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https://www.readbyqxmd.com/read/29766758/anti-inflammatory-peptide-attenuates-edema-and-promotes-bmp-2-induced-bone-formation-in-spine-fusion
#1
Juliane D Glaeser, Khosrowdad Salehi, Linda Kanim, Dmitriy Sheyn, Zachary NaPier, Phillip Behrens, Leslie Garcia, Jason M Cuéllar, Hyun W Bae
Recombinant human bone morphogenic protein-2 (BMP-2) loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft-tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft-tissue inflammation without affecting BMP-2-mediated spinal fusion in rat...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29763982/bone-graft-in-posterior-spine-fusion-for-adolescent-idiopathic-scoliosis-a-meta-analysis
#2
REVIEW
Nathan Kirzner, Luke Hilliard, Catherine Martin, Gerald Quan, Susan Liew, Ali Humadi
BACKGROUNDS: The aim of this study was to systematically analyse and perform a meta-analysis on the current available literature comparing the fusion rates and complications associated with use of autograft, allograft and bone substitutes to supplement posterior spinal fusion for adolescent idiopathic scoliosis (AIS). METHODS: The electronic databases including Embase, PubMed, Medline, Cinahl and Cochrane Library were searched to identify relevant studies. A total of 12 studies with 2389 patients were included for meta-analysis...
May 15, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29760731/recovery-of-donor-hematopoiesis-after-graft-failure-and-second-hematopoietic-stem-cell-transplantation-with-intraosseous-administration-of-mesenchymal-stromal-cells
#3
Nataliya Petinati, Nina Drize, Natalia Sats, Natalya Risinskaya, Andrey Sudarikov, Michail Drokov, Daria Dubniak, Alina Kraizman, Maria Nareyko, Natalia Popova, Maya Firsova, Larisa Kuzmina, Elena Parovichnikova, Valeriy Savchenko
Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells. Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after allogeneic bone marrow (BM) transplantation. Since only few MSCs reach the BM after intravenous injection, MSCs were implanted into the iliac spine. For 8 patients with GF after allo-BMT, another hematopoietic stem cell transplantation with simultaneous implantation of MSCs from their respective donors into cancellous bone was performed...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29744317/prospective-randomized-comparative-study-to-evaluate-epidural-fibrosis-and-surgical-outcome-in-patients-undergoing-lumbar-laminectomy-with-epidural-autologous-free-fat-graft-or-gelfoam-a-preliminary-study
#4
Shivender Sobti, Ashwani Grover, B Paul S John, Sarvpreet Singh Grewal, Uttam B George
Introduction: Epidural fibrosis (EF) contributes to unsatisfactory relief of symptoms and failed back syndrome after spine surgery. EF around the nerve root can be more refractory to treatment than the original disc herniation itself. Reoperation on the scar can produce more scarring. Few studies have been conducted regarding the type of material to be used for decreasing EF. Materials and Methods: The prospective randomized comparative study was conducted in the Department of Neurosurgery and Radiodiagnosis, of a tertiary care hospital...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29739435/biomechanical-analysis-of-iliac-crest-loading-following-cortico-cancellous-bone-harvesting
#5
Paul Schmitz, Christoph Cornelius Neumann, Carsten Neumann, Michael Nerlich, Sebastian Dendorfer
BACKGROUND: Iliac crest bone harvesting is a frequently performed surgical procedure widely used to treat bone defects. The objective of this study is to assess the biomechanical quantities related to risk for pelvic fracture after harvesting an autologous bone graft at the anterior iliac crest. METHODS: Finite element models with a simulated harvest site (sized 15 × 20 mm, 15 × 35 mm, 30 × 20 mm and 30 × 35 mm) in the iliac wing are created...
May 9, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29738366/effects-of-combined-magnetic-fields-treatment-and-nano-hydroxyapatite-coating-on-porous-biphasic-calcium-phosphate-bone-graft-in-rabbit-spinal-fusion-model
#6
Xianglong Zhuo, Chentian Li, Bing Li, Zhaoyang Li, Hongbin Lv, Jianjun Huang, Daqi Xu, Jianzhong Hu
STUDY DESIGN: An animal experimental study was designed to investigate the efficacy of combined magnetic fields (CMF) treatment and nano-hydroxyapatite (HA) coating in the biphasic calcium phosphate (BCP) graft in posterolateral lumbar fusion. OBJECTIVE: To evaluate the effects of CMF treatment and nano-HA/BCP and their combination effect in posterolateral lumbar fusion. SUMMARY OF BACKGROUND DATA: Enhancement of artificial bone graft bioeffects could improve spinal fusion outcomes...
June 1, 2018: Spine
https://www.readbyqxmd.com/read/29736802/management-of-aortic-injury-during-minimally-invasive-lateral-lumbar-interbody-fusion
#7
REVIEW
Michael M Safaee, Devin Zarkowsky, Charles M Eichler, Murat Pekmezci, Aaron J Clark
PURPOSE: Minimally invasive lateral approaches to the lumbar spine allow for interbody fusion with good visualization of the disk space, minimal blood loss, and decreased length of stay. Major neurologic, vascular, and visceral complications are rare with this approach; however, the steps in management for severe vascular injuries are not well defined. We present a case report of aortic injury during lateral interbody fusion and discuss the use of endovascular repair. METHODS: This study is a case report of an intraoperative aortic injury...
May 7, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29732428/minimum-ten-year-follow-up-of-spinal-stenosis-with-degenerative-spondylolisthesis-treated-with-decompression-and-dynamic-stabilization
#8
Kotryna Veresciagina, Arne Mehrkens, Stefan Schären, Bernhard Jeanneret
Background: The Dynesys system remains the most widely implanted posterior non-fusion pedicle screw system. Various study designs used in investigations with good to excellent short- and mid-term results have been reported in the current literature. However, there is a lack of information concerning long-term outcomes following treatment for spinal stenosis with degenerative spondylolisthesis. Methods: The aim of our study was twofold. Firstly, to assess whether the dynamic stabilization in situ with the Dynesys System without bone grafting provides enough stability to prevent progression of spondylolisthesis and secondarily to maintain significant clinical improvement in a long-term follow-up (FU)...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29732425/a-canadian-perspective-on-anterior-cervical-discectomies-practice-patterns-and-preferences
#9
Reena K Baweja, Michael Bennardo, Forough Farrokhyar, Amanda Martyniuk, Kesava Reddy
Background: The purpose of this study is to elucidate the current practice patterns of Canadian neurosurgeons with regards to anterior cervical discectomy (ACD). Methods: A one-page questionnaire was sent out using SurveyMonkey to all neurosurgeon members of the Canadian Neurological Sciences Federation (CNSF). End points were surgeon preference for ACD surgical method, graft source, the length of collar usage and the recommended time before returning to work. Results: Response rate was 74...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29720961/osteoporosis-therapy-with-denosumab-in-organ-transplant-recipients
#10
Jana Brunova, Simona Kratochvilova, Jitka Stepankova
Objective: Osteoporosis and fragility fractures represent serious complications for the solid organ transplant population. The recommended osteoporosis therapy for organ recipients involves supplementation with calcium and vitamin D and bisphosphonate administration. However, these options can prove limited for patients with impaired renal function. An alternative therapy option is offered by denosumab, a monoclonal antibody that targets receptor activator of nuclear factor kappa-B ligand...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29719912/vascularized-bone-grafting-for-reconstruction-of-oncologic-defects-in-the-spine-a-systematic-review-and-pooled-analysis-of-the-literature
#11
Rachel Pedreira, Charalampos Siotos, Brian H Cho, Stella M Seal, Deepa Bhat, Hannah M Carl, Michelle Seu, J P Wolinksy, Justin M Sacks
BACKGROUND:  Resection of primary spinal tumors requires reconstruction for restoration of spinal column stability. Traditionally, some combination of bone grafting and instrumentation is implemented. However, delayed healing environments are associated with pseudoarthrodesis and failure. Implementation of vascularized bone grafting (VBG) to complement hardware may present a solution. We evaluated the use of VBG in oncologic spinal reconstruction via systematic review and pooled analysis of literature...
May 2, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29707557/prepsoas-oblique-lateral-lumbar-interbody-fusion-in-deformity-surgery
#12
Catherine Miller, Puneet Gulati, Deepak Bandlish, Dean Chou, Praveen V Mummaneni
Interbody fusions are routinely used in deformity surgery to achieve both coronal and sagittal correction and attain increased fusion rates. Minimally invasive interbody techniques, including the prepsoas approach, are being utilized to decrease tissue disruption, blood loss, and patient morbidity with similar outcomes compared to traditional surgery. The prepsoas oblique lateral interbody fusion, accesses the spine between the iliac arteries or aorta and psoas muscle, and allows for exposure of the lumbar spine while avoiding some complications commonly seen with a direct lateral approach...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29707553/minimally-invasive-anterior-lateral-and-oblique-lumbar-interbody-fusion-a-literature-review
#13
REVIEW
David S Xu, Corey T Walker, Jakub Godzik, Jay D Turner, William Smith, Juan S Uribe
Lumbar interbody fusion involves insertion of a structural graft into an intervertebral disc space to promote bony arthrodesis. It is a well-established surgical strategy for multiple spinal disorders ranging from degenerative conditions to trauma, neoplastic diseases, and deformities requiring correction. Since the inception of lumbar interbody fusion, the most established techniques have been two posterior approaches, the posterior lumbar interbody fusion (PLIF) and the transforaminal lumbar interbody fusion (TLIF)...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29690741/-antiseptic-effect-of-compound-lysostaphin-disinfectant-and-its-preventive-effect-on-infection-of-artificial-dermis-after-graft-on-full-thickness-skin-defect-wound-in-rats
#14
J Jin, H Zhou, Z C Cui, L Wang, P F Luo, S Z Ji, X Y Hu, B Ma, G Y Wang, S H Zhu, Z F Xia
Objective: To study the antiseptic effect of compound lysostaphin disinfectant and its preventive effect on infection of artificial dermis after graft on full-thickness skin defect wound in rats. Methods: (1) Each one standard strain of Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus were selected. Each 20 clinical strains of Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus were collected from those isolated from wound exudates of burn patients hospitalized in our wards from January 2014 to December 2016 according to the random number table...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29673822/vascularized-spinous-process-graft-rotated-on-a-paraspinous-muscle-pedicle-for-lumbar-fusion-technique-description-and-early-clinical-experience
#15
Michael A Bohl, Kaith K Almefty, Mark C Preul, Jay D Turner, U Kumar Kakarla, Edward M Reece, Steve W Chang
BACKGROUND: Vascularized bone grafts (VBGs) are described as having superior osteogenicity, osteoconductivity, and osteoinductivity compared with other graft types, and have been used in high-risk patients to augment arthrodesis. Pedicled VBGs are rotated on an intact vascular pedicle and therefore maintain all the benefits of VBG, but avoid many of the challenges and additional morbidity of free-tissue transfer. This study describes a novel surgical technique for rotating vascularized spinous process into the posterolateral space for augmenting arthrodesis in patients undergoing posterolateral fusion (PLF)...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29655516/plga-%C3%AE-tcp-composite-scaffold-incorporating-salvianolic-acid-b-promotes-bone-fusion-by-angiogenesis-and-osteogenesis-in-a-rat-spinal-fusion-model
#16
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29652784/a-prospective-randomized-multicenter-study-comparing-silicated-calcium-phosphate-versus-bmp-2-synthetic-bone-graft-in-posterolateral-instrumented-lumbar-fusion-for-degenerative-spinal-disorders
#17
Marc Coughlan, Mark Davies, Adriaan K Mostert, Dharmin Nanda, Paul C Willems, Geoffrey Rosenberg, Richard Ferch
STUDY DESIGN: A prospective, Phase IV, multicenter, randomized study. OBJECTIVE: To compare vertebral fusion success rates following posterolateral fusion ((PLF)/posterolateral intertransverse fusion (PITF)) surgery. The surgical procedure combined posterior lumbar interbody fusion (PLIF) and PLF with internal fixation over one or two levels using silicated calcium phosphate (SiCaP) or bone morphogenetic protein (BMP)-2 as graft material in patients with a degenerative disorder of the lumbar spine...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29651874/in-vitro-and-in-vivo-evaluation-of-osteoinductivity-and-bone-fusion-ability-of-an-activin-a-bmp2-chimera-ab204-a-comparison-study-between-ab204-and-rhbmp-2
#18
Guang Bin Zheng, Jae Hyup Lee, Yuan-Zhe Jin
This study compared osteoinductivity and osteogenic capacity between AB204 and rhBMP-2 using hMSCs in vitro and a beagle's posterolateral spinal fusion model. Cultured hMSCs were treated with AB204 or rhBMP-2 with low to high doses. Three male beagles were performed posterolateral spinal fusion with biphasic calcium phosphate (2 ml) + AB204 or rhBMP-2 (20, 50 or 200 µg). They were euthanized after 8 weeks. The fusion rate and bone formation of spine samples were examined. AB204 had higher alkaline phosphatase activity, mineralization and osteogenic-related gene expression than rhBMP-2...
April 13, 2018: Growth Factors
https://www.readbyqxmd.com/read/29651329/ischaemia-of-the-medullary-cone-after-stent-graft-implantation-in-a-patient-with-abdominal-aortic-aneurysm-a-case-study
#19
Mariusz Wachowski, Michał Polguj, Janusz Ścibór, Agata Majos
Preoperative visualization of the Adamkiewicz artery - the vessel which is to a great extent responsible for supplying blood to the medullary cone - is an important step which must be taken before initiating restorative procedures in the aorta. We present a case of a 67-year-old patient who underwent an intravascular stent-graft implantation procedure, due to clinical signs of abdominal aortic aneurysm. Routine pre-operative computed tomography examination failed to demonstrate the Adamkiewicz artery. On the second day after the surgery, as a result of unexpected clinical deterioration, an magnetic resonance imaging examination of the lumbar spine was carried out...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29626690/traumatic-postero-lateral-c1-c2-dislocation-complicated-with-locked-lateral-mass-and-type-ii-odontoid-fracture-a-5-year-follow-up-a-case-report
#20
Zhu Minyu, Wu Shiyang, Chandoo Suraj, Huang Kelun, Lin Chaowei, Teng Honglin
STUDY DESIGN: case report: Objective: To document our experience in managing a rare complex of traumatic postero-lateral atlantoaxial dislocation combined with locked lateral mass and type II odontoid fracture. SUMMARY OF BACKGROUND DATA: METHOD: A 30 years-old male patient was referred to the author's department. He complained of a decrease in neck range of motion following a traffic accident. Neurological examination was normal. Computed tomography (CT) and open mouth X-ray showed a type II odontoid fracture and a postero-lateral dislocation with laterally locked left lateral mass at the C1-C2 level...
April 4, 2018: World Neurosurgery
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