Andrew J Hayes, David J Coker, Lukas Been, Veerle Wsm Boecxstaens, Sylvie Bonvalot, Franco De Cian, Luis de la Cruz-Merino, Carlos Duarte, Alexander Eggermont, Victor Farricha, Marco Fiore, Dirk Grünhagen, Robert Grützmann, Charles Honoré, Jens Jakob, Marko Hocevar, Winan van Houdt, Joseph Klauzner, Christoph Kettelhack, Angela Märten, Hector Martinez-Said, Maurice Matter, Audrey Michot, Maya Niethard, Elisabetta Pennacchioli, Lars E Podleska, Gregorio Rabago, Marco Rastrelli, Sophie Reijers, Matilde Ribeiro, Matthias Schwarzbach, Hayden A Snow, Miroslav Spacek, Stephan Stoldt, Alessandro Testori, Odysseas Zoras, Roger Olofsson Bagge
BACKGROUND: Isolated limb perfusion (ILP) is a well-established surgical procedure for the administration of high dose chemotherapy to a limb for the treatment of advanced extremity malignancy. Although the technique of ILP was first described over 60 years ago, ILP is utilised in relatively few specialist centres, co-located with tertiary or quaternary cancer centres. The combination of high dose cytotoxic chemotherapy and the cytokine tumour necrosis factor alpha (TNFα), mandates leakage monitoring to prevent potentially serious systemic toxicity...
March 6, 2024: European Journal of Surgical Oncology