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migraine Protein C reactive

Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
Ruxian Li, Yushuang Liu, Nan Chen, Yitong Zhang, Ge Song, Zhongling Zhang
BACKGROUND Migraine is a chronic disease that interferes with life quality and work productivity. Valproate shows protective effects against migraine, yet the underlying mechanisms are unclear. This study aimed to evaluate the potential effect of valproate on migraine using a rat model of nitroglycerin-induced trigeminovascular activation, as well as to explore the underlying mechanism. MATERIAL AND METHODS Intraperitoneal injection of nitroglycerin was conducted to induce trigeminovascular activation in rats...
September 12, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hatice Gamze Poyrazoglu, Umit Erkan Vurdem, Alev Arslan, Salih Uytun
Migraine is a commonly seen neurovascular disorder during childhood. Inflammation induced by the activation of cytokines and neuropeptides is implied in its pathophysiology. There is an association between inflammation and atherosclerosis in patients with migraine. In addition, there is a strong correlation between early atherosclerotic wall lesions and carotid intima-media thickness (CIMT). The study population consisted of 57 migraine patients aged 5-17 years, as well as 47 healthy children who served as the control group...
October 2016: Neurological Sciences
Jaydip Ray Chaudhuri, K Rukmini Mridula, Anthati S Keerthi, P Swathi Prakasham, Banda Balaraju, V C S Srinivasarao Bandaru
AIMS: To investigate the association between circulating Chlamydia pneumoniae (C pneumoniae) immunoglobulin G (IgG) antibody and migraine in Indian patients. METHODS: A total of 300 migraine patients and 150 age-matched and sex-matched controls were recruited from the Department of Neurology at Yashoda Hospital in Hyderabad, India, during the study period between August 2011 and July 2013. All patients and controls were assessed for the presence of the C pneumoniae IgG antibody and also C-reactive protein (CRP) as well as for depression, which was assessed by the Hamilton Depression Rating Scale (HDRS)...
2016: Journal of Oral & Facial Pain and Headache
You-Fan Peng, Li-Qiu Xie, Yang Xiang, Gui-Dan Xu
BACKGROUND: Increased levels of C-reactive protein (CRP) have been considered as a marker in assessing neurogenic inflammation of migraine patients. An inverse relationship between serum bilirubin and CRP has been observed in various diseases. Therefore, we analyzed serum bilirubin levels in migraine patients, and investigated the relationship between serum bilirubin and CRP in migraineurs. METHODS: A total of 86 newly diagnosed migraine patients were consecutively recruited to this study...
November 2016: Journal of Clinical Laboratory Analysis
You-Fan Peng, Ying Wei, Yu-Hua Qin, Ye-Sheng Wei, Yuan-Ji Teng
No abstract text is available yet for this article.
September 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Mustafa Ceylan, Omer Faruk Bayraktutan, Sinan Becel, Ömer Atis, Ahmet Yalcin, Dilcan Kotan
BACKGROUND: Several studies have been conducted on the inflammatory aspects of migraine. Pentraxins are a novel and important part of innate immunity as a superfamily of acute phase proteins. In our study, we aimed to demonstrate the relationship between migraine and the serum levels of pentraxin-3 (PTX-3), C-reactive protein (CRP), fibrinogen and D-dimer. METHODS: We recruited 30 migraine patients (in both the attack and interictal period) and 30 healthy controls...
May 2016: Cephalalgia: An International Journal of Headache
Nermin Tanik, Asuman Celikbilek, Aslı Metin, Ayse Yesim Gocmen, Levent Ertugrul Inan
Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine. The release of proinflammatory cytokines during migraine results in recurrent sterile neurogenic inflammation. This study aimed to determine the correlation between RBP4 and hs-CRP levels, and migraine, which is considered an inflammatory disease. The study included 48 migraine patients and 40 age- and gender-matched controls. Migraine was diagnosed according to International Classification of Headache Disorders-II...
October 2015: Neurological Sciences
Kiyan Heshmat-Ghahdarijani, Shaghayegh Haghjooy Javanmard, Seyed Ali Sonbolestan, Mohammad Saadatnia, Seyed Ahmad Sonbolestan
BACKGROUND: In most of the studies, the association of vascular events is limited to migraine with aura or it is stronger in this group, whereas the link between migraine without aura (MO) and vascular events remained uncertain. Therefore, we decided to evaluate endothelial function by chemical and functional markers of endothelium in MO and compare with normal population. METHODS: In this study, 39 patients and 25 healthy subjects were enrolled and flow-mediated dilatation (FMD), C-reactive protein (CRP), nitrite and nitrate were measured in these two groups...
2015: International Journal of Preventive Medicine
Aynur Yilmaz Avci, Hatice Lakadamyali, Serap Arikan, Ulku Sibel Benli, Munire Kilinc
BACKGROUND: Migraine is a common headache disorder that may be associated with vascular disease and cerebral white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) scan. High sensitivity C-reactive protein (hs-CRP) is a marker of inflammation that may predict subclinical atherosclerosis. However, the relation between migraine, vascular risks, and WMHs is unknown. We evaluated hs-CRP levels and the relation between hs-CRP level and WMHs in adult migraine patients. METHODS: This case-control study included 432 subjects (216 migraine patients [without aura, 143 patients; with aura, 73 patients]; 216 healthy control subjects without migraine; age range 18-50 y)...
2015: Journal of Headache and Pain
Yannick Fogoum Fogang, Massaman Camara, Amadou Gallo Diop, Mansour Mouhamadou Ndiaye
BACKGROUND: Neurocysticercosis is a major cause of neurological symptoms in developing countries. We report a case of cerebral neurocysticercosis presenting as episodic migraine without aura, with clinico-radiological correlations and discuss the possible causal influence of neurocysticercosis on the pathomechanisms of migraine. CASE PRESENTATION: We report a 24 year-old male consulting for a one year history of recurrent headaches. He described bilateral frontal and/or temporal attacks of throbbing headache, moderate to severe in intensity, worsened by head movements and accompanied by nausea, photophobia and phonophobia...
2014: BMC Neurology
Giuseppe Lippi, Camilla Mattiuzzi, Gianfranco Cervellin
Abstract Migraine is a highly prevalent and frequently disabling disorder. Since the pathogenesis of this condition has a strong inflammatory component and migraine is significantly associated with cardiovascular disease, we assess whether C-reactive protein (CRP) may be epidemiologically or casually linked with migraine. An electronic search on Medline, Scopus and Web of Science produced 17 studies reporting original data about the epidemiological association between CRP and migraine (1 retrospective, 1 interventional, 14 cross-sectional and 1 both interventional and cross-sectional)...
September 2014: Clinical Chemistry and Laboratory Medicine: CCLM
Ann C Raddant, Andrew F Russo
OBJECTIVE: To examine calcitonin gene-related peptide (CGRP) gene expression under inflammatory conditions using trigeminal ganglia organ cultures as an experimental system. These cultures have increased proinflammatory signaling that may mimic neurogenic inflammation in the migraine state. BACKGROUND: The trigeminal nerve sends peripheral pain signals to the central nervous system during migraine. Understanding the dynamic processes that occur within the trigeminal nerve and ganglion may provide insights into events that contribute to migraine pain...
March 2014: Headache
Bryan Dunn, Chad McCalla, Brian Hiestand, Mary Claire O'Brien
We describe the clinical presentation, radiographic findings, management, and outcome of a subdural empyema in a 14-year-old male with history of recent partially treated acute sinusitis. Subdural empyema is a rare but life threatening complication, usually following paranasal sinusitis, otitis media, mastoiditis, cranial surgery, a skull fracture, or from distant spread from sites such as a pulmonary infection. The initial evaluation should include a thorough history and physical examination, complete blood count, electrolytes, C-reactive protein, erythrocyte sedimentation rate, chest x-ray, urinalysis, and neuroimaging of the brain with intravenous contrast...
December 2013: Pediatric Emergency Care
A Fava, D Pirritano, D Consoli, M Plastino, F Casalinuovo, S Cristofaro, C Colica, C Ermio, M De Bartolo, C Opipari, R Lanzo, A Consoli, D Bosco
BACKGROUND AND PURPOSE: Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. The aim of this study was to assess serum glucose, insulin levels and insulin resistance (IR) in a sample of episodic migraineurs, chronic migraineurs and non-pain healthy controls...
February 2014: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Fernanda Camboim Rockett, Alexandre da Silveira Perla, Ingrid D Schweigert Perry, Márcia L Fagundes Chaves
BACKGROUND: Studies suggest a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting. The aim of this study was to investigate traditional and newly recognized risk factors as well as other surrogate markers of cardiovascular risk in obese and normal weight women with migraine. METHODS: Fifty-nine adult female probands participated in this case-control study. The sample was divided into normal weight and obese migraineurs and age- and body mass index-matched control groups...
2013: Journal of Headache and Pain
I Güzel, N Taşdemir, Y Celik
BACKGROUND AND PURPOSE: Migraine is a frequent form of head-ache. Although many mechanisms describing onset of migraine with and without visual aura have been suggested, the aetiology of migraine headaches is still not clear. Neurogenic inflammation may play a key role in the development of migraine headaches. We evaluated the discriminative power of serum levels of C-reactive protein (CRP) and transforming growth factor beta 1 (TGF-β1) in patients who presented to our clinic with migraine headaches with or without visual aura...
July 2013: Neurologia i Neurochirurgia Polska
Wei-guang Meng, Lai Shi, Ling-yan Wu, Ling-yan Lai, Rui-xia Song, Shao-zhen Huang
OBJECTIVE: To observe the clinical effect and mechanism of migraine treated with pine needle moxibustion. METHODS: Forty-three patients were randomly divided into 2 groups of pine needle moxibustion group (group A, 21 cases) and medicated thread moxibustion of Zhuang medicine group (group B, 22 cases). Same acu-points were selected as the main points for both groups, namely Fengchi (GB 20), Baihui (GV 20), Taiyang (EX-HN 5), Shuaigu (GB 8), Cuanzhu (BL 2), Sizhukong (TE 23), Yanglingquan (GB 34), Waiguan (TE 5) and Ashi points...
June 2012: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Gretchen E Tietjen, Jagdish Khubchandani, Nabeel A Herial, Kavit Shah
OBJECTIVES: Migraine is a risk factor for stroke in young women. Biomarker studies implicate endothelial activation as a possible mechanism. Emerging relationships of childhood adversity with migraine, and with inflammation, a component of endothelial activation, suggest that it may play a role in the migraine-stroke association. Our objective is to evaluate the relationship between adverse childhood experiences (ACEs), migraine, and vascular biomarker levels in premenopausal women. METHODS: Vascular and metabolic biomarkers from women 18-50 years, including 125 with migraine (interictal) and 50 without migraine, were evaluated...
June 2012: Headache
C Napon, J Kabore
Cerebral venous thrombosis (CVT) is a rare cerebral vascular pathology with highly variable clinical features and outcome. The purpose of this report is to describe a case of CVT of the cavernous sinus that presented as painful ophthalmoplegia. A 26-year-old woman with a contraceptive implant for seven months consulted at the Neurology Department of Yalgado Ouedrago hospital for a painful ophthalmoplegia that was initially diagnosed and treated as ophthalmoplegia migraine. One month later, clinical symptoms had progressed to asymmetric muscle weakness in all four limbs, right cerebellum ataxia and involvement of the trigeminal ophthalmic branch...
August 2010: Médecine Tropicale: Revue du Corps de Santé Colonial
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