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Cerebral microbleeds

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https://www.readbyqxmd.com/read/28208146/serum-lipid-fractions-and-cerebral-microbleeds-in-a-healthy-japanese-population
#1
Shingo Mitaki, Atsushi Nagai, Hiroaki Oguro, Shuhei Yamaguchi
BACKGROUND: Cerebral microbleeds (CMBs) are associated with focal hemosiderin deposits and represent a form of cerebral small vessel disease. To date, indefinite and inconsistent reports are available regarding the association between serum lipid fractions and CMBs. In addition, these previous studies did not include Asian populations, who may have a higher risk of cerebral hemorrhage. The purpose of this study was to examine the associations between serum lipid fractions and CMBs in healthy Japanese subjects...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28207801/kidney-dysfunction-and-cerebral-microbleeds-in-neurologically-healthy-adults
#2
Sang Hyuck Kim, Dong Wook Shin, Jae Moon Yun, Ji Eun Lee, Jae-Sung Lim, Be Long Cho, Hyung-Min Kwon, Jin-Ho Park
INTRODUCTION: Cerebral microbleed (CMB) is a potent risk factor for overt cerebrovascular disease. Although some studies indicated the possible role of renal dysfunction as a risk factor of CMB, the findings could not be generalized. This study aimed to investigate the association between renal dysfunction and cerebral microbleed (CMB) in neurologically healthy adults. MATERIALS AND METHODS: A total of 2,518 subjects who underwent brain MRI as part of health screening were involved in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28202831/-development-of-intracerebral-hemorrhage-and-subarachnoid-hemorrhage-shortly-after-cerebral-infarction-onset-in-an-adult-patient-with-moyamoya-disease
#3
Jun Yoshida, Yoshitaka Kubo, Kenji Yoshida, Kohei Chida, Masakazu Kobayashi, Kuniaki Ogasawara
Here we describe the case of a patient with moyamoya disease who developed cerebral infarction followed shortly by subarachnoid hemorrhage and intracerebral hemorrhage. A 50-year-old woman presenting with sudden and transient weakness of the left lower limb was transferred to a local hospital. Magnetic resonance imaging(MRI)revealed cerebral infarction in the corpus callosum and in the bilateral frontal lobes induced by moyamoya disease. Pyramidal tract was not affected. The patient was treated with an anti-platelet agent(ozagrel sodium 160mg/day)and did not undergo intentional antihypertensive therapy...
February 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28178408/epidemiology-risk-factors-and-clinical-features-of-intracerebral-hemorrhage-an-update
#4
REVIEW
Sang Joon An, Tae Jung Kim, Byung-Woo Yoon
Intracerebral hemorrhage (ICH) is the second most common subtype of stroke and a critical disease usually leading to severe disability or death. ICH is more common in Asians, advanced age, male sex, and low- and middle-income countries. The case fatality rate of ICH is high (40% at 1 month and 54% at 1 year), and only 12% to 39% of survivors can achieve long-term functional independence. Risk factors of ICH are hypertension, current smoking, excessive alcohol consumption, hypocholesterolemia, and drugs. Old age, male sex, Asian ethnicity, chronic kidney disease, cerebral amyloid angiopathy (CAA), and cerebral microbleeds (CMBs) increase the risk of ICH...
January 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28169884/mri-progression-of-cerebral-small-vessel-disease-and-cognitive-decline-in-patients-with-hypertension
#5
Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W de Leeuw, Abraham A Kroon, Robert J van Oostenbrugge
OBJECTIVE: Hypertension is associated with cognitive deficits, probably because it is a major risk factor for the development of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds, which are MRI markers of cerebral small vessel disease. Studies into associations between presence or progression of these MRI markers and cognitive decline in hypertensive patients are rare. We investigated the association of baseline presence and progression of MRI markers of cerebral small vessel disease with cognitive decline over 4 years in patients with hypertension...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28158198/cerebral-microbleeds-in-a-neonatal-rat-model
#6
Brianna Carusillo Theriault, Seung Kyoon Woo, Jason K Karimy, Kaspar Keledjian, Jesse A Stokum, Amrita Sarkar, Turhan Coksaygan, Svetlana Ivanova, Volodymyr Gerzanich, J Marc Simard
BACKGROUND: In adult humans, cerebral microbleeds play important roles in neurodegenerative diseases but in neonates, the consequences of cerebral microbleeds are unknown. In rats, a single pro-angiogenic stimulus in utero predisposes to cerebral microbleeds after birth at term, a time when late oligodendrocyte progenitors (pre-oligodendrocytes) dominate in the rat brain. We hypothesized that two independent pro-angiogenic stimuli in utero would be associated with a high likelihood of perinatal microbleeds that would be severely damaging to white matter...
2017: PloS One
https://www.readbyqxmd.com/read/28157096/only-white-matter-hyperintensities-predicts-post-stroke-cognitive-performances-among-cerebral-small-vessel-disease-markers-results-from-the-tabasco-study
#7
Jeremy Molad, Efrat Kliper, Amos D Korczyn, Einor Ben Assayag, Dafna Ben Bashat, Shani Shenhar-Tsarfaty, Orna Aizenstein, Ludmila Shopin, Natan M Bornstein, Eitan Auriel
BACKGROUND: White matter hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA). However, WMH are only one among other radiological markers of cerebral small vessel disease (SVD). OBJECTIVE: The aim of this study was to determine whether adding other SVD markers to WMH improves prediction of post-stroke cognitive performances. METHODS: Consecutive first-ever stroke or TIA patients (n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) study were enrolled...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28154972/convexity-subarachnoid-haemorrhage-has-a-high-risk-of-intracerebral-haemorrhage-in-suspected-cerebral-amyloid-angiopathy
#8
D Wilson, I C Hostettler, G Ambler, G Banerjee, H R Jäger, D J Werring
The risk of future symptomatic intracerebral haemorrhage (sICH) remains uncertain in patients with acute convexity subarachnoid haemorrhage (cSAH) associated with suspected cerebral amyloid angiopathy (CAA). We assessed the risk of future sICH in patients presenting to our comprehensive stroke service with acute non-traumatic cSAH due to suspected CAA, between 2011 and 2016. We conducted a systematic search and pooled analysis including our cohort and other published studies including similar cohorts. Our hospital cohort included 20 patients (mean age 69 years; 60% male); 12 (60%) had probable CAA, and 6 (30%) had possible CAA according to the modified Boston criteria; two did not meet CAA criteria because of age <55 years, but were judged likely to be due to CAA...
February 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28145796/identification-of-neurovascular-changes-associated-with-cerebral-amyloid-angiopathy-from-subject-specific-hemodynamic-response-functions
#9
Rebecca J Williams, Bradley G Goodyear, Stefano Peca, Cheryl R McCreary, Richard Frayne, Eric E Smith, G Bruce Pike
Cerebral amyloid angiopathy (CAA) is a small-vessel disease preferentially affecting posterior brain regions. Recent evidence has demonstrated the efficacy of functional MRI in detecting CAA-related neurovascular injury, however, it is unknown whether such perturbations are associated with changes in the hemodynamic response function (HRF). Here we estimated HRFs from two different brain regions from block design activation data, in light of recent findings demonstrating how block designs can accurately reflect HRF parameter estimates while maximizing signal detection...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28143923/cerebral-microbleeds-as-predictors-of-mortality-the-framingham-heart-study
#10
José R Romero, Sarah R Preis, Alexa Beiser, Jayandra J Himali, Ashkan Shoamanesh, Philip A Wolf, Carlos S Kase, Vasan S Ramachandran, Charles DeCarli, Sudha Seshadri
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMB) represent a common magnetic resonance imaging marker of cerebral small vessel disease, increasingly recognized as a subclinical marker of stroke and dementia risk. CMB detection may reflect the cumulative effect of vascular risk burden and be a marker of higher mortality. We investigated the relation of CMB to risk of death in community dwelling participants free of stroke and dementia. METHODS: We evaluated 1963 Framingham Original and Offspring Cohort participants (mean age 67 years; 54% women) with available brain magnetic resonance imaging and mortality data...
January 31, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28130469/small-vessel-disease-burden-in-cerebral-amyloid-angiopathy-without-symptomatic-hemorrhage
#11
Gregoire Boulouis, Andreas Charidimou, Michael J Jessel, Li Xiong, Duangnapa Roongpiboonsopit, Panagiotis Fotiadis, Marco Pasi, Alison Ayres, M Emily Merrill, Kristin M Schwab, Jonathan Rosand, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
OBJECTIVE: Cerebral amyloid angiopathy (CAA) is a common age-related small vessel disease (SVD). Patients without intracerebral hemorrhage (ICH) typically present with transient focal neurologic episodes (TFNEs) or cognitive symptoms. We sought to determine if SVD lesion burden differed between patients with CAA first presenting with TFNEs vs cognitive symptoms. METHODS: A total of 647 patients presenting either to a stroke department (n = 205) or an outpatient memory clinic (n = 442) were screened for eligibility...
January 27, 2017: Neurology
https://www.readbyqxmd.com/read/28126551/exploring-the-origins-of-echo-time-dependent-quantitative-susceptibility-mapping-qsm-measurements-in-healthy-tissue-and-cerebral-microbleeds
#12
Matthew J Cronin, Nian Wang, Kyle S Decker, Hongjiang Wei, Wen-Zhen Zhu, Chunlei Liu
Quantitative susceptibility mapping (QSM) is increasingly used to measure variation in tissue composition both in the brain and in other areas of the body in a range of disease pathologies. Although QSM measurements were originally believed to be independent of the echo time (TE) used in the gradient-recalled echo (GRE) acquisition from which they are derived; recent literature (Sood et al., 2016) has shown that these measurements can be highly TE-dependent in a number of brain regions. In this work we systematically investigate possible causes of this effect through analysis of apparent frequency and QSM measurements derived from data acquired at multiple TEs in vivo in healthy brain regions and in cerebral microbleeds (CMBs); QSM data acquired in a gadolinium-doped phantom; and in QSM data derived from idealized simulated phase data...
January 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/28122904/evolution-of-cerebral-microbleeds-after-cranial-irradiation-in-medulloblastoma-patients
#13
Duangnapa Roongpiboonsopit, Hugo J Kuijf, Andreas Charidimou, Li Xiong, Anastasia Vashkevich, Sergi Martinez-Ramirez, Helen A Shih, Corey M Gill, Anand Viswanathan, Jorg Dietrich
OBJECTIVE: To characterize the temporal and spatial pattern of cerebral microbleeds (CMBs) after cranial irradiation in patients with medulloblastoma. METHODS: We retrospectively identified patients with medulloblastoma treated with craniospinal irradiation at the Massachusetts General Hospital between 1999 and 2015. Longitudinal MRI including T2*-weighted gradient-recalled echo (GRE) sequences were reviewed, and the prevalence, spatial pattern, and risk factors associated with CMBs were characterized...
January 25, 2017: Neurology
https://www.readbyqxmd.com/read/28104729/neurologic-outcomes-after-early-surgery-for-infective-endocarditis-in-patients-with-combined-cerebral-septic-embolism
#14
Do Yeon Kim, Hwan Wook Kim, Keon Hyon Jo
OBJECTIVES: This study followed the results of any development of neurologic outcomes according to the presence or absence of cerebral stroke in infective endocarditis patients after early cardiac surgery. We also analysed the neurologic outcomes regardless of cerebral microbleeds in cerebral embolic patients after cardiac surgery. METHODS: We retrospectively studied 55 patients with left-sided infective endocarditis who underwent early surgery and hospitalization between May 2010 and May 2015...
January 18, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28095899/what-is-the-relationship-between-type-2-diabetes-mellitus-status-and-the-neuroradiological-correlates-of-cerebral-small-vessel-disease-in-adults-protocol-for-a-systematic-review
#15
Clark Funnell, Mary M Doyle-Waters, Samuel Yip, Thalia Field
BACKGROUND: Cerebral small vessel disease (CSVD) is a common cause of stroke, dementia, and functional decline. In recent years, neuroradiologic correlates of CSVD have been identified. These imaging findings, best characterized on magnetic resonance imaging (MRI), include some combination of white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and cerebral atrophy. Though some cohorts have reported that participants with type 2 diabetes mellitus (T2DM), an important risk factor for CSVD, may have a distinct neuroradiologic phenotype, this relationship is not well-characterized...
January 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28089561/characterizing-deep-white-matter-hyperintensities-in-patients-with-symptomatic-isolated-cortical-superficial-siderosis
#16
Dimitri Renard, Lavinia Tatu, Christophe Demattei, Christophe Hirtz, Sylvain Lehmann, Eric Thouvenot
BACKGROUND: In patient with cerebral amyloid angiopathy (CAA) presenting with lobar hemorrhage (LH), magnetic resonance imaging (MRI) white matter hyperintensities (WMH) tend to be predominant in posterior regions with the "multiple subcortical spots" WMH pattern as the most frequent topographical WMH pattern. Our aim was to analyze WMH severity and topographical distribution in patients with cortical superficial siderosis (CSS). METHODS: We retrospectively analyzed MRIs from consecutive symptomatic isolated (i...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28089254/volumetric-analysis-of-carotid-plaque-components-and-cerebral-microbleeds-a-correlative-study
#17
Luca Saba, Roberto Sanfilippo, Michele di Martino, Michele Porcu, Roberto Montisci, Pierleone Lucatelli, Michele Anzidei, Marco Francone, Jasjit S Suri
PURPOSE: The purpose of this work was to explore the association between carotid plaque volume (total and the subcomponents) and cerebral microbleeds (CMBs). MATERIALS AND METHODS: Seventy-two consecutive (male 53; median age 64) patients were retrospectively analyzed. Carotid arteries were studied by using a 16-detector-row computed tomography scanner whereas brain was explored with a 1.5 Tesla system. CMBs were studied using a T2*-weighted gradient-recalled echo sequence...
January 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#18
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28065404/cerebral-microbleeds-and-risk-of-intracerebral-hemorrhage-post-intravenous-thrombolysis
#19
Ramin Zand, Georgios Tsivgoulis, Mantinderpreet Singh, Michael McCormack, Nitin Goyal, Muhammad Fawad Ishfaq, Reza Bavarsad Shahripour, Katherine Nearing, Lucas Elijovich, Anne W Alexandrov, David S Liebeskind, Andrei V Alexandrov
BACKGROUND: Stroke patients who have cerebral micro bleeds (CMBs) could be potentially at a greater risk for symptomatic intracerebral hemorrhage (sICH) than those patients without CMBs. The aim of our study was to investigate whether the presence and burden of CMBs are associated with post IVT sICH. METHODS: In this multicenter study, consecutive patients treated with intravenous tissue plasminogen activator were prospectively identified and analyzed. Patients without magnetic resonance imaging (MRI) within 24 hours of treatment were excluded...
January 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28062861/incidence-locations-and-longitudinal-course-of-cerebral-microbleeds-in-european-moyamoya
#20
Holger Wenz, Ralf Wenz, Máté Maros, Gregory Ehrlich, Mansour Al-Zghloul, Christoph Groden, Alex Förster
BACKGROUND AND PURPOSE: Cerebral microbleeds (cMBs) have previously been linked with especially high incidence in Asian patients with moyamoya together with high tendency to bleed. This, presumably, is characteristic of patients with moyamoya. Herein, we, therefore, investigate retrospectively the frequency, location, and longitudinal course of cMBs in a large German cohort. METHODS: We included all patients with moyamoya who underwent standard magnetic resonance imaging, including T2*-weighted images, in our department between 1998 and 2015...
January 6, 2017: Stroke; a Journal of Cerebral Circulation
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