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Breast cancer MRI, mass segmentation

Harini Veeraraghavan, Brittany Z Dashevsky, Natsuko Onishi, Meredith Sadinski, Elizabeth Morris, Joseph O Deasy, Elizabeth J Sutton
We present a segmentation approach that combines GrowCut (GC) with cancer-specific multi-parametric Gaussian Mixture Model (GCGMM) to produce accurate and reproducible segmentations. We evaluated GCGMM using a retrospectively collected 75 invasive ductal carcinoma with ERPR+ HER2- (n = 15), triple negative (TN) (n = 9), and ER-HER2+ (n = 57) cancers with variable presentation (mass and non-mass enhancement) and background parenchymal enhancement (mild and marked). Expert delineated manual contours were used to assess the segmentation performance using Dice coefficient (DSC), mean surface distance (mSD), Hausdorff distance, and volume ratio (VR)...
March 19, 2018: Scientific Reports
J J Zhang, X T Yang, X S Du, J X Zhang, L N Hou, J L Niu
Objective: To investigate the magnetic resonance imaging (MRI) findings and clinicopathological features of primary lesions in patients with occult breast cancer (OBC). Methods: The imaging reports from the Breast Imaging Reporting and Data System in 2013 were retrospectively analyzed to investigate the morphology and the time signal intensity curve (TIC) of breast lesions in patients with OBC. The clinical and pathological characteristics of these patients were also included. Results: A total of 34 patients were enrolled...
January 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Sona A Chikarmane, Aya Y Michaels, Catherine S Giess
OBJECTIVE: The purpose of this study is to assess the frequency of reclassification of nonmass enhancement (NME) as background parenchymal enhancement (BPE) and to determine positive predictive values (PPVs) of NME descriptors using the revised BI-RADS atlas. MATERIALS AND METHODS: A retrospective review of our institution's MRI database from January 1, 2009, through March 30, 2012, identified 6220 contrast-enhanced breast MRI examinations. All findings prospectively assessed as NME and rated as BI-RADS categories 3, 4, and 5 (n = 386) were rereviewed in consensus by two radiologists who were blinded to pathologic findings with the fifth edition of the BI-RADS lexicon...
November 2017: AJR. American Journal of Roentgenology
Füsun Taşkın, Aykut Soyder, Ahmet Tanyeri, Veli Süha Öztürk, Alparslan Ünsal
PURPOSE: We aimed to assess the effectiveness of magnetic resonance imaging (MRI)-guided vacuum-assisted breast biopsy (VABB), evaluate and compare the characteristics and histopathologic findings of lesions, and overview the follow-up results of benign lesions. METHODS: MRI findings and histopathologic results of breast lesions biopsied by MRI-guided VABB between 2013 and 2016 were retrospectively analyzed. MRI findings closely related with malignancy were investigated in particular...
September 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
A J Maxwell, Y Y Lim, E Hurley, D G Evans, A Howell, S Gadde
AIM: To determine the frequency of and reasons for false-negative breast magnetic resonance imaging (MRI) examinations in high-risk women undergoing annual screening. MATERIALS AND METHODS: The family history clinic database was interrogated and women at high risk of breast cancer who had undergone screening MRI and been diagnosed with breast cancer within 2 years of the MRI examination were identified. All available MRI examinations were reviewed and classified by two radiologists...
March 2017: Clinical Radiology
Necdet Poyraz, Ganime Dilek Emlik, Abdussamet Batur, Ebubekir Gundes, Suat Keskin
BACKGROUND: Granulomatous mastitis is a rare and benign inflammatory breast disease that may clinically and radiologically mimic breast cancer. OBJECTIVES: The aim of this study was to evaluate the features of idiopathic granulomatous mastitis (IGM) on breast magnetic resonance imaging (MRI) with mammographic and sonographic findings. PATIENTS AND METHODS: A retrospective analysis was conducted on 20 patients with IGM who had been diagnosed by needle core or excisional biopsy at a single institution between 2006 and 2012...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Ravza Yilmaz, Ali Aslan Demir, Atilla Kaplan, Dilek Sahin, Enver Ozkurt, Memduh Dursun, Gulden Acunas
PURPOSE: To identify the magnetic resonance imaging (MRI) appearance of idiopathic granulomatous mastitis, and the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) in distinguishing idiopathic granulomatous mastitis (IGM) from malignant breast lesions. MATERIAL AND METHODS: A total of 37 women (mean age 36 + 8; range 20-67 years) with histopathologic diagnoses of idiopathic granulomatous mastitis were enrolled in the study. Five patients had bilateral IGM, which were evaluated as ten cases...
November 2016: La Radiologia Medica
Yun Hee Cho, Kyu Ran Cho, Eun Kyung Park, Bo Kyoung Seo, Ok Hee Woo, Sung Bum Cho, Jeoung Won Bae
BACKGROUND: In preoperative assessment of breast cancer, MRI has been shown to identify more additional breast lesions than are detectable using conventional imaging techniques. The characterization of additional lesions is more important than detection for optimal surgical treatment. Additional breast lesions can be included in focus, mass, and non-mass enhancement (NME) on MRI. According to the fifth edition of the breast imaging reporting and data system (BI-RADS®), which includes several changes in the NME descriptors, few studies to date have evaluated NME in preoperative assessment of breast cancer...
January 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Peng Gu, Won-Mean Lee, Marilyn A Roubidoux, Jie Yuan, Xueding Wang, Paul L Carson
Segmentation of an ultrasound image into functional tissues is of great importance to clinical diagnosis of breast cancer. However, many studies are found to segment only the mass of interest and not all major tissues. Differences and inconsistencies in ultrasound interpretation call for an automated segmentation method to make results operator-independent. Furthermore, manual segmentation of entire three-dimensional (3D) ultrasound volumes is time-consuming, resource-intensive, and clinically impractical. Here, we propose an automated algorithm to segment 3D ultrasound volumes into three major tissue types: cyst/mass, fatty tissue, and fibro-glandular tissue...
February 2016: Ultrasonics
Lucia Manganaro, Ilaria D'Ambrosio, Silvia Gigli, Francesca Di Pastena, Guglielmo Giraldi, Stefano Tardioli, Marialuisa Framarino, Lucio Maria Porfiri, Laura Ballesio
PURPOSE: Assessing the role of breast MRI compared to galactography in patients with unilateral bloody or serous-bloody nipple discharge. MATERIALS AND METHODS: Retrospective study including 53 unilateral discharge patients who performed galactography and MRI. We evaluated the capability of both techniques in identifying pathology and distinguishing between nonmalignant and malignant lesions. Lesions BIRADS 1/2 underwent follow-up, while the histological examination after surgery has been the gold standard to assess pathology in lesions BIRADS 3/4/5...
2015: BioMed Research International
Albert Gubern-Mérida, Robert Martí, Jaime Melendez, Jakob L Hauth, Ritse M Mann, Nico Karssemeijer, Bram Platel
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly being used for the detection and diagnosis of breast cancer. Compared to mammography, DCE-MRI provides higher sensitivity, however its specificity is variable. Moreover, DCE-MRI data analysis is time consuming and depends on reader expertise. The aim of this work is to propose a novel automated breast cancer localization system for DCE-MRI. Such a system can be used to support radiologists in DCE-MRI analysis by marking suspicious areas...
February 2015: Medical Image Analysis
Fatima Nayeem, Hyunsu Ju, Donald G Brunder, Manubai Nagamani, Karl E Anderson, Tuenchit Khamapirad, Lee-Jane W Lu
Women with high breast density (BD) have a 4- to 6-fold greater risk for breast cancer than women with low BD. We found that BD can be easily computed from a mathematical algorithm using routine mammographic imaging data or by a curve-fitting algorithm using fat and nonfat suppression magnetic resonance imaging (MRI) data. These BD measures in a strictly defined group of premenopausal women providing both mammographic and breast MRI images were predicted as well by the same set of strong predictor variables as were measures from a published laborious histogram segmentation method and a full field digital mammographic unit in multivariate regression models...
2014: International Journal of Breast Cancer
Jacob Levman, Ellen Warner, Petrina Causer, Anne Martel
Cancer screening with magnetic resonance imaging (MRI) is currently recommended for very high risk women. The high variability in the diagnostic accuracy of radiologists analyzing screening MRI examinations of the breast is due, at least in part, to the large amounts of data acquired. This has motivated substantial research towards the development of computer-aided diagnosis (CAD) systems for breast MRI which can assist in the diagnostic process by acting as a second reader of the examinations. This retrospective study was performed on 184 benign and 49 malignant lesions detected in a prospective MRI screening study of high risk women at Sunnybrook Health Sciences Centre...
October 2014: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Joo Yeon Kim, Yun Ju Kim, Sung Hun Kim, Bong Joo Kang, Byung Joo Song
Breast cancer is rare in children and adolescents. In particular, there are very few cases of invasive ductal carcinoma in childhood. We report a case of invasive ductal carcinoma of the breast in a 14-year-old girl presenting as a palpable mass. While the tumor demonstrated a relatively benign appearance on ultrasound, magnetic resonance imaging revealed typical malignant features. Several polymorphisms of single nucleotide variation were observed on gene analysis. The patient underwent breast conserving surgery and received subsequent concurrent chemo-radiation therapy...
November 2014: Pediatric Radiology
Young Ju Lee, Bo Bae Choi, Kwang Sun Suh
BACKGROUND: Invasive cribriform carcinoma (ICC) of the breast is a rare type of invasive carcinoma which shows a favorable prognosis and a lower frequency of axillary nodal metastases. Few imaging findings related to ICC have been reported. PURPOSE: To evaluate imaging findings with multiple imaging techniques in ICC of the breast. MATERIAL AND METHODS: Twenty-eight cases of histopathologically proven ICC of the breast were gathered for this study...
June 2015: Acta Radiologica
Hongmin Cai, Yanxia Peng, Caiwen Ou, Minsheng Chen, Li Li
PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly used for breast cancer diagnosis as supplementary to conventional imaging techniques. Combining of diffusion-weighted imaging (DWI) of morphology and kinetic features from DCE-MRI to improve the discrimination power of malignant from benign breast masses is rarely reported. MATERIALS AND METHODS: The study comprised of 234 female patients with 85 benign and 149 malignant lesions...
2014: PloS One
Kumi Hasegawa, Toshihiro Matsui, Haruhiko Aoyagi, Tsuyoshi Yoshida, Jun Kaneko, Shizuaki Maejima
We report a case of a 55-year-old woman who underwent mastectomy and axillary lymph node dissection for right breast cancer( T2N1cM0) 7 years previously. She had been experiencing chest pain for 1 year. Ultrasonography( US) showed a low echoic mass, 1 cm in diameter, near the rib in the right breast (class 5).Magnetic resonance imaging (MRI) and positron emission tomography( PET)-computed tomography( CT) scans revealed an 8-cm wide, segmentally enhancing soft tissue lesion and enhanced lymph nodes at the right edge of the sternum...
November 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Liqiong Lv, Yun Zhao, Hui Liu, Zhongyi Peng
A 41-year-old female was admitted into hospital due to recurrent abdominal pain with bloating. An enteroscopy was carried out and stenosis in the lower jejunal lumen was identified. This led to a diagnosis of small bowel obstruction caused by inflammation. During the laparotomy, the resection and anastomosis of a narrow segment of small intestine was performed. In combination with the results of immunohistochemical analysis, the postoperative pathology indicated the presence of a poorly differentiated/undifferentiated carcinoma of the small intestine, which was considered to have arisen from breast cancer...
September 2013: Experimental and Therapeutic Medicine
Mai Okubo, Keiichiro Tada, Takayoshi Niwa, Kotoe Nishioka, Eiichi Tsuji, Toshihisa Ogawa, Yasuyuki Seto
BACKGROUND: The management of cancer in the axillary area depends on the etiology of the tumor. CASE REPORT: A 37-year-old woman presented with a 2 cm mass in the axillary fossa. Core needle biopsy revealed adenocarcinoma. There were no abnormal breast findings on physical examination, mammography, or ultrasonography. However, enhanced magnetic resonance imaging (MRI) and positron emission tomography (PET) showed a segmentally-distributed, abnormal area in the upper-outer quadrant, continuous with the axillary mass...
2013: World Journal of Surgical Oncology
Krish Ramachandaran, Sam Aziz, Stephen Phillips, Salman Gohar
SESSION TYPE: Cardiovascular Student/Resident Case Report Posters IPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Neoplastic metastases to the heart and pericardium are more common than primary cardiac tumors. Cardiac metastasis occurs in as many as 22-31% of lung cancer patients. The majority experience pericardial metastasis while myocardial metastasis is described in 5.3-10.6% of patients. Often silent, these are rarely recognized prior to postmortem examination. ECG changes are rare and usually demonstrate non-specific ST and T wave abnormalities...
October 1, 2012: Chest
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