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Yu-Jiao Yang, Shuai Wang, Biao Zhang, Hong-Bin Shen
As a relatively new technology to solve the 3D structure of a protein or protein complex, the Single-Particle Reconstruction (SPR) of cryo-EM images shows much superiority and is in a rapidly developing stage. Resolution measurement in SPR, which evaluates the quality of a reconstructed 3D density map, plays a critical role for promoting methodology development of SPR and structural biology. Due to there is no benchmark map in a new structure generation, how to realize the resolution estimation of a new map is still an open problem...
May 21, 2018: Journal of Chemical Information and Modeling
Gitte H Bruun, Jeanne Mv Bang, Lise L Christensen, Sabrina Brøner, Ulrika Ss Petersen, Barbara Guerra, Alexander Gb Grønning, Thomas K Doktor, Brage S Andresen
Familial dysautonomia (FD) is a severe genetic disorder causing sensory and autonomic dysfunction. It is predominantly caused by a c.2204+6T>C mutation in the IKBKAP gene. This mutation decreases the 5' splice site strength of IKBKAP exon 20 leading to exon 20 skipping and decreased amounts of full-length IKAP protein. We identified a binding site for the splicing regulatory protein hnRNP A1 downstream of the IKBKAP exon 20 5'-splice site. We show that hnRNP A1 binds to this splicing regulatory element (SRE) and that two previously described inhibitory SREs inside IKBKAP exon 20 are also bound by hnRNP A1...
May 14, 2018: Nucleic Acids Research
Josette Garnier, Antsiva Ramarson, Gilles Billen, Sylvain Théry, Dominique Thiéry, Vincent Thieu, Camille Minaudo, Florentina Moatar
The Grafs-Seneque/Riverstrahler model was implemented for the first time on the Loire River for the 2002-2014 period, to explore eutrophication after improvement of wastewater treatments. The model reproduced the interannual levels and seasonal trends of the major water quality variables. Although eutrophication has been impressively reduced in the drainage network, a eutrophication risk still exists at the coast, as shown by the N-ICEP indicator, pointing out an excess of nitrogen over silica and phosphorus...
May 10, 2018: Science of the Total Environment
Leanda D Mason, Philip W Bateman, Grant W Wardell-Johnson
Ecological traps attract biota to low-quality habitats. Landscape traps are zones caught in a vortex of spiralling degradation. Here, we demonstrate how short-range endemic (SRE) traits may make such taxa vulnerable to ecological and landscape traps. Three SRE species of mygalomorph spider were used in this study: Idiommata blackwalli, Idiosoma sigillatum and an undescribed Aganippe sp. Mygalomorphs can be long-lived (>43 years) and select sites for permanent burrows in their early dispersal phase. Spiderlings from two species, I...
2018: PeerJ
Nisha Joy, Y P Maimoonath Beevi, E V Soniya
BACKGROUND: The central tenet of 'genome content' has been that the 'non-coding' parts are highly enriched with 'microsatellites' or 'Simple Sequence Repeats' (SSRs). We presume that the presence and change in number of repeat unit (n) of SSRs in different genomic locations may or may not become beneficial, depending on the position of SSRs in a gene. Very few studies have looked into the existence of SSRs in the hair-pin precursors of miRNAs (pre-miRNAs). The interplay between SSRs and miRNAs is not yet clearly understood...
May 9, 2018: BMC Genetics
Eberechukwu Onukwugha, Husam Albarmawi, Kai Sun, C Daniel Mullins, Abdalla Aly, Arif Hussain
INTRODUCTION: Men diagnosed with metastatic prostate cancer (PCa) are at increased risk for skeletal complications which are associated with significant morbidity and mortality. Although both the urologist and the medical oncologist play important roles in the management of patients with advanced PCa, there is limited information regarding their role in the context of skeletal complications. The current study investigated these relationships among newly diagnosed metastatic patients with PCa...
April 30, 2018: Urologic Oncology
Hiroko Nishida
Osteolytic bone disease, characterized by bone pain, increased risk of pathologic fractures, tumor-induced hypercalcemia known as skeletal-related events (SREs), is a frequent complication of patients with multiple myeloma (MM) and persists even in the absence of active disease, resulting in a major cause of morbidity and mortality. The interaction between myeloma cells and their surrounding cells in the bone marrow (BM) microenvironment promotes both myeloma cell growth and bone destruction and forms the vicious cycle of MM bone disease...
March 2, 2018: Hematology Reports
Tomohiro Kagawa, Mina Kozai, Masashi Masuda, Nagakatsu Harada, Otoki Nakahashi, Mari Tajiri, Ryouhei Yoshikawa, Mari Nakao, Yuichiro Takei, Masayuki Iwano, Eiji Takeda, Yutaka Taketani, Hironori Yamamoto
The physiological activity of the steroid derived hormone vitamin D is regulated by several enzymatic steps. Both 25-hydroxy vitamin D3 1α-hydroxylase (CYP27B1) and 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) modulate blood levels of 1,25-dihydroxyvitamin D3 , an activated form of vitamin D. We previously demonstrated that CYP27B1 expression was trans-activated by sterol regulatory element binding protein 1 (SREBP1), although whether SREBP1 also regulates CYP24A1 transcription was unclear. Here we investigated the ability of SREBP1 to affect CYP24A1 transcription...
April 10, 2018: Biochemical and Biophysical Research Communications
Bonnie B Blanchfield, Bijay Acharya, Elizabeth Mort
BACKGROUND: More than half of the 50 states (27) and the District of Columbia require reporting of Serous Reportable Events (SREs). The goal is to hold providers accountable and improve patient safety, but there is little information about the administrative cost of this reporting requirement. This study was conducted to identify costs associated with investigating and reporting SREs. METHODS: This qualitative study used case study methods that included interviewing staff and review of data and documents to investigate each SRE occurring at one academic medical center during fiscal year 2013...
April 2018: Joint Commission Journal on Quality and Patient Safety
Roger von Moos, Jean-Jacques Body, Oliver Guenther, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, João Pereira, Nikos Maniadakis, Guy Hechmati, Susan Talbot, Harm Sleeboom
Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland...
March 2018: Journal of Bone Oncology
Debajyoti Bhowmik, Dionne M Hines, Michele Intorcia, Rolin L Wade
AIMS: To estimate incremental healthcare resource utilization (HRU) and costs associated with skeletal-related events (SREs) secondary to multiple myeloma (MM), and HRU and cost differences in patients with one vs multiple SREs. METHODS: Adults with MM diagnosis between January 1, 2010-December 31, 2014, with benefits coverage ≥12 months pre- and ≥6 months post-diagnosis were followed to last coverage date or December 31, 2015, excluding patients with prior anti-myeloma treatment or cancers...
April 12, 2018: Journal of Medical Economics
Yue Zhong, Adriana Valderrama, Jianying Yao, Prina Donga, Pinar Bilir, Peter J Neumann
OBJECTIVES: To evaluate the economic burden of treating skeletal-related events (SREs) in prostate cancer (PC) patients with bone metastasis from an insurer perspective. METHODS: We conducted a retrospective cohort analysis using claims data. PC patients with bone metastasis were identified in the MarketScan Databases between January 1, 2004, and March 1, 2014. The propensity score matching approach was used to match patients with SREs to those without SREs. A pseudo-SRE date was assigned to the control group...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Vijayakumar Ramaraj, Rajyoganandh S Vijayaraman, Veena Hemanth, Sudha Rangarajan, Anupma Jyoti Kindo
Background & objectives: : Dermatophytes are keratinophilic fungi that infect keratinized tissues of human and animal origin. Trichophyton mentagrophytes is considered to be a species complex composed of several strains, which include both anthropophiles and zoophiles. Accurate discrimination is critical for comprehensive understanding of the clinical and epidemiological implications of the genetic heterogeneity of this complex. Molecular strain typing renders an effective way to discriminate each strain...
November 2017: Indian Journal of Medical Research
Hongwei Zhang, Wei Zhu, Ewelina Biskup, Weige Yang, Ziang Yang, Hong Wang, Xiaochun Qiu, Chengjiao Zhang, Guangxia Hu, Guangfu Hu
Purpose: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. Methods: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed...
June 2018: Journal of Bone Oncology
Masood Umer, Yasir Mohib, Muhammed Atif, Muhammad Nazim
Background: Renal cell carcinoma account for 3% of all cancers, with peak incidence between 60 and 70 years of age predominantly affecting male population. Renal carcinoma is the most common malignancy of kidney constitutes for 80-90% of renal neoplasm with an overall 45% five years survival rate. Majority are diagnosed incidentally during investigation for other disease process of abdomen. Classical triad of gross hematuria, pain and palpable mass in abdomen is rare accounting to only 6-10%...
March 2018: Annals of Medicine and Surgery
Noopur Raje, Garson David Roodman, Wolfgang Willenbacher, Kazuyuki Shimizu, Ramón García-Sanz, Evangelos Terpos, Lisa Kennedy, Lorenzo Sabatelli, Michele Intorcia, Guy Hechmati
OBJECTIVE: A large, pivotal, phase 3 trial in patients with newly diagnosed multiple myeloma (MM) demonstrated that denosumab, compared with zoledronic acid, was non-inferior for the prevention of skeletal-related events (SREs), extended the observed median progression-free survival (PFS) by 10.7 months, and showed significantly less renal toxicity. The cost-effectiveness of denosumab vs zoledronic acid in MM in the US was assessed from societal and payer perspectives. METHODS: The XGEVA Global Economic Model was developed by integrating data from the phase 3 trial comparing the efficacy of denosumab with zoledronic acid for the prevention of SREs in MM...
May 2018: Journal of Medical Economics
Ruoyu Wang, Latif Kalin
This study investigated potential changes in flow, total suspended solid (TSS) and nutrient (nitrogen and phosphorous) loadings under future climate change, land use/cover (LULC) change and combined change scenarios in the Wolf Bay watershed, southern Alabama, USA. Four Global Circulation Models (GCMs) under three Special Report Emission Scenarios (SRES) of greenhouse gas were used to assess the future climate change (2016-2040). Three projected LULC maps (2030) were employed to reflect different extents of urbanization in future...
February 2018: Journal of Environmental Sciences (China)
John Ashcroft, Ignacio Duran, Herbert Hoefeler, Vito Lorusso, Diana Lueftner, Marco Campioni, Michele Intorcia, Amit Bahl
OBJECTIVES: Patients with multiple myeloma (MM) often experience debilitating skeletal-related events (SREs: pathologic fracture, radiation to bone [RB], surgery to bone [SB] or spinal cord compression [SCC]). This is the first comprehensive, prospective, observational analysis of healthcare resource utilisation (HRU), independently attributed to SREs by investigators, in patients with MM. METHODS: Eligible patients had lytic bone lesions, life expectancy ≥6 months, Eastern Cooperative Oncology Group performance status ≤2 and ≥1 SRE in the 97 days before enrolment...
May 2018: European Journal of Haematology
Helene Sertznig, Frank Hillebrand, Steffen Erkelenz, Heiner Schaal, Marek Widera
Alternative splicing plays a key role in the HIV-1 life cycle and is essential to maintain an equilibrium of mRNAs that encode viral proteins and polyprotein-isoforms. In particular, since all early HIV-1 proteins are expressed from spliced intronless and late enzymatic and structural proteins from intron containing, i.e. splicing repressed viral mRNAs, cellular splicing factors and splicing regulatory proteins are crucial for the replication capacity. In this review, we will describe the complex network of cis-acting splicing regulatory elements (SREs), which are mainly localized in the neighbourhoods of all HIV-1 splice sites and warrant the proper ratio of individual transcript isoforms...
March 2018: Virology
Takefumi Satoh, Dianne Ledesma, Nariaki Yoshihara
Objective: Although androgen deprivation therapy (ADT) has improved the survival and quality of life of patients with prostate cancer, resistance to treatment inevitably results in transition to a castration resistant state (CRPC) and, in advanced cases, bone metastasis, leading to skeletal related events (SRE). In order to understand the current burden on patients in Japan, there is a need to estimate the healthcare costs of CRPC treatment in current clinical practice. Methods: This retrospective observational cohort study utilized claims data from 13 national university hospitals through the Platform for Clinical Information Statistical Analysis database...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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