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https://www.readbyqxmd.com/read/29917057/a-bayesian-space-time-model-for-clustering-areal-units-based-on-their-disease-trends
#1
Gary Napier, Duncan Lee, Chris Robertson, Andrew Lawson
Population-level disease risk across a set of non-overlapping areal units varies in space and time, and a large research literature has developed methodology for identifying clusters of areal units exhibiting elevated risks. However, almost no research has extended the clustering paradigm to identify groups of areal units exhibiting similar temporal disease trends. We present a novel Bayesian hierarchical mixture model for achieving this goal, with inference based on a Metropolis-coupled Markov chain Monte Carlo ((MC)$^3$) algorithm...
June 18, 2018: Biostatistics
https://www.readbyqxmd.com/read/29915811/related-factors-of-early-mortality-in-young-adults-with-cerebral-hemorrhage
#2
Hong Xia Zhou, Nina Hao, Xiao Lin Xu
Background: The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking. Methods: We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29915256/geriatric-influenza-death-gid-score-a-new-tool-for-predicting-mortality-in-older-people-with-influenza-in-the-emergency-department
#3
Jui-Yuan Chung, Chien-Chin Hsu, Jiann-Hwa Chen, Wei-Lung Chen, Hung-Jung Lin, How-Ran Guo, Chien-Cheng Huang
Although influenza may cause death in the geriatric population, the best method for predicting mortality in this population is still unclear. We retrospectively recruited older people (≥65 yr) with influenza visiting the emergency department (ED) of a medical center between January 1, 2010, and December 31, 2015. We performed univariate and multivariate logistic regression to identify independent mortality predictors and then developed a prediction score. Four hundred nine older ED patients with a nearly equal sex ratio were recruited...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915124/-17p12-influences-hematoma-volume-and-outcome-in-spontaneous-intracerebral-hemorrhage
#4
Sandro Marini, William J Devan, Farid Radmanesh, Laura Miyares, Timothy Poterba, Björn M Hansen, Bo Norrving, Jordi Jimenez-Conde, Eva Giralt-Steinhauer, Roberto Elosua, Elisa Cuadrado-Godia, Carolina Soriano, Jaume Roquer, Christina E Kourkoulis, Alison M Ayres, Kristin Schwab, David L Tirschwell, Magdy Selim, Devin L Brown, Scott L Silliman, Bradford B Worrall, James F Meschia, Chelsea S Kidwell, Joan Montaner, Israel Fernandez-Cadenas, Pilar Delgado, Steven M Greenberg, Arne Lindgren, Charles Matouk, Kevin N Sheth, Daniel Woo, Christopher D Anderson, Jonathan Rosand, Guido J Falcone
BACKGROUND AND PURPOSE: Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH. METHODS: We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29914560/predictive-factors-of-intracranial-bleeding-in-head-trauma-patients-receiving-antiplatelet-therapy-admitted-to-an-emergency-department
#5
Farès Moustafa, Jean Roubin, Bruno Pereira, Alain Barres, Jennifer Saint-Denis, Christophe Perrier, Marine Mondet, Frederic Dutheil, Jeannot Schmidt
BACKGROUND: In head trauma cases involving antiplatelet agent treatment, the French Society of Emergency Medicine recommends performing computed tomography (CT) scans to detect brain lesions, 90% of which are normal. The value of CT is still debatable given the scarce number of studies and controversial results. METHODS: We used the RATED registry (Registry of patient with Antithrombotic agents admitted to an Emergency Department, NCT02706080) to assess factors of cerebral bleeding related to antiplatelet agents following head trauma...
June 19, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29913345/variation-in-and-factors-associated-with-psychosocial-interventions-for-hospitalised-self-harm-patients-in-new-south-wales-australia
#6
Wei Du, Matt Luther, Jane Desborough, Mark Rogalewicz, Nicholas Glasgow
OBJECTIVE: Psychosocial interventions demonstrate benefits during care for self-harm patients, however their adoption in hospital care remain largely unknown. This study aimed to evaluate the variation in and factors associated with psychosocial intervention use when treating self-harm patients at New South Wales (NSW) public hospitals. METHOD: We used the all-inclusive NSW Admitted Patient Data from July 2001 to June 2014. The primary outcome was receipt of hospital based psychosocial intervention...
June 12, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29911438/different-scoring-systems-to-predict-6-week-mortality-in-cirrhosis-patients-with-acute-variceal-bleeding-a-retrospective-analysis-of-202-patients
#7
Fang Wang, Shu Cui, Fengmei Wang, Fenghui Li, Fei Tang, Xu Zhang, Yanying Gao, Hongmin Lv
OBJECTIVE: Determine the optimal scoring system for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with acute variceal bleeding (AVB). Prediction effects of six scoring systems, AIMS65 score, Glasgow-Blatchford (GBS) score, full Rockall (FRS) score, the model for end-stage liver disease (MELD), the MELD-Na model and the Child-Turcotte-Pugh (CTP) score were analyzed in this study. METHODS: A total of 202 liver cirrhosis patients with AVB were enrolled between 1 January 2014, and 31 December 2014...
June 17, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29910991/unfamiliar-face-matching-with-photographs-of-infants-and-children
#8
Robin S S Kramer, Jerrica Mulgrew, Michael G Reynolds
Background: Infants and children travel using passports that are typically valid for five years (e.g. Canada, United Kingdom, United States and Australia). These individuals may also need to be identified using images taken from videos and other sources in forensic situations including child exploitation cases. However, few researchers have examined how useful these images are as a means of identification. Methods: We investigated the effectiveness of photo identification for infants and children using a face matching task, where participants were presented with two images simultaneously and asked whether the images depicted the same child or two different children...
2018: PeerJ
https://www.readbyqxmd.com/read/29909182/diffuse-axonal-injury-dai-in-moderate-to-severe-head-injured-patients-pure-dai-vs-non-pure-dai
#9
Moinay Kim, Jae Sung Ahn, Wonhyoung Park, Suk Kyung Hong, Sang Ryong Jeon, Sung Woo Roh, Seungjoo Lee
OBJECTIVE: Diffuse axonal injury (DAI) is known to be associated with poor outcome. DAI often associates with other intracranial injuries but their distinct features have not been established. In this retrospective cohort study, we compared clinical outcomes between pure and non-pure DAI patients. PATIENTS AND METHODS: Total of 1047 traumatic brain injury (TBI) patients visited our institute between 2011 and 2017. Age ranged between 15-85 years old and Glasgow coma scale (GCS) score less than 13 were included...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29907629/cataract-surgery-refractive-outcomes-representative-standards-in-a-national-health-service-setting
#10
Kerr Brogan, Charles J M Diaper, Alan P Rotchford
BACKGROUND/AIMS: To report refractive outcomes from an National Health Service (NHS) cataract surgery service and assess if results meet suggested benchmark standard. METHODS: Details of all patients undergoing cataract surgery in the Southern General and New Victoria hospitals in Glasgow, UK, between November 2006 and December 2016 were prospectively entered into an electronic database. Patients were reviewed 4 weeks postoperatively in the eye clinic and underwent refraction at their local optometrist prior to this appointment...
June 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29907220/validation-of-the-american-association-for-the-surgery-of-trauma-s-emergency-general-surgery-breast-infection-grading-system
#11
Brittany L Murphy, Matthew C Hernandez, Nimesh D Naik, Amy E Glasgow, Victor Y Kong, Damian L Clarke, Humza Y Saleem, Jennifer M Racz, Elizabeth B Habermann, Martin D Zielinski
BACKGROUND: The American Association for the Surgery of Trauma (AAST) developed emergency general surgery (EGS) grading systems for multiple diseases to standardize classification of disease severity. The grading system for breast infections has not been validated. We aimed to validate the AAST breast infection grading system. METHODS: Multi-institutional retrospective review of all adult patients with a breast infection diagnosis at Mayo Clinic Rochester 1/2015-10/2015 and Pietermaritzburg South African Hospital 1/2010-4/2016 was performed...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29905916/epidemiological-trends-of-traumatic-brain-and-spinal-cord-injury-in-puerto-rico-from-november-10th-2006-through-may-24th-2011
#12
Ricardo H Brau, Yaritza Acevedo-Salas, Katya Giovannetti
OBJECTIVE: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today. METHODS: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Quantitative variables were expressed as means and averages (plus/minus standard deviation); bivariate cross-tabulation and multiple regression analyses were employed to identify risk factors and compare epidemiological patterns of injury related variables...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905761/high-preoperative-plasma-fibrinogen-and-serum-albumin-score-is-associated-with-poor-survival-in-operable-esophageal-squamous-cell-carcinoma
#13
S Sun, P Chen, L Meng, L Li, Z Mo, C Sun, Y Wang, F Liang
This study was performed to investigate the prognostic significance of a cumulative score based on the preoperative plasma fibrinogen and serum albumin (FA score) in operable esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative fibrinogen, and albumin concentrations were retrospectively reviewed in patients who underwent transthoracic esophagectomy. The optimal cutoff value was defined as 4.0 g/L for fibrinogen according to previous studies and as 41.0 g/L for albumin for the lower quartile...
June 14, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29905513/isolated-subdural-hematomas-in-mild-traumatic-brain-injury-part-1-the-association-between-radiographic-characteristics-and-neurosurgical-intervention
#14
Alessandro Orlando, A Stewart Levy, Benjamin A Rubin, Allen Tanner, Matthew M Carrick, Mark Lieser, David Hamilton, Charles W Mains, David Bar-Or
OBJECTIVE Isolated subdural hematomas (iSDHs) are one of the most common intracranial hemorrhage (ICH) types in the population with mild traumatic brain injury (mTBI; Glasgow Coma Scale score 13-15), account for 66%-75% of all neurosurgical procedures, and have one of the highest neurosurgical intervention rates. The objective of this study was to examine how quantitative hemorrhage characteristics of iSDHs in patients with mTBI at admission are associated with subsequent neurosurgical intervention. METHODS This was a 3...
June 15, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29900267/data-on-orphan-tear-lipid-analogs-synthesis-and-binding-to-tear-lipocalin
#15
Ben J Glasgow, Adil R Abduragimov
Data found in this article include the structures of the orphan tear lipids and their analogs that are binding candidates to tear lipocalin, the mass spectrum of products of collision induced dissociation of putative synthesized compounds of synthesized (O-oleoyl)-16 hydroxypalmitic acid. These data and analyses support the research article "Interaction of ceramides and tear lipocalin" Glasgow et al. (2018) [1].
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899304/validation-of-different-nutritional-assessment-tools-in-predicting-prognosis-of-patients-with-soft-tissue-spindle-cell-sarcomas
#16
Hiromi Sasaki, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi, Takao Setoguchi
Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil⁻lymphocyte ratio (NLR), platelet⁻lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer...
June 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29898869/characteristics-and-prognosis-of-patients-admitted-to-a-hospital-emergency-department-for-traumatic-brain-injury-and-with-anticoagulant-or-antiplatelet-treatment
#17
Oriol Yuguero, Marianela Guzman, Teresa Castañ, Carles Forné, Gisela Galindo, Jesus Pujol
BACKGROUND AND OBJECTIVE: To determine mortality and complications of patients with traumatic brain injury (TBI) with antiplatelet or anticoagulant treatment in a hospital emergency department. MATERIALS AND METHODS: Study of hospital cohorts of the 243 patients who attended with pure TBI to the emergency service of the Arnau de Vilanova University Hospital in Lleida between June 1, 2015 and June 1, 2016. Sociodemographic, clinical and other variables related to clinical management were collected...
June 10, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29897851/clinical-trial-of-fluid-infusion-rates-for-pediatric-diabetic-ketoacidosis
#18
Nathan Kuppermann, Simona Ghetti, Jeff E Schunk, Michael J Stoner, Arleta Rewers, Julie K McManemy, Sage R Myers, Lise E Nigrovic, Aris Garro, Kathleen M Brown, Kimberly S Quayle, Jennifer L Trainor, Leah Tzimenatos, Jonathan E Bennett, Andrew D DePiero, Maria Y Kwok, Clinton S Perry, Cody S Olsen, T Charles Casper, J Michael Dean, Nicole S Glaser
BACKGROUND: Diabetic ketoacidosis in children may cause brain injuries ranging from mild to severe. Whether intravenous fluids contribute to these injuries has been debated for decades. METHODS: We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neurologic outcomes in children with diabetic ketoacidosis. Children were randomly assigned to one of four treatment groups in a 2-by-2 factorial design (0...
June 14, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29896571/are-traditional-scoring-systems-for-severity-stratification-of-acute-pancreatitis-sufficient
#19
Thaddaeus Tan Jun Kiat, Sivaraj K Gunasekaran, Sameer P Junnarkar, Jee Keem Low, Winston Woon, Vishal G Shelat
Backgrounds/Aims: Ranson's score (RS) and Glasgow score (GS) have been utilized to stratify the severity of acute pancreatitis (AP). The aim of this study was to validate RS and GS for stratifying the severity of acute pancreatitis and audit our experience of managing AP. Methods: We conducted a retrospective review of patients treated for AP from July 2009 to September 2016. Final severity was determined using the revised Atlanta classification. Mortality and complications were analyzed...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29895035/cost-analysis-of-cot-side-screening-methods-for-neonatal-hypoglycaemia
#20
Matthew J Glasgow, Jane E Harding, Richard Edlin
BACKGROUND: Babies at risk of neonatal hypoglycaemia are often screened using cot-side glucometers, but non-enzymatic glucometers are inaccurate, potentially resulting in over-treatment and under-treatment, and low values require laboratory confirmation. More accurate enzymatic glucometers are available but at apparently higher costs. OBJECTIVE: Our objective was to compare the cost of screening for neonatal hypoglycaemia using point-of-care enzymatic and non-enzymatic glucometers...
June 12, 2018: Neonatology
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