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https://www.readbyqxmd.com/read/29331007/anaesthetic-management-of-nesidioblastosis-in-two-infants
#1
Muhammad Saad Yousuf, Mohsin Nazir Butt, Fauzia Anis Khan
Nesidioblastosis is the most common cause of non-transient, recurrent and persistent hypoglycaemia in neonates and infants. It is a disorder of diffuse proliferation of beta cells of the pancreas leading to hyperinsulinemia and hypoglycaemia. The main aim is to prevent the severe episodes of hypoglycaemia which can cause damage to the brain and/or mental retardation. In this case report we present two cases of nesidioblastosis and their perioperative anaesthetic course for near-total pancreatectomy. First case was a 7 months old female who had repeated episodes of convulsions since birth...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29330550/a-metabolomics-pilot-study-on-desmoid-tumors-and-novel-drug-candidates
#2
Kelly A Mercier, Mushriq Al-Jazrawe, Raymond Poon, Zachery Acuff, Benjamin Alman
Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F mutations of the beta-catenin encoding gene (CTNNB1). Using broad spectrum metabolomics, differences were investigated between paired normal fibroblast and desmoid tumor cells from affected patients...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330435/beta-catenin-cleavage-enhances-transcriptional-activation
#3
Tatiana Goretsky, Emily M Bradford, Qing Ye, Olivia F Lamping, Tomas Vanagunas, Mary Pat Moyer, Patrick C Keller, Preetika Sinh, Josep M Llovet, Tianyan Gao, Qing-Bai She, Linheng Li, Terrence A Barrett
Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and cancer. Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat552). Biochemical analysis of nuclear extracts from cancer biopsies revealed the existence of low molecular weight (LMW) pβ-Cat552, increased to the exclusion of full size (FS) forms of β-catenin. LMW β-catenin lacks both termini, leaving residues in the armadillo repeat intact...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324234/sphingosine-1-phosphate-mediates-the-therapeutic-effects-of-bone-marrow-mesenchymal-stem-cell-derived-microvesicles-on-articular-cartilage-defect
#4
Chuan Xiang, Kun Yang, Zhiyong Liang, Yulong Wan, Yanwei Cheng, Dong Ma, Heng Zhang, Weiyu Hou, Panfeng Fu
Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular components to target cells, yet their function in disease is just being explored. However, the therapeutic effects of MVs in cartilage injury and degeneration remain unknown. We found MVs contained high levels of sphingosine-1-phosphate (S1P) compared with the original bone marrow mesenchymal stem cells (MSCs). The enrichment of S1P in MVs was mediated by sphingosine kinase 1 (SphK1), but not by sphingosine kinase 2 (SphK2)...
December 15, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29322786/ccaat-enhancer-binding-protein-%C3%AE-promotes-tumor-growth-and-inhibits-apoptosis-in-prostate-cancer-by-methylating-estrogen-receptor-%C3%AE
#5
D Li, J Liu, S Huang, X Bi, B Wang, Q Chen, H Chen, X Pu
The CCAAT enhancer binding protein β (C/EBPβ) is overexpressed at late stages in carcinogenesis of prostate cancer (PCa), suggesting that it could potentially contribute to progression of PCa. Estrogen receptor beta (ERβ) is a tumor suppressor gene in PCa. However, whether C/EBPβ could regulate ERβ by promoter methylation is still poorly understood.In this study, expression levels of C/EBPβ and ERβ in two PC lines (LNCap and PC-3), prostatic epithelial cell line (RWPE-1), forty-eight paired non-cancerous and cancerous peripheral blood samples were examined via qRT-PCR, western blotting and methylation-specific PCR...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321082/long-noncoding-rna-atb-promotes-proliferation-migration-and-invasion-in-bladder-cancer-by-suppressing-microrna-126
#6
Xingquan Zhai, Wei Xu
This study was aimed to explore the biological functions of long non-coding RNA activated by transforming growth factor-beta (lncRNA-ATB) in bladder cancer cells. For the expressions of lncRNA-ATB, miR-126 and KRAS, T24 cells were transfected with their specific vectors/shRNA or mimic/inhibitor. Then, cell viability, migration, invasion and apoptosis, as well as the protein levels of apoptosis-related factors and PI3K/AKT and mTOR signal pathways were measured, respectively. Further, the relationships of lncRNA-ATB and miR-126 or miR-126 and KRAS were analyzed by dual-luciferase report assay...
January 10, 2018: Oncology Research
https://www.readbyqxmd.com/read/29315824/cytokine-secreting-microparticles-engineer-the-fate-and-the-effector-functions-of-t-cells
#7
Fatemeh S Majedi, Mohammad Mahdi Hasani-Sadrabadi, Yoko Kidani, Timothy J Thauland, Alireza Moshaverinia, Manish J Butte, Steven J Bensinger, Louis-S Bouchard
T-cell immunotherapy is a promising approach for cancer, infection, and autoimmune diseases. However, significant challenges hamper its therapeutic potential, including insufficient activation, delivery, and clonal expansion of T-cells into the tumor environment. To facilitate T-cell activation and differentiation in vitro, core-shell microparticles are developed for sustained delivery of cytokines. These particles are enriched by heparin to enable a steady release of interleukin-2 (IL-2), the major T-cell growth factor, over 10+ d...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29306057/the-effects-of-omega-3-and-vitamin-e-co-supplementation-on-parameters-of-mental-health-and-gene-expression-related-to-insulin-and-inflammation-in-subjects-with-polycystic-ovary-syndrome
#8
Mehri Jamilian, Azadeh Shojaei, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Maryam Karamali, Mohsen Taghizadeh, Hamidreza Jamilian, Somayeh Alaeinasab, Sadegh Jafarnejad, Zatollah Asemi
OBJECTIVE: The aim of this study was to evaluate the effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). METHODS: Forty PCOS women were allocated into two groups and treated with 1000mg omega-3 fatty acids plus 400 IU vitamin E supplements (n = 20) or placebo (n = 20) per day for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention...
December 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29304720/the-effect-of-cholesterol-overload-on-mouse-kidney-and-kidney-derived-cells
#9
Shoko Honzumi, Miho Takeuchi, Mizuki Kurihara, Masachika Fujiyoshi, Masashi Uchida, Kenta Watanabe, Takaaki Suzuki, Itsuko Ishii
INTRODUCTION: Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has not been clarified. Therefore, the present study aimed to investigate the influence of cholesterol overload using mouse kidney tissue and kidney-derived cultured cells. METHODS: C57BL/6 mice were fed normal diet (ND) or 1.25% cholesterol-containing high-cholesterol diet (HCD) for 11 weeks, and we used megalin as a proximal tubule marker for immunohistology...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29301269/enhancing-of-osseointegration-with-propolis-loaded-tio%C3%A2-nanotubes-in-rat-mandible-for-dental-implants
#10
Nithideth Somsanith, Yu-Kyoung Kim, Young-Seok Jang, Young-Hee Lee, Ho-Keun Yi, Jong-Hwa Jang, Kyoung-A Kim, Tae-Sung Bae, Min-Ho Lee
TiO₂ nanotubes (TNT) formation is beneficial for improving bone cell-material interaction and drug delivery for Ti dental implants. Among the natural drugs to be installed in TNT, selected propolis has antibacterial and anti-inflammatory properties. It is a resinous natural product which is collected by the honeybees from the various types of plants with their salivary enzymes. This study concludes that TNT loaded with a propolis (PL-TNT-Ti) dental implant has the ability to improve osseointegration. The propolis particles were embedded within the TNT or adhered to the top...
January 1, 2018: Materials
https://www.readbyqxmd.com/read/29301205/effect-of-the-heat-treated-ti6al4v-alloy-on-the-fibroblastic-cell-response
#11
Mercedes Paulina Chávez-Díaz, María Lorenza Escudero-Rincón, Elsa Miriam Arce-Estrada, Román Cabrera-Sierra
Two heat treatments were carried out below (Ti6Al4V800) and above (Ti6Al4V1050) Ti6Al4V beta-phase transformation temperature (980 °C), with the purpose of studying the effect of microstructure on the adhesion and proliferation of fibroblast cells, as well as their electrochemical behavior. These alloys were seeded with 10,000 L929 fibroblast cells and immersed for 7 days in the cell culture at 37 °C, pH 7.40, 5% CO₂ and 100% relative humidity. Cell adhesion was characterized by Scanning Electron Microscopy (SEM) and Electrochemical Impedance Spectroscopy (EIS) techniques...
December 30, 2017: Materials
https://www.readbyqxmd.com/read/29298131/a-systematic-review-of-p53-regulation-of-oxidative-stress-in-skeletal-muscle
#12
Kaitlyn Beyfuss, David A Hood
BACKGROUND: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied stress and thus requires further analysis. METHODS: A systematic review was performed following an electronic search of Pubmed, Google Scholar, and ScienceDirect databases...
January 3, 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29289465/investigating-the-role-of-transcription-factors-of-pancreas-development-in-pancreatic-cancer
#13
REVIEW
Ahmad Abu Turab Naqvi, Gulam Mustafa Hasan, Md Imtaiyaz Hassan
Pancreatic cancer (PC) is the seventh most common cause of cancer-related deaths worldwide that kills more than 300,000 people every year. Prognosis of PC is very poor with a five-year survival rate about 5%. The most common and highly observed type of PC is pancreatic ductal adenocarcinoma (PDAC). It is preceded by the progression of precursor lesions such as Pancreatic Intraepithelial Neoplasia (PanIN), Intraductal Papillary Neoplasm (IPMN) and Mucinous Cystic Neoplasm (MCN). PanIN is the most common among these premalignant lesions...
December 24, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29285014/microrna-503-contribute-to-pancreatic-beta-cell-dysfunction-by-targeting-the-mtor-pathway-in-gestational-diabetes-mellitus
#14
Ke Xu, Dezhi Bian, Lanxiang Hao, Fei Huang, Min Xu, Jie Qin, Yanmei Liu
Loss of pancreatic β cells is involved in pathogenesis of gestational diabetes mellitus (GDM). Recently, several studies have elucidated the connection between microRNAs (miRNAs) and diabetes mellitus (DM), but the role of miRNAs in GDM remains unclear. The aim of this study was to evaluate the potential functions of miRNAs in GDM and to investigate the underlying mechanisms of action. First, we explored the expression profile of miRNAs in placenta tissue from GDM patients using microarray. Validation analysis was performed in peripheral blood specimens using quantitative reverse transcription PCR (qRT-PCR)...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/29284013/creating-a-stem-cell-niche-in-the-inner-ear-using-self-assembling-peptide-amphiphiles
#15
Akihiro J Matsuoka, Zafar A Sayed, Nicholas Stephanopoulos, Eric J Berns, Anil R Wadhwani, Zachery D Morrissey, Duncan M Chadly, Shun Kobayashi, Alexandra N Edelbrock, Tomoji Mashimo, Charles A Miller, Tammy L McGuire, Samuel I Stupp, John A Kessler
The use of human embryonic stem cells (hESCs) for regeneration of the spiral ganglion will require techniques for promoting otic neuronal progenitor (ONP) differentiation, anchoring of cells to anatomically appropriate and specific niches, and long-term cell survival after transplantation. In this study, we used self-assembling peptide amphiphile (PA) molecules that display an IKVAV epitope (IKVAV-PA) to create a niche for hESC-derived ONPs that supported neuronal differentiation and survival both in vitro and in vivo after transplantation into rodent inner ears...
2017: PloS One
https://www.readbyqxmd.com/read/29275517/sarsasapogenin-suppresses-a%C3%AE-overproduction-induced-by-high-glucose-in-ht-22-cells
#16
Meng-Ya Zhang, Yu Li, Shen-Yuan Yin, Li Kong, Xiao-Li Liu, Xiao-Xing Yin, Yao-Wu Liu
The aim of this study is to investigate effects and potential mechanisms of sarsasapogenin (Sar), an active component purified from Rhizoma Anemarrhenae, on high glucose-induced amyloid-beta (Aβ) peptide overproduction in HT-22 cells. HT-22 cells were divided into normal glucose; high glucose (HG); HG co-treated with low, middle, and high concentration of Sar (1, 5, 25 μmol/L); and peroxisome proliferator-activated receptor γ (PPARγ) agonist (10 μmol/L pioglitazone). After treatment for 24 h, protein expression of Aβ and β-site Aβ precursor protein cleaving enzyme 1 (BACE1) and activated PPARγ level were determined by Western blot; Aβ42 levels were also measured by using both immunofluorescence and ELISA methods...
December 23, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29274868/galectin-3-mediates-tumor-cell-stroma-interactions-by-activating-pancreatic-stellate-cells-to-produce-cytokines-via-integrin-signaling
#17
Wei Zhao, Jaffer A Ajani, Guha Sushovan, N Ochi, Rosa Hwang, Margarete Hafley, Randy L Johnson, Robert S Bresalier, Craig D Logsdon, Zhiqian Zhang, Shumei Song
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is characterized by activated pancreatic stellate cells (PSCs), abundance of extracellular matrix (ECM), and production of cytokines and chemokines. Galectin 3 (GAL3), a β galactoside-specific lectin, contributes to PDAC development but its effects on the stroma and cytokine production are unclear. METHODS: The effect of recombinant human GAL3 (rGAL3) on activation of PSC, production of cytokines, and ECM proteins were determined by proliferation, invasion, cytokine array, and quantitative PCR...
December 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29274352/oxytocin-is-present-in-islets-and-plays-a-role-in-beta-cell-function-and-survival
#18
Shruti Mohan, Dawood Khan, R Charlotte Moffett, Nigel Irwin, Peter R Flatt
Oxytocin is associated mainly with modulating reproductive function. However, studies suggest that oxytocin also plays a role in endocrine pancreatic function. In the present study, islet expression of oxytocin and its related receptor was confirmed in mouse islets as well as cultured rodent and human beta-cells. Oxytocin significantly stimulated glucose-induced insulin secretion from isolated mouse islets. Similar insulinotropic actions were also observed in rodent BRIN BD11 and human 1.1B4 beta-cells. Positive effects of oxytocin on insulin secretion were almost fully annulled by the oxytocin receptor antagonist, atosiban...
December 20, 2017: Peptides
https://www.readbyqxmd.com/read/29259721/characterization-of-polydactyly-derived-chondrocyte-sheets-versus-adult-chondrocyte-sheets-for-articular-cartilage-repair
#19
Miki Maehara, Masato Sato, Eriko Toyoda, Takumi Takahashi, Eri Okada, Tomomi Kotoku, Masahiko Watanabe
Background: We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However, regenerative medicine with autologous chondrocyte sheets requires the harvesting of tissue from healthy regions, and the quality of this tissue varies between individuals. To overcome such limitations, allogeneic transplantation is a promising treatment method, particularly for articular cartilage repair...
2017: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29259085/a-specialized-peptidoglycan-synthase-promotes-salmonella-cell-division-inside-host-cells
#20
Sónia Castanheira, Juan J Cestero, Gadea Rico-Pérez, Pablo García, Felipe Cava, Juan A Ayala, M Graciela Pucciarelli, Francisco García-Del Portillo
Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts. We discovered in Salmonella enterica serovar Typhimurium a gene absent in nonpathogenic bacteria and encoding a peptidoglycan synthase with 63% identity to penicillin-binding protein 3 (PBP3). PBP3 is an essential cell division-specific peptidoglycan synthase that builds the septum required to separate daughter cells...
December 19, 2017: MBio
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