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Implant passivity

L Athlani, E Gaisne, P Bellemère
The TACTYS(®) implant is a new anatomic gliding articular and modular prosthesis for the proximal interphalangeal (PIP) joint. We report preliminary results with a minimum follow-up of 2 years. Twenty-two patients with a mean age of 63 years were operated on at a single center by two senior hand surgeons. Indications were painful and stiff PIP joints. The joint damage was caused by osteoarthritis (18 cases), post-traumatic arthritis (3) and rheumatoid arthritis (1). All prostheses were implanted through a dorsal mid-line transtendinous approach...
June 2016: Hand Surgery and Rehabilitation
Rebecca N Howie, Timothy L Foutz, Curtis C Cathcart, Jeff S Burmeister, Steve C Budsberg
OBJECTIVE: To investigate the relationship between tibiofemoral kinematics before and after total knee replacement (TKR) in vitro. ANIMALS: Eight canine hemipelves. METHODS: A modified Oxford Knee Rig was used to place cadaveric limbs through a range of passive motion allowing the kinematics of the stifle to be evaluated. Four measurements were performed: a control stage, followed by a cranial cruciate transection stage, then following TKR with the musculature intact stage, and finally TKR with removal of limb musculature stage...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Ratika Parkash, Bernard Thibault, Iqwal Mangat, Benoit Coutu, Matthew Bennett, Jeffrey Healey, Atul Verma, Francois Philippon, Roopinder Sandhu, Douglas Cameron, Felix Ayala-Paredes, Laurence Sterns, Vidal Essebag, Teresa Kus, Pablo Nery, Elizabeth Stephenson, Raymond Yee, Derek Exner, Satish Toal, David Birnie, George Wells, Andrew Krahn
BACKGROUND: The Riata lead under advisory has posed a unique clinical scenario where inside-out abrasion results in externalization of conductor cables, with a higher risk of electrical failure. We developed a comprehensive registry to assist with clinical management of this lead. METHODS AND RESULTS: This Canadian registry reports the findings of 3763 (74.2% of all Riata leads in Canada) Riata leads under advisory, with a mean follow-up time of 8.9±1.5 years. The overall electrical failure rate was 5...
October 2016: Circulation. Arrhythmia and Electrophysiology
Si-Wei Wang, Song-Yang Zhong, Li-Jun Lou, Ze-Fu Hu, Hua-Yu Sun, Hai-Yan Zhu
The aim of this study was to investigate the effect of passive immunotherapy using intravenous immunoglobulin (IVIG) on unexplained recurrent spontaneous abortion (RSA). Live birth rates were analysed and binary data were calculated using risk ratio and 95% confidence interval. Meta-analysis of 11 studies showed that the difference in the live birth rate between the IVIG treatment and placebo groups was on the margin of significance (RR = 1.25, 95% CI 1.00 to 1.56, P = 0.05). Both cumulative and trial sequential meta-analyses indicated potential beneficial effect of IVIG but the evidence was inconclusive...
September 16, 2016: Reproductive Biomedicine Online
Christoph Windisch, Steffen Brodt, Eric Röhner, Georg Matziolis
PURPOSE: It is an established fact that post-operative (p.o.) soft-tissue swelling and lymphoedema after total knee arthroplasty (TKA) have a major influence on the p.o. early functional outcome. Kinesio taping has a proven clinical effect in increasing lymph drainage. Despite the decades of experience gained and the assumed positive effects, hardly any investigations have been conducted to date on the influence of Kinesio taping on the p.o. healing process after TKA. The objective of the present study was to test the hypothesis that Kinesio taping used as a lymph application leads to a reduction of p...
September 29, 2016: International Orthopaedics
Aloisio Oro Spazzin, Bernardo Camargo, Atais Bacchi
This technique describes the fabrication of frameworks for immediate complete-arch implant-supported prostheses to ensure that the dimensional alterations that occur during the casting procedure do not interfere with passivity. As sectioning and soldering are not necessary, there is no delay in the fabrication process, and the framework is not weakened. Titanium abutments for interim screw-retained prostheses are prepared on the definitive cast, and framework waxing preserves the access holes to the screws...
September 16, 2016: Journal of Prosthetic Dentistry
Rachael W Quinn, Arthur A Bert, Gabriel L Converse, Eric E Buse, Stephen L Hilbert, William B Drake, Richard A Hopkins
BACKGROUND: Cardiac allometric organ growth after pediatric valve replacement can lead to patient-prosthesis size mismatch and valve re-replacement, which could be mitigated with allogeneic decellularized pulmonary valves treated with collagen conditioning solutions to enhance biological and mechanical performance, termed "bioengineered valves." In this study, we evaluated functional, dimensional, and biological responses of these bioengineered valves compared with traditional cryopreserved valves implanted in lambs during rapid somatic growth...
October 2016: Journal of Thoracic and Cardiovascular Surgery
Hanan Nejer Al-Otaibi, Ahlam Almutairi, Jawza Alfarraj, Wejdan Algesadi
PURPOSE: To examine the effect of different torque application techniques (torqued, retorqued once, and retorqued twice) on the removal torque of implant-supported fixed complete dental prostheses. MATERIALS AND METHODS: Four Nobel Biocare implants (4.3 × 13 + 3; 13-mm thread height + 3-mm collar height) were stabilized temporarily inside four holes made in an acrylic mandibular master model. A metal framework was constructed, casted, and finished using a standardized technique...
September 15, 2016: International Journal of Oral & Maxillofacial Implants
Mei Methawasin, Joshua G Strom, Rebecca E Slater, Vanessa Fernandez, Chandra Saripalli, Henk Granzier
BACKGROUND: Left ventricular (LV) stiffening contributes to heart failure with preserved ejection fraction (HFpEF), a syndrome with no effective treatment options. Increasing the compliance of titin in the heart has become possible recently through inhibition of the splicing factor RNA binding motif-20. Here, we investigated the effects of increasing the compliance of titin in mice with diastolic dysfunction. METHODS: Mice in which the RNA recognition motif (RRM) of one of the RNA binding motif-20 alleles was floxed and that expressed the MerCreMer transgene under control of the αMHC promoter (referred to as cRbm20(ΔRRM) mice) were used...
October 11, 2016: Circulation
Bingjie Zhang, Hui Zheng, Bo Huang, Wenzhi Li, Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na, Wei Xie
Histone modifications are fundamental epigenetic regulators that control many crucial cellular processes. However, whether these marks can be passed on from mammalian gametes to the next generation is a long-standing question that remains unanswered. Here, by developing a highly sensitive approach, STAR ChIP-seq, we provide a panoramic view of the landscape of H3K4me3, a histone hallmark for transcription initiation, from developing gametes to post-implantation embryos. We find that upon fertilization, extensive reprogramming occurs on the paternal genome, as H3K4me3 peaks are depleted in zygotes but are readily observed after major zygotic genome activation at the late two-cell stage...
September 14, 2016: Nature
Cassondra L Williams, James W Hicks
Mammals and birds maintain high arterial partial pressure of oxygen (P O2) values in order to preserve near complete hemoglobin (Hb) oxygen (O2) saturation. In diving mammals and birds, arterial O2 follows a primarily monotonic decline and then recovery quickly after dives. In laboratory studies of submerged freshwater turtles, arterial O2 depletion typically follows a similar pattern. However, in these studies, turtles were disturbed, frequently tethered to external equipment and either confined to small tanks or breathing holes...
September 12, 2016: Journal of Experimental Biology
Rui Liang, Katrina Knight, William Barone, Robert W Powers, Alexis Nolfi, Stacy Palcsey, Steven Abramowitch, Pamela A Moalli
BACKGROUND: The use of wide pore lightweight polypropylene mesh to improve anatomical outcomes in the surgical repair of prolapse has been hampered by mesh complications. One of the prototype prolapse meshes has been found to negatively impact the vagina by inducing a decrease in smooth muscle volume and contractility and the degradation of key structural proteins (collagen and elastin), resulting in vaginal degeneration. Recently, bioscaffolds derived from extracellular matrix have been used to mediate tissue regeneration and have been widely adopted in tissue engineering applications...
September 8, 2016: American Journal of Obstetrics and Gynecology
Chance M Witt, Charles J Lenz, Henry H Shih, Elisa Ebrille, Andrew N Rosenbaum, Htin Aung, Martin van Zyl, Kevin K Manocha, Abhishek J Deshmukh, David O Hodge, Siva K Mulpuru, Yong-Mei Cha, Raul E Espinosa, Samuel J Asirvatham, Christopher J McLeod
PURPOSE: Optimal atrial pacemaker lead position and fixation mechanism have not been determined with regard to effect on complications. We aimed to determine the association between atrial lead-related complications and varying atrial lead tip positions and lead fixation mechanisms. METHODS: All patients who underwent dual-chamber pacemaker implant between 2004 and 2014 were retrospectively reviewed for atrial lead tip position and fixation type. Lead-related complications were assessed by electronic medical record review...
September 9, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Francesco Baino, Isabel Potestio
In the treatment of severe oculo-orbital traumas, intraocular malignancies or other life-threatening conditions it is sometimes necessary to surgically remove the patient's diseased eye. Following the removal of the eye, an orbital implant is inserted into the anophthalmic socket in order to provide satisfactory volume replacement and restore the aesthetic appearance of a normal eye. Over the last decades, the implant design and the criteria of materials selection evolved from simple non-porous polymeric sphere to devices with more complex shape and functionalities for ensuring better clinical outcomes in the long-term...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Nusrat Matin, Paulo W Pires, Hannah Garver, William F Jackson, Anne M Dorrance
OBJECTIVE: Chronic hypertension induces detrimental changes in the structure and function of surface cerebral arteries. Very little is known about parenchymal arterioles (PAs), which perfuse distinct neuronal populations in the cortex and may play a role in cerebrovascular disorders. We investigated the effect of deoxycorticosterone acetate (DOCA)-salt induced hypertension on endothelial function and artery structure in PAs and middle cerebral arteries (MCAs). METHODS: Uninephrectomized male Sprague-Dawley rats were implanted with a subcutaneous pellet containing DOCA (150 mg/kg b...
September 2, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Waqas Hameed, Syed Khurram Azmat, Moazzam Ali, Muhammad Ishaque, Ghazunfer Abbas, Erik Munroe, Rebecca Harrison, Wajahat Hussain Shamsi, Ghulam Mustafa, Omar Farooq Khan, Safdar Ali, Aftab Ahmed
BACKGROUND: The use of long-acting reversible contraceptive (LARC) methods is very low in Pakistan with high discontinuation rates mainly attributed to method-related side effects. Mixed evidence is available on the effectiveness of different client follow-up approaches used to ensure method continuation. We compared the effectiveness of active and passive follow-up approaches in sustaining the use of LARC-and within 'active' follow-up, we further compared a telephone versus home-based approach in rural Punjab, Pakistan...
2016: PloS One
Kuo-Ching Mei, Jie Bai, Silvia Lorrio, Julie Tzu-Wen Wang, Khuloud T Al-Jamal
Nanocarriers take advantages of the enhanced permeability and retention (EPR) to accumulate passively in solid tumors. Magnetic targeting has shown to further enhance tumor accumulation in response to a magnetic field gradient. It is widely known that passive accumulation of nanocarriers varies hugely in tumor tissues of different tumor vascularization. It is hypothesized that magnetic targeting is likely to be influenced by such factors. In this work, magnetic targeting is assessed in a range of subcutaneously implanted murine tumors, namely, colon (CT26), breast (4T1), lung (Lewis lung carcinoma) cancer and melanoma (B16F10)...
November 2016: Biomaterials
Bruce G Pound
Increased use is being made of nitinol for implants that are exposed to gastric fluid. However, few corrosion studies have involved nitinol in an appropriate acidified chloride solution. In this work, the electrochemical behavior of electropolished (EP) nitinol was examined in simulated gastric fluid, the corresponding neutral solution with the same concentration (0.6%) of NaCl, and 0.9% NaCl. Cyclic potentiodynamic polarization was used to evaluate the susceptibility to pitting corrosion, while electrochemical impedance spectroscopy was used to examine the passive oxide film...
August 29, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
G M Shanthini, N Sakthivel, Ranjini Menon, P Y Nabhiraj, J A Gómez-Tejedor, J M Meseguer-Dueñas, J L Gómez Ribelles, J B M Krishna, S Narayana Kalkura
Novel Cellulose (Cel) reinforced polyvinyl alcohol (PVA)-Silica (Si) composite which has good stability and in vitro degradation was prepared by lyophilization technique and implanted using N(3+) ions of energy 24keV in the fluences of 1×10(15), 5×10(15) and 1×10(16)ions/cm(2). SEM analysis revealed the formation of microstructures, and improved the surface roughness on ion implantation. In addition to these structural changes, the implantation significantly modified the luminescent, thermal and mechanical properties of the samples...
November 20, 2016: Carbohydrate Polymers
Jeon Mi Lee, Jinsei Jung, In Seok Moon, Sung Huhn Kim, Jae Young Choi
OBJECTIVES/HYPOTHESIS: We compared the audiologic benefits of active middle ear implants with those of passive middle ear implants with hearing aids in mixed hearing loss, and also compared the outcomes of stapes vibroplasty with those of round window vibroplasty. STUDY DESIGN: Retrospective chart review. METHODS: Thirty-four patients with mixed hearing loss due to chronic otitis media were treated with a middle ear implant. Of these, 15 were treated with a passive middle ear implant (conventional ossiculoplasty with a partial ossicular replacement prosthesis), nine with an active middle ear implant coupling to the stapes, and 10 with an active middle ear implant coupling to the round window...
August 25, 2016: Laryngoscope
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