Tiantian Zhang, Yiyang Wang, Youliang Sun, Meiyue Song, Junling Pang, Mingyao Wang, Zhe Zhang, Peiran Yang, Yiling Chen, Xianmei Qi, Huan Zhou, Zhenzong Han, Yanjiang Xing, Ying Liu, Baicun Li, Jiangfeng Liu, Juntao Yang, Jing Wang
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of proteins and play an important role in studying disease mechanisms. To investigate changes in post-translational modifications of proteins in silicosis, combined quantitative proteome, acetylome, and succinylome analyses were performed with lung tissues from silica-injured and healthy mice using liquid chromatography-mass spectrometry...
April 17, 2024: Molecular & Cellular Proteomics: MCP