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Breast cancer, MRI, imaging processing

Spiros A Kostopoulos, Katerina G Vassiou, Eleftherios N Lavdas, Dionisis A Cavouras, Ioannis K Kalatzis, Pantelis A Asvestas, Dimitrios L Arvanitis, Ioannis V Fezoulidis, Dimitris T Glotsos
Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with gadolinium constitutes one of the most promising protocols for boosting up the sensitivity in breast cancer detection. The aim of this study was twofold: first to design an image processing methodology to estimate the vascularity of the breast region in DCE-MRI images and second to investigate whether the differences in the composition/texture and vascularity of normal, benign and malignant breasts may serve as potential indicators regarding the presence of the disease...
August 26, 2016: Magnetic Resonance Imaging
Sarah Vinnicombe
Magnetic resonance imaging (MRI) of the breast is the most sensitive imaging technique for the diagnosis and local staging of primary breast cancer and yet, despite the fact that it has been in use for 20 years, there is little evidence that its widespread uncritical adoption has had a positive impact on patient-related outcomes.This has been attributed previously to the low specificity that might be expected with such a sensitive modality, but with modern techniques and protocols, the specificity and positive predictive value for malignancy can exceed that of breast ultrasound and mammography...
2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Lu Wang, Yunwen Yan, Xiaofeng Wang, Longxiang Tao, Quan Chen, Yunpeng Bian, Xiaoxuan He, Yikang Liu, Weiping Ding, Yongqiang Yu, Bensheng Qiu
RATIONALE AND OBJECTIVES: Chemotherapy has many side effects on breast cancer patients, including cognition and other brain functions impairment, which can be studied using functional magnetic resonance imaging (fMRI). Our study aimed at investigating the executive function alternations of breast cancer patients after chemotherapy using resting-state fMRI. MATERIALS AND METHODS: This study included 32 breast cancer patients (BC group) and 24 control subjects (HC group)...
October 2016: Academic Radiology
Hetao Chen, Yu Wang, Tong Wang, Dongxing Shi, Zengrong Sun, Chunhui Xia, Baiqi Wang
Breast cancer (BC) is a serious disease to threat lives of women. Numerous studies have proved that BC originates from cancer stem cells (CSCs). But at present, no one approach can quickly and simply identify breast cancer stem cells (BCSCs) in solid tumor. Nanotechnology is probably able to realize this goal. But in study process, scientists find it seems that nanomaterials with one modality, such as magnetic resonance imaging (MRI) or fluorescence imaging (FI), have their own advantages and drawbacks. They cannot meet practical requirements in clinic...
2016: Journal of Nanobiotechnology
Craig K Abbey, Yirong Wu, Elizabeth S Burnside, Adam Wunderlich, Frank W Samuelson, John M Boone
Breast cancer risk prediction algorithms are used to identify subpopulations that are at increased risk for developing breast cancer. They can be based on many different sources of data such as demographics, relatives with cancer, gene expression, and various phenotypic features such as breast density. Women who are identified as high risk may undergo a more extensive (and expensive) screening process that includes MRI or ultrasound imaging in addition to the standard full-field digital mammography (FFDM) exam...
February 27, 2016: Proceedings of SPIE
Marco Moschetta, Michele Telegrafo, Leonarda Rella, Amato Antonio Stabile Ianora, Giuseppe Angelelli
BACKGROUND: The use of an abbreviated magnetic resonance (MR) protocol has been recently proposed for cancer screening. The aim of our study is to evaluate the diagnostic accuracy of an abbreviated MR protocol combining short TI inversion recovery (STIR), turbo-spin-echo (TSE)-T2 sequences, a pre-contrast T1, and a single intermediate (3 minutes after contrast injection) post-contrast T1 sequence for characterizing breast lesions. MATERIALS AND METHODS: A total of 470 patients underwent breast MR examination for screening, problem solving, or preoperative staging...
June 2016: Clinical Breast Cancer
Koki Kosami, Tsuneaki Kenzaka, Yuka Sagara, Kensuke Minami, Masami Matsumura
BACKGROUND: Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a mild encephalopathy caused by various pathological processes, but encephalopathy due to bacteria is rare. CASE PRESENTATION: We report the case of a 45-year-old Japanese woman who on receiving chemotherapy for advanced breast cancer developed an altered mental status and dysarthria soon after fever from infection of a subcutaneous implantable port. Staphylococcus aureus was detected in her blood cultures...
2016: BMC Infectious Diseases
Sean D Raj, Vivek G Sahani, Beatriz E Adrada, Marion E Scoggins, Constance T Albarracin, Piyanoot Woodtichartpreecha, Flavia E Posleman Monetto, Gary J Whitman
Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign breast condition. PASH is thought to be hormonally responsive, and it is usually identified in premenopausal and perimenopausal women. PASH may also be seen in postmenopausal woman on hormone replacement therapy (HRT). Approximately 53% of patients with PASH present with abnormalities on screening mammography, and 44% of patients with PASH present with palpable abnormalities. On imaging studies, PASH appears similar to fibroadenomas. On mammography, PASH is usually seen as a noncalcified, circumscribed mass...
February 2, 2016: Current Problems in Diagnostic Radiology
Lorena Consolino, Dario Livio Longo, Walter Dastrù, Juan Carlos Cutrin, Daniela Dettori, Stefania Lanzardo, Salvatore Oliviero, Federica Cavallo, Silvio Aime
Tumour progression depends on several sequential events that include the microenvironment remodelling processes and the switch to the angiogenic phenotype, leading to new blood vessels recruitment. Non-invasive imaging techniques allow the monitoring of functional alterations in tumour vascularity and cellularity. The aim of this work was to detect functional changes in vascularisation and cellularity through Dynamic Contrast Enhanced (DCE) and Diffusion Weighted (DW) Magnetic Resonance Imaging (MRI) modalities during breast cancer initiation and progression of a transgenic mouse model (BALB-neuT mice)...
July 15, 2016: International Journal of Cancer. Journal International du Cancer
Louise M Henderson, Mary W Marsh, Thad Benefield, Elizabeth Pearsall, Danielle Durham, Bruce F Schroeder, J Michael Bowling, Cheryl A Viglione, Bonnie C Yankaskas
PURPOSE: Mammography technologists' level of training, years of experience, and feedback on technique may play an important role in the breast-cancer screening process. However, information on the mammography technologist workforce is scant. METHODS: In 2013, we conducted a survey mailed to 912 mammography technologists working in 224 facilities certified by the Mammography Quality Standards Act in North Carolina. Using standard survey methodology, we developed and implemented a questionnaire on the education and training, work experiences, and workplace interactions of mammography technologists...
December 2015: Journal of the American College of Radiology: JACR
Laura C Rose, Deepak K Kadayakkara, Guan Wang, Amnon Bar-Shir, Brooke M Helfer, Charles F O'Hanlon, Dara L Kraitchman, Ricardo L Rodriguez, Jeff W M Bulte
UNLABELLED: Stromal vascular fraction (SVF) cells are used clinically for various therapeutic targets. The location and persistence of engrafted SVF cells are important parameters for determining treatment failure versus success. We used the GID SVF-1 platform and a clinical protocol to harvest and label SVF cells with the fluorinated ((19)F) agent CS-1000 as part of a first-in-human phase I trial ( identifier NCT02035085) to track SVF cells with magnetic resonance imaging during treatment of radiation-induced fibrosis in breast cancer patients...
December 2015: Stem Cells Translational Medicine
D Geffroy, I Doutriaux-Dumoulins
Clinical examination of the nipple is part of normal breast screening procedures. Abnormal processes of benign or malignant nature may be reflected by erythema, erosion, swelling or acquired inversion. In patients presenting with a persistent unilateral nipple lesion, it is advisable to collect a sample to exclude Paget's disease of the nipple, a rare form of ductal carcinoma in situ (DCIS). Imaging should be performed to detect breast cancer, which is found in more than 80% of cases, and determine its possible multifocal nature...
October 2015: Diagnostic and Interventional Imaging
F Maxwell, C de Margerie Mellon, M Bricout, E Cauderlier, M Chapelier, M Albiter, P Bourrier, M Espié, E de Kerviler, C de Bazelaire
The nodal status in breast cancer is a major prognostic factor in terms of survival. It also plays a role in the therapeutic decision-making process. Therefore, the evaluation of lymph node involvement in breast cancer is imperative in establishing a personalized treatment scheme. The sentinel lymph node procedure has proved successful for small breast tumors (T1-T2), limiting axillary lymphadenectomy and its side effects without changing overall survival. Even so, a substantial number of women must undergo axillary lymphadenectomy during a second surgery when the analysis of the sentinel node discloses major nodal involvement...
October 2015: Diagnostic and Interventional Imaging
Rubel Chakravarty, Sudipta Chakraborty, Ashutosh Dash
Breast cancer is the leading cause of cancer deaths among women of all ages worldwide. With advances in molecular imaging procedures, it has been possible to detect breast cancer in its early stage, determine the extent of the disease to administer appropriate therapeutic protocol and also monitor the effects of treatment. By accurately characterizing the tumor properties and biological processes involved, molecular imaging can play a crucial role in minimizing the morbidity and mortality associated with breast cancer...
2015: Mini Reviews in Medicinal Chemistry
Jacob E D Levman, Cristina Gallego-Ortiz, Ellen Warner, Petrina Causer, Anne L Martel
Magnetic resonance imaging (MRI)-enabled cancer screening has been shown to be a highly sensitive method for the early detection of breast cancer. Computer-aided detection systems have the potential to improve the screening process by standardizing radiologists to a high level of diagnostic accuracy. This retrospective study was approved by the institutional review board of Sunnybrook Health Sciences Centre. This study compares the performance of a proposed method for computer-aided detection (based on the second-order spatial derivative of the relative signal intensity) with the signal enhancement ratio (SER) on MRI-based breast screening examinations...
February 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Hyunee Yim, Doo Kyoung Kang, Yong Sik Jung, Gyeong Sik Jeon, Tae Hee Kim
OBJECTIVE: Our purpose was to evaluate imaging findings of breast cancers according to the dominant stroma type by using kinetic curve analysis and model-based perfusion parameters from dynamic contrast-enhanced magnetic resonance imaging. METHODS: From March 2011 to September 2011, 64 cancers in 64 patients were included for data analysis. Kinetic curve analysis and model based perfusion parameters (Ktrans, Kep and Ve) were obtained using dynamic contrast-enhanced magnetic resonance imaging and post-processing software...
January 2016: Magnetic Resonance Imaging
Gene Young Cho, Linda Moy, Sungheon G Kim, Ana Paula Klautau Leite, Steven H Baete, James S Babb, Daniel K Sodickson, Eric E Sigmund
OBJECTIVE: To measure background parenchymal enhancement (BPE) and compare with other contrast enhancement values and diffusion-weighted MRI parameters in healthy and cancerous breast tissue at the clinical level. MATERIALS AND METHODS: This HIPAA-compliant, IRB approved retrospective study enrolled 77 patients (38 patients with breast cancer - mean age 51.8 ± 10.0 years; 39 high-risk patients for screening evaluation - mean age 46.3 ± 11.7 years), who underwent contrast-enhanced 3T breast MRI...
October 2015: European Journal of Radiology
Elisabetta Grecchi, Jim O'Doherty, Mattia Veronese, Charalampos Tsoumpas, Gary J Cook, Federico E Turkheimer
UNLABELLED: (18)F-fluoride PET/CT offers the opportunity for accurate skeletal metastasis staging, compared with conventional imaging methods. (18)F-fluoride is a bone-specific tracer whose uptake depends on osteoblastic activity. Because of the resulting increase in bone mineralization and sclerosis, the osteoblastic process can also be detected morphologically in CT images. Although CT is characterized by high resolution, the potential of PET is limited by its lower spatial resolution and the resulting partial-volume effect...
September 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
David K Woolf, Anwar R Padhani, Andreas Makris
The use of imaging in the arena of primary treatment for breast cancer is gaining importance as a technique for assessing response to chemotherapy as well as assessing the underlying tumor biology. Both mammography and ultrasound have traditionally been used, in addition to clinical evaluation, to evaluate response to treatment although they have shed little light on the underlying biological processes. Functional magnetic resonance imaging techniques have the ability to assess response to treatments in addition to providing valuable information on changes in tumor perfusion, vascular permeability, oxygenation, cellularity, proliferation, and metabolism both at baseline and after treatment...
May 2015: Journal of the National Cancer Institute. Monographs
Sanne Menning, Michiel B de Ruiter, Dick J Veltman, V Koppelmans, Clemens Kirschbaum, Willem Boogerd, Liesbeth Reneman, Sanne B Schagen
An increasing body of literature indicates that chemotherapy (ChT) for breast cancer (BC) is associated with adverse effects on the brain. Recent research suggests that cognitive and brain function in patients with BC may already be compromised before the start of chemotherapy. This is the first study combining neuropsychological testing, patient-reported outcomes, and multimodal magnetic resonance imaging (MRI) to examine pretreatment cognition and various aspects of brain function and structure in a large sample...
2015: NeuroImage: Clinical
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