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https://www.readbyqxmd.com/read/28550800/2-phthalimidethanol-and-2-phthalimidethyl-nitrate-inhibit-mechanical-allodynia-neutrophil-recruitment-and-cytokine-and-chemokine-production-in-a-murine-model-of-articular-inflammation
#1
Adriana M Godin, Débora P Araújo, Raquel R Menezes, Ana M S de Brito, Ivo S F Melo, Giovanna M E Coura, Leandro F S Bastos, Flávio A Amaral, Mauro M Teixeira, Ângelo de Fátima, Márcio M Coelho, Renes R Machado
BACKGROUND: Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitrate (PTD-NO) in a murine model of antigen-induced articular inflammation. METHODS: Articular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mBSA) in the knee joint of immunized male C57BL/6J mice...
February 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28550789/eversion-stripping-of-the-esophagus-with-intraesophageal-insufflation-a-case-report
#2
Masahiro Kimura, Takaya Nagasaki, Yoshiyuki Kuwabara, Hironori Tanaka, Motoki Hato, Satoshi Taniwaki, Akira Mitsui, Yasuyuki Shibata, Kotaro Mizuno, Yoichiro Mori, Nobuo Ochi, Shuhei Ueno, Yuki Eguchi
INTRODUCTION: Patients with esophageal cancer frequently cannot tolerate thoracotomy due to their overall debilitated condition. Moreover, some patients have severe adhesions in the thoracic cavity. Eversion stripping of the esophagus is an option for resection in these patients. PRESENTATION OF CASE: A 64-year-old man was admitted to our institution with the chief complaint of epigastric pain. Endoscopic examination showed a protruding lesion 22cm from the incisors, with a superficial and circumferential mucosal irregularity on the distal side of the lesion...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28550786/two-giant-peritoneal-loose-bodies-were-simultaneously-found-in-one-patient-a-case-report-and-review-of-the-literature
#3
Qingxing Huang, Aihong Cao, Jun Ma, Zhenhua Wang, Jianhong Dong
INTRODUCTION: Peritoneal loose body(PLB) is usually small, therefore giant Peritoneal loose body(gPLB) with a diameter >5cm has rarely been described in the literatures. We report a case of two gPLB simultaneously found in one patient. PRESENTATION OF CASE: A healthy 79-year-old man palpated himself a solid mass with alternating localizations in his peritoneal cavity 6 months ago. It was not the complaint of frequency of urinatior until he saw the doctor a week ago...
May 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28550270/a-quantitative-evaluation-of-pleural-effusion-on-computed-tomography-scans-using-b-spline-and-local-clustering-level-set
#4
Lei Song, Jungang Gao, Sheng Wang, Youmin Guo
Estimation of the pleural effusion's volume is an important clinical issue. The existing methods cannot assess it accurately when there is large volume of liquid in the pleural cavity and/or the patient has some other disease (e.g. pneumonia). In order to help solve this issue, the objective of this study is to develop and test a novel algorithm using B-spline and local clustering level set method jointly, namely BLL. The BLL algorithm was applied to a dataset involving 27 pleural effusions detected on chest CT examination of 18 adult patients with the presence of free pleural effusion...
May 24, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28549955/a-peculiar-case-of-type-1-endoleak-after-nellix-endovascular-aneurysm-sac-sealing-clinical-presentation-and-management
#5
O Martinelli, L Irace, R Gattuso, C Belli, M Fresilli, B Gossetti
We report one case of type 1 endoleak (EL) with an outflow via a lumbar artery following Nellix endovascular aneurysm sealing (EVAS) in order to discuss the specific peculiarities and management of this complication. A 64-year-old man ( ASA 3) underwent Nellix EVAS for an asymptomatic infra-renal aortic aneurysm. The 6-month Duplex scanning ultrasound and magnetic resonance imaging showed a type IA endoleak with an outflow via a lumbar artery (LA) combined with a stable aneurysmal sac size. The subsequent 9-month imaging controls showed no changes of the endoleak cavity but there was a slight enlargement in proximal neck size associated with the distal migration of both Nellix grafts...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549261/small-spontaneously-ruptured-gastrointestinal-stromal-tumor-in-the-small-intestine-causing-hemoperitoneum-a-case-report
#6
Shuichi Fukuda, Yoshinori Fujiwara, Tomoko Wakasa, Keisuke Inoue, Kotaro Kitani, Hajime Ishikawa, Masanori Tsujie, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
INTRODUCTION: Gastrointestinal stromal tumors (GISTs) are clinically asymptomatic until they reach a significant size; therefore, GISTs that are 2cm or less are typically asymptomatic. Patients with symptomatic GISTs typically present with abdominal pain, gastrointestinal bleeding, or a palpable mass but rarely present with hemoperitoneum. PRESENTATION OF CASE: A 72-year-old Japanese man presented to us with acute onset abdominal pain. Physical examination showed peritoneal irritation in the lower abdomen...
May 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28549260/identification-of-oral-cavity-biofilm-forming-bacteria-and-determination-of-their-growth-inhibition-by-acacia-arabica-tamarix-aphylla-l-and-melia-azedarach-l-medicinal-plants
#7
Muhammad Khalid, Danial Hassani, Muhammad Bilal, Zahid Ali Butt, Muhammad Hamayun, Ayaz Ahmad, Danfeng Huang, Anwar Hussain
OBJECTIVE: Biofilms are complex, multi-species bacterial communities that colonize the oral cavity in the form of plaque and are known to cause dental caries and periodontal disease. Present study demonstrated the potential of three selected medicinal plants against isolated and identified dental biofilm forming strains. METHODS: Pathogenic bacteria from dental biofilms were isolated, cultured, identified by phylogenetic analysis using PCR-based 16S ribosomal RNA (or 16S rRNA) nucleotide sequences and were analyzed for their biofilm forming capability...
May 18, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28548883/simultaneous-detection-of-oral-pathogens-in-subgingival-plaque-and-prostatic-fluid-of-men-with-periodontal-and-prostatic-diseases
#8
John Estemalik, Catherine Demko, Nabil F Bissada, Nishant Joshi, Donald Bodner, Eswar Shankar, Sanjay Gupta
BACKGROUND: Chronic prostatitis (CP) and benign prostatic hyperplasia (BPH) are complex inflammatory conditions for which the etiological determinants are still poorly defined. Periodontitis is caused by subgingival colonizing bacteria in the oral cavity. The causal effect of periodontal disease on prostatic inflammation has not been established. The purpose of this study is to isolate oral pathogens from expressed prostatic secretions of patients with periodontal disease and chronic prostatitis or benign prostatic hyperplasia...
May 26, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28548826/protein-nanocage-based-photo-controlled-nitric-oxide-releasing-platform
#9
Xiao Li, Yajie Zhang, Jian Sun, Weijian Chen, Xuewei Wang, Fenli Shao, Yuyu Zhu, Fude Feng, Yang Sun
A photoactive NO releasing system was constructed by incorporation of NO-bound Fe-S clusters into horse spleen apoferritin cavities with high loading efficacy. The composites retained intact core-shell structure and indicated advantages such as enhanced stability, reduced cytotoxicity, efficient cellular uptake, and photo-controlled NO releasing property.
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28548658/distinctive-microbiomes-and-metabolites-linked-with-weight-loss-after-gastric-bypass-but-not-gastric-banding
#10
Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown
Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) are anatomically different bariatric operations. RYGB achieves greater weight loss compared with LAGB. Changes in the gut microbiome have been documented after RYGB, but not LAGB, and the microbial contribution to sustainable surgical weight loss warrants further evaluation. We hypothesized that RYGB imposes greater changes on the microbiota and its metabolism than LAGB, and that the altered microbiota may contribute to greater weight loss...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548570/embolic-mycotic-encephalitis-in-a-cow-following-mortierella-wolfii-infection-of-a-surgery-site
#11
Benjamin Curtis, Charlotte Hollinger, Ailam Lim, Matti Kiupel
A 5-y-old Holstein dairy cow had surgery for a suspected displaced abomasum 10 d postpartum, developed acute neurologic signs at day 19, and was found dead 21 d postpartum. At autopsy, there was a peri-incisional intramuscular abscess that communicated with the peritoneal cavity, as well as hemorrhage and malacia involving the brain, and multiple nodules in the liver, kidneys, and lungs. Fungal hyphae were seen histologically at the surgery site, on the surface of the liver, and in lesions of severe necrotizing vasculitis in the lungs, kidneys, brain, and liver...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28548537/dispersive-time-delay-dynamical-systems
#12
Alexander Pimenov, Svetlana Slepneva, Guillaume Huyet, Andrei G Vladimirov
We present a theoretical approach to investigate the effect of dispersion in dynamical systems commonly described by time-delay models. The introduction of a polarization equation provides a means to introduce dispersion as a distributed delay term. The expansion of this term in power series, as usually performed to study the propagation of waves in spatially extended systems, can lead to the appearance of spurious instabilities. This approach is illustrated using a long cavity laser, where in the normal dispersion regime both the experiment and theory show a stable operation, while a modulation instability, commonly referred as the Benjamin-Feir instability, is observed in the anomalous dispersion regime...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548534/erratum-realization-of-the-dicke-model-using-cavity-assisted-raman-transitions-phys-rev-lett-113-020408-2014
#13
Markus P Baden, Kyle J Arnold, Arne L Grimsmo, Scott Parkins, Murray D Barrett
This corrects the article DOI: 10.1103/PhysRevLett.113.020408.
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548485/clinically-relevant-detection-of-streptococcus-pneumoniae-with-dna-antibody-nanostructures
#14
Jinping Wang, May Ching Leong, Eric Zhewei Leong, Win Sen Kuan, David T Leong
Streptococcus pneumoniae (SP) is a pathogenic bacterium and a major cause of community-acquired pneumonia that could be fatal if left untreated. Therefore, rapid and sensitive detection of SP is crucial to enable targeted treatment during SP infections. In this study, DNA tetrahedron (DNA TH) with a hollow structure is anchored on gold electrodes to construct an electrochemical immunosensor for rapid detection of pneumococcal surface protein A (PspA) peptide and SP lysate from synthetic and actual human samples...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28548328/epithelioid-trophoblastic-tumor-of-the-uterus-a-case-report-with-radiologic-pathologic-correlation
#15
Ayumi Ohya, Kayoko Higuchi, Hisashi Shimojo, Yasunari Fujinaga, Masumi Kadoya, Shigeki Shiohara
Herein, we report a rare case of an epithelioid trophoblastic tumor of the uterus with radiologic-pathologic correlation in a 56-year-old postmenopausal woman. On T2-weighted magnetic resonance (MR) imaging, the tumor appeared as a hypointense irregular mass compared with the surrounding myometrium of the uterine corpus and encircled the cavity of the lower uterine segment. On dynamic contrast-enhanced MR images, the tumor appeared as a hypovascular mass and an inhomogeneously hyperintense mass in the delayed phase...
May 26, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28548290/metacarpal-growth-during-adolescence-in-a-longitudinal-south-african-cohort
#16
A Magan, L H Nyati, L K Micklesfield, S A Norris, J M Pettifor
To monitor the drift of the periosteal and endocortical surfaces during metacarpal growth longitudinally, radiogrammetry was carried out on hand-wrist x-rays of 572 children from the Birth to Twenty Bone Health Cohort annually from ages 9-21 years. This is the largest collection of longitudinal x-rays in African children. The 2(nd) metacarpal bone length, bone width and medullary width were measured using digital vernier callipers on a total of 4730 x-rays. Superimposition by Translation and Rotation (SITAR) was used to obtain age at peak metacarpal length velocity (PLV)...
May 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28548231/combination-therapy-with-telmisartan-and-parecoxib-induces-regression-of-endometriotic-lesions
#17
Anca Nenicu, Yuan Gu, Christina Körbel, Michael D Menger, Matthias W Laschke
BACKGROUND AND PURPOSE: Telmisartan suppresses the development of endometriotic lesions. However, the drug also up-regulates the expression of cyclooxygenase (COX)-2, which has been suggested to promote the progression of endometriosis. Accordingly, we herein analysed whether a combination therapy with telmisartan and a COX-2 inhibitor may be more effective in the treatment of endometriotic lesions than application of telmisartan alone. EXPERIMENTAL APPROACH: Endometriotic lesions were induced in the peritoneal cavity of C57BL/6 mice, which were daily treated with an intraperitoneal (i...
May 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28548030/everolimus-inhibited-multiple-isoforms-of-udp-glucuronosyltransferases-ugts
#18
Zuo Du, Guang Wang, Yun-Feng Cao, Cui-Min Hu, Kun Yang, Yong-Zhe Liu, Chun-Ze Zhang, Wei-Hua Zhang, Zhi-Tu Zhu, Hong-Zhi Sun, Xiao-Yu Sun, Mo Hong, Zhong-Ze Fang
1. Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and has been clinically utilized to prevent the rejection of organ transplants. This study aims to determine the inhibition of everolimus on the activity of phase II drug-metabolizing enzymes UDP-glucuronosyltransferases (UGTs). 2. The results showed that 100 uM of everolimus exerted more than 80% inhibition towards UGT1A1, -1A3, and -2B7. UGT1A3 and UGT2B7 were selected to elucidate the inhibition mechanism, and in silico docking showed that hydrogen bonds and hydrophobic interactions mainly contributed to the strong binding of everolimus towards the activity cavity of UGT1A3 and UGT2B7...
May 26, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28547929/tehran-s-tie-a-simple-trick-to-fix-the-trocar-to-the-abdominal-wall-and-close-the-entry-site-of-first-trocar-in-laparoscopic-surgery
#19
Bijan Mohammadhosseini
INTRODUCTION: Trocar dislodgment can occur frequently during minimally invasive surgery. Closing the entry port at the fascial layer after the end of a long laparoscopic surgery is time-consuming. Here, I introduce Tehran's Tie, a simple trick to overcome these problems. MATERIALS AND SURGICAL TECHNIQUE: After the first trocar site has been created with the open technique and before the first port is inserted, the fascial wound is grasped with a loop of nylon thread, similar to a transverse matrix suture...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28547928/application-of-endobronchial-ultrasonography-in-laparoscopic-liver-segmentectomy-in-an-animal-model
#20
Tomoyuki Abe, Tsuyoshi Kobayashi, Seiichi Shimizu, Michinori Hamaoka, Hiroshi Iwako, Masakazu Hashimoto, Yoshihiro Mikuriya, Shintaro Kuroda, Hirotaka Tashiro, Hideki Ohdan
INTRODUCTION: This study investigated whether laparoscopic ultrasound-guided segment staining and real-time ultrasound-guided hepatectomy, with endobronchial ultrasonography equipped with a guide sheath, would be useful for laparoscopic liver segmentectomy in a porcine model. MATERIAL AND SURGICAL TECHNIQUE: The abdominal cavity (in two pigs) was reached via a 12-mm umbilical trocar. An artificial tumor was created by radiofrequency ablation within the intended resection area...
May 2017: Asian Journal of Endoscopic Surgery
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