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https://www.readbyqxmd.com/read/28419139/skeletal-related-events-and-mortality-among-men-diagnosed-with-advanced-prostate-cancer-the-impact-of-alternative-measures-of-radiation-to-the-bone
#1
Eberechukwu Onukwugha, Young Kwok, Jay P Ciezki, Candice Yong, Catherine Plaisant, Chandana A Reddy, C Daniel Mullins, Brian Seal, Adriana Valderrama, Arif Hussain
PURPOSE/OBJECTIVE(S): Skeletal-related events (SREs), which include radiation to the bone (RtB), can occur among patients with bone metastasis (BM). There is a recognized potential for misclassification of RtB when using claims data. We compared alternative measures of RtB to better understand their impact on SRE prevalence and SRE-related mortality. METHODS AND MATERIALS: We analyzed data for stage IV prostate cancer (PCa) cases identified between 2005 and 2009 in the Surveillance, Epidemiology, and End Results registry linked with Medicare claims...
2017: PloS One
https://www.readbyqxmd.com/read/28393865/prediction-of-the-potential-geographic-distribution-of-the-ectomycorrhizal-mushroom-tricholoma-matsutake-under-multiple-climate-change-scenarios
#2
Yanlong Guo, Xin Li, Zefang Zhao, Haiyan Wei, Bei Gao, Wei Gu
Effective conservation and utilization strategies for natural biological resources require a clear understanding of the geographic distribution of the target species. Tricholoma matsutake is an ectomycorrhizal (ECM) mushroom with high ecological and economic value. In this study, the potential geographic distribution of T. matsutake under current conditions in China was simulated using MaxEnt software based on species presence data and 24 environmental variables. The future distributions of T. matsutake in the 2050s and 2070s were also projected under the RCP 8...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28392837/denosumab-treatment-in-the-management-of-patients-with-advanced-prostate-cancer-clinical-evidence-and-experience
#3
REVIEW
Miriam Hegemann, Jens Bedke, Arnulf Stenzl, Tilman Todenhöfer
Osteoprotective therapies have become an essential component in the management of advanced prostate cancer (PC) patients as bone metastases (BMs) have a major impact on morbidity and mortality. Denosumab is a fully humanized antibody targeting the receptor activator of nuclear factor κB ligand (RANKL), which has been approved by the European Medicines Agency (EMA) in Europe and the United States (US) Food and Drug Administration (FDA) in the US for prevention of skeletal-related events (SREs) in patients with solid tumors and BMs, including PC...
March 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28359783/systematic-analysis-of-splicing-defects-in-selected-primary-immunodeficiencies-related-genes
#4
Lucie Grodecká, Pavla Hujová, Michal Kramárek, Tereza Kršjaková, Tatiana Kováčová, Katarína Vondrášková, Barbora Ravčuková, Kristýna Hrnčířová, Přemysl Souček, Tomáš Freiberger
Both variants affecting splice sites and those in splicing regulatory elements (SREs) can impair pre-mRNA splicing, eventually leading to severe diseases. Despite the availability of many prediction tools, prognosis of splicing affection is not trivial, especially when SREs are involved. Here, we present data on 92 in silico-/55 minigene-analysed variants detected in genes responsible for the primary immunodeficiencies development (namely BTK, CD40LG, IL2RG, SERPING1, STAT3, and WAS). Of 20 splicing-affecting variants, 16 affected splice site while 4 disrupted potential SRE...
March 27, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28342963/new-insights-into-cellular-cholesterol-acquisition-promoter-analysis-of-human-hmgcr-and-sqle-two-key-control-enzymes-in-cholesterol-synthesis
#5
Vicky Howe, Laura J Sharpe, Anika V Prabhu, Andrew J Brown
BACKGROUND: The two control points of cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and squalene monooxygenase (SQLE) are known targets of the transcription factor sterol-regulatory element binding protein-2 (SREBP-2). Yet the location of the sterol-regulatory elements (SREs) and cofactor binding sites, nuclear factor-Y (NF-Y) and specificity protein 1 (Sp1), have not been satisfactorily mapped in the human SQLE promoter, or at all in the human HMGCR promoter...
March 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28324052/skeletal-complications-and-mortality-in-thyroid-cancer-a-population-based-study
#6
Palak Choksi, Maria Papaleontiou, Cui Guo, Francis Worden, Mousumi Banerjee, Megan Haymart
Context: Although bone is a common site for tumor metastases, the burden of bone events [bone metastases and skeletal-related events (SREs)] in patients with thyroid cancer is not well known. Objective: To measure the prevalence of bone events and their impact on mortality in patients with thyroid cancer. Patients, Design, and Setting: We identified patients diagnosed with thyroid cancer between 1991 and 2011 from the linked Surveillance Epidemiology and End Results-Medicare dataset...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28266062/k-t-accelerated-aortic-4d-flow-mri-in-under-two-minutes-feasibility-and-impact-of-resolution-k-space-sampling-patterns-and-respiratory-navigator-gating-on-hemodynamic-measurements
#7
Emilie Bollache, Alex J Barker, Ryan Scott Dolan, James C Carr, Pim van Ooij, Rouzbeh Ahmadian, Alex Powell, Jeremy D Collins, Julia Geiger, Michael Markl
PURPOSE: To assess the performance of highly accelerated free-breathing aortic four-dimensional (4D) flow MRI acquired in under 2 minutes compared to conventional respiratory gated 4D flow. METHODS: Eight k-t accelerated nongated 4D flow MRI (parallel MRI with extended and averaged generalized autocalibrating partially parallel acquisition kernels [PEAK GRAPPA], R = 5, TRes = 67.2 ms) using four ky -kz Cartesian sampling patterns (linear, center-out, out-center-out, random) and two spatial resolutions (SRes1 = 3...
March 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28220258/impact-of-denosumab-use-on-the-survival-of-untreated-non-squamous-non-small-cell-lung-cancer-patients-with-bone-metastases
#8
Hibiki Udagawa, Seiji Niho, Keisuke Kirita, Shigeki Umemura, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
PURPOSE: Denosumab reduces the incidence of skeletal-related events (SREs) in solid tumor patients with bone metastases (BM). However, there have been no detailed reports of the efficacy of denosumab in untreated non-squamous non-small cell lung cancer (NSCLC) patients with BM. METHODS: The medical records of patients with untreated non-squamous NSCLC and BM at diagnosis at our institution were reviewed retrospectively. The overall survival (OS) and the time to SREs were analyzed according to the treatment for the BM...
February 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28210558/bisphosphonate-related-osteonecrosis-of-jaws-in-advanced-stage-breast-cancer-was-detected-from-bone-scan-a-case-report
#9
Prakasit Chirappapha, Saowanee Kitudomrat, Thanaporn Thongjood, Rangsima Aroonroch
Bisphosphonates (BPs) are indicated to treat skeletal-related events (SREs) for cancer patients with bone metastasis. We report a 79-year-old woman with advanced stage breast cancer with bone metastasis who was prescribed BPs (zoledronate), then developed osteonecrosis of jaw. We provide a brief review of the pathogenesis, diagnosis and treatment of this complication.
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28205174/identifying-sterol-response-elements-within-promoters-of-genes
#10
Laura J Sharpe, Andrew J Brown
Cholesterol levels are under tight control within cells. This involves a complex interplay of balancing synthesis, uptake, and export. A major player in the transcriptional regulation of cholesterol levels is sterol regulatory element binding protein (SREBP). SREBP is upregulated in conditions of low cholesterol, and then binds to sterol regulatory elements (SREs) that exist within the promoters of genes involved in cholesterol synthesis and uptake.Here, we describe a method to identify sterol response elements (SREs) using in silico and experimental approaches...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28186130/identification-of-symmetrical-rna-editing-events-in-the-mitochondria-of-salvia-miltiorrhiza-by-strand-specific-rna-sequencing
#11
Bin Wu, Haimei Chen, Junjie Shao, Hui Zhang, Kai Wu, Chang Liu
Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR amplification and Sanger sequencing experiments. Putative sequences motifs were characterized. Comparative analyses were carried out between S. miltiorrhiza, Arabidopsis thaliana and Oryza sativa...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28137329/retrospective-analysis-of-patient-presentations-at-the-sydney-australia-royal-easter-show-from-2012-to-2014
#12
Nathan Crabtree, Shirley Mo, Leon Ong, Thuvarahan Jegathees, Daniel Wei, David Fahey, Jia Jenny Liu
Introduction Comprehensive studies on the relationship between patient demographics and subsequent treatment and disposition at a single mass-gathering event are lacking. The Sydney Royal Easter Show (SRES; Sydney Olympic Park, New South Wales, Australia) is an annual, 14-day, agricultural mass-gathering event occurring around the Easter weekend, attracting more than 800,000 patrons per year. In this study, patient records from the SRES were analyzed to examine relationships between weather, crowd size, day of week, and demographics on treatment and disposition...
January 31, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28134499/long-term-safety-of-monthly-zoledronic-acid-therapy-beyond-1%C3%A2-year-in-patients-with-advanced-cancer-involving-bone-lotess-a-multicentre-prospective-phase-4-study
#13
A A Khalafallah, M Slancar, W Cosolo, E Abdi, B Chern, R J Woodfield, M C Copeman
Malignant bone disease can cause significant morbidity. Monthly zoledronic acid (ZOL) reduces skeletal complications; however, limited data are available regarding long-term safety. We aimed to assess efficacy and safety of ZOL beyond 1 year of treatment. We prospectively evaluated 73 patients; breast cancer (n = 29), castrate-resistant prostate cancer (n = 13), multiple myeloma (n = 31) from 2006 to 2008 in 19 cancer centres. All patients were diagnosed with bone disease and had completed 1-2 years of monthly ZOL (4 mg) and received a further 1-2 years of therapy following contemporary guidelines for managing risks of osteonecrosis of the jaw (ONJ) and renal toxicity...
January 30, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28125763/continued-treatment-effect-of-zoledronic-acid-dosing-every-12-vs-4-weeks-in-women-with-breast-cancer-metastatic-to-bone-the-optimize-2-randomized-clinical-trial
#14
Gabriel N Hortobagyi, Catherine Van Poznak, W Graydon Harker, William J Gradishar, Helen Chew, Shaker R Dakhil, Barbara B Haley, Nicholas Sauter, Ramon Mohanlal, Ming Zheng, Allan Lipton
Importance: Zoledronic acid, a potent bisphosphonate, is commonly administered to patients with bone metastases to reduce the risk of skeletal-related events (SREs). However, there have been concerns regarding its long-term monthly administration. Objective: To examine whether zoledronic acid every 12 weeks was noninferior to zoledronic acid every 4 weeks in patients with metastatic breast cancer that involved the bone who had previously received a standard dosing regimen of zoledronic acid and/or pamidronate disodium...
January 26, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28108818/association-between-bone-scan-index-and-activities-of-daily-living-in-patients-with-advanced-non-small-cell-lung-cancer
#15
Ikuno Ito, Kimiteru Ito, Shinichi Takahashi, Mitsuko Horibe, Rui Karita, Chika Nishizaka, Takako Nagai, Kohei Hamada, Hiroyuki Sato, Naoko Shindo
PURPOSE: The aim of this retrospective cross-sectional study was to investigate the association between the bone scan index (BSI) and activities of daily living (ADL) in patients with advanced non-small cell lung cancer (NSCLC). METHODS: Among patients with advanced NSCLC, subjects who underwent bone scintigraphy were recruited from this study. Clinical information about patients, including the Barthel Index of ADL, was extracted from their medical charts. Variables including the age, sex, BSI, presence/absence skeletal-related events (SREs), diagnostic state (initial vs...
January 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28052080/societal-risk-evaluation-scheme-sres-scenario-based-multi-criteria-evaluation-of-synthetic-biology-applications
#16
Christopher L Cummings, Jennifer Kuzma
Synthetic biology (SB) applies engineering principles to biology for the construction of novel biological systems designed for useful purposes. From an oversight perspective, SB products come with significant uncertainty. Yet there is a need to anticipate and prepare for SB applications before deployment. This study develops a Societal Risk Evaluation Scheme (SRES) in order to advance methods for anticipatory governance of emerging technologies such as SB. The SRES is based upon societal risk factors that were identified as important through a policy Delphi study...
2017: PloS One
https://www.readbyqxmd.com/read/28050490/renal-cell-carcinoma-with-unusual-skeletal-metastasis-to-tibia-and-ankle-a-case-report-and-review-of-literature
#17
Kiran Shankar, Durgesh Kumar, Kariyanakatte Veeraiah Veerendra Kumar, Chennagiri Premlata
Renal Cell Carcinoma (RCC) accounts for 5% of the epithelial malignancies worldwide with clear cell carcinoma accounting for 85% of these malignancies. One third of these patients experience synchronous metastatic disease and 20-30% of the remaining patients experience metachronous metastatic RCC. Bony metastasis accounts for 20% of metastatic RCC. They most commonly affect the axial skeleton and rarely the long bones or the small bones of the hands and feet. Bone metastases from RCC are predominantly osteolytic in nature, leading to significant patient morbidity due to the associated Skeletal Related Events (SRE)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28045115/skeletal-related-events-significantly-impact-health-related-quality-of-life-in-metastatic-castration-resistant-prostate-cancer-data-from-prevail-and-affirm-trials
#18
F Saad, C Ivanescu, D Phung, Y Loriot, S Abhyankar, T M Beer, B Tombal, S Holmstrom
BACKGROUND: We investigated the impact of skeletal-related events (SREs) on health-related quality of life (HRQoL) in patients with metastatic castration-resistant prostate cancer (mCRPC) in phase III trials of enzalutamide versus placebo. METHODS: Patients with mCRPC experiencing at least one SRE during AFFIRM and PREVAIL were assessed for trajectory-adjusted mean change in HRQoL by first SRE using Functional Assessment of Cancer Therapy-Prostate (FACT-P; AFFIRM, three domains, and PREVAIL, nine domains) and EQ-5D (PREVAIL) instruments...
March 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28044212/skeletal-related-events-and-prognosis-in-urothelial-cancer-patients-with-bone-metastasis
#19
Yusuke Tsuda, Tohru Nakagawa, Yusuke Shinoda, Atsushi Kanatani, Taketo Kawai, Satoru Taguchi, Yukio Yamada, Ryoko Sawada, Haruki Kume, Yukio Homma, Sakae Tanaka, Hirotaka Kawano
BACKGROUND: The aim of the present study was to elucidate the details of bone metastasis (BM) and the resulting skeletal-related events (SREs), and survival and prognostic factors, in urothelial cancer (UC) patients with BM. METHODS: A total of 48 UC patients with BM who were treated at our institution between 1994 and 2013 were enrolled. Details of BM and SREs were investigated. The Kaplan-Meier method was used to estimate survival duration. Relationships between several clinical features and survival were analyzed using the log-rank test and the Cox hazard model...
January 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28039323/succession-of-splicing-regulatory-elements-determines-cryptic-5%C3%AE-ss-functionality
#20
Anna-Lena Brillen, Katrin Schöneweis, Lara Walotka, Linda Hartmann, Lisa Müller, Johannes Ptok, Wolfgang Kaisers, Gereon Poschmann, Kai Stühler, Emanuele Buratti, Stephan Theiss, Heiner Schaal
A critical step in exon definition is the recognition of a proper splice donor (5΄ss) by the 5' end of U1 snRNA. In the selection of appropriate 5΄ss, cis-acting splicing regulatory elements (SREs) are indispensable. As a model for 5΄ss recognition, we investigated cryptic 5΄ss selection within the human fibrinogen Bβ-chain gene (FGB) exon 7, where we identified several exonic SREs that simultaneously acted on up- and downstream cryptic 5΄ss. In the FGB exon 7 model system, 5΄ss selection iteratively proceeded along an alternating sequence of U1 snRNA binding sites and interleaved SREs which in principle supported different 3' exon ends...
April 20, 2017: Nucleic Acids Research
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