev
The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to the placenta and fetus. Host-pathogen interactions in the decidua during this early stage of infection remain poorly understood. Here, we assessed the dynamics of L. monocytogenes infection in primary human decidual organ cultures and in the murine decidua in vivo A high inoculum was necessary to infect both human and mouse deciduas, and the data support the existence of a barrier to initial colonization of the murine decidua...
August 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28395334/natural-killer-cell-deficiency-alters-placental-development-in-rats
#7
Stephen J Renaud, Regan L Scott, Damayanti Chakraborty, Mohammad A K Rumi, Michael J Soares
Natural killer (NK) cells are the most prevalent leukocyte population in the uterus during early pregnancy. Natural killer cells contribute to uterine vascular (spiral artery) remodeling in preparation for the increased demand on these vessels later in pregnancy. A second wave of spiral artery modification is directed by invasive trophoblast cells. The significance of the initial wave of NK-cell-mediated vascular remodeling in species exhibiting deep trophoblast invasion such as humans and rats is not known...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28161567/multi-resolution-cell-orientation-congruence-descriptors-for-epithelium-segmentation-in-endometrial-histology-images
#8
Guannan Li, Shan E Ahmed Raza, Nasir M Rajpoot
It has been recently shown that recurrent miscarriage can be caused by abnormally high ratio of number of uterine natural killer (UNK) cells to the number of stromal cells in human female uterus lining. Due to high workload, the counting of UNK and stromal cells needs to be automated using computer algorithms. However, stromal cells are very similar in appearance to epithelial cells which must be excluded in the counting process. To exclude the epithelial cells from the counting process it is necessary to identify epithelial regions...
January 22, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28110751/novel-regulators-of-hemodynamics-in-the-pregnant-uterus
#9
N C Clark, C A Pru, J K Pru
The uterus is a highly dynamic organ, undergoing dramatic physiological changes during normal cyclicity and pregnancy. Many of these changes involve remodeling of the uterine vasculature in order to provide oxygen and nutrients to the developing embryo/fetus. Vasculogenesis, angiogenesis, vasodilation/vasoconstriction, and vascular permeability are coordinated by a vast network of autocrine, paracrine, and endocrine-signaling factors that derive from a number of cellular sources at the maternal:fetal interface, as well as from tissue outside the uterus...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/27860312/cytochrome-p450-26a1-modulates-natural-killer-cells-in-mouse-early-pregnancy
#10
Chao-Yang Meng, Zhong-Yin Li, Wen-Ning Fang, Zhi-Hui Song, Dan-Dan Yang, Dan-Dan Li, Ying Yang, Jing-Pian Peng
Cytochrome P450 26A1 (CYP26A1) has a spatiotemporal expression pattern in the uterus, with a significant increase in mRNA and protein levels during peri-implantation. Inhibiting the function or expression of CYP26A1 can cause pregnancy failure, suggesting an important regulatory role of CYP26A1 in the maintenance of pregnancy. However, little is known about the exact mechanism involved. In this study, using a pCR3.1-cyp26a1 plasmid immunization mouse model and a Cyp26a1-MO (Cyp26a1-specific antisense oligos) knockdown mouse model, we report that the number of Dolichos biflorus agglutinin (DBA) lectin-positive uterine natural killer (uNK) cells was reduced in pCR3...
April 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27815424/activating-kir2ds4-is-expressed-by-uterine-nk-cells-and-contributes-to-successful-pregnancy
#11
Philippa R Kennedy, Olympe Chazara, Lucy Gardner, Martin A Ivarsson, Lydia E Farrell, Shiqiu Xiong, Susan E Hiby, Francesco Colucci, Andrew M Sharkey, Ashley Moffett
Tissue-specific NK cells are abundant in the pregnant uterus and interact with invading placental trophoblast cells that transform the maternal arteries to increase the fetoplacental blood supply. Genetic case-control studies have implicated killer cell Ig-like receptor (KIR) genes and their HLA ligands in pregnancy disorders characterized by failure of trophoblast arterial transformation. Activating KIR2DS1 or KIR2DS5 (when located in the centromeric region as in Africans) lower the risk of disorders when there is a fetal HLA-C allele carrying a C2 epitope...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27736914/induced-human-decidual-nk-like-cells-improve-utero-placental-perfusion-in-mice
#12
Ricardo C Cavalli, Ana Sofia Cerdeira, Elizabeth Pernicone, Henri A Korkes, Suzanne D Burke, Augustine Rajakumar, Ravi I Thadhani, Drucilla J Roberts, Manoj Bhasin, S Ananth Karumanchi, Hernan D Kopcow
Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral artery remodeling is associated with decreased placental perfusion, increased uterine artery resistance, and obstetric complications such as preeclampsia and intrauterine growth restriction. Ex vivo manipulation of human peripheral blood NK (pNK) cells by a combination of hypoxia, TGFß-1 and 5-aza-2'-deoxycytidine yields cells with phenotypic and in vitro functional similarities to dNK cells, called idNK cells...
2016: PloS One
https://www.readbyqxmd.com/read/27699222/maternal-obesity-drives-functional-alterations-in-uterine-nk-cells
#13
Sofie Perdu, Barbara Castellana, Yoona Kim, Kathy Chan, Lauren DeLuca, Alexander G Beristain
Over one-fifth of North American women of childbearing age are obese, putting these women at risk for a variety of detrimental chronic diseases. In addition, obesity increases the risk for developing major complications during pregnancy. The mechanisms by which obesity contributes to pregnancy complications and loss remain unknown. Increasing evidence indicates that obesity results in major changes to adipose tissue immune cell composition and function; whether or not obesity also affects immune function in the uterus has not been explored...
July 21, 2016: JCI Insight
https://www.readbyqxmd.com/read/27628753/regulation-of-apoptotic-pathways-during-endometriosis-from-the-molecular-basis-to-the-future-perspectives
#14
REVIEW
Vaclav Vetvicka, Antonio Simone Laganà, Francesca Maria Salmeri, Onofrio Triolo, Vittorio Italo Palmara, Salvatore Giovanni Vitale, Vincenza Sofo, Milena Králíčková
PURPOSE: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. This may provoke a breakdown in the peritoneal cavity homeostasis, with the consequent processes of immune alteration, documented by peripheral mononuclear cells recruitment and secretion of inflammatory cytokines in early phases and of angiogenic and fibrogenic cytokines in the late stages of the disease...
November 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27517034/paternal-hla-c-and-maternal-killer-cell-immunoglobulin-like-receptor-genotypes-in-the-development-of-autism
#15
Moriya Gamliel, Karen L Anderson, Richard P Ebstein, Nurit Yirmiya, David Mankuta
Killer-cell immunoglobulin-like receptors (KIRs) are a family of cell surface proteins found on natural killer cells, which are components of the innate immune system. KIRs recognize MHC class I proteins, mainly HLA-C and are further divided into two groups: short-tailed 2/3DS activating receptors and long-tailed 2/3DL inhibitory receptors. Based on the Barker Hypothesis, the origins of illness can be traced back to embryonic development in the uterus, and since KIR:HLA interaction figures prominently in the maternal-fetal interface, we investigated whether specific KIR:HLA combinations may be found in autism spectrum disorders (ASD) children compared with their healthy parents...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27446091/human-circulating-and-tissue-resident-cd56-bright-natural-killer-cell-populations
#16
REVIEW
Janine E Melsen, Gertjan Lugthart, Arjan C Lankester, Marco W Schilham
Two human natural killer (NK) cell subsets are usually distinguished, displaying the CD56(dim)CD16(+) and the CD56(bright)CD16(-/+) phenotype. This distinction is based on NK cells present in blood, where the CD56(dim) NK cells predominate. However, CD56(bright) NK cells outnumber CD56(dim) NK cells in the human body due to the fact that they are predominant in peripheral and lymphoid tissues. Interestingly, within the total CD56(bright) NK cell compartment, a major phenotypical and functional diversity is observed, as demonstrated by the discovery of tissue-resident CD56(bright) NK cells in the uterus, liver, and lymphoid tissues...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27433816/evaluation-of-elam-1-expression-alteration-in-endometriosis
#17
Hoda Bahrami, Reza Roozafzoon, Zinat Ghanbari, Neda Jegargooshe, Parvaneh Jafari, Mohammad Nazari, Saeed Heidari-Keshel
BACKGROUND: Endometriosis is a commonly-encountered gynecological disease characterized by the presence of endometrial glandular and stromal cells outside of the uterus. Several studies have been conducted on endometriosis, however its molecular mechanism and pathogenesis are still not completely clear. The role of ELAM-1 gene in mediating the adhesion of tumor cells to endothelial cells by binding to ELAM-1 ligands expressed by eosinophils, neutrophils, monocytes, natural killer cell effectors, T lymphocyte cells, and cancer (progenitor/stem) cells is well studied...
April 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/27040357/endogenous-tweak-is-critical-for-regulating-the-function-of-mouse-uterine-natural-killer-cells-in-an-immunological-model-of-pregnancy-loss
#18
Xuefeng Qi, Mingzhu Lei, Lijuan Qin, Mengjie Xie, Dandan Zhao, Jingyu Wang
Uterine natural killer (uNK) cells are the most abundant lymphocyte population in the feto-maternal interface during early gestation, and uNK cells play a significant role in the establishment and maintenance of pregnancy-related vascularization, as well as in tolerance to the fetus. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible molecule (Fn14), are involved in preventing local cytotoxicity and counterbalancing the cytotoxic function of uNK cells...
May 2016: Immunology
https://www.readbyqxmd.com/read/26992687/ly49-knockdown-in-mice-results-in-aberrant-uterine-crypt-formation-and-impaired-blastocyst-implantation
#19
Lucy Leon, Allison M Felker, Vanessa R Kay, Megan M Tu, Andrew P Makrigiannis, B Anne Croy
Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5-4.5 B6.Ly49(KD) uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility...
March 2016: Placenta
https://www.readbyqxmd.com/read/26985000/the-transcription-factor-nfil3-is-essential-for-normal-placental-and-embryonic-development-but-not-for-uterine-natural-killer-unk-cell-differentiation-in-mice
#20
Mackenzie L Redhead, Nathália A Portilho, Allison M Felker, Shuhiba Mohammad, Danielle L Mara, B Anne Croy
Mice ablated for the gene encoding the transcription factor Nfil3 lack peripheral natural killer (NK) cells but retain tissue-resident NK cells, particularly in mucosal sites, including virgin uterus. We undertook a time course histological study of implantation sites from syngeneically (Nfil3(-/-)) and allogeneically (BALB/c) mated Nfil3(-/-) females. We also examined implantation sites from Rag2(-/-)Il2rg(-/-) females preconditioned by adoptive transfer of Nfil3(-/-) marrow or uterine cell suspensions to identify the Nfil3(-/-) pregnancy aberrations that could be attributed to nonlymphoid cells...
May 2016: Biology of Reproduction
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