Hongdi Huang, Jianglin Pu, Yufang Zhou, Yang Fan, Yali Zhang, Yanling Li, Yangzhuo Chen, Yun Wang, Xiaomei Yu, Bulgin Dmitry, Zhu Zhou, Jianhong Wang
Chronic hyperglycaemia is a chief feature of diabetes mellitus and complicates with many systematic anomalies. Non-human primates (NHPs) are excellent for studying hyperglycaemia or diabetes and associated comorbidities, but lack behavioural observation. In the study, behavioural, brain imaging and histological analysis were performed in a case of spontaneously hyperglycaemic (HGM) Macaca fascicularis. The results were shown that the HGM monkey had persistent body weight loss, long-term hyperglycaemia, insulin resistance, dyslipidemia, but normal concentrations of insulin, C-peptide, insulin autoantibody, islet cell antibody and glutamic acid decarboxylase antibody...
June 2024: Clinical and Experimental Pharmacology & Physiology