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tertiary lymphoid organ

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https://www.readbyqxmd.com/read/28322850/absence-of-functional-fetal-regulatory-t-cells-in-humans-causes-in-utero-organ-specific-autoimmunity
#1
Eric J Allenspach, Laura S Finn, Mara H Rendi, Ahmet Eken, Akhilesh K Singh, Mohamed Oukka, Sean D Taylor, Matthew C Altman, Corinne L Fligner, Hans D Ochs, David J Rawlings, Troy R Torgerson
Regulatory T cells play a critical role in preventing fetal organ-specific autoimmunity in humans. Autopsies of neonatal IPEX patients shortly after birth demonstrate chronic exocrine-dominant pancreatitis with tertiary lymphoid structures containing expanded oligoclonal T/B lymphocytes.
March 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28321222/editorial-tertiary-lymphoid-organs-tlos-powerhouses-of-disease-immunity
#2
EDITORIAL
Changjun Yin, Sarajo Mohanta, Pasquale Maffia, Andreas J R Habenicht
No abstract text is available yet for this article.
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28235864/baff-induces-tertiary-lymphoid-structures-and-positions-t-cells-within-the-glomeruli-during-lupus-nephritis
#3
SunAh Kang, Yuri Fedoriw, Ethan K Brenneman, Young K Truong, Kristine Kikly, Barbara J Vilen
Tissue-specific immune responses play an important role in the pathology of autoimmune diseases. In systemic lupus erythematosus, deposits of IgG-immune complexes and the activation of complement in the kidney have long been thought to promote inflammation and lupus nephritis. However, the events that localize cells in non-lymphoid tertiary organs and sustain tissue-specific immune responses remain undefined. In this manuscript, we show that BAFF promotes events leading to lupus nephritis. Using an inducible model of systemic lupus erythematosus, we found that passive transfer of antinucleosome IgG into AID(-/-)MRL/lpr mice elevated autoantibody levels and promoted lupus nephritis by inducing BAFF production in the kidneys, and the formation of renal tertiary lymphoid structures (TLSs)...
April 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28217126/high-endothelial-venules-and-other-blood-vessels-critical-regulators-of-lymphoid-organ-development-and-function
#4
REVIEW
Ann Ager
The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer cells that initiate and sustain the development of lymphoid tissues. In adults, the blood vessels are structurally distinct from those in other organs due to the requirement for high levels of lymphocyte recruitment under non-inflammatory conditions. In lymph nodes (LNs) and Peyer's patches, high endothelial venules (HEVs) especially adapted for lymphocyte trafficking form a spatially organized network of blood vessels, which controls both the type of lymphocyte and the site of entry into lymphoid tissues...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28197375/tumor-infiltrating-lymphocyte-composition-organization-and-pd-1-pd-l1-expression-are-linked-in-breast-cancer
#5
Laurence Buisseret, Soizic Garaud, Alexandre de Wind, Gert Van den Eynden, Anais Boisson, Cinzia Solinas, Chunyan Gu-Trantien, Céline Naveaux, Jean-Nicolas Lodewyckx, Hugues Duvillier, Ligia Craciun, Isabelle Veys, Denis Larsimont, Martine Piccart-Gebhart, John Stagg, Christos Sotiriou, Karen Willard-Gallo
The clinical relevance of tumor-infiltrating lymphocytes (TIL) in breast cancer (BC) has been clearly established by their demonstrated correlation with long-term positive outcomes. Nevertheless, the relationship between protective immunity, observed in some patients, and critical features of the infiltrate remains unresolved. This study examined TIL density, composition and organization together with PD-1 and PD-L1 expression in freshly collected and paraffin-embedded tissues from 125 patients with invasive primary BC...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28195090/mixed-phenotypic-acute-leukemia-series-from-tertiary-care-center
#6
Ravikiran N Pawar, Sambhunath Banerjee, Subhajit Bramha, Shekhar Krishnan, Arpita Bhattacharya, Vaskar Saha, Anupam Chakrapani, Saurabh Bhave, Mammen Chandy, Reena Nair, Mayur Parihar, Neeraj Arora, D K Mishra
INTRODUCTION: Mixed-phenotype acute leukemias (MPALs) are a heterogeneous group of rare leukemias constituting approximately 2%-5% of all leukemias, in which assigning a single lineage of origin is not possible. They are diagnosed by either the presence of antigens of more than one lineage or by the presence of dual population of blasts belonging to two or more lineages. We highlight the clinicopathological, immunophenotype, and genetic data of a cohort (n = 14) of patients diagnosed and treated at our center...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28183530/tnf%C3%AE-are-mice-display-abnormal-lymphatics-and-develop-tertiary-lymphoid-organs-in-the-mesentery
#7
Sonia Rehal, Pierre-Yves von der Weid
Chronic inflammatory diseases are associated with a persistent and enhanced response to environmental antigens. As an adaptive response to this exaggerated immune state, affected tissue typically develops tertiary lymphoid organs. Studies of Crohn disease (CD), a chronic inflammatory disease of the intestinal tract, report tertiary lymphoid organs present within the mucosal wall, along with other lymphatic diseases, such as lymphangiogenesis and obstructed lymphatic vessels. These observations suggest that downstream mesenteric lymphatic vessels and lymph drainage into mesenteric lymph nodes may be compromised...
February 6, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28162296/-efficacy-of-pd-1-pd-l1%C3%A2-immune-checkpoint-inhibitors-and-pd-l1%C3%A2-testing-in-thoracic-cancers
#8
Michaël Duruisseaux, Isabelle Rouquette, Julien Adam, Alexis Cortot, Aurélie Cazes, Laure Gibault, Diane Damotte, Sylvie Lantuejoul
Tumoral immune environment is a major component of cancer. Its composition and its organization represent a reproducible characteristic of tumors and a validated prognostic factor. In non-small cell lung cancer (NSCLC), cytotoxic T CD8+ lymphocyte density, associated with a Th1 environment and tertiary lymphoid structures impacts survival. Tumor cell-immune cell interaction is targeted by PD1/PD-L1 inhibitors. In advanced NSCLC, PD1/PD-L1 inhibitors are more effective than second-line chemotherapy. Pembrolizumab outperforms first-line chemotherapy in NSCLC strongly positive for PD-L1...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28033681/high-endothelial-venules-associated-with-t-cell-subsets-in-the-inflamed-gut-of-newly-diagnosed-inflammatory-bowel-disease-patients
#9
C S Horjus Talabur Horje, C Smids, J W R Meijer, M J Groenen, M K Rijnders, E G van Lochem, P J Wahab
Naive and central memory T lymphocytes (TN and TCM ) can infiltrate the inflamed gut mucosa in inflammatory bowel disease (IBD) patients. Homing of these subsets to the gut might be explained by ectopic formation of tertiary lymphoid organs (TLOs), containing high endothelial venules (HEVs). We aimed to evaluate the presence of HEVs and TLOs in inflamed intestinal mucosa of newly diagnosed, untreated IBD patients in relation to the presence of TN and TCM lymphocytes. IBD patients (n = 39) and healthy controls (n = 8) were included prospectively...
April 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936003/growth-of-murine-splenic-tissue-is-suppressed-by-lymphotoxin-%C3%AE-receptor-signaling-lt%C3%AE-r-originating-from-splenic-and-non-splenic-tissues
#10
Novica M Milićević, Klaus Nohroudi, Friederike Schmidt, Hendrik Schmidt, Cornelia Ringer, Grith Lykke Sorensen, Živana Milićević, Jürgen Westermann
Development and maintenance of secondary lymphoid organs such as lymph nodes and spleen essentially depend on lymphotoxin β-receptor (LTβR) signaling. It is unclear, however, by which molecular mechanism their size is limited. Here, we investigate whether the LTβR pathway is also growth suppressing. By using splenic tissue transplantation it is possible to analyze a potential contribution of LTβR signaling inside and outside of the implanted tissue. We show that LTβR signaling within the endogenous spleen and within non-splenic tissues both significantly suppressed the regeneration of implanted splenic tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27881983/high-endothelial-venules-and-lymphatic-vessels-in-tertiary-lymphoid-organs-characteristics-functions-and-regulation
#11
REVIEW
Nancy H Ruddle
High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition. HEVs bring in naïve and central memory cells and LVs transport antigen, antigen-presenting cells, and lymphocytes in and out of LNs. Tertiary lymphoid organs (TLOs) are accumulations of lymphoid and stromal cells that arise and organize at ectopic sites in response to chronic inflammation in autoimmunity, microbial infection, graft rejection, and cancer...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27877173/stromal-fibroblasts-in-tertiary-lymphoid-structures-a-novel-target-in-chronic-inflammation
#12
REVIEW
Francesca Barone, David H Gardner, Saba Nayar, Nathalie Steinthal, Christopher D Buckley, Sanjiv A Luther
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and stromal cells that provide ectopic hubs for acquired immune responses. TLS share phenotypical and functional features with secondary lymphoid organs (SLO); however, they require persistent inflammatory signals to arise and are often observed at target sites of autoimmune disease, chronic infection, cancer, and organ transplantation. Over the past 10 years, important progress has been made in our understanding of the role of stromal fibroblasts in SLO development, organization, and function...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27872626/antigen-presenting-cells-and-antigen-presentation-in-tertiary-lymphoid-organs
#13
REVIEW
Catherine E Hughes, Robert A Benson, Marija Bedaj, Pasquale Maffia
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27865168/peristrut-microhemorrhages-a-possible-cause-of-in-stent-neoatherosclerosis
#14
Zaven Terzian, T Christian Gasser, Francis Blackwell, Fabien Hyafil, Liliane Louedec, Catherine Deschildre, Walid Ghodbane, Richard Dorent, Antonino Nicoletti, Marion Morvan, Mohammed Nejjari, Laurent Feldman, Graciela Pavon-Djavid, Jean-Baptiste Michel
BACKGROUND: In-stent neoatherosclerosis is characterized by the delayed appearance of markers of atheroma in the subintima, but the pathophysiology underlying this new disease entity remains unclear. METHODS AND RESULTS: We collected 20 human coronary artery stents by removal from explanted hearts. The mean duration of stent implantation was 34 months. In all samples, neoatherosclerosis was detected, particularly in peristrut areas. It consisted of foam cells and cholesterol clefts, with or without calcification, associated with neovascularization...
January 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27826298/tertiary-lymphoid-organs-in-central-nervous-system-autoimmunity
#15
REVIEW
Meike Mitsdoerffer, Anneli Peters
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients. Autoreactive T cells are important drivers of the disease; however, the efficacy of B cell depleting therapies uncovered an essential role for B cells in disease pathogenesis. They can contribute to inflammatory processes via presentation of autoantigen, secretion of pro-inflammatory cytokines, and production of pathogenic antibodies...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27799933/ectopic-lymphoid-structures-powerhouse-of-autoimmunity
#16
REVIEW
Elisa Corsiero, Alessandra Nerviani, Michele Bombardieri, Costantino Pitzalis
Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, and systemic lupus erythematosus. ELS are characterized by the formation of organized T/B cells aggregates, which can acquire follicular dendritic cells network supporting an ectopic germinal center response. In this review, we shall summarize the mechanisms that regulate the formation of ELS in tertiary lymphoid organs, with particular emphasis on the role of lymphoid chemokines in both formation and maintenance of ELS, the role of emerging positive and negative regulators of ELS development and function, including T follicular helper cells and IL-27, respectively...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27799872/potential-of-cells-and-cytokines-chemokines-to-regulate-tertiary-lymphoid-structures-in-human-diseases
#17
REVIEW
Feifeng Jing, Eun Young Choi
Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues involved in chronic inflammation, autoimmune diseases, transplant rejection and cancer. They exhibit almost all the characteristics of secondary lymphoid organs (SLO), which are associated with adaptive immune responses; as such, they contain organized B-cell follicles with germinal centers, distinct areas containing T cells and dendritic cells, high endothelial venules, and lymphatics. In this review, we briefly describe the formation of SLO, and describe the cellular subsets and molecular cues involved in the formation and maintenance of TLS...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27780741/tertiary-lymphoid-organs-in-recalcitrant-chronic-rhinosinusitis
#18
Aden Lau, Susan Lester, Sophia Moraitis, Judy Ou, Alkis J Psaltis, Shaun McColl, Maureen Rischmueller, Peter-John Wormald, Sarah Vreugde
No abstract text is available yet for this article.
October 22, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27777573/artery-tertiary-lymphoid-organs-powerhouses-of-atherosclerosis-immunity
#19
Changjun Yin, Sarajo Kumar Mohanta, Prasad Srikakulapu, Christian Weber, Andreas J R Habenicht
Artery tertiary lymphoid organs (ATLOs) are atherosclerosis-associated lymphoid aggregates with varying degrees of complexity ranging from small T/B-cell clusters to well-structured lymph node-like though unencapsulated lymphoid tissues. ATLOs arise in the connective tissue that surrounds diseased arteries, i.e., the adventitia. ATLOs have been identified in aged atherosclerosis-prone hyperlipidemic apolipoprotein E-deficient (ApoE(-/-)) mice: they are organized into distinct immune cell compartments, including separate T-cell areas, activated B-cell follicles, and plasma cell niches...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27752256/understanding-immune-cells-in-tertiary-lymphoid-organ-development-it-is-all-starting-to-come-together
#20
REVIEW
Gareth W Jones, David G Hill, Simon A Jones
Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer, and allograft rejection. These highly ordered structures resemble the cellular composition of lymphoid follicles typically associated with the spleen and lymph node compartments. Although TLOs within tissues show varying degrees of organization, they frequently display evidence of segregated T and B cell zones, follicular dendritic cell networks, a supporting stromal reticulum, and high endothelial venules...
2016: Frontiers in Immunology
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