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https://www.readbyqxmd.com/read/27896639/seom-clinical-guideline-for-bone-metastases-from-solid-tumours-2016
#1
C Grávalos, C Rodríguez, A Sabino, M Á Seguí, J A Virizuela, A Carmona, J Cassinello, D Isla, C Jara, M Martín
Bone metastases are common in many advanced solid tumours, being breast, prostate, thyroid, lung, and renal cancer the most prevalent. Bone metastases can produce skeletal-related events (SREs), defined as pathological fracture, spinal cord compression, need of bone irradiation or need of bone surgery, and hypercalcaemia. Patients with bone metastases experience pain, functional impairment and have a negative impact on their quality of life. Several imaging techniques are available for diagnosis of this disease...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27877227/incidence-and-predictors-of-bone-metastases-bm-and-skeletal-related-events-sres-in-small-cell-lung-cancer-sclc-a-swiss-patient-cohort
#2
Katrin Conen, Raphael Hagmann, Viviane Hess, Alfred Zippelius, Sacha I Rothschild
Objectives: Bone metastases (BM) and skeletal-related events (SREs) are frequent complications in patients with lung cancer. Whereas in non-small-cell lung cancer (NSCLC) incidence, prognostic impact, and risk factors are well established, there is only little knowledge in patients with small cell lung cancer (SCLC). We retrospectively evaluated the incidence of BM, SRE and their treatment in a SCLC patient cohort treated at our hospital. We further assessed the role of Lactate Dehydrogenase (LDH), a possible predictor of BM development in SCLC patients...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27867312/sustainable-grassland-systems-a-modelling-perspective-based-on-the-north-wyke-farm-platform
#3
L Wu, X Zhang, B A Griffith, T H Misselbrook
The North Wyke Farm Platform (NWFP) provides data from the field- to the farm-scale, enabling the research community to address key issues in sustainable agriculture better and to test models that are capable of simulating soil, plant and animal processes involved in the systems. The tested models can then be used to simulate how agro-ecosystems will respond to changes in the environment and management. In this study, we used baseline datasets generated from the NWFP to validate the Soil-Plant-Atmosphere Continuum System (SPACSYS) model in relation to the dynamics of soil water content, water loss from runoff and forage biomass removal...
July 2016: European Journal of Soil Science
https://www.readbyqxmd.com/read/27861625/computational-identification-of-tissue-specific-splicing-regulatory-elements-in-human-genes-from-rna-seq-data
#4
Eman Badr, Mahmoud ElHefnawi, Lenwood S Heath
Alternative splicing is a vital process for regulating gene expression and promoting proteomic diversity. It plays a key role in tissue-specific expressed genes. This specificity is mainly regulated by splicing factors that bind to specific sequences called splicing regulatory elements (SREs). Here, we report a genome-wide analysis to study alternative splicing on multiple tissues, including brain, heart, liver, and muscle. We propose a pipeline to identify differential exons across tissues and hence tissue-specific SREs...
2016: PloS One
https://www.readbyqxmd.com/read/27804097/differentiating-the-effects-of-climate-and-land-use-change-on-european-biodiversity-a-scenario-analysis
#5
Jan E Vermaat, Fritz A Hellmann, Astrid J A van Teeffelen, Jelle van Minnen, Rob Alkemade, Regula Billeter, Carl Beierkuhnlein, Luigi Boitani, Mar Cabeza, Christian K Feld, Brian Huntley, James Paterson, Michiel F WallisDeVries
Current observed as well as projected changes in biodiversity are the result of multiple interacting factors, with land use and climate change often marked as most important drivers. We aimed to disentangle the separate impacts of these two for sets of vascular plant, bird, butterfly and dragonfly species listed as characteristic for European dry grasslands and wetlands, two habitats of high and threatened biodiversity. We combined articulations of the four frequently used SRES climate scenarios and associated land use change projections for 2030, and assessed their impact on population trends in species (i...
November 1, 2016: Ambio
https://www.readbyqxmd.com/read/27797240/prevalence-and-survival-patterns-of-patients-with-bone-metastasis-from-common-cancers-in-thailand
#6
Areerak Phanphaisarn, Jayantorn Patumanond, Jongkolnee Settakorn, Parunya Chaiyawat, Jeerawan Klangjorhor, Dumnoensun Pruksakorn
BACKGROUND: Bone metastasis is a single condition but presents with various patterns and severities. Skeletal- related events (SREs) deteriorate overall performance status and reduce quality of life. However, guidelines for early detection and management are limited. This study includes a survey of the prevalence of bone metastasis in cases with common cancers in Thailand as well as a focus on survival patterns and SREs. MATERIALS AND METHODS: A retrospective cohort analysis was conducted using a database of the Chiang Mai Cancer Registry and the Musculoskeletal Tumor Registry of the OLARN Center, Chiang Mai University...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27781160/predictions-of-potential-geographical-distribution-and-quality-of-schisandra-sphenanthera-under-climate-change
#7
Yanlong Guo, Haiyan Wei, Chunyan Lu, Bei Gao, Wei Gu
Climate change will significantly affect plant distribution as well as the quality of medicinal plants. Although numerous studies have analyzed the effect of climate change on future habitats of plants through species distribution models (SDMs), few of them have incorporated the change of effective content of medicinal plants. Schisandra sphenanthera Rehd. et Wils. is an endangered traditional Chinese medical plant which is mainly located in the Qinling Mountains. Combining fuzzy theory and a maximum entropy model, we obtained current spatial distribution of quality assessment for S...
2016: PeerJ
https://www.readbyqxmd.com/read/27736957/high-potency-vegfrs-met-fms-triple-blockade-by-tas-115-concomitantly-suppresses-tumor-progression-and-bone-destruction-in-tumor-induced-bone-disease-model-with-lung-carcinoma-cells
#8
Hidenori Fujita, Akira Gomori, Yayoi Fujioka, Yuki Kataoka, Kenji Tanaka, Akihiro Hashimoto, Takamasa Suzuki, Kenjiro Ito, Tomonori Haruma, Hiromi Yamamoto-Yokoi, Naomoto Harada, Motomu Sakuragi, Nobuyuki Oda, Kenichi Matsuo, Masaki Inada, Kazuhiko Yonekura
Approximately 25-40% of patients with lung cancer show bone metastasis. Bone modifying agents reduce skeletal-related events (SREs), but they do not significantly improve overall survival. Therefore, novel therapeutic approaches are urgently required. In this study, we investigated the anti-tumor effect of TAS-115, a VEGFRs and HGF receptor (MET)-targeted kinase inhibitor, in a tumor-induced bone disease model. A549-Luc-BM1 cells, an osteo-tropic clone of luciferase-transfected A549 human lung adenocarcinoma cells (A549-Luc), produced aggressive bone destruction associated with tumor progression after intra-tibial (IT) implantation into mice...
2016: PloS One
https://www.readbyqxmd.com/read/27730756/risk-of-skeletal-related-events-among-elderly-prostate-cancer-patients-by-site-of-metastasis-at-diagnosis
#9
Arif Hussain, Abdalla Aly, C Daniel Mullins, Yi Qian, Jorge Arellano, Eberechukwu Onukwugha
The purpose of this study was to estimate the risk of developing skeletal-related events (SREs) based on site of metastasis at diagnosis and identify other predictors of developing SREs among metastatic prostate cancer patients. We conducted a retrospective cohort study using linked SEER (Surveillance, Epidemiology, and End Results) and Medicare data and identified men over the age of 65 with incident metastatic prostate cancer diagnosed during 2005-2009. SREs included radiation (RAD), pathological fractures (PF), bone surgery (BS), and spinal cord compression (SCC)...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27716496/bone-targeted-therapy-use-in-patients-with-bone-metastases-from-lung-cancer-a-systematic-review-of-randomized-controlled-trials
#10
Nathalie LeVasseur, Mark Clemons, Brian Hutton, Risa Shorr, Carmel Jacobs
BACKGROUND: Patients with advanced lung cancer commonly have bone metastases. Compared with other malignancies, the use of bone-targeted agents (e.g. bisphosphonates and denosumab) is less common in lung cancer patients. This may be due to the perception that bone-targeted agents are less effective in this population. OBJECTIVE: To perform a systematic review to evaluate data from randomized trials of bone-targeted agents in lung cancer patients with bone metastases...
September 20, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27666299/therapeutic-management-of-bone-metastasis-in-prostate-cancer-an-update
#11
Fable Zustovich, Davide Pastorelli
Bone metastases affect the majority of patients with castration-resistant prostate cancer (CRPC), resulting in significant morbidity and mortality. This review describes the current therapies available for the management of CRPC patients with bone metastases. Areas covered: Studies on the use of currently available therapeutic approaches for palliating pain, delaying skeletal-related events (SREs) and prolonging survival in CRPC patients with bone metastases have been examined. PubMed database was searched in May 2016 starting with the following keywords: ('castration-resistant prostate cancer' OR 'CRPC') AND 'bone metastases', and approximately 270 results were retrieved...
October 6, 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27662441/bone-metastases-and-skeletal-related-events-in-medullary-thyroid-carcinoma
#12
Jian Yu Xu, William A Murphy, Denái R Milton, Camilo Jimenez, Sarika N Rao, Mouhammed Amir Habra, Steven G Waguespack, Ramona Dadu, Robert F Gagel, Anita K Ying, Maria E Cabanillas, Steven P Weitzman, Naifa L Busaidy, Rena V Sellin, Elizabeth Grubbs, Steven I Sherman, Mimi I Hu
CONTEXT: Bone metastases (BM) can lead to devastating skeletal related events (SREs) in cancer patients. Data regarding medullary thyroid carcinoma (MTC) with BM are lacking. OBJECTIVE: We evaluated the natural history of BM and SREs in MTC patients identified by a cancer center tumor registry. SETTING: A tertiary cancer center. PATIENTS AND MAIN OUTCOME MEASURES: We retrospectively reviewed charts of MTC patients with BM who received care from 1991-2014 to characterize BM and SREs...
September 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27647403/-clinical-significance-of-combined-detection-of-urine-ntx-and-serum-ictp-for-breast-cancer-patients-with-bone-metastases
#13
C J Wu, L X Ma, J Zhu, J J Liu, Y Cheng
Objective: To study the clinical significance and prognostic value of combined detection of urinary N-terminal telopeptide of type Ⅰ collagen (NTx) and serum C-terminal telopeptide of type Ⅰ collagen (ICTP) in breast cancer patients with bone metastases. Methods: Serum and urine samples from 68 women with advanced breast cancer who received the treatment in Jilin Cancer Hospital between October 2012 and October 2008 were collected before and 2 months after treatment. Among them, 35 patients had bone metastases (group A), including 12 cases with single bone metastasis and 23 cases with multiple bone metastases...
September 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27501059/the-safety-and-efficacy-of-radium-223-dichloride-for-the-treatment-of-advanced-prostate-cancer
#14
James M Wilson, Christopher Parker
INTRODUCTION: A number of drugs have been shown to extend life expectancy in castration-resistant prostate cancer (CRPC). Skeletal related events (SREs) secondary to bone metastases cause significant morbidity for men with CRPC. The α-emitting radiopharmaceutical radium-223 dichloride has been shown to improve overall survival, time to symptomatic skeletal events (SSEs) and quality of life in CRPC. AREAS COVERED: The development of radium-223 from pre-clinical studies to the evidence of efficacy and safety from a phase 3 trial is discussed as well as its pharmacokinetics and metabolism...
September 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27487236/safety-of-denosumab-versus-zoledronic-acid-in-patients-with-bone-metastases-a-meta-analysis-of-randomized-controlled-trials
#15
Fengxia Chen, Feifei Pu
INTRODUCTION: Bone metastases lead to local bone destruction and skeletal complications. Bisphosphonates, particlulaly zoledronic acid (ZA), play a central role in the treatment of bone metastases. Some studies have shown that denosumab may delay and prevent SREs in metastatic bone disease more effectively than ZA; therefore, we systematically reviewed and assessed the safety of denosumab and ZA. METHODS: The PubMed, EMBASE, Cochrane Library, Web of Science with Conference Proceedings, Elsevier, and China National Knowledge Infrastructure (CNKI) databases were searched up to October 2015...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27478111/opioid-use-among-metastatic-prostate-cancer-patients-with-skeletal-related-events
#16
Avin Yaldo, Lonnie Wen, Augustina Ogbonnaya, Adriana Valderrama, Jonathan Kish, Michael Eaddy, Charles Kreilick, Krishna Tangirala, Katarzyna Shields
PURPOSE: The development of skeletal-related events (SREs) (pathologic fracture, need for surgery and/or radiation to bone, spinal cord compression, and hypercalcemia of malignancy) in metastatic prostate cancer (MPC) is associated with worsened pain and compromised quality of life. Opioids are frequently used throughout the course of SRE treatment. This study describes the treatment patterns and incremental use of opioids in MPC patients diagnosed with SREs. METHODS: PC patients with bone metastases newly diagnosed with an SRE between January 1, 2005, and September 30, 2014, were identified using MarketScan Commercial and Medicare databases...
August 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27473773/impact-of-climate-change-on-soil-thermal-and-moisture-regimes-in-serbia-an-analysis-with-data-from-regional-climate-simulations-under-sres-a1b
#17
D T Mihailović, N Drešković, I Arsenić, V Ćirić, V Djurdjević, G Mimić, I Pap, I Balaž
We considered temporal and spatial variations to the thermal and moisture regimes of the most common RSGs (Reference Soil Groups) in Serbia under the A1B scenario for the 2021-2050 and 2071-2100 periods, with respect to the 1961-1990 period. We utilized dynamically downscaled global climate simulations from the ECHAM5 model using the coupled regional climate model EBU-POM (Eta Belgrade University-Princeton Ocean Model). We analysed the soil temperature and moisture time series using simple statistics and a Kolmogorov complexity (KC) analysis...
November 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27468396/bone-scan-index-predicts-skeletal-related-events-in-patients-with-metastatic-breast-cancer
#18
Ai Idota, Masataka Sawaki, Akiyo Yoshimura, Masaya Hattori, Yoshitaka Inaba, Isao Oze, Toyone Kikumori, Yasuhiro Kodera, Hiroji Iwata
BACKGROUND: Bone Scan Index (BSI) expresses tumor burden in bone as a percentage of total skeletal mass, but its significance for metastatic breast cancer patients is unknown. We investigated whether baseline BSI is associated with skeletal-related events (SREs) or survival and identified the cut-off BSI score for predicting SREs in metastatic breast cancer patients. METHODS: We retrospectively reviewed 144 patients with bone metastatic breast cancer. Bone scan examinations were performed and BSI was calculated using the Bonenavi(®) automated method...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27468198/impact-of-biliary-stent-related-events-in-patients-diagnosed-with-advanced-pancreatobiliary-tumours-receiving-palliative-chemotherapy
#19
Angela Lamarca, Christina Rigby, Mairéad G McNamara, Richard A Hubner, Juan W Valle
AIM: To determine the impact (morbidity/mortality) of biliary stent-related events (SRE) (cholangitis or stent obstruction) in chemotherapy-treated pancreatico-biliary patients. METHODS: All consecutive patients with advanced pancreatobiliary cancer and a biliary stent in-situ prior to starting palliative chemotherapy were identified retrospectively from local electronic case-note records (Jan 13 to Jan 15). The primary end-point was SRE rate and the time-to-SRE (defined as time from first stenting before chemotherapy to date of SRE)...
July 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27455850/breast-cancer-and-bone-metastases-a-call-for-appropriate-treatment
#20
Diana Lüftner, Daniela Niepel
PURPOSE: The aim of this study is to provide an overview of the potential barriers to uptake of bone-targeted agents for the prevention of skeletal-related events (SREs) in patients with breast cancer and bone metastases. METHODS: A top-line literature review was conducted to identify trends in and barriers to initiating bone-targeted therapy in patients with metastatic breast cancer. RESULTS: The majority of patients with bone metastases that are secondary to breast cancer clearly benefit from treatment with a bone-targeted agent such as the RANK ligand inhibitor denosumab or the bisphosphonate zoledronic acid, because both delay the onset of SREs...
October 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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