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https://www.readbyqxmd.com/read/28107237/evaluating-a-posterior-approach-for-surgical-treatment-of-thoracolumbar-pseudarthrosis-in-ankylosing-spondylitis
#1
Ting Wang, Dechun Wang, Yanan Cong, Chuqiang Yin, Shuzhong Li, Xiaoliang Chen
STUDY DESIGN: Retrospective study of a posterior approach for surgical treatment of thoracolumbar pseudarthrosis in ankylosing spondylitis (AS). OBJECTIVE: The aim of the current study was to report the surgical results of symptomatic thoracolumbar pseudarthrosis in AS through a posterior approach. SUMMARY OF BACKGROUND DATA: Spinal pseudarthrosis is a well-known complication in AS. The condition may complicate with mechanical back pain, spinal deformity, and sometimes neurological deficits...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107234/comparison-between-acrylic-cage-and-polyetheretherketone-peek-cage-in-single-level-anterior-cervical-discectomy-and-fusion-a-randomized-clinical-trial
#2
Majid R Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized-controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral disks. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiological disk height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteointegration and stability, has not been identified yet...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106498/performing-concurrent-operations-in-academic-vascular-neurosurgery-does-not-affect-patient-outcomes
#3
Corinna C Zygourakis, Janelle Lee, Julio Barba, Errol Lobo, Michael T Lawton
OBJECTIVE Concurrent surgeries, also known as "running two rooms" or simultaneous/overlapping operations, have recently come under intense scrutiny. The goal of this study was to evaluate the operative time and outcomes of concurrent versus nonconcurrent vascular neurosurgical procedures. METHODS The authors retrospectively reviewed 1219 procedures performed by 1 vascular neurosurgeon from 2012 to 2015 at the University of California, San Francisco. Data were collected on patient age, sex, severity of illness, risk of mortality, American Society of Anesthesiologists (ASA) status, procedure type, admission type, insurance, transfer source, procedure time, presence of resident or fellow in operating room (OR), number of co-surgeons, estimated blood loss (EBL), concurrent vs nonconcurrent case, severe sepsis, acute respiratory failure, postoperative stroke causing neurological deficit, unplanned return to OR, 30-day mortality, and 30-day unplanned readmission...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28106355/comparative-study-of-fiberoptic-guided-versus-intubating-laryngeal-mask-airway-assisted-awake-orotracheal-intubation-in-patients-with-unstable-cervical-spine-a-randomized-controlled-trial
#4
Tanmay Jadhav, Kamath Sriganesh, Madhusudan K Reddy, Dhritiman Chakrabarti
BACKGROUND: A safe airway technique minimizes intubation-associated cervical-spine movement and consequent neurological injury in patients with unstable cervical spine (UCS). Awake fiberoptic-guided intubation (FGI) is preferred in patients with UCS. Alternatively, intubating laryngeal mask airway assisted intubation (ILMA-AI) can be performed both during elective and emergency, requires less expertise and is cost-effective. This study evaluated cervical-spine movement during FGI and ILMA-AI in patients with UCS...
January 20, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28105177/-18-f-fluoroethyl-l-tyrosine-positron-emission-tomography-guided-diagnosis-of-a-malignant-intramedullary-spinal-cord-tumor
#5
Sied Kebir, Okka Kimmich, Pitt Niehusmann, Florian C Gaertner, Markus Essler, Jennifer Landsberg, Thomas Klockgether, Matthias Simon, Ulrich Herrlinger, Martin Glas
Diagnosis in patients with a suspected malignant intramedullary lesion that requires biopsy for definitive diagnosis may be challenging, as spinal cord surgery carries the risk of irreversible neurological deficits. The current study presents the first case of (18)F-fluoroethyl-L-tyrosine ((18)F-FET) positron emission tomography (PET) imaging in a patient with a spinal cord tumor. The patient was unsuitable for magnetic resonance imaging due to his implanted cardiac defibrillator. (18)F-FET PET indicated a high-grade malignancy of the spinal cord, justifying tumor biopsy...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104525/regional-spinal-cord-atrophy-is-associated-with-poor-outcome-after-surgery-on-intramedullary-spinal-cord-ependymoma-a-new-aspect-of-delayed-neurological-deterioration
#6
Bedjan Behmanesh, Florian Gessler, Johanna Quick-Weller, Andrea Spyrantis, Lioba Imöhl, Volker Seifert, Gerhard Marquardt
BACKGROUND: A considerable number of patients suffer delayed neurological deficits even after a successful removal of intramedullary spinal cord ependymoma. The underlying pathology remains unknown. Radiological findings could be an explanation for poor outcome after surgery. METHODS: We conducted a retrospective study of all cases treated from 1980 to 2016 in our department. Included were all patients with intramedullary spinal cord ependymoma treated with microsurgical excision...
January 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28104254/processing-speed-and-distractibility-in-multiple-sclerosis-the-role-of-sleep
#7
Viral P Patel, Lisa A S Walker, Anthony Feinstein
BACKGROUND: The effects of sleep disturbances on cognitive performance under distraction in multiple sclerosis (MS) are not known. The objective of the present study was to explore the association between an index of sleep (i.e. daytime somnolence), distractibility and the hallmark cognitive deficit in people with MS (i.e. processing speed). METHODS: MS participants (n=102) were recruited from outpatient neurology clinics. All participants completed the traditional Symbol Digit Modalities Test (SDMT)...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28102171/lumbar-disc-herniation-causing-cauda-equina-syndrome-in-a-paediatric-patient-a-case-report
#8
Mohamad Irshad, Khurshid Ahmad, Hilal Ahmad Malla
Lumbar disc disease occurs mainly in the adult population. A disc prolapse in the paediatric population is very rare. Cauda equine syndrome resulting from compression of the cauda equina is a rare syndrome and is one of the few spinal surgical emergencies. Here we present a 13-year-old boy with pain in the lumbar region radiating bilaterally to the lower limbs, with asymmetrical weakness of lower the limbs, perianal hypoaesthesia and urinary retention. MRI of lumbar spine confirmed disc protrusion at the L3-L4 level with severe spinal canal stenosis...
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28101763/mir-126-affects-brain-heart-interaction-after-cerebral-ischemic-stroke
#9
Jieli Chen, Chengcheng Cui, Xiaoping Yang, Jiang Xu, Poornima Venkat, Alex Zacharek, Peng Yu, Michael Chopp
Cardiovascular diseases are approximately three times higher in patients with neurological deficits than in patients without neurological deficits. MicroRNA-126 (MiR-126) facilitates vascular remodeling and decreases fibrosis and is emerging as an important factor in the pathogenesis of cardiovascular diseases and cerebral stroke. In this study, we tested the hypothesis that decreased miR-126 after ischemic stroke may play an important role in regulating cardiac function. Wild-type (WT), specific conditional-knockout endothelial cell miR-126 (miR-126(EC-/-)), and miR-126 knockout control (miR-126(fl/fl)) mice were subjected to distal middle cerebral artery occlusion (dMCAo) (n = 10/group)...
January 19, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28101620/-home-based-telerehabilitation-after-stroke
#10
M Keidel, F Vauth, J Richter, B Hoffmann, H Soda, B Griewing, M Scibor
The use of modern information and telecommunication technologies enables telerehabilitation of neurological deficits in the domestic environment. The current state of studies on rehabilitative teletherapy for improvement of motor function and mobility deficits due to stroke is reviewed. Two neurolinguistic proof of concept studies investigating the efficacy of online interactive telespeech therapy are reported, which compared virtual screen to screen interactive telerehabilitation of aphasia after stroke and dysarthrophonia in Parkinson's disease to conventional face to face rehabilitation...
January 18, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28101446/hypertonicity-clinical-entities-manifestations-and-treatment
#11
REVIEW
Helbert Rondon-Berrios, Christos Argyropoulos, Todd S Ing, Dominic S Raj, Deepak Malhotra, Emmanuel I Agaba, Mark Rohrscheib, Zeid J Khitan, Glen H Murata, Joseph I Shapiro, Antonios H Tzamaloukas
Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and long-term neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia. Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake, gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia. Hypernatremia can be hypervolemic, euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and, if present, sodium deficit, and correction of the underlying pathophysiologic process that led to hypernatremia...
January 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28101166/hsp70-inducer-17-allylamino-demethoxygeldanamycin-provides-neuroprotection-via-anti-inflammatory-effects-in-a-rat-model-of-traumatic-brain-injury
#12
Youquan Gu, Jun Chen, Tianhong Wang, Chaoning Zhou, Zhaodong Liu, Lanhua Ma
Traumatic brain injury (TBI) is the predominant cause of mortality in young adults and children living in China. TBI induces inflammatory responses; in addition, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 are important pro-inflammatory cytokines. Considering the observation that Hsp-70 overexpression can exert neuroprotection, identifying a drug that is able to induce the upregulation of Hsp70 has the potential to be a promising therapy for the treatment of neurological diseases. Thus, the present study assessed the clinical effectiveness of an anticancer drug and Hsp70 activator, 17-allylamino-demethoxygeldanamycin (17-AAG), to evaluate its potential as a treatment for patients with TBI...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100089/assistive-technology-outcomes-in-post-secondary-students-with-disabilities-the-influence-of-diagnosis-gender-and-class-level
#13
Matt P Malcolm, Marla C Roll
This study investigated how outcomes of assistive technology (AT) services for college students with disabilities are influenced by diagnosis, gender and class-level (e.g., Freshman). Students' pre- and post-intervention ratings of their performance and satisfaction of common academic tasks (using the Canadian Occupational Performance Measure, COPM) were analyzed, as well as students' responses on a survey about AT service provision, use, and preferences. Data from 455 students revealed "learning disability" to be the most prevalent diagnosis (38%), similar numbers of females and males served, and Freshmen (23...
January 19, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28099107/case-238-spontaneous-pneumothorax-secondary-to-intrapulmonary-necrobiotic-rheumatoid-nodule
#14
Ammar A Chaudhry, Maryam Gul, Abbas A Chaudhry, William Moore
History A 54-year-old white woman with a history of rheumatoid arthritis who was taking glucocorticoids and methotrexate presented to the emergency department in December with worsening shortness of breath and chest heaviness for 1 week. She reported additional symptoms of weakness, headache, and arthralgia primarily involving her bilateral hands, wrist, ankles, and feet. She denied experiencing fevers, syncope or presyncope, focal neurologic deficits, chest pain, nausea, vomiting, unintentional weight loss, or recent trauma...
February 2017: Radiology
https://www.readbyqxmd.com/read/28098937/sodium-selenate-treatment-improves-symptoms-and-seizure-susceptibility-in-a-malin-deficient-mouse-model-of-lafora-disease
#15
Gentzane Sánchez-Elexpuru, José M Serratosa, Marina P Sánchez
OBJECTIVE: To search for new therapies aimed at ameliorating the neurologic symptoms and epilepsy developing in patients with Lafora disease. METHODS: Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes. Epm2a(-/-) and Epm2b(-/-) mice display neurologic and behavioral abnormalities similar to those found in patients. Selenium is a potent antioxidant and its deficiency has been related to the development of certain diseases, including epilepsy...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28097491/small-interfering-rna-targeting-dickkopf-1-contributes-to-neuroprotection-after-intracerebral-hemorrhage-in-rats
#16
Zhihua Li, Xi Chen, Xiaoyang Zhang, Xiuhua Ren, Xuemei Chen, Jing Cao, Weidong Zang, Xianzhi Liu, Fuyou Guo
Excessive Dickkopf-1 (Dkk-1) plays a vital role in secondary brain injury following ischemic stroke and psychotic disease. However, it is unclear whether an increased expression of Dkk-1 occurred after intracerebral hemorrhage (ICH). The present study examined the potential role of Dkk-1 after ICH. ICH was induced by a single injection of autologous blood into the basal ganglia of rats. Dkk-1 protein levels in brain tissue and serum were detected by enzyme-linked immunosorbent assay after ICH. Rats were treated with small interfering RNA targeting Dkk-1 (siDkk-1) or vehicle following ICH...
January 17, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28096971/carthamus-tinctorius-l-ameliorates-brain-injury-followed-by-cerebral-ischemia-reperfusion-in-rats-by-antioxidative-and-anti-inflammatory-mechanisms
#17
Pin-Kuei Fu, Tai-Long Pan, Chi-Yu Yang, Kee-Ching Jeng, Nou-Ying Tang, Ching-Liang Hsieh
OBJECTIVES: Carthamus tinctorius L. (CT) or safflower is widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia-reperfusion (I/R) brain injury and elucidated the underlying mechanism. MATERIALS AND METHODS: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096833/utility-of-serum-concentration-of-protein-s100-at-admission-to-the-medical-intensive-care-unit-in-prediction-of-permanent-neurological-injury
#18
Piotr Knapik, Małgorzata Knapik, Robert Partyka, Iwona Broll, Daniel Cieśla, Maciej Wawrzyńczyk, Danuta Kokocińska, Przemysław Jałowiecki
INTRODUCTION: Admission to the intensive care unit (ICU) may be preceded by dramatic events leading to permanent neurological injury. Plasma S100 protein levels are proved to be clinically useful in predicting neurological outcome following cardiac arrest. It is unclear, however, whether this may be extrapolated to a broader population of ICU patients. AIM: To assess the utility of plasma S100 protein in predicting death, permanent neurological damage, or unfavourable outcome at admission to the intensive care unit...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28096675/the-role-of-heme-oxygenase-1-ho-1-in-the-regulation-of-inflammatory-reaction-neuronal-cell-proliferation-and-apoptosis-in-rats-after-intracerebral-hemorrhage-ich
#19
Xuezheng Fan, Linshen Mu
OBJECTIVE: To investigate the role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH). METHODS: Thirty-six adult Sprague Dawley (SD) male rats were randomly divided into sham operation, ICH and zinc protoporphyrin (ZPP) group. Rats (except for the sham operation group) were given 50 μL stereotactic injection of autologous blood from the femoral artery into the caudate nucleus, to establish an ICH model...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28094161/disinhibition-in-children-with-attention-deficit-hyperactivity-disorder-changes-in-oxy-hb-on-near-infrared-spectroscopy-during-rock-paper-scissors-task
#20
Sayaka Ishii, Yoshimi Kaga, Tomoko Tando, Kakuro Aoyagi, Fumikazu Sano, Hideaki Kanemura, Kanji Sugita, Masao Aihara
OBJECTIVE: Attention-deficit/hyperactivity disorder (AD/HD) is a common developmental disorder. Many reports have suggested that symptoms of AD/HD are related to frontal lobe dysfunctions, particularly disinhibition. However, measuring neurological findings with biomarkers during frontal functional tasks has sometimes been difficult in children with AD/HD. This study aimed to investigate frontal inhibitory function objectively in children with AD/HD during "rock, paper, scissors" (RPS) tasks, as a familiar game for Japanese children, using near-infrared spectroscopy (NIRS)...
January 13, 2017: Brain & Development
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