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https://www.readbyqxmd.com/read/29166764/merkel-cell-carcinoma-metastatic-to-pleural-fluid-a-case-report
#1
Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional and distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases had been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC could give patients good chances to get recently advanced therapeutic options...
November 23, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29166561/structural-characterization-of-native-and-modified-encapsulins-as-nanoplatforms-for-in-vitro-catalysis-and-cellular-uptake
#2
Rindia M Putri, Carolina Allende-Ballestero, Daniel Luque, Robin Klem, Katerina-Asteria Rousou, Aijie Liu, Christoph H-H Traulsen, W Frederik Rurup, Melissa S T Koay, Jose R Castón, Jeroen J L M Cornelissen
Recent years have witnessed the emergence of bacterial semi-organelle encapsulins as promising platforms for bio-nanotechnology. To advance the development of encapsulins as nanoplatforms, a functional and structural basis of these assemblies is required. Encapsulin from Brevibacterium linens is known to be a protein-based vessel for an enzyme cargo in its cavity, which could be replaced with a foreign cargo resulting in a modified encapsulin. Here, we characterize the native structure of B. linens encapsulins with both native and foreign cargo using cryo-electron microscopy (cryo-EM)...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29166425/anatomy-of-the-sphenopalatine-artery-and-its-implications-for-transnasal-neurosurgery
#3
M Eordogh, A Grimm, I Gawish, L Patonay, R Reisch, H R Briner, G Baksa
BACKGROUND: The knowledge of sinonasal vasculature is inevitable in transnasal neurosurgery. We performed an anatomical study on the sphenopalatine artery from the perspective of skull base procedures. METHODOLOGY: To analyse the anatomical landmarks of the sphenopalatine artery, arterial skull corrosion casts (26 head halves) underwent endoscopic transnasal phantom surgery. Furthermore, we performed microsurgical dissection on formaldehyde-fixated cadavers with arterial perfusion (14 head halves) as well as studied Cone Beam CT-scans of anonymised patients and cadavers (115 head sides)...
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29166313/the-perineal-turnover-perforator-flap-a-new-and-simple-technique-for-perineal-reconstruction-after-extralevator-abdominoperineal-excision
#4
Maria Chasapi, Mohamed Maher, Peter Mitchell, Milind Dalal
BACKGROUND: Extralevator abdominoperineal excision (ELAPE) is increasingly used to treat locally advanced low rectal cancer as it has been related to superior oncological outcomes than traditional abdominoperineal excision.However, ELAPE also has been associated with high perineal wound morbidity rates as it creates a larger perineal cavity than standard abdominoperineal excision. This greater defect, along with the effects of preoperative chemoradiation on wound healing, makes uneventful perineal reconstruction post-ELAPE a real challenge for the plastic surgeon...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166126/nutrient-sensing-biology-in-mammals-and-birds
#5
Eugeni Roura, Simon R Foster
Nutrient sensing mechanisms have emerged as the fringe articulating nutritional needs with dietary choices. Carbohydrate, amino acid, fatty acid, mineral, and water sensing receptors are highly conserved across mammals and birds, consisting of a repertoire of 22 genes known to date. In contrast, bitter receptors are highly divergent and have a high incidence of polymorphisms within and between mammals and birds and are involved in the adaptation of species to specific environments. In addition, the expression of nutrient sensing genes outside the oral cavity seems to mediate the required decision-making dialogue between the gut and the brain by translating exogenous chemical stimuli into neuronal inputs, and vice versa, to translate the endogenous signals relevant to the nutritional status into specific appetites and the control of feed intake...
November 20, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29166033/mapping-nanoscale-hotspots-with-single-molecule-emitters-assembled-into-plasmonic-nanocavities-using-dna-origami
#6
Rohit Chikkaraddy, V A Turek, Nuttawut Kongsuwan, Felix Benz, Cloudy Carnegie, Tim Van De Goor, Bart de Nijs, Angela Demetriadou, Ortwin Hess, Ulrich F Keyser, Jeremy J Baumberg
Fabricating nanocavities in which optically-active single quantum emitters are precisely positioned, is crucial for building nanophotonic devices. Here we show that self-assembly based on robust DNA-origami constructs can precisely position single molecules laterally within sub-5nm gaps between plasmonic substrates that support intense optical confinement. By placing single-molecules at the center of a nanocavity, we show modulation of the plasmon cavity resonance before and after bleaching the chromophore, and obtain enhancements of ≥ 4×10(3) with high quantum yield (≥ 50%)...
November 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/29165750/our-experience-in-the-management-of-csf-otorrhea-a-transmastoid-approach-with-middle-ear-cavity-obliteration-and-a-middle-cranial-fossa-approach
#7
Asli Cakir Cetin, Nuri Karabay, Enis Alpin Guneri
In this report, we present two cases of patients with cerebrospinal fluid (CSF) otorrhea who underwent surgical repair through either a transmastoid or middle cranial fossa approach. In our first case, a 34-year-old male after head trauma with conductive hearing loss and a House-Brackmann grade 2 facial palsy was found to have a soft tissue mass protruding through his right tympanic membrane. Radiological examination revealed a wide tegmen tympani defect. He underwent surgery via a transmastoid approach with repair of the defect and blind sac closure of the external auditory canal after middle ear cavity obliteration...
November 1, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165409/-mo-dified-scleral-buckling-for-additional-fixation-of-the-retina-with-endovitreal-magnetic-implant-experimental-study
#8
E G Kazimirova, V V Shiryaev, P V Lyskin, E Yu Kramarenko
Scleral buckling (SB) has been regaining its popularity in the treatment of retinal detachments. On large clinical material, it has been proved to be the technique of choice in phakic patients with retinal detachment of moderate severity. A combined procedure that incorporates features of episcleral as well as intravitreal surgeries has also become widely used. Aim - to investigate the prospects for increasing technical potential of SB, particularly, to investigate the possibility of additional atraumatic mechanical fixation of the retina from within the vitreous cavity...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165408/-mitomycin-c-after-endoscopic-endonasal-dacryocystorhinostomy
#9
E L At'kova, G V Ramenskaya, A O Root, N N Krakhovetskiy, V D Yartsev, S D Yartsev, A E Petukhov, I E Shokhin
Mitomycin-C (MMC) is the most frequently used agent for prevention of excessive scarring at the osteotomy site after endoscopic endonasal dacryocystorhinostomy (EEDCR), which, however, being applied during the final stage of the surgery, shows questionable effectiveness. AIM: to evaluate the effectiveness of a new administration route of mitomycin C in EEDCR. MATERIAL AND METHODS: The study included 86 patients (95 cases) in the age range of 62.3±9 years with primary acquired nasolacrimal duct obstruction...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165406/-the-significance-of-fibroblasts-in-experimental-modeling-of-proliferative-vitreoretinopathy
#10
I P Khoroshilova-Maslova, N L Leparskaya, E A Vorotelyak, A V Vasiliev
AIM: to investigate the role of heterogeneous fibroblasts in the development of epiretinal membrane in eyes with modeled proliferative vitreoretinopathy. MATERIAL AND METHODS: The material for investigation were 6 eyes of 3 Chinchilla rabbits. Suspended fibroblasts (fibroblasts of the human skin - 200000 cells in 0.1 ml) were injected into the vitreous cavity via the pars plana. The animals were followed up for 1 month and then made out of the experiment. The eyes were enucleated and fixed in 10% neutral buffered formalin for routine histological examination...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165077/physicochemical-and-toxic-properties-of-novel-genipin-drug-delivery-systems-prepared-by-mechanochemistry
#11
Wenhao Xu, Murong Wen, Weike Su, Alexander V Dushkin, Lubov P Suntsova, Irina D Markova, Olga Yu Selyutina, Nikolay E Polyakov
Complexes of Genipin and differents water-soluble adjuvant polysaccharides such as arabinogalactane, hydroxyethyl starch, fibergum,and oligosaccharides β-CD and HP-β-CD,were synthesized as drug delivery system using mechanochemical technology. We have investigated physicochemical properties, stability, and hepatotoxicity of the synthesized complexes in solid state and aqueous solution. The formation of the complexes was evidenced by different physical and spectroscopy assays, and the stability constants of our synthesized Genipin-based complexes were also calculated...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29165026/comparative-evaluation-of-oral-and-dento-maxillofacial-manifestation-of-patients-with-sickle-cell-diseases-and-beta-thalassemia-major
#12
Salmeh Kalbassi, Mohammad Reza Younesi, Vahid Asgary
BACKGROUND: Regarding the importance of oral and dental health in patients with hemoglobinopathies and also due to the different results of different studies in this background, in patients with beta thalassemia (BTM) and sickle cell disease (SCD), this study aimed to evaluate and compare the oral and dental manifestations of patients with BTM and SCD. MATERIAL AND METHODS: In this cross-sectional study during the years 2014-2017, a total of 175 patients (with documented BTM or SCD attending to Tehran, Mashhad, Isfahan, and Tabriz cities central hospitals) were randomly recruited...
November 22, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29164856/aerosol-crosslinked-crown-ether-diols-melded-with-poly-vinyl-alcohol-as-specialized-microfibrous-li-adsorbents
#13
Lawrence A Limjuco, Grace Masbate Nisola, Rey Eliseo Castillo Torrejos, Jeong Woo Han, Ho Seong Song, Khino J Parohinog, Sangho Koo, Seong-Poong Lee, Wook-Jin Chung
Crown ether (CE)-based Li(+) adsorbent microfibers (MFs) were successfully fabricated through a combined use of CE diols, electrospinning, and aerosol crosslinking. The 14-16 membered CEs, with varied ring sub-units and cavity dimensions, have two hydroxyl groups for covalent attachments to poly(vinyl alcohol) (PVA) as the chosen matrix. The CE diols were blended with PVA and transformed into microfibers via electrospinning, a highly effective technique in minimizing CE loss during MF fabrication. Subsequent aerosol glutaraldehyde (GA) crosslinking of the electrospun CE/PVA MFs stabilized the adsorbents in water...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29164566/drug-related-oral-malodour-halitosis-a-literature-review
#14
M Torsten, G Gómez-Moreno, A Aguilar-Salvatierra
Dry mouth (xerostomia), is a fairly common, well-researched condition, which is an indirect cause of oral malodour. This systematic literature review looked into another cause of bad breath: adverse drug reactions in the orofacial region causing halitosis. The study focused on extraoral halitosis, and its subdivisions, particularly blood borne halitosis in which malodourous compounds in the blood stream are carried to the lungs, passively diffused across the pulmonary alveolar membrane to enter the breath. An electronic search was conducted in various databases...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164508/eus-guided-transrectal-evacuation-of-organized-pelvic-collection-following-roux-en-y-gastric-bypass-after-failure-of-radiological-and-surgical-approach
#15
Gianfranco Donatelli, Jean-Loup Dumont, Fabrizio Cereatti, Bruto Randone, Bruno Meduri, Panagiotis Lainas, Hadrien Tranchart, Ibrahim Dagher
INTRODUCTION: Postoperative collections are an important cause of morbidity following obesity surgery. Surgical revision is most often required if general sepsis is present. Conservative treatment consists of broad spectrum antibiotics and percutaneous drainage of any collection. EUS drainage is a new technique that is gaining momentum allowing an easy access to collections close to the GI tract. MATERIALS AND METHODS: We present the case report of a 39-year-old woman who underwent to robotic Roux-en-Y gastric bypass for morbid obesity...
November 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29164486/adaptation-and-probiotic-potential-of-lactobacilli-isolated-from-the-oral-cavity-and-intestines-of-healthy-people
#16
Yulia Chervinets, Vyacheslav Chervinets, Boris Shenderov, Ekaterina Belyaeva, Andrey Troshin, Sergey Lebedev, Valery Danilenko
The present study shows that, from 300 Lactobacillus strains isolated from the oral cavity and large intestine of 600 healthy people, only 9 had high antagonistic activity against pathogens and opportunistic pathogens. All antagonistic strains of lactobacilli have been identified by 16S rRNA sequencing and assigned to four species: Lactobacillus fermentum, Lactobacillus rhamnosus, Lactobacillus plantarum, and Lactobacillus casei. In addition, these lactobacilli appeared to be nonpathogenic and had some probiotic potential: the strains produced lactic acid and bacteriocins, showed high sensitivity to broad-spectrum antibiotics, and were capable of forming biofilms in vitro...
November 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29164473/clinicopathological-and-immunohistochemical-study-of-head-and-neck-langerhans-cell-histiocytosis-from-latin-america
#17
Natália Rocha Bedran, Román Carlos, Bruno Augusto Benevenuto de Andrade, Ana Paula Silva Bueno, Mário José Romañach, Cristiane Bedran Milito
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior caused by the accumulation of CD1a(+)/CD207(+) histiocytes, associated with a variable number of eosinophils, lymphocytes, plasma cells and multinucleated giant cells, most commonly observed in male children. LCH is uncommon in the head and neck region, occurring as ulcerated and reddened plaques or nodules that cause destruction of adjacent soft tissues and bone. The exact etiology of LCH is still unknown and controversial, with possible etiologic role of viruses, including Epstein-Barr virus (EBV)...
November 21, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29164415/decrease-of-insoluble-glucan-formation-in-streptococcus-mutans-by-co-cultivation-with-enterococcus-faecium-t7-and-glucanase-addition
#18
Shin-Hye Yu, So-Hyung Kwak, Thi Thanh Hanh Nguyen, Ye-Seul Seo, Chaeri Song, Il Kyoon Mok, Doman Kim
OBJECTIVES: To develop preventive canine oral health bio-materials consisting of probiotics and glucanase to reduce insoluble glucan and volatile sulfur compound formation. RESULTS: Co-cultivation of Enterococcus faecium T7 with Streptococcus mutans at inoculation ratio of 3:1 (v/v) resulted in 25% reduction in the growth of Streptococcus mutans. Amounts of soluble and insoluble glucans produced by S. mutans were decreased to 70 and 55%, respectively. Insoluble glucan was decreased from 0...
November 21, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29164124/sterile-reverse-osmosis-water-combined-with-friction-are-optimal-for-channel-and-lever-cavity-sample-collection-of-flexible-duodenoscopes
#19
Michelle J Alfa, Harminder Singh, Zoann Nugent, Donald Duerksen, Gale Schultz, Carol Reidy, Patricia DeGagne, Nancy Olson
Introduction: Simulated-use buildup biofilm (BBF) model was used to assess various extraction fluids and friction methods to determine the optimal sample collection method for polytetrafluorethylene channels. In addition, simulated-use testing was performed for the channel and lever cavity of duodenoscopes. Materials and methods: BBF was formed in polytetrafluorethylene channels using Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Sterile reverse osmosis (RO) water, and phosphate-buffered saline with and without Tween80 as well as two neutralizing broths (Letheen and Dey-Engley) were each assessed with and without friction...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29162950/intrauterine-insemination-fundamentals-revisited
#20
EDITORIAL
Gautam N Allahbadia
Intrauterine insemination (IUI) is an assisted conception technique that involves the deposition of a processed semen sample in the upper uterine cavity, overcoming natural barriers to sperm ascent in the female reproductive tract. It is a cost-effective, noninvasive first-line therapy for selected patients with functionally normal tubes, and infertility due to a cervical factor, anovulation, moderate male factor, unexplained factors, immunological factor, and ejaculatory disorders with clinical pregnancy rates per cycle ranging from 10 to 20%...
December 2017: Journal of Obstetrics and Gynaecology of India
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