keyword
MENU ▼
Read by QxMD icon Read
search

Neurologic deficit

keyword
https://www.readbyqxmd.com/read/29161368/management-of-cardiac-tamponade-in-catheter-ablation-of-atrial-fibrillation-single-centre-15%C3%A2-year-experience-on-5222-procedures
#1
Rikuta Hamaya, Shinsuke Miyazaki, Hiroshi Taniguchi, Shigeki Kusa, Hiroaki Nakamura, Hitoshi Hachiya, Takatsugu Kajiyama, Tomonori Watanabe, Miyako Igarashi, Kenzo Hirao, Yoshito Iesaka
Aims: Cardiac tamponade during atrial fibrillation (AF) ablation is infrequent but potentially fatal. This study aimed to retrospectively investigate the incidence, management, and outcomes of tamponade in large patient series. Methods and results: The study analysed 5222 AF ablation procedures in 3483 patients between 2002 and 2016 under a heparin-bridge anticoagulation protocol. Cardiac tamponade occurred in 51 procedures/patients, and the incidence was 0...
November 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29161264/proprioceptive-assessment-in-clinical-settings-evaluation-of-joint-position-sense-in-upper-limb-post-stroke-using-a-robotic-manipulator
#2
Sara Contu, Asif Hussain, Simone Kager, Aamani Budhota, Vishwanath A Deshmukh, Christopher W K Kuah, Lester H L Yam, Liming Xiang, Karen S G Chua, Lorenzo Masia, Domenico Campolo
Proprioception is a critical component for motor functions and directly affects motor learning after neurological injuries. Conventional methods for its assessment are generally ordinal in nature and hence lack sensitivity. Robotic devices designed to promote sensorimotor learning can potentially provide quantitative precise, accurate, and reliable assessments of sensory impairments. In this paper, we investigate the clinical applicability and validity of using a planar 2 degrees of freedom robot to quantitatively assess proprioceptive deficits in post-stroke participants...
2017: PloS One
https://www.readbyqxmd.com/read/29161257/regulation-of-camp-and-gsk3-signaling-pathways-contributes-to-the-neuronal-conversion-of-glioma
#3
Jinsoo Oh, Yongbo Kim, Lihua Che, Jeong Beom Kim, Gyeong Eon Chang, Eunji Cheong, Seok-Gu Kang, Yoon Ha
Glioma is the most malignant type of primary central nervous system tumors, and has an extremely poor prognosis. One potential therapeutic approach is to induce the terminal differentiation of glioma through the forced expression of pro-neural factors. Our goal is to show the proof of concept of the neuronal conversion of C6 glioma through the combined action of small molecules. We investigated the various changes in gene expression, cell-specific marker expression, signaling pathways, physiological characteristics, and morphology in glioma after combination treatment with two small molecules (CHIR99021, a glycogen synthase kinase 3 [GSK3] inhibitor and forskolin, a cyclic adenosine monophosphate [cAMP] activator)...
2017: PloS One
https://www.readbyqxmd.com/read/29160692/s100a9-protein-aggregates-boost-hippocampal-glutamate-modifying-monoaminergic-neurochemistry-a-glutamate-antibody-sensitive-outcome-on-alzheimer-like-memory-decline
#4
Marina A Gruden, Tatiana V Davydova, Vladimir S Kudrin, Chao Wang, Victor B Narkevich, Ludmilla A Morozova-Roche, Robert D E Sewell
Alzheimer's disease (AD) involves dementia conceivably arising from integrated inflammatory processes, amyloidogenesis and neuronal apoptosis. Glutamate can also cause neuronal death via excitotoxicity and this is similarly implicated in some neurological diseases. The aim was to examine treatment with in vitro generated pro-inflammatory protein S100A9 aggregate species alone or with glutamate antibodies (Glu-Abs) on Morris water maze (MWM) spatial learning and memory performance in 12-month old mice. Amino acid and monoamine cerebral neurotransmitter metabolic changes were concurrently monitored...
November 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29160411/spirometry-in-schoolchildren-for-field-studies-does-testing-on-different-days-change-the-result-of-the-exam
#5
Janaina Cristina Scalco, Rafaela Coelho Minsky, Camila Isabel Santos Schivinski
OBJECTIVE: To analyze if there is variation in the results of spirometry performed by healthy schoolchildren on different days. METHODS: Cross-sectional study with healthy schoolchildren aged 7 to 12 years old, in Florianópolis, Santa Catarina, Southern Brazil. Prepubescent children, non-athletes, born at full term, without cardiorespiratory, rheumatic, musculoskeletal, neurological and visual or hearing deficit were included. The child's health was assessed by a health questionnaire and by the survey International Study of Asthma and Allergies in Childhood...
November 13, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29160373/the-role-of-histone-deacetylase-inhibitors-in-regulation-of-akt-gsk-3%C3%AE-signaling-pathway-in-mice-following-transient-focal-cerebral-ischemia
#6
Bo Zhao, Lian Liu, Yan Leng, Quan Yuan, Jiabao Hou, Yang Wu, Wenwei Gao
PURPOSE: To investigate whether the neuroprotective effect of TSA on cerebral ischemia reperfusion injury is mediated by the activation of Akt/GSK-3β signaling pathway. METHODS: Mice were randomly divided into four groups (n=15): sham group (S); ischemia reperfusion group (IR); ischemia reperfusion and pretreated with TSA group (IR+T); ischemia reperfusion and pretreated with TSA and LY294002 group (IR+T+L). The model of cerebral ischemia reperfusion was established by 1h of MCAO following 24h of reperfusion...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29160008/clinical-diagnosis-and-treatment-outcomes-for-parapharyngeal-space-schwannomas-a-single-institution-review-of-21-cases
#7
Yoichiro Sato, Yorihisa Imanishi, Toshiki Tomita, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoshihiro Watanabe, Mariko Sekimizu, Kaoru Ogawa
BACKGROUND: Because the incidence of schwannoma arising from the parapharyngeal space (PPS) is very low, no studies have analyzed extirpation methods and postoperative neurological complications exclusively in PPS schwannomas. METHODS: The preoperative diagnosis and clinical outcomes of surgical treatment in 21 patients with PPS schwannoma who underwent surgery were investigated. RESULTS: Neurological deficit of the involved nerve developed in all patients regardless of the extirpation method used...
November 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/29159732/the-pgc-1%C3%AE-activator-zln005-ameliorates-ischemia-induced-neuronal-injury-in-vitro-and-in-vivo
#8
Yazhou Xu, John Alimamy Kabba, Wenchen Ruan, Yunjie Wang, Shunyi Zhao, Xiaoyue Song, Luyong Zhang, Jia Li, Tao Pang
Oxidative stress is a great challenge to neurons following cerebral ischemia. PGC-1α has been shown to act as a potent modulator of oxidative metabolism. In this study, the effects of ZLN005, a small molecule that activate PGC-1α, against oxygen-glucose deprivation (OGD)- or ischemia-induced neuronal injury in vitro and in vivo were investigated. Transient middle cerebral artery occlusion (tMCAO) was performed in rats and ZLN005 was administered intravenously at 2 h, 4 h, or 6 h after ischemia onset. Infarct volume and neurological deficit score were detected to evaluate the neuroprotective effects of ZLN005...
November 20, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29157263/ldl-receptor-blockade-reduces-mortality-in-a-mouse-model-of-ischaemic-stroke-without-improving-tissue-type-plasminogen-activator-induced-brain-haemorrhage-towards-pre-clinical-simulation-of-symptomatic-ich
#9
Be'eri Niego, Brad R S Broughton, Heidi Ho, Christopher G Sobey, Robert L Medcalf
BACKGROUND: Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstacle for a broader uptake of this beneficial treatment. rt-PA also undermines cerebral vasculature stability in a multimodal process which involves engagement with LDL receptor-related protein 1 (LRP-1), potentially underlying the development of sICH...
November 21, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29157191/neuronal-vacuolization-in-feline-panleukopenia-virus-infection
#10
Vanessa M Pfankuche, Wendy K Jo, Erhard van der Vries, Nicole Jungwirth, Stephan Lorenzen, Albert D M E Osterhaus, Wolfgang Baumgärtner, Christina Puff
Feline panleukopenia virus (FPV) infections are typically associated with anorexia, vomiting, diarrhea, neutropenia, and lymphopenia. In cases of late prenatal or early neonatal infections, cerebellar hypoplasia is reported in kittens. In addition, single cases of encephalitis are described. FPV replication was recently identified in neurons, although it is mainly found in cells with high mitotic activity. A female cat, 2 months old, was submitted to necropsy after it died with neurologic deficits. Besides typical FPV intestinal tract changes, multifocal, randomly distributed intracytoplasmic vacuoles within neurons of the thoracic spinal cord were found histologically...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29155979/epigenetic-editing-of-the-dlg4-psd95-gene-improves-cognition-in-aged-and-alzheimer-s-disease-mice
#11
Fernando J Bustos, Estibaliz Ampuero, Nur Jury, Rodrigo Aguilar, Fahimeh Falahi, Jorge Toledo, Juan Ahumada, Jaclyn Lata, Paula Cubillos, Berta Henríquez, Miguel V Guerra, Jimmy Stehberg, Rachael L Neve, Nibaldo C Inestrosa, Ursula Wyneken, Marco Fuenzalida, Steffen Härtel, Miguel Sena-Esteves, Lorena Varela-Nallar, Marianne G Rots, Martin Montecino, Brigitte van Zundert
The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzheimer's disease and Huntington's disease. The epigenetic mechanisms that (dys)regulate transcription of Dlg4/PSD95, or other plasticity genes, are largely unknown, limiting the development of targeted epigenome therapy. We analysed the Dlg4/PSD95 epigenetic landscape in hippocampal tissue and designed a Dlg4/PSD95 gene-targeting strategy: a Dlg4/PSD95 zinc finger DNA-binding domain was engineered and fused to effector domains to either repress (G9a, Suvdel76, SKD) or activate (VP64) transcription, generating artificial transcription factors or epigenetic editors (methylating H3K9)...
November 16, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29155066/unruptured-versus-ruptured-avms-outcome-analysis-from-a-multicentric-consecutive-series-of-545-surgically-treated-cases
#12
Marco Cenzato, Fulvio Tartara, Giuseppe D'Aliberti, Carlo Bortolotti, Francesco Cardinale, Gianfranco Ligarotti, Alberto Debernardi, Alessia Fratianni, Edoardo Boccardi, Roberto Stefini, Francesco Zenga, Riccardo Boccaletti, Andrea Lanterna, Giacomo Pavesi, Paolo Ferroli, Carmelo Sturiale, Alessandro Ducati, Andrea Cardia, Maurizio Piparo, Luca Valvassori, Mariangela Piano
Recent literature strongly challenged indications to perform preventive surgery in unruptured AVM. claiming that invasive AVM treatment is associated with a significant risk of complications and thus conservative management may be a preferable alternative in many patients. On the other hand, the recent improvement of surgical instrumentation and treatment strategies (both surgical and interventional) yielded much better outcomes than those achieved only a decade ago. Therefore, even among the specialists, a wide variety of opinions, concerning the treatment of unruptured AVM, can be found...
November 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29154998/intraoperative-vertebroplasty-during-surgical-decompression-and-instrumentation-for-aggressive-vertebral-hemangiomas-a-retrospective-study-of-39-patients-and-review-of-the-literature
#13
Ben Wang, Song Bo Han, Liang Jiang, Xiao Guang Liu, Shao Min Yang, Na Meng, Feng Wei, Zhong Jun Liu
BACKGROUND CONTEXT: Aggressive (Enneking Stage 3, S3) vertebral hemangiomas (VHs) are rare, which might require surgery. However, the choice of surgery for S3 VHs remains controversial because of the rarity of these lesions. PURPOSE: We reported our experience of treating S3 VHs, and evaluated the effectiveness and safety of intraoperative vertebroplasty during decompression surgery for S3 VHs. STUDY DESIGN: This is a retrospective study. PATIENT SAMPLE: Thirty-nine patients with a definitive pathological diagnosis of aggressive VHs who underwent primary decompression surgery in our department were included in this study...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154937/effect-of-human-recombinant-prourokinase-rhpro-uk-on-thromboembolic-stroke-in-rats
#14
Chun-Hua Hao, Wen-Xia Ding, Qian Sun, Xin-Xin Li, Wei-Ting Wang, Zhuan-You Zhao, Li-da Tang
We evaluated the efficacy and safety of human recombinant prourokinase ( rhpro-UK) on thromboembolic stroke in rats. 60 rats with thromboembolic stroke were divided into 6 groups(n=10). The model group was given saline, the reagent groups were given rhpro-UK (5, 10, 20×10(4) U/kg), and positive control groups were given urokinase (UK) 10×10(4) U/kg and recombinant tissue plasminogen activator (rt-PA) 9mg/kg through intravenous infusion at 1.5h after embolism. And other 10 rats without occluded by autologous blood clots as the sham group were given saline...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154389/latent-autoimmune-diabetes-and-limbic-encephalitis-with-antibodies-against-glutamic-acid-decarboxylase
#15
Stoyan Popkirov, Seena Sebastian, Fatme Seval Ismail, Jörg Wellmer
Antibodies against glutamic acid decarboxylase (GAD) are a hallmark of type 1 diabetes and its late-onset variant, latent autoimmune diabetes of the adult (LADA).(1) While cerebrovascular disease and dementia are common causes of cognitive dysfunction and neurological deficits in diabetic patients,(2,3) rare autoimmune disorders of the central nervous system such as stiff-person syndrom or limbic encephalits can also occur on the basis of shared GAD autoimmunity.(4,5).
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29154038/dna-damage-and-neurodegenerative-phenotypes-in-aged-ciz1-null-mice
#16
Mohammad Moshahid Khan, Jianfeng Xiao, Damini Patel, Mark S LeDoux
Cell-cycle dysfunction and faulty DNA repair are closely intertwined pathobiological processes that may contribute to several neurodegenerative disorders. CDKN1A interacting zinc finger protein 1 (CIZ1) plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint. Germline or somatic variants in CIZ1 have been linked to several neural and extra-neural diseases. Recently, we showed that germline knockout of Ciz1 is associated with motor and hematological abnormalities in young adult mice...
November 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29153844/treatment-of-brain-disease-in-the-mucopolysaccharidoses
#17
REVIEW
Maurizio Scarpa, Paul J Orchard, Angela Schulz, Patricia I Dickson, Mark E Haskins, Maria L Escolar, Roberto Giugliani
The mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases caused by lysosomal enzyme deficits that lead to glycosaminoglycan accumulation, affecting various tissues throughout the body based on the specific enzyme deficiency. These disorders are characterized by their progressive nature and a variety of somatic manifestations and neurological symptoms. There are established treatments for some MPS disorders, but these mostly alleviate somatic and non-neurological symptoms and do not cure the disease...
October 16, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29153599/lps-induced-cortical-kynurenic-acid-and-neurogranin-nfat-signaling-is-associated-with-deficits-in-stimulus-processing-during-pavlovian-conditioning
#18
A Oliveros, K Wininger, J Sens, M K Larsson, X C Liu, S Choi, A Faka, L Schwieler, G Engberg, S Erhardt, D S Choi
The N-Methyl-d-Aspartate receptor (NMDAR) antagonist kynurenic acid (KYNA) and the post-synaptic calmodulin binding protein neurogranin (Nrgn) have been implicated in neurological and neuropsychiatric conditions including Alzheimer's disease and schizophrenia. This study indicates that systemic dual-lipopolysaccharide (LPS) injections increases KYNA in the medial prefrontal cortex (mPFC), which is accompanied with increased phosphorylation of nuclear factor kappa chain of activated B cells (NFκB) and activation of the nuclear factor of activated T- cells (NFAT)...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29152736/protein-deficiency-decreases-stereotypic-behavior-frequency-and-prevalence-and-activity-in-the-striped-mouse-rhabdomys-dilectus-chakae
#19
Neville Pillay, Rebecca Rimbach
Diverse motivational triggers, including diet, elicit stereotypic behavior. We investigated whether diets comprised of different protein levels but similar levels of energy were associated with the occurrence of locomotor stereotypies in the striped mouse Rhabdomys dilectus chakae. In a first experiment, 20 stereotypic and 20 non-stereotypic (10 subjects per sex and per group) juvenile (40 days old) subjects were placed on baseline (BP), high (HP) or low protein (LP) diet treatments (120 subjects in total)...
November 20, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29152471/internal-carotid-artery-dissection-in-brazilian-jiu-jitsu
#20
Zeferino Demartini, Maxweyd Rodrigues Freire, Roberto Oliver Lages, Alexandre Novicki Francisco, Felipe Nanni, Luana A Maranha Gatto, Gelson Luis Koppe
Carotid artery dissection is a significant cause of stroke in young patients. It may be asymptomatic and go undiagnosed, or minimal transient manifestations may follow, commanding a higher index of suspicion than ordinarily exists to avoid misdiagnosis. Reported herein is a 27-year-old man who suffered extracranial internal carotid artery dissection while practicing a Brazilian Jiu-Jitsu submission maneuver. The patient's condition suddenly deteriorated one week later due to distal embolization and stroke. Despite endovascular treatment, with stenting of the cervical carotid artery, neurologic deficits remained...
June 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
keyword
keyword
70746
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"