keyword
MENU ▼
Read by QxMD icon Read
search

zolendronic acid

keyword
https://www.readbyqxmd.com/read/27858122/increased-cd14-and-decreased-cd14-populations-of-monocytes-48%C3%A2-h-after-zolendronic-acid-infusion-in-breast-cancer-patients
#1
A Kyrgidis, M P Yavropoulou, R Lagoudaki, C Andreadis, K Antoniades, D Kouvelas
: It has been proposed that bisphosphonates cause osteonecrosis of the jaws through impairment of the monocyte population function and proliferation. Such changes have been confirmed in jaw tissues, ex vivo. In this clinical study, we report for the first time a similar pattern of changes in peripheral blood monocytes. INTRODUCTION: The aim of this study is to examine the effect of zolendronic acid administration in the peripheral blood white cell population, seeking a plausible pathophysiological link between bisphosphonates and osteonecrosis of the jaw...
November 17, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27727926/effect-of-intravenous-zolendronic-acid-on-bone-mineral-density-in-post-menopausal-women-with-low-bone-mineral-density
#2
L A Gauri, B R Ajay, A Thanned, Q Fatima
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27122094/the-enhancing-effect-of-a-laser-photochemotherapy-with-cisplatin-or-zolendronic-acid-in-primary-human-osteoblasts-and-osteosarcoma-cells-in-vitro
#3
Paul Günther Baptist Heymann, Thomas Ziebart, Peer Wolfgang Kämmerer, Robert Mandic, Akram Saydali, Andreas Braun, Andreas Neff, Guy Florian Draenert
BACKGROUND: Photodynamic therapies (PDT) have become increasingly popular in the adjuvant treatment of different tumour entities. Chemotherapeutic agents, such as cisplatin may be used in combination with low-level laser therapy (LLLT) as laser photochemotherapy. The aim of this study was to investigate the effect of LLLT on cell bioviability of normal and malignant bone cells under chemotherapeutic conditions with either cisplatin or zolendronic acid in vitro. METHODS: Primary human osteoblasts (HOB) and an osteosarcoma cell line (Saos-2) were treated with different concentrations of zolendronic acid or cisplatin and irradiated twice with a diode laser (wavelength 670 nm, 120 s, energy outputs of 100mW/cm(2) , continuous wave mode)...
April 28, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27025032/-prevention-of-the-bones-metastases-occurrence-in-the-patients-with-renal-cell-cancer
#4
S I Boychuk, A G Dedkov, L G Yugrinova
Diagnostic significance of estimation of the tartratresistent acid phosphatase (bone TRAP--5b) activity was studied for prognosis of occurrence of metastases in bones (MB) in patients with a renal-cell cancer (RCC). The risk of the MB occurrence was determined in patients after surgical treatment. A skeleton affection rate in patients, to whom zolendronic acid was prescribed, was trustworthy bigger, than such while conduction of treatment. So, application of bisphosphonates is recommended, in particular--zolendronic acid in dosage 4 mg every month under control of the bone TRAP--5b activity with objective of prophylaxis of the MB occurrence in patients, suffering RCC...
December 2015: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/26920844/guided-bone-regeneration-in-osteoporotic-conditions-following-treatment-with-zoledronic-acid
#5
Nikos Mardas, Juliano Busetti, José Antonio Poli de Figueiredo, Luis André Mezzomo, Roberta Kochenborger Scarparo, Nikolaos Donos
OBJECTIVES: To evaluate new bone formation in calvarial critical size defects (CSD) under dense polytetrafluoroethylene (d-PTFE), microporous membranes for guided bone regeneration (GBR) in healthy, osteoporotic and osteoporotic treated with zoledronic acid (ZA) rats. METHODS: Forty-eight, female, 6-month old Wistar rats were included in the study. Osteoporosis was induced by ovariectomy (OVX) and calcium-deficient diet in 32 rats. Sixteen OVX rats were treated with a single dose of Zolendronic Acid (ZA) (OZ), while 16 OVX rats received no treatment (O)...
February 26, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/26843726/osteonecrosis-of-the-jaw-after-bisphosphonates-treatment-in-patients-with-multiple-myeloma
#6
Svetlana Krstevska, Sonja Genadieva Stavric, Lidija Cevrevska, Borce Georgjievski, Oliver Karanfilski, Tatjana Sotirova, Trajan Balkanov
BACKGROUND: Bone lytic lesion in Multiple myeloma are the most commonly presented symptoms which require treatment with bisphosphonates (BPs). BPs are providing supportive care, reducing the rate of skeletal morbidity but evidently not abolishing it, the criteria for stopping their administration have to be different from those used for classic antineoplastic drugs, and they should not be stopped when metastatic bone disease is progressing. Osteonecrosis of the jaw (ONJ) has been associated recently with the use of BPs...
December 2015: Medical Archives
https://www.readbyqxmd.com/read/26533634/comparative-effectiveness-and-cost-effectiveness-of-generic-alendronate-risendronate-denosumab-and-zolendronic-acid-for-secondary-prevention-of-fragility-fractures-perliminay-results
#7
G Hagen
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26464407/not-all-st-segment-changes-are-myocardial-injury-hypercalcaemia-induced-st-segment-elevation
#8
Adam Orville Strand, Thein Tun Aung, Ajay Agarwal
ST-segment elevation myocardial infarction is an important, life-threatening diagnosis that requires quick diagnosis and management. We describe the case of an 83-year-old man with coronary artery disease, ischaemic cardiomyopathy with left ventricular ejection fraction of 15%, newly diagnosed multiple myeloma that had an initial ECG showing ST-segment elevation in anterior leads V1-3 and ST-segment depression in lateral leads concerning for an ST-segment elevation myocardial infarction. Troponins were negative and his calcium was 3...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26328198/mandibular-osteonecrosis-due-to-bisphosphonate-use
#9
Ahmet Şalvarcı, Serdar Altınay
Due to their efficient osteoclastic inhibitor effect in bone metabolism and antiangiogenic activity, bisphosphonates are widely used in many cancer diseases particularly in prostate cancers with bone metastasis, lung cancer, breast cancer and multiple myeloma, as well as in systemic diseases such as osteoporosis, osteopenia, Paget disease and osteogenesis imperfect for the last 13 years. Prostate cancer is a common cancer in males and it is the leading cause of bone metastasis. Mandibular metastasis is rarely encountered during the course of prostate cancer...
March 2015: Turkish Journal of Urology
https://www.readbyqxmd.com/read/26324291/-medical-treatment-of-osteoporosis-in-men
#10
Pia A Eiken, Peter Vestergaard
One in five men over the age of 50 years will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk compared to women. Three bisphosphonates (alendronate, risedronate and zolendronic acid), denosumab, strontium ranelate and teriparatide are currently approved in Denmark for the treatment of osteoporosis in men. This review summarizes the available therapeutic options.
August 31, 2015: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/26136802/severe-polyarthritis-secondary-to-zolendronic-acid-a-case-report-and-literature-review
#11
Sarah Louise White, Alyssa Jacob, Celia Gregson, Ashok Bhalla
Intravenous zolendronic acid is an established anti-resorptive treatment for post-menopausal osteoporosis and is usually well tolerated. Common side effects, including the classical 'acute phase response', are consented for prior to treatment. However, rare but serious adverse reactions to zolendronic acid have been described. We report the case of an older patient with osteoporosis and osteoarthritis who presented within 12 hours of her first zolendronic acid infusion with evidence of a severe acute polyarthritis affecting her peripheral appendicular skeleton, in joints affected by pre-existing osteoarthritis...
January 2015: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/25068266/fractures-and-mortality-in-relation-to-different-osteoporosis-treatments
#12
COMPARATIVE STUDY
Huifeng Yun, Elizabeth Delzell, Kenneth G Saag, Meredith L Kilgore, Michael A Morrisey, Paul Muntner, Robert Matthews, Lingli Guo, Nicole Wright, Wilson Smith, Cathleen Colón-Emeric, Christopher M O'Connor, Kenneth W Lyles, Jeffrey R Curtis
OBJECTIVES: Few studies have assessed the effectiveness of different drugs for osteoporosis (OP). We aimed to determine if fracture and mortality rates vary among patients initiating different OP medications. METHODS: We used the Medicare 5% sample to identify new users of intravenous (IV) zoledronic acid (n=1.674), oral bisphosphonates (n=32.626), IV ibandronate (n=492), calcitonin (n=2.606), raloxifene (n=1.950), or parathyroid hormone (n=549). We included beneficiaries who were ≥65 years of age, were continuously enrolled in fee-for-service Medicare and initiated therapy during 2007-2009...
May 2015: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/25042648/catheter-based-inhibition-of-arterial-calcification-by-bisphosphonates-in-an-experimental-atherosclerotic-rabbit-animal-model
#13
Andreas Synetos, Konstantinos Toutouzas, Georgios Benetos, Maria Drakopoulou, Georgios Trantalis, Rafail Kotronias, George Agrogiannis, Eleftherios Tsiamis, Spyridon Deftereos, Periklis Davlouros, Eustratios Patsouris, Christodoulos Stefanadis
BACKGROUND: Vascular calcification is an active process, sharing common molecular mechanisms with bone formation. Bisphosphonates are components, which inhibit calcification. The aim of the present study was to evaluate the safety and effectiveness of local delivery of the bisphosphonate zoledronate on inhibition of calcium formation in the arterial wall in an experimental animal model. METHODS: Sixteen New Zealand rabbits were placed on vitamin D enriched atherogenic diet for 3 weeks...
September 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/24574674/bisphosphonate-induced-osteoradionecrosis
#14
Ruchi Bhuyan, Sanat Bhuyan, Rajat G Panigrahi, Antarmayee Panigrahi
Bisphosphonates (BPs) are a class of agents used to treat osteoporosis and malignant bone metastasis. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. This case presentation focuses on a 62-year-old man with a 3-year history of monthly use of Zometa (zolendronic acid) for treatment of multiple myeloma, resulting in BP-related osteoradionecrosis of the jaws (BRONJ). This new entity remains a challenge with diagnosis as well as treatment...
September 2013: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/24074253/denosumab-as-a-promising-novel-bone-targeted-agent-in-castration-resistant-prostate-cancer
#15
Athanasios Dellis, Athanasios G Papatsoris
Fortunately, more therapeutic progress has been achieved during the last 3 years for patients with castration resistant prostate cancer (CRPC) than during the previous 30 years. During this limited time frame, six compounds (sipuleucel-T, cabazitaxel, denosumab, abiraterone, radium-223 and enzalutamide, listed in chronologic order) yielded positive results in Phase III trials (Fizazi K. Nonhormone therapy for metastatic castration-resistant prostate cancer. Soc Clin Oncol Educ Book 2013;2013:161-5; Papatsoris AG, Karamouzis MV, Papavassiliou AG...
January 2014: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/23548455/effect-of-immobilization-off-loading-and-zoledronic-acid-on-bone-mineral-density-in-patients-with-acute-charcot-neuroarthropathy-a-prospective-randomized-trial
#16
RANDOMIZED CONTROLLED TRIAL
Toni-Karri Pakarinen, Heikki-Jussi Laine, Heikki Mäenpää, Mika Kähönen, Pentti Mattila, Jorma Lahtela
BACKGROUND: Bisphosphonates are commonly used as an adjuvant in the management of acute Charcot neuroarthropathy (CNA), although the clinical efficacy of the treatment is controversial. The aim of the present study is to investigate the effect of immobilization and zoledronic acid on bone mineral density (BMD) changes during the treatment of acute CNA. METHODS: Thirty-five patients with acute midfoot CNA were randomly assigned to treatment with either zolendronic acid or placebo...
June 2013: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/23334521/use-of-bisphosphonates-in-metastatic-breast-cancer-single-institution-review-at-the-dr-h-bliss-murphy-cancer-centre
#17
Laura Murphy, Joy McCarthy, Farah McCrate, Kara Laing, Erin Powell, Melanie Seal, Scott Edwards
PURPOSE: Bone metastases occur in 65-75% of patients with metastatic breast cancer. These patients are at risk of developing skeletal-related events (SREs). SREs are defined as any pathological fracture, spinal cord compression, hypercalcemia, and surgery or radiation required for treatment of bone metastases. Bisphosphonates are used to prevent the development of SREs. The purpose of this study is to review the incidence of SREs in metastatic breast cancer patients with bony disease in Newfoundland and Labrador and to determine if there is an association between SREs and the type of bisphosphonate therapy given...
June 2013: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/23103102/-bisphosphonate-related-osteonecrosis-of-the-jaw-and-infection-with-actinomyces
#18
REVIEW
J Alberto Arranz Caso, Elena Flores Ballester, Stephanie Ngo Pombe, Victor López Pizarro, José Luis Dominguez-Mompello, Andrés Restoy Lozano
BACKGROUND AND OBJECTIVE: Bisphosphonate related osteonecrosis of the jaw (BRONJ) has raised considerable interest since its recent description. Its pathogenesis is not yet clarified; formerly it has been considered a non-infectious complication, but recent studies seem to implicate bacteria of the genus Actinomyces. The objective of this study is to analyze the cases of BRONJ in our institution. PATIENTS AND METHODS: Review of medical records of patients diagnosed of BRONJ in the Maxillofacial Surgery Unit of our hospital...
December 15, 2012: Medicina Clínica
https://www.readbyqxmd.com/read/22189812/hypercalcemia-and-acute-kidney-injury-caused-by-abuse-of-a-parenteral-veterinary-compound-containing-vitamins-a-d-and-e
#19
Paulo Novis Rocha, Caroline Sancho Santos, Maria Olinda Avila, Carolina Lara Neves, Marilia Bahiense-Oliveira
A previously healthy 19 year-old male presented to the hospital with anorexia, nausea, and vomiting. Laboratory studies were significant for hypercalcemia (peak calcium value of 14.8 mg/dL) and acute kidney injury (peak serum creatinine of 2.88 mg/dL). He admitted to using a parenteral formulation of vitamins A, D and E restricted for veterinary use containing 20,000,000 IU of vitamin A; 5,000,000 IU of vitamin D3; and 6,800 IU of vitamin E per 100 mL vial. The patient stated to have used close to 300 mL of the product over the preceding year...
December 2011: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/21887097/a-rare-case-of-zolendronate-infusion-complication-leading-to-glaucoma-filtration-surgery
#20
A Khan, G Lascaratos, T Rane-Malcolm, R Sanders
Zolendronic acid is a nitrogenous biphosphonate commonly used as an intravenous infusion for the management of Paget's disease, osteoporosis, and hypercalcemia of malignancy. We report a rare and challenging complication of zolendronate infusion: unilateral acute anterior uveitis followed by persistently raised intraocular pressure despite being on four different classes of antiglaucoma medication. The challenge was that the patient required topical steroid to treat her uveitis in the background of known glaucoma with corresponding steroid response...
2011: Clinical Ophthalmology
keyword
keyword
70766
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"