Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Esther Janssen, Jan Willem van Dalen, Mengfei Cai, Mina A Jacob, José Marques, Marco Duering, Edo Richard, Anil M Tuladhar, Frank-Erik de Leeuw, Nina Hilkens
Purpose: There is evidence that blood pressure variability (BPV) is associated with cerebral small vessel disease (SVD) and may therefore increase the risk of stroke and dementia. It remains unclear if BPV is associated with SVD progression over years. We examined whether visit-to-visit BPV is associated with white matter hyperintensity (WMH) progression over 14 years and MRI markers after 14 years. Materials and methods: We included participants with SVD from the Radboud University Nijmegen Diffusion tensor Magnetic resonance-imaging Cohort (RUNDMC) who underwent baseline assessment in 2006 and follow-up in 2011, 2015 and 2020...
December 2024: Blood Pressure
#22
JOURNAL ARTICLE
Luis Prats-Sanchez, Pol Camps-Renom, Philip S Nash, Duncan Wilson, Gareth Ambler, Jonathan G Best, Marina Guasch-Jiménez, Anna Ramos-Pachón, Alejandro Martinez-Domeño, Álvaro Lambea-Gil, Garbiñe Ezcurra Díaz, Daniel Guisado-Alonso, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y Lip, Hakan Ay, Simon Jung, Natan M Bornstein, Thomas Gattringer, Sebastian Eppinger, Dianne H van Dam-Nolen, Masatoshi Koga, Kazunori Toyoda, Felix Fluri, Thanh G Phan, Velandai K Srikanth, Ji Hoe Heo, Hee-Joon Bae, Peter J Kelly, Toshio Imaizumi, Julie Staals, Sebastian Köhler, Yusuke Yakushiji, Dilek Necioglu Orken, Eric E Smith, Joanna M Wardlaw, Francesca M Chappell, Stephen D Makin, Jean-Louis Mas, David Calvet, Régis Bordet, Christopher P Chen, Roland Veltkamp, Nagaendran Kandiah, Robert J Simister, Frank-Erik De Leeuw, Stefan T Engelter, Nils Peters, Yannie O Soo, Annaelle Zietz, Jeroen Hendrikse, Werner H Mess, David J Werring, Joan Marti-Fabregas
BACKGROUND AND OBJECTIVES: The association between statin use and the risk of intracranial hemorrhage (ICrH) following ischemic stroke (IS) or transient ischemic attack (TIA) in patients with cerebral microbleeds (CMBs) remains uncertain. This study investigated the risk of recurrent IS and ICrH in patients receiving statins based on the presence of CMBs. METHODS: We conducted a pooled analysis of individual patient data from the Microbleeds International Collaborative Network, comprising 32 hospital-based prospective studies fulfilling the following criteria: adult patients with IS or TIA, availability of appropriate baseline MRI for CMB quantification and distribution, registration of statin use after the index stroke, and collection of stroke event data during a follow-up period of ≥3 months...
April 9, 2024: Neurology
#23
JOURNAL ARTICLE
Jasmin Annica Keller, Sigurdur Sigurdsson, Bárbara Schmitz Abecassis, Ilse M J Kant, Mark A Van Buchem, Lenore J Launer, Matthias J P van Osch, Vilmundur Gudnason, Jeroen de Bresser
BACKGROUND AND OBJECTIVES: Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals at increased risk for dementia. We aimed to identify different brain MRI phenotypes by hierarchical clustering analysis based on combined neurovascular and neurodegenerative brain MRI markers and to determine the long-term dementia risk within the brain MRI phenotype subgroups. METHODS: Hierarchical clustering analysis based on 32 combined neurovascular and neurodegenerative brain MRI markers in community-dwelling individuals of the Age-Gene/Environment Susceptibility Reykjavik Study was applied to identify brain MRI phenotypes...
April 9, 2024: Neurology
#24
EDITORIAL
Zurab Nadareishvili, Aristeidis H Katsanos, Ashkan Shoamanesh
No abstract text is available yet for this article.
April 9, 2024: Neurology
#25
JOURNAL ARTICLE
Yu Guo, Qing Peng, Chen Ling
No abstract text is available yet for this article.
March 11, 2024: JAMA Neurology
#26
JOURNAL ARTICLE
E A Mkhitaryan, V V Fateeva, P R Kamchatnov
Cerebral amyloid angiopathy (CAA) is a progressive disease characterized by the deposition of β-amyloid in the walls of blood vessels in the brain, which leads to their damage and disruption of normal blood flow. Morphologically, CAA is characterized by both isolated lesions (microhemorrhages with the appearance of cortical superficial siderosis, lacunar infarctions) and widespread changes (hyperintensity of the deep and periventricular white matter, expansion of the perivascular spaces) of cortical and subcortical localization...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#27
JOURNAL ARTICLE
Nashwan Naji, Myrlene Gee, Glen C Jickling, Derek J Emery, Feryal Saad, Cheryl R McCreary, Eric E Smith, Richard Camicioli, Alan H Wilman
T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) is commonly included in brain studies for structural imaging using magnitude images; however, its phase images can provide an opportunity to assess microbleed burden using quantitative susceptibility mapping (QSM). This potential application for MPRAGE-based QSM was evaluated using in vivo and simulated measurements. Possible factors affecting image quality were also explored. Detection sensitivity was evaluated against standard multiecho gradient echo (MEGE) QSM using 3-T in vivo data of 15 subjects with a combined total of 108 confirmed microbleeds...
March 11, 2024: NMR in Biomedicine
#28
REVIEW
Andreas Charidimou, Eric E Smith
Cerebral microbleeds (CMBs) detected on blood-sensitive magnetic resonance imaging sequences are usually a sign of an underlying cerebral small vessel disease such as sporadic cerebral amyloid angiopathy or sporadic nonamyloid small vessel pathology (eg, arteriolosclerosis). Much of the enduring interest in CMBs relates to their high prevalence (partly due to the widespread use of magnetic resonance imaging) in the context of stroke, cognitive impairment and in healthy individuals, and the clinical uncertainties created about the safety of antithrombotic medications due to their association with both future hemorrhagic and ischemic stroke...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
#29
JOURNAL ARTICLE
Hui Hong, Daniel J Tozer, Hugh S Markus
BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia. METHODS: In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
#30
JOURNAL ARTICLE
Zhiliang Zhang, Zhongxiang Ding, Fenyang Chen, Rui Hua, Jiaojiao Wu, Zhefan Shen, Feng Shi, Xiufang Xu
BACKGROUND: Cerebral small vessel disease lacks specific clinical manifestations, and extraction of valuable features from multimodal images is expected to improve its diagnostic accuracy. In this study, we used deep learning techniques to segment cerebral small vessel disease imaging markers in multimodal magnetic resonance images and analyze them with clinical risk factors. METHODS AND RESULTS: We recruited 211 lacunar stroke patients and 83 control patients. The patients' cerebral small vessel disease markers were automatically segmented using a V-shaped bottleneck network, and the number and volume were calculated after manual correction...
2024: International Journal of General Medicine
#31
JOURNAL ARTICLE
Xiao Luo, Hui Hong, Kaicheng Li, Qingze Zeng, Xiaocao Liu, Luwei Hong, Jixuan Li, Xinyi Zhang, Siyan Zhong, Xiaopei Xu, Yanxing Chen, Minming Zhang, Peiyu Huang
BACKGROUND: Financial capacity is vital for the elderly, who possess a substantial share of global wealth but are vulnerable to financial fraud. OBJECTIVE: We explored the link between small vessel disease (SVD) and financial capacity in cognitively unimpaired (CU) older adults via both cross-sectional and longitudinal analyses. METHODS: 414 CU participants underwent MRI and completed the Financial Capacity Instrument-Short Form (FCI-SF). Subsequent longitudinal FCI-SF data were obtained from 104, 240, and 141 participants at one, two, and four years, respectively...
March 8, 2024: Journal of Alzheimer's Disease: JAD
#32
JOURNAL ARTICLE
Regina von Rennenberg, Christian H Nolte, Thomas G Liman, Simon Hellwig, Christoph Riegler, Jan F Scheitz, Marios K Georgakis, Rong Fang, Felix J Bode, Gabor C Petzold, Peter Hermann, Inga Zerr, Michael Goertler, Kathleen Bernkopf, Silke Wunderlich, Martin Dichgans, Matthias Endres
BACKGROUND: Subclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown. METHODS AND RESULTS: We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study...
March 8, 2024: Journal of the American Heart Association
#33
JOURNAL ARTICLE
Emma A Koemans, Ingeborg Rasing, Sabine Voigt, Thijs W van Harten, Reinier G J van der Zwet, Kanishk Kaushik, Manon R Schipper, Nelleke van der Weerd, Erik W van Zwet, Ellis S van Etten, Matthias J P van Osch, Bea Kuiperij, Marcel M Verbeek, Gisela M Terwindt, Steven M Greenberg, Marianne A A van Walderveen, Marieke J H Wermer
BACKGROUND: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. We investigated the presence and abnormality of the most common biomarkers in the largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date. METHODS: We included cross-sectional data from participants with (pre)symptomatic D-CAA and controls without CAA. We investigated CAA-related cerebral small vessel disease markers on 3T-MRI, cerebrovascular reactivity with functional 7T-MRI (fMRI) and amyloid-β40 and amyloid-β42 levels in cerebrospinal fluid...
March 6, 2024: Stroke; a Journal of Cerebral Circulation
#34
JOURNAL ARTICLE
Sensitivity of the Boston Criteria Version 2.0 in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.
Reinier van der Zwet, Emma Koemans, Sabine Voigt, Rosemarie van Dort, Ingeborg Rasing, Kanishk Kaushik, Thijs van Harten, Manon Schipper, Gisela M Terwindt, Thijs van Osch, Marianne Aa van Walderveen, Ellis van Etten, Marieke Wermer
BACKGROUND AND AIM: The revised Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) add two radiological markers to the existing criteria: severe visible perivascular spaces in the centrum semiovale and white matter hyperintensities (WMH) in a multispot pattern. This study aims to determine the sensitivity of the updated criteria in mutation carriers with Dutch-type hereditary CAA (D-CAA) in an early and later disease stage. METHODS: In this cross-sectional study, we included presymptomatic and symptomatic D-CAA mutation carriers from our prospective natural history study (AURORA) at the Leiden University Medical Center between 2018 and 2021...
March 6, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#35
JOURNAL ARTICLE
Hui Zhang, Peng Cao, Henry K F Mak, Edward S Hui
Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all adults over 60 years old develop small vessel disease (SVD). The fact that a wide range of neuropathologies could only explain up to 43% of the variation in age-related cognitive impairment suggests that other factors, such as cognitive reserve, may play a role in the brain's resilience against aging-related cognitive decline. This study aims to examine the relationship between structural-functional-connectivity coupling (SFC), and aging, cognitive abilities and reserve, and SVD-related neuropathologies using a cohort of n = 176 healthy elders from the Harvard Aging Brain Study...
March 6, 2024: GeroScience
#36
JOURNAL ARTICLE
Yinqiong Huang, Siyun Wang, Chi Cai, Xinwei Huang, Yan Chen, Xiaohong Wu, Yiping Zhang, Yan Zhang, Xiahong Lin
AIM: The retina and brain share similar anatomical and physiological features. Thus, retinal imaging by optical coherence tomography angiography (OCTA) might be a potential tool for the early diagnosis of diabetic cerebral small vessel disease (CSVD). In this study, we aimed to evaluate retinal vascular density (VD) in diabetic CSVD by OCTA imaging and explore the associations between retinal VD and cerebral magnetic resonance imaging (MRI) markers and cognitive function. METHODS: In total, 131 patients were enrolled, including CSVD (n = 43) and non-CSVD groups (n = 88)...
March 4, 2024: Diabetes, Obesity & Metabolism
#37
JOURNAL ARTICLE
Chu-Yun Xiao, Ya-Hui Ma, Yong-Li Zhao, Jia-Yao Liu, Lan Tan
This study explored the associations between peripheral immunity with cerebral small vessel diseases. Older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative were investigated. Peripheral blood was obtained, and magnetic resonance imaging was performed to measure cerebral microbleeds (CMB), lacunar infarctions (LI), and white matter hyperintensities (WMH). Multivariable-adjusted regression models, linear mixed-effects models, and the Spearman correlations were used to evaluate the associations...
February 16, 2024: Neurobiology of Aging
#38
JOURNAL ARTICLE
Wenhua Zhang, Ruiming Wang, Fangying Shi
OBJECTIVE: The purpose of this study is to the relationship between peripheral apolipoproteins and cerebral small vessel disease (CSVD) imaging markers. METHODS: We reviewed the data of a population that above 40 years old with CSVD, while free of known dementia or acute stroke. We evaluated CSVD imaging markers, including white matter hyperintensities (WMHs), enlarged perivascular spaces (EPVS), lacunas, microbleeds by MRI scans, and measured peripheral apolipoproteins...
February 20, 2024: Clinical Neurology and Neurosurgery
#39
REVIEW
Shuqian Man, Songkuan Chen, Zhihua Xu, Hongxia Zhang, Zhenyu Cao
BACKGROUND: Microcirculatory variations have been observed in the normal-appearing white matter (NAWM) of individuals affected by cerebral small vessel disease (CSVD). These variations collectively possess the potential to trigger neuroinflammation and edema, ultimately leading to an elevation in extracellular fluid (ECF). Nevertheless, the specific alterations in ECF within the NAWM of CSVD patients have remained inadequately understood. METHODS: We reviewed the clinical and imaging characteristics of a cohort comprising 129 patients diagnosed with CSVD to investigate alterations in the ECF within NAWM...
February 22, 2024: Journal of Integrative Neuroscience
#40
REVIEW
Liu-Yun Wu, Yuek Ling Chai, Irwin K Cheah, Rachel S L Chia, Saima Hilal, Thiruma V Arumugam, Christopher P Chen, Mitchell K P Lai
Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, in vivo visualization of cerebral vasculature abnormities and detection of CSVD, including lacunes, microinfarcts, microbleeds and white matter lesions, is now possible, but remains a resource-, skills- and time-intensive approach...
March 2024: Ageing Research Reviews
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
