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https://www.readbyqxmd.com/read/28227129/modeling-of-pharyngoesophageal-segment-during-tracheoesophageal-phonation-in-total-laryngectomy-patients-with-preliminary-validation
#1
Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos, Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos, Siwei Bai, Michal Szczesniak, Socrates Dokos, Ian Cook, Julia Maclean, Teng Zhang
For patients with large or recurrent laryngeal cancer, total laryngectomy surgery is usually performed. In the absence of a larynx, tracheoesophageal (TE) voice is the gold standard for alaryngeal phonation. The mechanisms underlying TE voice are unknown, but pharyngoesophageal (PE) segment vibration has been shown to play a key role. The aim of this study was to systematically explore the mechanics of PE segment vibration during TE phonation. A 2D axisymmetric finite-element model with two domains representing the air and PE wall was developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226713/automatic-workflow-for-narrow-band-laryngeal-video-stitching
#2
Sara Moccia, Veronica Penza, Gabriele Omodeo Vanone, Elena De Momi, Leonardo S Mattos, Sara Moccia, Veronica Penza, Gabriele Omodeo Vanone, Elena De Momi, Leonardo S Mattos, Elena De Momi, Leonardo S Mattos, Gabriele Omodeo Vanone, Veronica Penza, Sara Moccia
In narrow band (NB) laryngeal endoscopy, the clinician usually positions the endoscope near the tissue for a correct inspection of possible vascular pattern alterations, indicative of laryngeal malignancies. The video is usually reviewed many times to refine the diagnosis, resulting in loss of time since the salient frames of the video are mixed with blurred, noisy, and redundant frames caused by the endoscope movements. The aim of this work is to provide to the clinician a unique larynx panorama, obtained through an automatic frame selection strategy to discard non-informative frames...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225775/genetic-polymorphisms-and-plasma-levels-of-bcl11a-contribute-to-the-development-of-laryngeal-squamous-cell-carcinoma
#3
Jian Zhou, Yue Yang, Duo Zhang, Liang Zhou, Lei Tao, Li-Ming Lu
OBJECTIVE: We investigated the association between B-cell lymphoma/leukaemia 11A (BCL11A) rs11886868 and rs4671393 polymorphism, plasma BCL11A concentration, and the hazard of developing laryngeal squamous cell carcinoma (LSCC). PARTICIPANTS AND METHOD: In this research, 330 LSCC patients, 310 healthy controls, and 155 vocal leukoplakia patients were genotyped for the BCL11A (rs11886868 C/T and rs4671393 A/G) genotypes by pyrosequencing; the BCL11A concentration was measured using ELISA...
2017: PloS One
https://www.readbyqxmd.com/read/28225552/potential-clinical-significance-of-perioperative-levels-of-mrna-in-plasma-from-patients-with-cancer-of-the-larynx-or-hypopharynx
#4
Dolores C García-Olmo, J Diego Contreras, María G Picazo, Jesús López-Torres, Damián García-Olmo
BACKGROUND: The use of plasma as a "liquid biopsy" has gained increasing attention. The purpose of the present study was to evaluate the diagnostic and prognostic utility of the perioperative detection and quantitation of mRNAs encoding human telomerase reverse transcriptase (hTERT) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in plasma from patients with cancer of the larynx or hypopharynx. METHODS: We recruited 47 patients with laryngeal cancer and 2 patients with hypopharyngeal cancer, plus 27 healthy subjects...
February 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28225537/laryngeal-sensitivity-testing-in-youth-with-exercise-inducible-laryngeal-obstruction
#5
Irena Hočevar-Boltežar, Uroš Krivec, Maja Šereg-Bahar
Exercise-inducible laryngeal obstruction (EILO) has been recognized as a not rare respiratory problem in youth practicing sports. The aim of the study was to test the mechanosensitivity of the larynx, and to identify the factors affecting it in a group of youth with proven EILO. Laryngeal sensory testing was performed in 54 adolescents and young adults with EILO. Laryngeal mucosal alterations were assessed according to the Reflux Finding Score (RFS). The data concerning diseases possibly affecting the upper airway, findings of previously performed flexible videolaryngoscopy during exercise, and RFS score were compared between the participants with laryngeal hyposensitivity and those with normal sensitivity...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28224653/air-sacculitis-in-three-rhesus-macaques-macaca-mulatta-and-one-japanese-macaque-m-%C3%A2-fuscata
#6
Cassandra O Cullin, Lois M A Colgin, Anne D Lewis
Bacterial infection of the laryngeal air sacs (air sacculitis) is infrequently reported in nonhuman primates, where it leads to chronic respiratory disease. It is particularly uncommon in macaques; however, we report here suppurative air sacculitis with extension to adjacent cervical tissues in three rhesus macaques and one Japanese macaque. Staphylococcus aureus, Streptococcus sp., and an anaerobic bacterium were isolated.
February 22, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28224637/compound-motor-action-potential-duration-and-latency-are-markers-of-recurrent-laryngeal-nerve-injury
#7
Neel K Bhatt, Andrea M Park, Mohammad T Al-Lozi, Derrick C Gale, Randal C Paniello
OBJECTIVE: Compound motor action potential (CMAP) can quantitatively evaluate innervation following injury to the recurrent laryngeal nerve (RLN) in canines. CMAP duration (the total time of CMAP) and latency (the time between the nerve impulse and the onset of action potentials) have not been assessed following RLN injury. STUDY DESIGN: Animal study. METHODS: Twelve canine hemilaryngeal preparations were investigated. Baseline CMAP duration and latency were derived...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28224630/the-current-status-of-human-laryngeal-transplantation-in-2017-a-state-of-the-field-review
#8
REVIEW
Giri Krishnan, Charles Du, Jonathan M Fishman, Andrew Foreman, David G Lott, Gregory Farwell, Peter Belafsky, Suren Krishnan, Martin A Birchall
OBJECTIVES: Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure. DATA SOURCES: MEDLINE, Embase, Current Index to Nursing and Allied Health Literature, Web of Science and Scopus, and the Gray literature...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28223858/the-therapeutic-usage-of-botulinum-toxin-botox-in-non-cosmetic-head-and-neck-conditions-an-evidence-based-review
#9
REVIEW
Kamran Habib Awan
Botulinum toxin (Botox) is an exotoxin produced from Clostridium botulinum. It blocks the release of acetylcholine from the cholinergic nerve end plates resulting in inactivity of the muscles or glands innervated. The efficacy of Botox in facial aesthetics is well established; however, recent literature has highlighted its utilization in multiple non-cosmetic medical and surgical conditions. The present article reviews the current evidence pertaining to Botox use in the non-cosmetic head and neck conditions...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28220529/airway-support-during-neonatal-resuscitation-how-effective-is-a-laryngeal-mask
#10
Elaine M Boyle
No abstract text is available yet for this article.
February 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28220308/aberrant-expression-of-cdk8-regulates-the-malignant-phenotype-and-associated-with-poor-prognosis-in-human-laryngeal-squamous-cell-carcinoma
#11
MingHua Li, XiaoDan Zhao, Ying Liu, Jun An, Hui Xiao, Chao Wang
CDK8, a member of the transcriptional subtype of the cyclin-dependent kinases (CDKs) family, shows remarkable cancer tissue specific expression profile and rather more selective contribution to the regulation of gene expression levels involved in some signaling pathways. However, the effect of CDK8 on the malignant phenotype of human laryngeal squamous cell carcinoma (LSCC) cells and the potential molecular mechanisms remain unclear. In the present study, we evaluated the expression levels of CDK8 by quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry in tissue samples of 60 LSCC patients...
February 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28219984/motor-neurons-tune-premotor-activity-in-a-vertebrate-central-pattern-generator
#12
Kristy J Lawton, Wick M Perry, Ayako Yamaguchi, Erik Zornik
Central patterns generators (CPGs) are neural circuits that drive rhythmic motor output without sensory feedback. Vertebrate CPGs are generally believed to operate in a top-down manner in which premotor interneurons activate motor neurons that in turn drive muscles. In contrast, the frog (Xenopus laevis) vocal CPG contains a functionally unexplored neuronal projection from the motor nucleus to the premotor nucleus, indicating a recurrent pathway that may contribute to rhythm generation. In this study we characterized the function of this bottom-up connection...
February 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28219396/concurrent-chemoradiotherapy-with-conventional-fractionated-radiotherapy-and-low-dose-daily-cisplatin-plus-weekly-docetaxel-for-t2n0-glottic-cancer
#13
Jun-Ichi Saitoh, Katsuyuki Shirai, Masumi Imaeda, Atsushi Musha, Takanori Abe, Masato Shino, Yukihiro Takayasu, Katsumasa Takahashi, Kazuaki Chikamatsu, Takashi Nakano
BACKGROUND: To assess the efficacy of concurrent chemoradiotherapy (CCRT) with daily low-dose cisplatin (CDDP) plus weekly docetaxel (DTX) for patients with T2N0 glottic cancer. METHODS: Between January 2004 and December 2013, 62 treatment-naive patients with histologically proven T2N0 glottic cancer were treated with concurrent chemoradiotherapy. Radiation therapy (RT; 2 Gy daily fractions up to a total dose of 66 Gy) was administered in combination with daily low-dose CDDP (6 mg/m(2), five times a week), plus weekly DTX (10 mg/m(2)) for up to 4 weeks from the commencement of RT...
February 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28219331/a-comparison-of-videolaryngoscopes-for-tracheal-intubation-in-predicted-difficult-airway-a-feasibility-study
#14
Maria Vargas, Antonio Pastore, Fulvio Aloj, John G Laffey, Giuseppe Servillo
BACKGROUND: Videolaryngoscopy has become increasingly attractive for the routine management of the difficult airway. Glidescope® is well studied in the literature while imago V-Blade® is a recent videolaryngoscope. This is a feasibility study with 1:1 case-control sequential allocation comparing Imago V-Blade ® and Glidescope® in predicted difficult airway settings. METHODS: Two senior anesthesiologists with no clinical experience in video assisted intubation but previously trained in a simulated scenario, performed the endotracheal intubations with Imago V-Blade® and Glidescope®...
February 20, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28219323/a-preliminary-assessment-of-the-lma-protector%C3%A2-in-non-paralysed-patients
#15
Ban Leong Sng, Farida Binte Ithnin, Deepak Mathur, Eileen Lew, Nian-Lin Reena Han, Alex Tiong-Heng Sia
BACKGROUND: The LMA Protector™ is the latest CE marked single use supraglottic airway device. This airway device provides access and functional separation of the respiratory and digestive tracts. There are two ports (male, female ports) to provide suction in the laryngeal region and insertion of the gastric tube. The aim of our study is to assess the ease of use, airway quality, device positioning, airway leak and complications associated with initial clinical experience in LMA Protector™ usage...
February 20, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28218212/laryngeal-mask-airway-for-cesarean-delivery-a-5-year-retrospective-cohort-study
#16
Zhi-Yu Geng, Dong-Xin Wang
BACKGROUND: The laryngeal mask airway (LMA) is the most commonly used rescue airway in obstetric anesthesia. The aim of this retrospective cohort study was to evaluate the application of the LMA in parturients undergoing cesarean delivery (CD) for 5 years in our hospital. As a secondary objective, we investigated the incidence of airway-related complication in obstetric general anesthesia (GA). METHODS: We collected electronic data for all obstetric patients who received GA for CD between January 2010 and December 2014 in Peking University First Hospital...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28217048/radiofrequency-ablation-of-hepatocellular-carcinomas-a-new-spectrum-of-anesthetic-experience-at-a-tertiary-care-hospital-in-pakistan
#17
Faisal Shamim, Ali Asghar, Saman Tauheed, Muhammad Yahya
BACKGROUND: Radiofrequency ablation (RFA) is a minimally invasive technique of tumor destruction for patients with hepatic cancer who are not candidates for conventional therapy. The therapy required general anesthesia (GA) or sedation to ensure patient safety and comfort. The study is aimed to report and evaluate factors that influenced the periprocedural anesthetic management, drugs used, and complications during and immediately after RFA procedure for hepatocellular carcinoma. METHODS: For this retrospective study, we included 46 patients who underwent percutaneous RFA under GA or conscious sedation from January 2010 to June 2013 in Aga Khan University Hospital, Pakistan...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28217020/correlation-of-positron-emission-tomography-computed-tomography-scan-with-smoking-tumor-size-stage-and-differentiation-in-head-and-neck-cancer-patients
#18
Jordan L Pleitz, Partha Sinha, Emily V Dressler, Rony K Aouad
The goal of this study was to identify associations between positron emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) in patients presenting with head and neck squamous cell carcinoma (SCC) with tumor site, size, histologic differentiation, smoking, and diabetes. Charts of patients with oropharyngeal and laryngeal SCC who underwent (18)F-fluorodeoxyglucose PET/CT scans were reviewed between May 2007 and August 2013. Statistical analyses included modeling log-transformed SUVmax values by tumor site, size, histologic differentiation, smoking status, and diabetes using unadjusted linear regressions...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28216713/vocal-cord-closure-leading-to-inadequate-ventilation-with-laryngeal-mask-airway-proseal%C3%A2-in-a-paralysed-patient-during-laparoscopic-surgery
#19
Harihar Vishwanath Hegde, Krishna Sagar Sriram
No abstract text is available yet for this article.
January 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28216207/musculoskeletal-pain-and-occupational-variables-in-teachers-with-voice-disorders-and-in-those-with-healthy-voices-a-pilot-study
#20
Jhonatan da Silva Vitor, Larissa Thaís Donalonso Siqueira, Vanessa Veis Ribeiro, Janine Santos Ramos, Alcione Ghedini Brasolotto, Kelly Cristina Alves Silverio
PURPOSE: This study aimed to compare musculoskeletal pain perception in teachers with voice disorders and in those with healthy voices, and to investigate the relationship between musculoskeletal pain and occupational variables (ie, work journey per week and working period). METHOD: Forty-three classroom teachers were divided into two groups: dysphonic group (DG), 32 classroom teachers with voice complaints and voice disorders; and non-DG, 11 classroom teachers without voice complaints and who are vocally healthy...
February 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
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