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https://www.readbyqxmd.com/read/29467943/the-modified-glasgow-prognostic-score-is-an-independent-prognostic-indicator-in-neoadjuvantly-treated-adenocarcinoma-of-the-esophagogastric-junction
#1
Gerd Jomrich, Marlene Hollenstein, Maximilian John, Andreas Baierl, Matthias Paireder, Ivan Kristo, Aysegül Ilhan-Mutlu, Reza Asari, Matthias Preusser, Sebastian F Schoppmann
The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 patients from a prospective database undergoing surgical resection after neoadjuvant treatment between 2003 and 2014 were evaluated. mGPS was scored as 0, 1, or 2 based on CRP (>1...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29465035/-insufficient-ct-scan-in-visualizing-an-intracerebral-parenchymal-damage-in-a-six-month-old-boy
#2
Louise Kollander Jakobsen, Jacob Madsen, Maria Terase F Simonsen, Søren Kjærgaard
A six-month-old boy fell over, and a crochet hook penetrated his skin underneath his left eye. The hook was removed, and an emergency physician found a Glasgow Coma Scale score of 6-7. A CT scan showed no cerebral or ophthalmic injury. However, the patient was persistently apathic with head- and gaze direction towards the left and a facial nerve palsy. An MRI showed a linear intracerebral lesion stretching through pons into the cerebellar vermis. The patient had neuropaediatric rehabilitation and recovered fully within months...
February 12, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29463862/intraoperative-head-drift-and-eye-movement-two-under-addressed-challenges-during-cataract-surgery
#3
Kerr Brogan, Basu Dawar, David Lockington, Kanna Ramaesh
PURPOSE: To objectively measure head drift during cataract surgery, and subjectively simulate eye movements and assess impact on surgical technique. MATERIALS AND METHODS: Twelve consecutively recorded routine cataract operations in the Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, were reviewed. The speculum was used as a fixed point and correlated with a superimposed virtual ruler to measure maximum head drift in each direction throughout the operations...
February 21, 2018: Eye
https://www.readbyqxmd.com/read/29462087/prognosis-of-diffuse-axonal-injury-with-traumatic-brain-injury
#4
Stephen S Humble, Laura D Wilson, Li Wang, Drew A Long, Miya A Smith, Jonathan C Siktberg, Mina F Mirhoseini, Aashim Bhatia, Sumit Pruthi, Matthew A Day, Susanne Muehlschlegel, Mayur B Patel
BACKGROUND: Determine the prognostic impact of MRI-defined DAI after TBI on functional outcomes, quality of life, and 3-year mortality. METHODS: This retrospective single center cohort included adult trauma patients (age>17y) admitted from 2006-2012 with TBI. Inclusion criteria were positive head CT with brain MRI within 2 weeks of admission. Exclusion criteria included penetrating TBI or prior neurologic condition. Separate ordinal logistic models assessed DAI's prognostic value for following scores: 1)hospital-discharge Functional Independence Measure (FIM); 2)long-term Glasgow Outcome Scale-Extended (GOSE); and 3)long-term Quality of Life after Brain Injury-Overall Scale (QOLIBRI-OS)...
February 17, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29460097/prognostic-role-of-high-sensitivity-c-reactive-protein-and-interleukin-6-in-glioma-and-meningioma-patients
#5
Adomas Bunevicius, Andrius Radziunas, Sarunas Tamasauskas, Arimantas Tamasauskas, Edwards R Laws, Giorgio Iervasi, Robertas Bunevicius, Vytenis Deltuva
High sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) can be important prognostic indicators of brain tumor patients. We investigated the association of circulating IL-6 and hsCRP concentrations with discharge outcomes and survival of glioma and meningioma patients. One-hundred and sixty-three (115 women; median age 57 years) patients admitted for meningioma (n = 94), high-grade glioma (n = 48) and low-grade glioma (n = 21) surgery were enrolled in this prospective cohort study. Serum samples were collected within 24 h of admission...
February 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29457942/management-of-chronic-oedema-in-patients-with-multiple-morbidity
#6
Marie Todd
Marie Todd, Lymphoedema Clinical Nurse Specialist, Specialist Lymphoedema Service, Glasgow, discusses the difficulties of caring for people with compounding conditions.
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457562/quality-of-life-outcomes-in-cochlear-implantation-of-children-with-profound-and-multiple-learning-disability
#7
Richard Benjamin Speaker, Jennifer Roberston, Cristina Simoes-Franklin, Fergal Glynn, Peter Walshe, Laura Viani
This study was performed to investigate the effect of cochlear implantation on the Quality of Life (QoL) of children with profound and multiple learning disability (PMLD). This cohort of children has been viewed historically as poor candidates for cochlear implantation as they generally have poor speech and hearing outcomes. The Irish National Cochlear Implant Program's prospectively maintained database was examined for all children implanted from July 1996 to July 2015. All charts of the 381 children implanted during this time were reviewed retrospectively; 16 children met criteria for being PMLD...
May 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29456939/outcomes-of-bone-anchored-hearing-aid-implant-at-universiti-kebangsaan-malaysia-medical-centre-ukmmc
#8
Suhana Abdul Rahim, Bee-See Goh, Safinaz Zainor, Roslenda Abdul Rahman, Asma Abdullah
The cross sectional study was conducted in Universiti Kebangsaan Malaysia Medical Center (UKMMC), Malaysia from August 2012 to December 2013. All patients implanted with in UKMMC from December 2001 until December 2012 was included. Glasgow Benefit Inventory (GBI) questionnaires and UKMMC questionnaires were used as part of the assessment tool. The GBI is a scoring which measures the change in health status produced by surgical interventions. UKMMC questionnaires was invented by our department to assess questions related to social and life style of patients and also the cosmetic perspective Baha implant and other daily related activities...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456849/high-preoperative-glasgow-prognostic-score-is-a-negative-prognostic-factor-for-patients-with-endometrial-carcinoma
#9
Kohei Nakamura, Kentaro Nakayama, Toshiko Minamoto, Tomoka Ishibashi, Kaori Sanuki, Hitomi Yamashita, Ruriko Ono, Hiroki Sasamori, Takayoshi Komatsu-Fujii, Masako Ishikawa, Satoru Kyo
The aim of the present study was to determine the prognostic value of the Glasgow prognostic score (GPS) in endometrial carcinoma (EC). Patients with EC who underwent surgery at the Shimane University Hospital between January 1997 and December 2013 were enrolled (n=118). The associations between pretreatment GPS and clinical parameters, including age, histological type, International Federation of Gynecology and Obstetrics stage, tumor grade, carbohydrate antigen 19-9 and carcinoembryonic antigen levels, progression-free survival (PFS), and overall survival (OS), were investigated...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456340/acute-febrile-encephalopathy-in-children-a-prospective-study-of-clinical-features-etiology-mortality-and-risk-factors-from-western-india
#10
Kirti Gupta, Charul S Purani, Anirban Mandal, Amitabh Singh
Introduction: Acute febrile encephalopathy (AFE) in children is a medical emergency and could be a manifestation of many systemic and central nervous system pathologies. The clinical features of AFE are nonspecific and etiological spectrum variable depending on the studied population. Materials and Methods: A prospective, observational study was carried out including children aged between 1 month and 12 years with AFE admitted to the Pediatric Intensive Care Unit of a tertiary care hospital in Western India...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29454810/predictors-of-functional-outcome-after-hanging-injury
#11
Chia-Lung Kao, I-Lin Hsu
PURPOSE: Suicide becomes a serious problem in today's society and hanging is a common method of suicide. We want to find the factors which can predict the final functional outcomes of these cases. METHODS: All patients who presented to Accident and Emergency Department (ED) of the National Cheng Kung University Hospital from 1st January 2005 to 31th December 2013 with a hanging injury were included in this study. All cases were divided into good outcome group and bad outcome group according to Glasgow Outcome Scale (GOS)...
January 31, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29452965/reversal-of-antiplatelet-therapy-in-traumatic-intracranial-hemorrhage-does-timing-matter
#12
Urmil Pandya, Alexander Malik, Michael Messina, Abdul-Rahman Albeiruti, Chance Spalding
Reversal of antiplatelet therapy with platelet transfusion in traumatic intracranial hemorrhage remains controversial. Several studies have examined this topic but few have investigated whether the timing of transfusion affects outcomes. Patients admitted to a level 1 trauma center from 1/1/14 to 3/31/16 with traumatic intracranial hemorrhage taking pre-injury antiplatelet therapy were retrospectively analyzed. Patients on concurrent pre-injury anticoagulant therapy were excluded. Per institutional guideline, patients on pre-injury clopidogrel received 2 doses of platelets while patients on pre-injury aspirin received 1 dose of platelets...
February 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29452747/accuracy-of-clinician-practice-compared-with-three-head-injury-decision-rules-in-children-a-prospective-cohort-study
#13
Franz E Babl, Ed Oakley, Stuart R Dalziel, Meredith L Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Susan Donath, Stephen Hearps, Charlotte Molesworth, Louise Crowe, Silvia Bressan, Mark D Lyttle
STUDY OBJECTIVE: Three clinical decision rules for head injuries in children (Pediatric Emergency Care Applied Research Network [PECARN], Canadian Assessment of Tomography for Childhood Head Injury [CATCH], and Children's Head Injury Algorithm for the Prediction of Important Clinical Events [CHALICE]) have been shown to have high performance accuracy. The utility of any of these in a particular setting depends on preexisting clinician accuracy. We therefore assess the accuracy of clinician practice in detecting clinically important traumatic brain injury...
February 13, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29452322/end-stage-liver-disease-in-patients-with-intracranial-hemorrhage-is-associated-with-increased-mortality-a-cohort-study
#14
Carlito Lagman, Daniel T Nagasawa, John P Sheppard, Cheng Hao Jacky Chen, Thien Nguyen, Giyarpuram N Prashant, Tianyi Niu, Alexander M Tucker, Won Kim, Nader Pouratian, Fady M Kaldas, Ronald W Busuttil, Isaac Yang
BACKGROUND: End-stage liver disease (ESLD) is a devastating consequence of hepatocyte destruction that is associated with intracranial hemorrhage (ICH). OBJECTIVE: To determine if ESLD in patients with ICH is associated with increased mortality. METHODS: We performed a single-center, retrospective cohort study of 53 patients (33 ESLD and 20 non-ESLD patients) who received neurosurgical care between 2006 and 2017. The exposure of interest was ESLD defined clinically as severely impaired liver function and at least one major complication of liver failure...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452150/cerebral-blood-flow-velocity-and-autoregulation-in-paediatric-patients-following-a-global-hypoxic-ischaemic-insult
#15
Marlina E Lovett, Tensing Maa, Melissa G Chung, Nicole F O'Brien
AIM: To describe the cerebral blood flow velocity pattern and investigate cerebral autoregulation using transcranial Doppler ultrasonography (TCD) following a global hypoxic-ischaemic (HI) event in children. METHODS: This was a prospective, observational study in a quaternary-level paediatric intensive care unit. Intubated children, newborn to 17 years admitted to the PICU following HI injury (asphyxia, drowning, cardiac arrest) were eligible for inclusion. TCD was performed daily until post-injury day 8, discharge, or death, whichever occurred earliest...
February 13, 2018: Resuscitation
https://www.readbyqxmd.com/read/29449141/neurometabolites-alteration-in-the-acute-phase-of-mild-traumatic-brain-injury-mtbi-an-in-vivo-proton-magnetic-resonance-spectroscopy-1h-mrs-study
#16
Vigneswaran Veeramuthu, Pohchoo Seow, Vairavan Narayanan, Jeannie Hsiu Ding Wong, Li Kuo Tan, Aditya Tri Hernowo, Norlisah Ramli
RATIONALE AND OBJECTIVES: Magnetic resonance spectroscopy is a noninvasive imaging technique that allows for reliable assessment of microscopic changes in brain cytoarchitecture, neuronal injuries, and neurochemical changes resultant from traumatic insults. We aimed to evaluate the acute alteration of neurometabolites in complicated and uncomplicated mild traumatic brain injury (mTBI) patients in comparison to control subjects using proton magnetic resonance spectroscopy (1H magnetic resonance spectroscopy)...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29444899/comparison-of-glasgow-admission-prediction-score-and-amb-score-in-predicting-need-for-inpatient-care
#17
Allan Cameron, Dominic Jones, Eilidh Logan, Colin A O'Keeffe, Suzanne M Mason, David J Lowe
AIM: We compared the abilities of two established clinical scores to predict emergency department (ED) disposition: the Glasgow Admission Prediction Score (GAPS) and the Ambulatory Score (Ambs). METHODS: The scores were compared in a prospective, multicentre cohort study. We recruited consecutive patients attending ED triage at two UK sites: Northern General Hospital in Sheffield and Glasgow Royal Infirmary, between February and May 2016. Each had a GAPS and Ambs calculated at the time of triage, with the triage nurses and treating clinicians blinded to the scores...
February 14, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29442459/the-usefulness-of-routinely-used-malnutrition-screening-tools-in-predicting-anemia-in-lung-cancer-patients
#18
Katarzyna A Zabłocka-Słowińska, Monika Kosacka, Irena Porębska, Konrad Pawełczyk, Marcin Gołecki, Jadwiga Biernat, Halina Grajeta
BACKGROUND: Anemia and malnutrition are frequently observed during lung cancer development, and the associations between them have been researched. However, no study concerning the utility of routinely used nutritional screening tools in predicting anemia in lung cancer has been performed. OBJECTIVES: The aim of this study was to assess the usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients. MATERIAL AND METHODS: Eighty-five male patients were recruited to this study...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442239/randomized-double-blind-clinical-trial-of-combined-treatment-with-megestrol-acetate-plus-celecoxib-versus-megestrol-acetate-alone-in-cachexia-anorexia-syndrome-induced-by-gi-cancers
#19
Bizhan Kouchaki, Ghasem Janbabai, Abbas Alipour, Shahram Ala, Samaneh Borhani, Ebrahim Salehifar
PURPOSE: Previous studies reported promising efficacy for celecoxib in the treatment of cancer cachexia. We designed this study to test the hypothesis that combination therapy with megestrol acetate (MA) plus celecoxib is superior to MA alone. METHODS: Ninety eligible gastrointestinal cancer patients randomly received either MA 320 mg/day plus placebo (arm1) or MA 320 mg/day plus celecoxib 200 mg/day (arm2). Patients were evaluated at baseline, then 1 and 2 months after starting interventions...
February 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29439832/factors-associated-with-positive-margins-in-women-undergoing-breast-conservation-surgery
#20
Brittany L Murphy, Judy C Boughey, Michael G Keeney, Amy E Glasgow, Jennifer M Racz, Gary L Keeney, Elizabeth B Habermann
OBJECTIVE: To identify factors predicting positive margins at lumpectomy prompting intraoperative reexcision in patients with breast cancer treated at a large referral center. PATIENTS AND METHODS: We reviewed all breast cancer lumpectomy cases managed at our institution from January 1, 2012, through December 31, 2013. Associations between rates of positive margin and patient and tumor factors were assessed using χ 2 tests and univariate and adjusted multivariate logistic regression, stratified by ductal carcinoma in situ (DCIS) or invasive cancer...
February 10, 2018: Mayo Clinic Proceedings
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